588 research outputs found
Alexey Feofilaktovich Pisemsky as dramatist
No full textIf an artist were to reproduce on canvas Pisemsky's Muse, from the evidence of the scattered "objective detailed"
analyses of his critics, the Muse would definitely be the ugliest thing that any author could choose for his "inspirational" source.
The purpose of this study is to illustrate the unfair
position accorded Pisemsky in Russian dramaturgy and to assign him a proper place in Russian drama by fresh evaluation of his abilities as the dramatist.
The Introduction suggests the possible reasons for which Pisemsky was placed in an oblivion. It also argues that the scepticism, which penetrated some of his works, even if it were somewhat peculiar to him in nature, was definitely aroused by the confusing multi-party Russia of the 1860's and 1870's. Chapter One retraces the more important themes in Russian drama in an attempt to place Pisemsky in the tradition.
Chapter Two is a detailed analysis of the lingering critical attitudes toward Pisemsky which claim that his works lacked the revolutionary zeal for improvement of Russia, and that he was not a playwright but an author of
pamphlets.
In Chapter Three an attempt is made to define the main aspects of Pisemsky's art through his letters and views implicit in his plays. It is also suggested in this Chapter that Pisemsky's plays were revolutionary in their own way, and that they were not directed at the "yawning space", but, to people, directed with harsh rebuke, yet with sincere hope in an eventually brighter future. Chapter Four and the Conclusion are devoted to the analyses of his plays in an effort to show that many of them, in their theme, structure, form and other traditional elements of drama, indeed secure him much better place in Russian dramaturgy than hitherto given him.Arts, Faculty ofCentral, Eastern, and Northern European Studies, Department ofGraduat
The presentation of death in L. N. Tolstoy's prose.
No full textThis study treats in detail one of the significant themes of world literature in the narratives of the Russian writer L. N. Tolstoy. The theme of death, its modalities, motifs and related aspects, occur frequently in all of Tolstoy's artistic and philosophical writings. He presents this theme in connection with other dominant themes such as appearance and reality, falsity and truth, the attempts and failures to materialize individuals' objectives, all in various contexts of life--both private and public, and especially military life. The selection of themes such as sexuality, violence, or the transgression of moral laws, also affects the presentation of the theme of death. Instead of focusing on one pair of dominant semantic fields, Tolstoy (in the majority of his narratives) connects several of them equally. There are very few of his works in which one semantic field dominates. In accordance with Realist poetics, Tolstoy presents the theme of death directly; references to death on an allegorical or symbolic level occur in only a few of his narratives. In his early works, Tolstoy varies not only the fundamental modalities, but also the basic modes of violent and natural death. The presentation of a theme in a narrative differs depending on the length of the narrative. In his shorter prose fiction, Tolstoy concentrates the theme of death into specific passages, while its presentation in the longer narratives is distributed throughout the texts. In presenting the various characters, his narrators reveal their philosophies of life, which are particularly apparent in the borderline situation of death and dying. Members of different social classes display, as a rule, contrasting philosophies in revealing their attitudes and reactions--a trend which is again noticeable both in Tolstoy's major prose and in his late narratives. The author's focus on introspection (although in his early prose members of the lower classes are excluded from this technique) continues to play an important role in his late work as well. The author uses typical narrative devices such as anticipation, retrospection, association and paradox in the depiction of this complex theme as he attempts to 'de-romanticize', 'de-sensationalize' and 'de-dramatize' this topic. Despite the general tendency to omit the actual moment of death, there are a few works in which the horror of violent death shocks the reader. As for artistic development in presenting this theme, Tolstoy continues to employ a basic stock of devices and techniques already manifest in his early works
The presentation of death in L. N. Tolstoy's prose.
No full textThis study treats in detail one of the significant themes of world literature in the narratives of the Russian writer L. N. Tolstoy. The theme of death, its modalities, motifs and related aspects, occur frequently in all of Tolstoy's artistic and philosophical writings. He presents this theme in connection with other dominant themes such as appearance and reality, falsity and truth, the attempts and failures to materialize individuals' objectives, all in various contexts of life--both private and public, and especially military life. The selection of themes such as sexuality, violence, or the transgression of moral laws, also affects the presentation of the theme of death. Instead of focusing on one pair of dominant semantic fields, Tolstoy (in the majority of his narratives) connects several of them equally. There are very few of his works in which one semantic field dominates. In accordance with Realist poetics, Tolstoy presents the theme of death directly; references to death on an allegorical or symbolic level occur in only a few of his narratives. In his early works, Tolstoy varies not only the fundamental modalities, but also the basic modes of violent and natural death. The presentation of a theme in a narrative differs depending on the length of the narrative. In his shorter prose fiction, Tolstoy concentrates the theme of death into specific passages, while its presentation in the longer narratives is distributed throughout the texts. In presenting the various characters, his narrators reveal their philosophies of life, which are particularly apparent in the borderline situation of death and dying. Members of different social classes display, as a rule, contrasting philosophies in revealing their attitudes and reactions--a trend which is again noticeable both in Tolstoy's major prose and in his late narratives. The author's focus on introspection (although in his early prose members of the lower classes are excluded from this technique) continues to play an important role in his late work as well. The author uses typical narrative devices such as anticipation, retrospection, association and paradox in the depiction of this complex theme as he attempts to 'de-romanticize', 'de-sensationalize' and 'de-dramatize' this topic. Despite the general tendency to omit the actual moment of death, there are a few works in which the horror of violent death shocks the reader. As for artistic development in presenting this theme, Tolstoy continues to employ a basic stock of devices and techniques already manifest in his early works
The database of the Danish Renal Cancer Group
No full textAstrid Christine Petersen,1 Mette Søgaard,2 Frank Mehnert,2 Erik Højkjær Larsen,3 Frede Donskov,4 Nessn H Azawi,5 Bjarne Kromann-Andersen6 1Department of Pathology, Aalborg University Hospital, Aalborg, 2Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, 3Department of Urology, Odense University Hospital, Odense, 4Department of Oncology, Aarhus University Hospital, Aarhus, 5Department of Urology, Zealand University Hospital, Roskilde, 6Department of Urology, Herlev and Gentofte Hospital, Copenhagen, Denmark Aim of the database: The main purpose of the database of the Danish Renal Cancer Group (DaRenCaData) is to improve the quality of renal cancer treatment in Denmark and secondarily to conduct observational research. Study population: DaRenCaData includes all Danish patients with a first-time diagnosis of renal cancer in the Danish National Pathology Registry since August 1, 2010. Main variables: DaRenCaData holds data on demographic characteristics, treatments, and pathology collected through linkage to central registries and online registration of a few clinical key variables. Eight quality indicators have been selected for monitoring treatment quality and outcome after renal cancer. Descriptive data: The incidence of renal cancer in Denmark has increased from 12.7 per 100,000 population-years in 2010–2011 to 15.9 per 100,000 population-years in 2014–2015. A total of 3,977 Danish patients with renal cancer have been enrolled in the database in the period August 1, 2010–July 31, 2015. The completeness of data registration has increased substantially since the first years of the database. A tendency toward smaller and less advanced tumors, less invasive surgery, and a shorter hospital stay was observed, while the postoperative morbidity and mortality remained stable. Concurrently, the 1-year survival has improved and was 84.1% in 2014–2015. Conclusion: DaRenCaData provides valuable information on quality of and outcome after renal cancer treatment. Efforts to improve collection and registration of data are ongoing. Keywords: kidney cancer, database, clinical quality, indicators, incidence, survival, observational researc
Nivolumab + ipilimumab (N+I) vs sunitinib (S) dans le traitement de première ligne du carcinome rénal avancé (aRCC) dans l’étude CheckMate 214 : suivi à 4 ans et analyse en sous-groupe des patients (pts) non néphrectomisés
No full textObjectifs
Dans la CheckMate 214, N + I était supérieur à S chez les pts de pronostic intermédiaire/défavorable (IP) et chez les pts en ITT. Nous rapportons ici la survie, la réponse selon un comité de revue des examens radiologiques indépendant (IRRC) et la tolérance après 4 ans minimum de suivi, et une analyse exploratoire post-hoc dans un sous-groupe de pts sans néphrectomie préalable présentant une lésion cible au niveau du rein.
Méthodes
Les pts avec aRCC à cellules claires ont été randomisés selon un rapport 1 :1 avec N 3 mg/kg + I 1 mg/kg toutes les 3 semaines × 4 puis N 3 mg/kg toutes les 2 semaines vs S 50 mg par jour pendant 4 semaines, suivi d’une fenêtre thérapeutique de 2 semaines, par cycle. Critères d’évaluation : survie globale (OS), taux de réponse objective (ORR) et survie sans progression (PFS) selon IRRC en utilisant les critères RECIST v1.1 chez les patients IP (primaire), ITT (secondaire) et favorable (FAV ; exploratoire).
Résultats
Une OS supérieure avec N + I vs S était maintenue chez les pts IP (HR 0,65) et ITT (HR 0,69) ; la différence d’OS est restée non significative chez les pts FAV (HR 0,93 ; Tableau 1). L’ORR était plus élevé, avec plus de patients toujours en réponse avec N + I vs S chez les pts IP (65 % vs 50 %) et ITT (65 % vs 52 %). Chez les pts FAV, l’ORR était plus faible avec N + I vs S, mais davantage de réponses étaient en cours (65 % contre 56 %). Le taux de réponse complète (CR) était plus élevé avec N + I v S quel que soit le groupe IMDC (Tableau 1). La PFS était conforme aux rapports précédents. L’incidence des EI liés au traitement de tout grade et de grade ≥ 3 est restée inchangée. Dans le sous-groupe exploratoire de patients non néphrectomisés et avec une lésion cible au niveau rénal, le HR de l’OS (0,63) était cohérent avec celles des pts I/P et ITT ; L’ORR était plus élevé avec N + I vs S (34 % contre 15 %) sans CR dans les deux bras, et le HR de la PFS était de 0,99 (Tableau 1 ; n = 53 contre 55). Une réduction des lésions rénales cibles de ≥ 30 % s’est produite chez 35 % vs 20 % (N + I vs S) des pts.
Conclusion
Après 4 ans de suivi, le bénéfice clinique (OS, ORR) était maintenu avec N + I vs S chez les pts IP et ITT. Les réponses avec N + I étaient durables sans nouveau signal de toxicité. Un rétrécissement des lésions rénales a été observé chez les pts non néphrectomisés traités par N + I, et l’OS dans ce sous-groupe était cohérente avec celle la population globale de l’étude
Living with Advanced Kidney Cancer and Treatment with Cabozantinib: Through the Eyes of the Patient and the Physician
No full textArticle full text
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be found here. https://link.springer.com/article/10.1007/s40487-018-0057-7
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A SoC-FPGA based readout platform for the free-running AMBER data acquisition system
No full textOwing to a change in the scope of physics research, the AMBER spectrometer at CERN is undergoing an update on its instrumentation and trigger strategy for the data acquisition system. One of the key updates is the adoption of a free-running and trigger-less operation, which differs from the predecessor of AMBER, COMPASS, by working in a continuous mode but in an event-based triggered way
What Is Injury in Ice Hockey: An Integrative Literature Review on Injury Rates, Injury Definition, and Athlete Exposure in Men’s Elite Ice Hockey
No full textInjuries in men’s elite ice hockey have been studied over the past 40 years, however, there is a lack of consensus on definitions of both injury and athlete exposure. These inconsistencies compromise the reliability and comparability of the research. While many individual studies report injury rates in ice hockey, we are not aware of any literature reviews that have evaluated the definitions of injury and athlete exposure in men’s elite ice hockey. The purpose of this integrative review was to investigate the literature on hockey musculoskeletal injury to determine injury rates and synthesize information about the definitions of injury and athlete exposure. Injury rates varied from 13.8/1000 game athlete exposures to 121/1000 athlete exposures as measured by player-game hours. The majority of variability between studies is explained by differences in the definitions of both injury and athlete exposure. We were unable to find a consensus injury definition in elite ice hockey. In addition, we were unable to observe a consistent athlete exposure metric. We recommend that a consistent injury definition be adopted to evaluate injury risk in elite ice hockey. We recommend that injuries should be defined by a strict list that includes facial lacerations, dental injuries, and fractures. We also recommend that athlete exposure should be quantified using player-game hours
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