1,385 research outputs found
sj-docx-1-ggm-10.1177_23337214221116233 – Supplemental material for A Scoping Review and Conceptual Framework Examining the Role of Sleep Disturbance in Financial Exploitation in Older Adults
No full textSupplemental material, sj-docx-1-ggm-10.1177_23337214221116233 for A Scoping Review and Conceptual Framework Examining the Role of Sleep Disturbance in Financial Exploitation in Older Adults by Jessica R. Armendariz, S. Duke Han and Constance H. Fung in Gerontology and Geriatric Medicine</p
Analysis of click-evoked otoacoustic emissions by concentration of frequency and time: Preliminary results from normal hearing and Ménière’s disease ears
No full text© 2018 Author(s). The presence of click-evoked (CE) otoacoustic emissions (OAEs) has been clinically accepted as an indicator of normal cochlear processing of sounds. For treatment and diagnostic purposes, however, clinicians do not typically pay attention to the detailed spectrum and waveform of CEOAEs. A possible reason is due to the lack of noise-robust signal processing tools to estimate physiologically meaningful time-frequency properties of CEOAEs, such as the latency of spectral components. In this on-going study, we applied a modern tool called concentration of frequency and time (ConceFT, [1]) to analyze CEOAE waveforms. Randomly combined orthogonal functions are used as windowing functions for time-frequency analysis. The resulting spectrograms are subject to nonlinear time-frequency reassignment so as to enhance the concentration of time-varying sinusoidal components. The results after reassignment could be further averaged across the random choice of windows. CEOAE waveforms are acquired by a linear averaging paradigm, and longitudinal data are currently being collected from patients with Ménière's disease (MD) and a control group of normal hearing subjects. When CEOAE is present, the ConceFT plots show traces of decreasing but fluctuating instantaneous frequency against time. For comparison purposes, same processing methods are also applied to analyze CEOAE data from cochlear mechanics simulation
Men's Appearance and Political Careers in Han China
No full textAbstract
This article examines the connection between appearance and political careers in Han China, discussing what was valued in the physical features, dress, and manners of the men who governed China's first long-lasting empire. Noticing important shifts over the course of the Han, the author argues that the revival of the classical notion of weiyi 威儀 (dignified manners) from the mid-Western Han well into the Eastern Han had important implications for the definition and self-perception of the empire's governing elite. The article closes with an examination of how the Han elite grappled with the problems presented by the deceptiveness of appearance.</jats:p
sj-docx-1-jag-10.1177_07334648221091556 – Supplemental material for Impact of the COVID-19 Pandemic on Older Adult Driving in the United States
No full textSupplemental material, sj-docx-1-jag-10.1177_07334648221091556 for Impact of the COVID-19 Pandemic on Older Adult Driving in the United States by Marian E. Betz, Nicole R. Fowler, S. Duke Han, Linda L. Hill, Rachel L. Johnson, Lauren Meador, Faris Omeragic, Ryan A. Peterson and Carolyn DiGuiseppi in Journal of Applied Gerontology</p
The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population.
No full textBackground: Seventeen loci have been found to be associated with bladder cancer risk by genome-wide association studies (GWAS) in European population. However, little is known about contribution of low-frequency and rare variants to bladder cancer susceptibility, especially in Eastern population. Methods: We performed a three-stage case-control study including 3,399 bladder cancer patients and 4,647 controls to identify low-frequency and rare variants associated with bladder cancer risk in Han Chinese. We examined exome-array data in 1,019 bladder cancer patients and 1,008 controls in discovery stage. Two replication stages were included to validate variants identified. Bonferroni adjustment was performed to define statistical significance. Logistic regression was conducted to evaluate single marker association with bladder cancer risk. We used SKAT-O method to perform gene level-based analysis. We also conduct additional experiments to explore the underlying mechanism of filtered gene(s). Results: We identified a novel rare coding variant (rs35356162 in UHRF1BP1: G > T, OR = 4.332, P = 3.62E-07 < 7.93E-07, Bonferroni cutoff) that increased bladder cancer risk in Han Chinese. Gene-level analysis showed a significant association of UHRF1BP1 (P = 4.47E-03) with bladder cancer risk. Experiments indicated down-regulation of UHRF1BP1 promoted migration and invasion through epithelial-mesenchymal transition in bladder cancer cell lines. Conclusion: The rare variant of UHRF1BP1, rs35356162, increases bladder cancer risk in Han Chinese and UHRF1BP1 might act as a tumor suppressor in bladder cancer development and progression. Summary: Little is known about potential contribution of low-frequency and rare variants to bladder cancer susceptibility. We performed a three-stage case-control study and identified a new rare variant, rs35356162 in UHRF1BP1, which increased bladder cancer risk in Han Chinese
From New London to Norwood: A Year in the Life of Eminent Domain
Get PDFA little more than a year after the U.S. Supreme Court\u27s decision in Kelo v. City of New London upheld the use of eminent domain for economic development, the Ohio Supreme Court became the first state supreme court to address a factual situation raising the same issues. In City of Norwood v. Horney, the Ohio court repudiated the Kelo rationale and rejected Norwood\u27s proposed takings. Property rights advocates quickly hailed Norwood as a model for other state courts to follow in defending individual land owners from eminent domain abuse. This Note argues that Norwood\u27s holding is incoherent and does nothing to resolve the language-based quagmire that inflames the eminent domain debate. This Note instead contends that the Connecticut Supreme Court\u27s more nuanced Kelo v. City of New London opinion is a superior state court model, which better captures the necessary balance between individual property rights and urban revitalization plans involving eminent domain
Author Correction: Federated learning enables big data for rare cancer boundary detection.
Get PDF10.1038/s41467-023-36188-7NATURE COMMUNICATIONS14
Harmine indusces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis
Get PDF© The Author(s) 2016.Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice. However its effect on adipose tissue browning is unknown. Here we reveal that harmine antagonizes high fat diet-induced adiposity. Harmine-treated mice gained less weight on a high fat diet and displayed increased energy expenditure and adipose tissue thermogenesis. In vitro, harmine potently induced the expression of thermogenic genes in both brown and white adipocytes, which was largely abolished by inhibition of RAC1/MEK/ERK pathway. Post-transcriptional modification analysis revealed that chromodomain helicase DNA binding protein 4 (CHD4) is a potential downstream target of harmine-mediated ERK activation. CHD4 directly binds the proximal promoter region of Ucp1, which is displaced upon treatment of harmine, thereby serving as a negative modulator of Ucp1. Thus, here we reveal a new application of harmine in combating obesity via this off-target effect in adipocytes.published_or_final_versio
A Randomized Controlled Trial of Standard Versus Intensified Tuberculosis Diagnostics on Treatment Decisions by Physicians in Northern Tanzania.
Get PDFRoutine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care [unconcentrated acid-fast (AFB) smears] on management of persons with suspected tuberculosis. Adults and children with suspected tuberculosis were randomized to standard (direct AFB smear only) or intensified (concentrated AFB smear and tuberculosis culture) diagnostics and followed for 8 weeks. The primary endpoint was appropriate treatment (i.e. antituberculosis therapy for those with tuberculosis, no antituberculous therapy for those without tuberculosis). Seventy participants were randomized to standard (n = 37, 52.9%) or intensive (n = 33, 47.1%) diagnostics. At 8 weeks, 100% (n = 22) of participants in follow up randomized to intensive diagnostics were receiving appropriate care, vs. 22 (88.0%) of 25 participants randomized to standard diagnostics (p = 0.14). Overall, 18 (25.7%) participants died; antituberculosis therapy was associated with lower mortality (9% who received antiuberculosis treatment died vs. 26% who did not, p = 0.04). Under field conditions in a high burden setting, the impact of intensified diagnostics was blunted by high early mortality. Enhanced availability of rapid diagnostics must be linked to earlier access to care for outcomes to improve
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