231 research outputs found
PRESSURE NARROWING OF THE ROTATIONAL LINES IN THE FUNDAMENTAL INDUCED INFRARED ABSORPTION BAND OF H. IN , AND GAS MIXTURES
No full textJ. De Remigis, J. W. Mactaggart and H. L. Welsh, Can. J. Phys. 49, 381 (1971). H. R. Zaidi and J. Van Kranendonk, Can J. Phys. 49, 385 (1971).""Author Institution: Department of Physics, University of TorontoIn a recent the observation of a density-dependent narrowing of the quadrupole-induced rotational lines in the pressure-induced fundamental infrared band of hydrogen in gas and liquid mixtures was reported. It was found that for Ar densities greater than 300 amagat the half-width of the S (1) line of hydrogen varies inversely as the Ar density. Zaidi and Van have interpreted this effect as a form of diffusional narrowing and have developed an expression for the half-width, , in terms of the mutual diffusion coefficient of hydrogen in argon. In this paper the results of similar experiments on para-, , , and pure are presented. In particular, the (O) line in exhibits the same density dependence as previously found for the (1) line. For and for the (1) line of varies inversely as the rare gas density for Kr and Xe densities greater than 380 and 246 amagat, respectively. By combining these results with the theory of Zaidi and Van Kranendonk the diffusion coefficients of in high density Ar, Kr and Xe gas are computed and found to compare favourably with the kinetic theory values
Thyroid dysfunctions secondary to cancer immunotherapy
No full textBackground: Immunotherapy is a firmly established pillar in the treatment of cancer, alongside the traditional approaches of surgery, radiotherapy, and chemotherapy. Like every treatment, also cancer immunotherapy causes a diverse spectrum of side effects, collectively referred to as immune-related adverse events. Objective: This review will examine the main forms of immunotherapy, the proposed mechanism(s) of action, and the incidence of thyroid dysfunctions. Methods: A comprehensive MEDLINE search was performed for articles published up to March 30, 2017. Results: Following the pioneering efforts with administration of cytokines such as IL-2 and IFN-g, which caused a broad spectrum of thyroid dysfunctions (ranging in incidence from 1 to 50%), current cancer immunotherapy strategies comprise immune checkpoint inhibitors, oncolytic viruses, adoptive T-cell transfer, and cancer vaccines. Oncolytic viruses, adoptive T-cell transfer, and cancer vaccines cause thyroid dysfunctions only rarely. In contrast, immune checkpoint blockers (such as anti-CTLA-4, anti-PD-1, anti-PD-L1) are associated with a high risk of thyroid autoimmunity. This risk is highest for anti-PD-1 and increases further when a combination of checkpoint inhibitors is used. Conclusions: Cancer patients treated with monoclonal antibodies that block immune checkpoint inhibitors are at risk of developing thyroid dysfunctions. Their thyroid status should be assessed at baseline and periodically after initiation of the immunotherapy
Circadian time structure of pituitary and adrenal response to CRF, TRH and LHRH
No full textIn six healthy males, aged 25.3 +/- 0.66, the pituitary and adrenal simultaneous response to CRF (1 microgram/kg), TRH (200 micrograms) and LH-RH (100 micrograms) was studied at the following times of different days: 0400, 0800, 1200, 1600, 2000 and 0000. Each test was preceded by a 8-hr fast after a meal containing 600 cal (CHO 50%, lipid 30%, protein 20%). The interval between two consecutive tests was 52 hrs and the starting time was randomized. The serum cortisol was measured before and after 60, 120, 180, 240 min. Serum TSH, Prolactin, FSH and LH were measured before and after 5, 10, 15, 30, 60, 90 and 120 min. The statistical analysis was reported by both mean chronograms (as absolute values and relative change or absolute difference from mesor) and mean cosinor on basal values and total (T.A.) or incremental (I.A.) areas after RH stimulus. Serum cortisol: a statistically significant circadian rhythm was found for basal values with a peak in the morning (phi at 1040; 95% C.L. 0808-1438). T.A. after RH stimulus as well appeared statistically higher again in the morning, whereas the I.A. presented an opposite phase with higher values at night (phi at 2133; 95% C.L. 2055-0312). Serum Prolactin: mean chronogram analysis showed significantly higher basal values at 0800 and lower values at 1600, whereas I.A. were significantly lower in the morning. Serum LH: basal values were statistically higher in the morning, while T.A. and I.A. showed an opposite behaviour with peaks in the night (T.A.: phi at 2015, 95% C.L. 1710-0035; I.A.: 0 2033; 95% C.L. 1736-0004).(ABSTRACT TRUNCATED AT 250 WORDS
Endocrinopathies: chronic thyroiditis, addison disease, pernicious anemia, graves’ disease, diabetes, and hypophysitis
No full textChronic lymphocytic thyroiditis (CLT), also known as Hashimoto thyroiditis, is an autoimmune disease characterized by lymphocytic infiltration of the thyroid gland, with the concomitant production of autoantibodies to thyroid antigens, primarily thyroglobulin and/or thyroperoxidase (TPO), formerly known as microsomal antigen (1). Although few epidemiological data are available, the prevalence of CLT is estimated to be 1 in 1,000 people, with an incidence of 0.2
to 2% and a female-to-male ratio of about 18:1 (1). Clinical signs and symptoms manifest slowly and may involve many systems of the body (1). Accumulations of hydrophilic mucoproteins with edema, a condition called myxedema, affects skin and connective tissue and can affect the appearance of
the individual. Lethargy may ensue, with a loss of mental acuity. Systems commonly affected are the gastrointestinal tract, the hemopoietic system, the endocrine system, and the urogenital system (1). Enlargement of the thyroid gland due to lymphocyte invasion, called goiter, is a frequent manifestation,
although there is an atrophic variation. Demonstration of autoantibodies to the thyroid antigens aids in the diagnosis of CLT, distinguishing it from other causes of hypothyroidism
ALICE Zero Degree Calorimeters. The new readout system in LHC Run 3
No full textThe Zero Degree Calorimeters (ZDC) were designed to provide the measurement of the event geometry and luminosity in heavy-ion operation.
The readout system was redesigned in order to operate in continuous mode without dead time at 2.5 MHz event rate.
The new acquisition chain is based on a commercial 12 bit digitizer with a sampling rate of about 1 GSps, assembled on an FPGA Mezzanine Card.
The signals produced by the 26 ZDC channels are digitized, and samples are processed through an FPGA to extract information such as timing, baseline average estimation and luminosity
[Chronobiological study of free thyroid hormones in hypothyroid and hyperthyroid subjects]
No full textPrevious reports demonstrate a circadian rhythm of the free thyroid hormones in healthy subjects. In this study we evaluated circadian variation of FT3 and FT4 in hyperthyroid and hypothyroid states. We considered six hyperthyroid patients, six hypothyroid patients and six control subjects. Blood samples were taken two hours apart from a catherterized arm vein. Data were evaluated by Halberg's cosinor analysis. The results show that FT3 and FT4 exhibit a circadian rhythm in healthy subjects, not evident in hyperthyroid and hypothyroid patients
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