147 research outputs found

    Description of nymphal instars and adult female of Kermes vermilio Planchon (Hemiptera, Coccoidea, Kermesidae), with a synopsis of the European and Mediterranean species

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    The morphology of the 1st-instar, 2nd-instar male and female, 3rd-instar female and adult female of Kermes vermilio Planchon (Hemiptera Coccoidea Kermesidae) are described and illustrated; micrographs of some morphological details are also provided. An identification key to instars and a table showing the present status of knowledge on the morphology of European and Mediterranean Kermes instars is included

    Guilaine J., Tusa S., Veneroso P. avec la coll. de Convertini F. (2009) – La Sicile et l’Europe campaniforme, la collection Veneroso à Sciacca

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    Lemercier Olivier. Guilaine J., Tusa S., Veneroso P. avec la coll. de Convertini F. (2009) – La Sicile et l’Europe campaniforme, la collection Veneroso à Sciacca. In: Bulletin de la Société préhistorique française, tome 106, n°4, 2009. pp. 824-825

    TCA cycle rewiring as emerging metabolic signature of hepatocellular carcinoma

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    Hepatocellular carcinoma (HCC) is a common malignancy. Despite progress in treatment, HCC is still one of the most lethal cancers. Therefore, deepening molecular mechanisms underlying HCC pathogenesis and development is required to uncover new therapeutic strategies. Metabolic reprogramming is emerging as a critical player in promoting tumor survival and proliferation to sustain increased metabolic needs of cancer cells. Among the metabolic pathways, the tricarboxylic acid (TCA) cycle is a primary route for bioenergetic, biosynthetic, and redox balance requirements of cells. In recent years, a large amount of evidence has highlighted the relevance of the TCA cycle rewiring in a variety of cancers. Indeed, aberrant gene expression of several key enzymes and changes in levels of critical metabolites have been observed in many solid human tumors. In this review, we summarize the role of the TCA cycle rewiring in HCC by reporting gene expression and activity dysregulation of enzymes relating not only to the TCA cycle but also to glutamine metabolism, malate/aspartate, and citrate/pyruvate shuttles. Regarding the transcriptional regulation, we focus on the link between NF-κB-HIF1 transcriptional factors and TCA cycle reprogramming. Finally, the potential of metabolic targets for new HCC treatments has been explored

    Cancer cell metabolism in hypoxia: Role of HIF-1 as key regulator and therapeutic target

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    In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells. Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is fundamental for bioenergetics. Nevertheless, tumor microenvironment is frequently characterized by low-oxygen conditions. Hypoxia-inducible factor 1 (HIF-1) is a pivotal modulator of the metabolic reprogramming which takes place in hypoxic cancer cells. In the hub of cellular bioenergetics, mitochondria are key players in regulating cellular energy. Therefore, a close crosstalk between mitochondria and HIF-1 underlies the metabolic and functional changes of cancer cells. Noteworthy, HIF-1 represents a promising target for novel cancer therapeutics. In this review, we summarize the molecular mechanisms underlying the interplay between HIF-1 and energetic metabolism, with a focus on mitochondria, of hypoxic cancer cells

    La coltivazione di alcune piante ornamentali esotiche: il caso della Thevetia peruviana, della Dodonaea viscosa, della Polygala myrtifolia e dell’Hebe salicifolia.

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    The paper reports the preliminary results of a research carried out within the project "New agronomic techniques and innovative cultural systems based on biodegradable and/or compostable pots" (SCIMAB), financed by the Italian National Operative Program (PON). Trials have been conducted in an unheated greenhouse located in Monopoli (BA), evaluating the morphological and physiological behavior, from the seeding or transplant to the marketing phase, of the studied plants placed in different pots. Results have shown that the cultural cycles length depend on the species, because of the propagation and of the adopted cultural techniques
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