656 research outputs found
CYTOKINE AND ADHESION MOLECULE EXPRESSION IN THE MINOR SALIVARY-GLANDS OF PATIENTS WITH SJOGRENS-SYNDROME AND CHRONIC SIALOADENITIS
No full textsj-docx-1-uro-10.1177_20514158211063964 – Supplemental material for A ‘real-world’ standard for radical prostatectomy: Analysis of the British Association of Urological Surgeons Complex Operations Reports, 2016–2018
No full textSupplemental material, sj-docx-1-uro-10.1177_20514158211063964 for A ‘real-world’ standard for radical prostatectomy: Analysis of the British Association of Urological Surgeons Complex Operations Reports, 2016–2018 by Joseph B John, John Pascoe, Sarah Fowler, Thomas Walton, Mark Johnson, Jonathan Aning, Benjamin Challacombe, Rory Bufacchi, Andrew J Dickinson and John S McGrath in Journal of Clinical Urology</p
sj-docx-1-uro-10.1177_20514158211033481 – Supplemental material for Setting standards for cystectomy using the British Association of Urological Surgeons Complex Operations Reports, 2016–2018
No full textSupplemental material, sj-docx-1-uro-10.1177_20514158211033481 for Setting standards for cystectomy using the British Association of Urological Surgeons Complex Operations Reports, 2016–2018 by Joseph B John, John Pascoe, Sarah Fowler, Edward Rowe, Alexandra Colquhoun, Benjamin Challacombe, Rory Bufacchi, Andrew J Dickinson and John S McGrath in Journal of Clinical Urology</p
Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: a systematic review
No full textHuman papillomavirus (HPV) in oral carcinoma (OSCC) and potentially malignant disorders (OPMD) is controversial. The primary aim was to calculate pooled risk estimates for the association of HPV with OSCC and OPMD when compared with healthy oral mucosa as controls. We also examined the effects of sampling techniques on HPV detection rates. Methods: Systematic review was performed using PubMed (January 1966-September 2010) and EMBASE (January 1990-September 2010). Eligible studies included randomized controlled, cohort and cross-sectional studies. Pooled data were analysed by calculating odds ratios, using a random effects model. Risk of bias was based on characteristics of study group, appropriateness of the control group and prospective design. Results: Of the 1121 publications identified, 39 cross-sectional studies met the inclusion criteria. Collectively, 1885 cases and 2248 controls of OSCC and 956 cases and 675 controls of OPMD were available for analysis. Significant association was found between pooled HPV-DNA detection and OSCC (OR=3.98; 95% CI: 2.62-6.02) and even for HPV16 only (OR=3.86; 95% CI: 2.16-6.86). HPV was also associated with OPMD (OR=3.87; 95% CI: 2.87-5.21). In a subgroup analysis of OPMD, HPV was also associated with oral leukoplakia (OR=4.03; 95% CI: 2.34-6.92), oral lichen planus (OR=5.12; 95% CI: 2.40-10.93), and epithelial dysplasia (OR=5.10; 95% CI: 2.03-12.80). Conclusions: The results suggest a potentially important causal association between HPV and OSCC and OPMD. © 2011 John Wiley & Sons A/S
A case of vulvovaginal gingival lichen planus in association with Good's syndrome.
No full textVulvovaginal gingival lichen planus (VVG LP) is a distinct variant of LP frequently associated with mucocutaneous scarring and vaginal stricture formation. Good’s Syndrome (thymoma with hypogammaglobulinemia) is a rare cause of immunodeficiency in adults. The clinical features, investigation findings, and challenges in the management of a patient presenting with VVG LP and Good’s Syndrome are discusse
“The SCARE guidelines: Consensus-based surgical case report guidelines” [Int. J. Surg. 34 (2016) 180–186]((2016) 34 (180–186)(S174391911630303X)(10.1016/j.ijsu.2016.08.014))
No full textThe publisher regrets that there was an error in the author list of this paper. The members of the SCARE Group were not tagged as a collaborator group. This has now been corrected. The names of the collaborator group are as follows: Raafat Afifi, Cairo University Raha Al-Ahmadi, King Faisal Specialist Hospital and Research Centre Joerg Albrecht, John H. Stroger Jr. Hospital of Cook County Abdulrahman Alsawadi, Colchester Hospital University NHS Foundation Trust Jeffrey Aronson, Radcliffe Infirmary, Oxford M. Hammad Ather, Aga Khan University Mohammad Bashashati, Texas Tech University Health Sciences Center Somprakas Basu, Banarus Hindu University Patrick Bradley, Nottingham University Hospitals Mushtaq Chalkoo, Hyderpora Ben Challacombe, Guy's and St Thomas’ NHS Foundation Trust Trent Cross, James Cook University Laura Derbyshire, North West Deanery Naheed Farooq, Central Manchester University Hospital Foundation Trust Jerome Hoffman, University of California Los Angeles Huseyin Kadioglu, Bezmialem Vakif University Veeru Kasivisvanathan, University College London Boris Kirshtein, Soroka University Medical Center Roberto Klappenbach, Simplemente Evita Hospital Daniel Laskin, Virginia Commonwealth University Diana Miguel, University Hospital Jena James Milburn, Queens Medical Centre Seyed Reza Mousavi, Shohada Medical Center Tajrish Oliver Muensterer, University Medicine Mainz James Ngu, Changi General Hospital Iain Nixon, East Kent University Hospitals Ashraf Noureldin, Cumberland Royal Infirmary Benjamin Perakath, Dr. Gray's Hospital Nicholas Raison, King's College London Kandiah Raveendran, Fatimah Hospital Timothy Sullivan, Minneapolis Heart Institute Achilleas Thoma, McMaster University Mangesh Thorat, Wolfson Institue of Preventative Medicine, Queen Mary University of London Michele Valmasoni, Università di Padova Samuele Massarut, Centro di Riferimento Oncologico Aviano, Italy Anil D'cruz, Tata Memorial Hospital Baskaran Vasudevan, MIOT Hospitals Salvatore Giordano, Turku University Hospital Gaurav Roy, Medanta-The Medicity Donagh Healy, University Hospital Waterford David Machado-Aranda, University of Michigan Bryan Carroll, Eastern Virginia Medical School David Rosin, University of West IndiesThe publisher would like to apologise for any inconvenience caused
The European Association of Urology Robotic Urology Section (ERUS) survey of robot-assisted radical prostatectomy (RARP)
No full textObjective To evaluate surgeons adherence to current clinical practice, with the available evidence, for robot-assisted radical prostatectomy (RARP) and offer a baseline assessment to measure the impact of the Pasadena recommendations. Recently, the European Association of Urology Robotic Urology Section (ERUS) supported the Pasadena Consensus Conference on best practices in RARP. Subjects and Methods This survey was performed in January 2012. A specific questionnaire was sent, by e-mail, to 145 robotic surgeons who were included in the mailing-list of ERUS members and working in different urological institutions. Participating surgeons were invited to answer a multiple-choice questionnaire including 24-items evaluating the main RARP surgical steps. Results In all, 116 (79.4%) invited surgeons answered the questionnaire and accepted to participate to the ERUS survey. In all, 47 (40.5%) surgeons performed > 100 RARPs; 41 (35.3%) between 50 and 100, and 28 (24.1%) < 50 yearly. The transperitoneal, antegrade technique was the preferred approach. Minimising bladder neck dissection and the use of athermal dissection of the neurovascular bundles (NVBs) were also popular. There was more heterogeneity in the use of energy for seminal vesicle dissection, the preservation of the tips of the seminal vesicle and the choice between intra- and interfascial planes during the antero-lateral dissection of the NVBs. There was also large variability in the posterior and/or anterior reconstruction steps. Conclusions The present study is the first international survey evaluating surgeon preferences during RARP. Considering that the results were collected before the publication of the Pasadena recommendations, the data might be considered an important baseline evaluation to test the dissemination and effects of the Pasadena recommendations in subsequent years
The European Association of Urology Robotic Urology Section (ERUS) survey of robot-assisted radical prostatectomy (RARP).
No full textOBJECTIVE: To evaluate surgeons adherence to current clinical practice, with the available evidence, for robot-assisted radical prostatectomy (RARP) and offer a baseline assessment to measure the impact of the Pasadena recommendations. Recently, the European Association of Urology Robotic Urology Section (ERUS) supported the Pasadena Consensus Conference on best practices in RARP. SUBJECTS AND METHODS: This survey was performed in January 2012. A specific questionnaire was sent, by e-mail, to 145 robotic surgeons who were included in the mailing-list of ERUS members and working in different urological institutions. Participating surgeons were invited to answer a multiple-choice questionnaire including 24-items evaluating the main RARP surgical steps. RESULTS: In all, 116 (79.4%) invited surgeons answered the questionnaire and accepted to participate to the ERUS survey. In all, 47 (40.5%) surgeons performed >100 RARPs; 41 (35.3%) between 50 and 100, and 28 (24.1%) <50 yearly. The transperitoneal, antegrade technique was the preferred approach. Minimising bladder neck dissection and the use of athermal dissection of the neurovascular bundles (NVBs) were also popular. There was more heterogeneity in the use of energy for seminal vesicle dissection, the preservation of the tips of the seminal vesicle and the choice between intra- and interfascial planes during the antero-lateral dissection of the NVBs. There was also large variability in the posterior and/or anterior reconstruction steps. CONCLUSIONS: The present study is the first international survey evaluating surgeon preferences during RARP. Considering that the results were collected before the publication of the Pasadena recommendations, the data might be considered an important baseline evaluation to test the dissemination and effects of the Pasadena recommendations in subsequent years
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome
No full textOBJECTIVE: Ectopic lymphoneogenesis can occur in the salivary glands of Sjögren's syndrome (SS) patients and is associated with local antigen-driven B cell responses, autoantibody formation, and potential lymphomatous transformation. CXCL13 and CCL21 have been identified in salivary glands, but their role in ectopic lymphoneogenesis in SS remains unclear. This study aimed to evaluate the microanatomic association between CXCL13 and CCL21 expression and the acquisition of lymphoid features in periductal foci. METHODS: Salivary glands from 37 SS patients and 9 chronic sialadenitis patients were analyzed by immunohistochemistry for T cell/B cell segregation, CD21+ follicular dendritic cell networks, and peripheral lymph node addressin (PNAd)-positive high endothelial venules (HEVs) in relationship to the size of the aggregates and the expression of CXCL13 and CCL21 within infiltrating cells, epithelium, and endothelium. RESULTS: Grade 1 aggregates (10-50 lymphocytes) demonstrated predominance of nonorganized CD3+ cells, while grade 2 (>50 lymphocytes) and grade 3 (>50 with germinal centers) showed a progressive increase in CD20+ B cells and T cell/B cell segregation. This higher degree of lymphoid organization was significantly related to an increased expression of CXCL13 within infiltrating cells and PNAd+ HEV-associated CCL21-producing cells. Conversely, no association between lymphoid organization and lymphoid chemokine expression by epithelial cells was observed. CONCLUSION: The acquisition of lymphoid features by inflammatory foci in SS is critically associated with the enlargement of the inflammatory foci and with the expression of CXCL13 and CCL21 within the infiltrate, but is not associated with their expression by epithelial cells. These data strongly support an active participation of CXCL13 and CCL21 in regulating the progressive organization and maintenance of periductal foci
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