15 research outputs found
Solid Precipitation and Visibility Measurements at the Centre for Atmospheric Research Experiments in Southern Ontario and Bratt’s Lake in Southern Saskatchewan
No full textAccurate measurement of solid precipitation (S) has a critical importance for proper understanding of the Earth’s hydrological cycle, validation of emerging technologies and weather prediction models, and developing parameterizations of severe weather elements such as visibility (Vis). However, measuring S is still a challenging problem, due mainly to wind effects. The wind effects are normally mitigated by using a Double-Fence Automated Reference (DFAR) system to reduce the wind speed (Ug). To contribute towards addressing some of these problems, we have analyzed datasets collected at two sites, Center for Atmospheric Research Experiments (CARE) and Bratt’s Lake, located in southern Ontario and southern Saskatchewan, Canada, respectively, using several instruments. The instruments at CARE include two Geonor gauges, one placed inside a DFAR (SDFAR) and the other inside a double Alter shield (DASG), a Pluvio2 gauge inside a single Alter shield (SASP), a HotPlate, a PARSIVEL2 disdrometer that measures S and fall velocity (V), and an FD12P senor that measures S and type and Vis. The instruments deployed in Bratt’s Lake includes a similar DFAR system and DAS Pluvio2 gauge. The results show that for the Ug observed in this study (Ug −1), both DASG and SASP have similar collection efficiency (CE) of near 70%. The transfer functions (TF) for DASG and SASP as a function of Ug and also Ug, and V were derived. The TF developed for the DASG that includes both Ug and V showed better agreement with observation than just Ug alone. The TF developed for DASG at CARE site was tested using the data collected in Bratt’s Lake and correlated well (R = 0.86), but slightly overestimated the S accumulation by about 12%. The S measured at CARE site using all the other instruments were correlated well with SDFAR (R = 0.9), but the PARSIVEL2 and FD12P overestimated and underestimated the snow amount, respectively, as compared the SDFAR. However, the HotPlate captured similar amount of S as the SDFAR. According to this study, the SDFAR showed good correlation with Vis
Directed acyclic subsequence graph—Overview
No full textAbstractThe subsequence matching problem is to decide, for given strings S and T, whether S is a subsequence of T. The string S is called the pattern and the string T the text. We consider the case of multiple texts and show how to solve the subsequence matching problem in time linear in the length of the pattern. For this purpose we build an automaton that accepts all subsequences of given texts. This automaton is called the Directed Acyclic Subsequence Graph (DASG). We prove an upper bound for its number of states. Furthermore, we consider a modification of the subsequence matching problem: given a string S and a finite language L, we are to decide whether S is a subsequence of any string in L. We suppose that a finite automaton accepting L is given and present an algorithm for building the DASG for language L. We also mention applications of the DASG to some problems related to subsequences
On-line & Incremental Update Properties of the Subsequence Automaton
No full textMany works deal with the subsequence matching problem using automata structures. It is to decide, given two sequences and , whether is a subsequence of . Automata like the Directed Acyclic Subsequence Graph (DASG) or the Subsequence Automaton (SA) accept all subsequences of a set of texts. We focus on this last structure and provide some useful results upon dynamically updates of the SA. Indeed, sequences are indexed as soon as they are processed, allowing to dynamically add or to remove sequences from the set of indexed texts. Moreover, the highlight of these properties also makes it possible to update this automaton whenever a sequence of the set is modified
On-line & Incremental Update Properties of the Subsequence Automaton
No full textMany works deal with the subsequence matching problem using automata structures. It is to decide, given two sequences and , whether is a subsequence of . Automata like the Directed Acyclic Subsequence Graph (DASG) or the Subsequence Automaton (SA) accept all subsequences of a set of texts. We focus on this last structure and provide some useful results upon dynamically updates of the SA. Indeed, sequences are indexed as soon as they are processed, allowing to dynamically add or to remove sequences from the set of indexed texts. Moreover, the highlight of these properties also makes it possible to update this automaton whenever a sequence of the set is modified
The BDA Dental Academic Staff Group Student Elective Workshop
No full textIn the current climate in dental education, many schools are re-evaluating the role of the student elective in the curriculum, with two schools no longer running elective programmes. In order to discuss the future of student electives in the dental curriculum, the Dental Academic Staff Group (DASG) of the British Dental Association organised a Student Elective Workshop, which attracted 42 delegates including nine student representatives. The following article is an account of the Workshop and its conclusions
A Genome-Wide Alternative Splicing Landscape Specifically Associated with Durable Rice Blast Resistance
No full textThe rice blast, caused by the hemibiotrophic plant pathogen Magnaporthe oryzae, is a devastating disease that threatens rice crop production worldwide. The molecular interactions that underlie the rice-M. oryzae interaction have received much attention. However, genome-wide research focusing on alternative splicing (AS) has not been well-studied in rice—M. oryzae interactions. AS in plants leads to diverse proteomes without an expansion in gene numbers to regulate cellular processes during abiotic or biotic stress. The Pi21 gene negatively regulates rice resistance to M. oryzae infection, and thus the Pi21-RNAi silenced transgenic line (#241) exhibits partial but durable resistance. We compared the AS landscape in #241 and “Nipponbare” (Nip) during interacting with M. oryzae Guy11, and the alternative 3′ splice-site (A3SS) is the most common AS type. GO enrichment analysis of #241-specific differentially alternatively spliced genes (DASGs) revealed that WRKY transcription factors (TFs), bHLH TFs, F-box protein with leucine rich repeats, AAA-type ATPase, and protein kinase were enriched in the GO terms “response to jasmonate acid (JA)” and “ethylene (ET)” at 24 h post-inoculation (hpi). At 48 hpi, one #241-specific DASG, ubiquitin gene (Os08g0295000), was predicted to be involved in endoplasmic reticulum (ER) stress. In silico analysis combined with PCR amplification confirmed that multiple isoforms are produced by Os08g0295000 and a skipped exon (SE) event results in isoform switching during interaction with M. oryzae. Protein–protein interaction (PPI) network analysis predicted that Os08g0295000-encoding proteins may interact with SNARE protein Q9LGF8 (Uniprot ID) to cooperatively regulate rice’s response to M. oryzae. This study uncovered the AS profile of rice in response to M. oryzae, which will help to explore the linkage between AS and durable rice resistance
Good triangulations yield good tours
No full textConsider the following heuristic for planar Euclidean instances of the traveling salesman problem (TSP): select a subset of the edges which induces a planar graph, and solve either the TSP or its graphical relaxation on that graph. In this paper, we give several motivations for considering this heuristic, along with extensive computational results. It turns out that the Delaunay and greedy triangulations make effective choices for the induced planar graph. Indeed, our experiments show that the resulting tours are on average within 0.1% of optimality.Scope and purposeThe traveling salesman problem (TSP) is a fundamental and well-known problem in combinatorial optimisation. It has many applications, for example in vehicle routing and machine scheduling. This paper proposes several heuristics methods for the Euclidean TSP, based on the use of triangulations, and gives extensive computational results
Вплив концентрації бактерій на протимікробну активність декаметоксину = Influence of concentration on bacteria the activity the antimicrobial activity decamethoxinum
No full textStukan Oksana. Вплив концентрації бактерій на протимікробну активність декаметоксину = Influence of concentration on bacteria the activity the antimicrobial activity decamethoxinum. Journal of Education, Health and Sport. 2015;5(6):291-296. ISSN 2391-8306. DOI 10.5281/zenodo.18614
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%286%29%3A291-296
https://pbn.nauka.gov.pl/works/566838
http://dx.doi.org/10.5281/zenodo.18614
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 21.04.2015. Revised 28.05.2015. Accepted: 14.06.2015.
УДК; 615.27
ВПЛИВ КОНЦЕНТРАЦІЇ БАКТЕРІЙ НА ПРОТИМІКРОБНУ АКТИВНІСТЬ ДЕКАМЕТОКСИНУ
Influence of concentration on bacteria the activity the antimicrobial activity decamethoxinum
О. К. Стукан
Oksana Stukan
ВНМУ ім.М.І.Пирогова, кафедра мікробіології, вірусології та імунології, Вінниця
Vinnitsky National Medical University named M.I.Pirogova, department of Microbiology
Abstract
The use domestic antiseptic preparations in medicine allowed considerably improve the efficiency prophylaxis and treatment of of many diseases infectious genesis. It is known that they are active in in the presence of the products tissue decay; operate in acidic and alkaline environments do not cause local irritating. Preparations fixed form based decamethoxinum have inhibitory and the bactericidal action on bacteria, viruses, fungi and detoxic effect on staphylococcal, diphtheritic exotoxin, possess good regenerative effect against allergies. The study was conducted at clinical strains of Staphylococcus aureus by standard serial dilutions. The results showed high activity and effectiveness of the drug decamethoxinum.
The use of domestic of antiseptics preparations in medicine allowed considerably improved the effectiveness prophylaxis and treatment of many diseases of infectious genesis. It is known that they are active in the presence of the products tissue decay; operate in acidic and an alkaline environments do not cause local irritating. Investigation of antimicrobial activity decamethoxinum (DCM), carried out in clinical strains of Staphylococcus aureus. From different medical patients, prophylactic establishments, we have removed and been identified 187 clinical strains of microorganisms. Results of the study of antimicrobial activity decamethoxinum on clinical strains of Staphylococcus aureus have shown the following. The minimum bacteriostatic the concentration of DCM was equal to 0,75 ± 0,06 mg / ml, the minimum bactericidal concentration DCM has increased to 1,5 ± 0,06 mg / ml. The dependence of the biological activity of antimicrobial compounds on the number of microorganisms due to a decrease the number of available of molecules existing centers the active compound of by microorganisms in the conditions of the saturated substrate. In the process of studying of sowing dose test microorganisms to antimicrobial activity of antiseptics preparations the following results. To explore dependence of actions on the magnitude of the microbial load in a clinical setting, we studied the effect DCM clinical strains are Staphylococcus aureus. MIC DCM for clinical strains of microbial load 10³ CFU / ml was equal 4,56 ± 0,93mkh / ml, while the load 106 CFU / mL DCM MIC was equal to 4,69 ± 1,6 mg / ml. MCC DCM microbial load of 109 cfu / ml was 9,57 ± 3,96 mg / ml.
Conclusion. Investigational antiseptic dasg decamethoxin has a wide range of antimicrobial activity on causative agents of nosocomial infections, retains a high antimicrobial activity, quickly detoxifies microorganisms. Our results demonstrated strong the activity of DCM clinical strains are Staphylococcus.
Key words: staphylococcus, clinical strains, CFU, decamethoxinum, antimicrobial activity, concentration
Резюме
Влияние концентрации бактерий на противомикробную активность декаметоксина. Использование отечественных антисептических препартов в медицине позволило значительно улучшить эфективность профилактики и лечения госпитальных заболеваний инфекционного генеза. Известно, что они проявляют активность в присутствии продуктов тканевого разпада; действуют в кислой и щелочной среде, не вызывают местного раздражающего эффекта. Лекарственные формы на основе декаметоксина владеют бактериостатическим и микробоцидным действием на бактерии, вирусы, грибы, а также имеют иннактивирующее действие на стафилококовый, дифтерийный экзотоксины, имеют отличное регенераторное и противоалергическое действие. Исследование проведено на клинических штаммах стафилококка методом стандартных серийных разведений. Результаты исследований показали высокую активность и эффективность препарата декаметоксина.
Ключевые слова: стафилококк, клинические штаммы, КОЕ декаметоксин, антимикробная активность, концентрация.
Резюме
Застосування вітчизняного антисептичного препаратів в медицині дозволило значно покращити ефективність профилактики та лікування госпітальних хвороб інфекційного генезу. Відомо, що вони проявляють активність в присутності продуктів тканинного розпаду; діють в кислому та лужному середовищах, не викликають місцеву подразнювальну дію. Лікарські фіксовані форми на основі декаметоксину володіють бактеріостатичною та мікробоцидною дією щодо бактерій, вірусів, грибів, а також детоксикуючою дією щодо стафілококового, дифтерійного екзотоксинів, мають гарну регенеративну та протиалергійну дію. Дослідження проведено на клінічних штамах стафілокока методом стандартних серійних розведень. Результати досліджень показали високу активність та ефективність препарату декаметоксину.
Ключові слова: стафілокок, клінічні штами, КУО, декаметоксин, антимікробна активність, концентрація
Ymagwedd egwyddorol at ddatblygu deunyddiau ar-lein i ddysgwyr Cymraeg i Oedolion
No full textYn y traethawd hwn, trafodir prosiect doethurol a chanddo ddau brif nod, sef: (1) cynhyrchu cyfres o adnoddau dysgu Cymraeg ar-lein yn arbennig ar gyfer Canolfan Iaith a Threftadaeth Cymru Nant Gwrtheyrn; a (2) ymchwilio i ac ysgrifennu traethawd ymchwil mewn maes cysylltiedig. Penderfynais gyfuno’r ddwy elfen, a defnyddio theori ac ymchwil fel sail ar gyfer y dasg greadigol. Fy ngobaith oedd dangos ymagwedd egwyddorol tuag at ddatblygu adnoddau e-ddysgu newydd, ac ysbrydoli eraill i wneud yr un fath yn y dyfodol, yn enwedig yng ngoleuni galwad diweddar Mac Giolla Chríost et al. (2012, t. 182) i ymarferwyr ym maes Cymraeg i Oedolion rannu ‘ymarfer da’.
Mae allbynnau’r Ddoethuriaeth hon yn gwneud dau brif gyfraniad at y maes. Y cyntaf o’r rhain yw’r gyfres o adnoddau e-ddysgu unigryw o’r enw “e-nant” a fydd yn dechrau cael traweffaith yn syth ar ddysgwyr sy’n mynychu cyrsiau lefel Mynediad yn Nant Gwrtheyrn o nawr ymlaen. Ar ben hynny, mae’r traethawd hwn yn dangos yn glir sut y gellir seilio datblygiad deunyddiau dysgu newydd ar egwyddorion ymchwil. Bydd hwn yn adnodd defnyddiol iawn i awduron deunyddiau’r dyfodol, oherwydd ei fod yn darparu enghreifftiau clir o’r byd go iawn o sut mae rhoi cysyniadau theoretig ar waith yn ymarferol.
Drwy ymgymryd ag ymchwil cyfrwng Cymraeg, yr wyf hefyd yn gwneud trydydd cyfraniad, sef hwyluso trafodaeth o bynciau tebyg drwy’r Gymraeg yn y dyfodol, a chyfrannu at godi statws y Gymraeg fel iaith academaidd – un o amcanion strategol Llywodraeth Cynulliad Cymru (2010). Casglwyd rhestr o dermau perthnasol i feysydd Caffael Ail Iaith a Dysgu Iaith drwy Gymorth Cyfrifiadur, y bydd ymchwilwyr y dyfodol yn gallu cyfeirio ati’n hawdd, a bathwyd sawl term newydd, er mwyn galluogi trafodaeth o gysyniadau nad ydynt erioed wedi’u trafod yn y Gymraeg o’r blaen.
This thesis discusses a doctoral project with two main aims: (1) to produce a series of online Welsh learning resources especially for the Nant Gwrtheyrn Welsh Language and Heritage Centre; and (2) to research and write a research thesis in a related field. I decided to combine the two elements, and to use theory and research as a base for the creative task. My hope was to demonstrate a principled approach towards developing new e-learning resources, and to inspire others to do likewise in the future, especially in light of Mac Giolla Chríost et al.'s (2012, t. 182) recent call for Welsh for Adults practitioners to share ‘good practice’.
The outputs of this Doctorate make two main contributions to the field. The first of these is the series of unique e-learning resources called “e-nant” which will immediately begin to have an impact on learners who attend Entry-level courses at Nant Gwrtheyrn from now on. In addition, this thesis clearly shows how the development of new learning materials can be based on research principles. This will be a very useful resource for future materials writers, since it provides clear real-world examples of how to put theoretical concepts into practice.
By undertaking Welsh-medium research, I also make a third contribution, namely to facilitate discussion of similar subjects through Welsh in the future, and to contribute towards raising the status of Welsh as an academic language – one of the Welsh Assembly Government’s (2010) strategic aims. A list of relevant terms was compiled for the fields of Second Language Acquisition and Computer-Assisted Language Learning, which future researchers will be able to refer to easily, and several new terms were coined, in order to enable discussion of concepts which have never before been discussed in the Welsh language
A Link Between Methylglyoxal and Heart Failure During HIV-1 Infection
No full textEarly-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg- PrkdcscidIl2rgtm1Wjl/SzJ humanized mice (Hu-mice), plasma from PLWH, and autopsied cardiac tissues from deceased HIV seropositive individuals were used to assess if there is a link between the glycolysis byproduct methylglyoxal (MG) and HF in the setting of HIV-1 infection. At five weeks post HIV infection, Hu-mice developed grade III-IV diastolic dysfunction (DD) with an associated two-fold increase in plasma MG. At sixteen-seventeen weeks post infection, cardiac ejection fraction and fractional shortening also declined by 26 and 35%, and plasma MG increased to four-fold higher than uninfected controls. Histopathological and biochemical analyses of cardiac tissues from Hu-mice 17 weeks post-infection affirmed MG increase with a concomitant decrease in expression of the MG-degrading enzyme glyoxalase-1 (Glo1). The endothelial cell marker CD31 was found to be lower, and coronary microvascular leakage and myocardial fibrosis were prominent. Increasing expression of Glo1 in Hu-mice five weeks post-infection using a single dose of an engineered AAV2/9 (1.7 × 1012 virion particles/kg), attenuated the increases in plasma and cardiac MG levels. Increasing Glo1 also blunted microvascular leakage, fibrosis, and HF seen at sixteen weeks post-infection, without changes in plasma viral loads. In plasma fromvirally suppressed PLWH,MG was also 3.7-fold higher. In autopsied cardiac tissues from seropositive, HIV individuals with low viral log, MG was 4.2-fold higher and Glo1 was 50% lower compared to uninfected controls. These data show for the first time a causal link between accumulation of MG and HF in the setting of HIV infection
