357 research outputs found
Dynamic Simulation of Turbidity and its Correction in Lak Chicot, Arkansas, U.S.A.
No full textLake Chicot is an oxbow lake that was created more than 600 years ago by
the meandering of the Mississippi River. It is located in Chicot County in
southeastern Arkansas adjacent to the present Mississippi River (Fig. 1). As
the largest natural lake in Arkansas, it earned an early reputation for its
good fishing and recreational value.Agricultural Research Service, U.S.D.A.
U.S. Army Corps of Engineers, Vicksburg DistrictStefan, Heinz G.; Dhamotharan, S.; Schiebe, Frank R,; Fu, A. Y.; Cardoni, John J.. (1989). Dynamic Simulation of Turbidity and its Correction in Lak Chicot, Arkansas, U.S.A.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/114132
Cooling Water Intake Manifold (Header) Study For The James H. Campbell Electric Power Generating Plant, Unit No. 3
No full textA seven-junction cooling water intake manifold was studied in a physical
model and by hydraulic analysis. The manifold, also referred to as a "header",
is one of four to be embedded in the bottom of Lake Michigan approximately
3500 ft offshore from the James H. Campbell Plant. Each header supports and
collects water from seven dual screen intake risers (subject of a separate
study). The primary objective of the study was to determine flow contribution
from each of seven risers and piezometric pressures along the header. It was
found that the flow rates ranged from 92 percent to 112 percent of the average
flow per riser. To achieve a higher degree of uniformity, an analysis was
made to determine how much additional headloss had to, be generated in each intake
riser in order to produce identical withdrawal rates in all seven risers.
A similar study was. Made for a partially balanced system where withdrawal rates
would not fall outside the 95 to 105 percent limits. In that case, headloss
generators were required in the two most downstream risers. Sharp edged
nozzles were designed for Risers 6 and 7, and experimentally tested. The total
piezometric pressure change through the partially balanced riser-manifold
system at a total withdrawal rate of 206 cfs was determined to be 13.8 inches
of water relative to the lake. The total energy headloss between the lake and
the downstream end of the manifold was determined to be 10.7 inches of water.Johnson Division UOP Inc., Consumer Power Company, Commonwealth Associates Inc.Stefan, Heinz; Shanmugham, Chitra; Dhamotharan, Dhamo S.. (1979). Cooling Water Intake Manifold (Header) Study For The James H. Campbell Electric Power Generating Plant, Unit No. 3. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/117294
Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation
No full text\ua9 Copyright \ua9 2021 Popova, Wang, Rajavel, Dhamotharan, L\ue1zaro, Gerke, Uhrig, Hoppert, Outeiro and Braus.Aggregation of α-synuclein (αSyn) into proteinaceous deposits is a pathological hallmark of a range of neurodegenerative diseases including Parkinson’s disease (PD). Numerous lines of evidence indicate that the accumulation of toxic oligomeric and prefibrillar αSyn species may underpin the cellular toxicity and spread of pathology between cells. Therefore, aggregation of αSyn is considered a priority target for drug development, as aggregation inhibitors are expected to reduce αSyn toxicity and serve as therapeutic agents. Here, we used the budding yeast S. cerevisiae as a platform for the identification of short peptides that inhibit αSyn aggregation and toxicity. A library consisting of approximately one million peptide variants was utilized in two high-throughput screening approaches for isolation of library representatives that reduce αSyn-associated toxicity and aggregation. Seven peptides were isolated that were able to suppress specifically αSyn toxicity and aggregation in living cells. Expression of the peptides in yeast reduced the accumulation of αSyn-induced reactive oxygen species and increased cell viability. Next, the peptides were chemically synthesized and probed for their ability to modulate αSyn aggregation in vitro. Two synthetic peptides, K84s and K102s, of 25 and 19 amino acids, respectively, significantly inhibited αSyn oligomerization and aggregation at sub-stoichiometric molar ratios. Importantly, K84s reduced αSyn aggregation in human cells. These peptides represent promising αSyn aggregation antagonists for the development of future therapeutic interventions
Transition Due to Aerofoil-Wake Boundary Layer Interaction
No full textThe laminar-turbulent transition due to the interaction of an upstream aerofoil wake on a downstream flat plate boundary layer is studied experimentally. Measurements conducted on the flat plate boundary layer for four different aerofoil heights (hw ) above the flat plate demonstrate the evolution of both a non-modal disturbance profile and a longitudinal streaky structure in the pre-transition region. Sensitivity to aerofoil height suggests that this experimental arrangement would enable more systematic investigations of the receptivity mechanisms in multi-element configurations than possible using grid turbulence-induced transition
- …
