112 research outputs found
«Nazariy va amaliy tadqiqotlar xalqaro jurnali» Ilmiy jurnal. Fevral 2022 y. - "International journal of theoretical and practical research" Scientific Journal. Ferbruary, 2022. - «Международный журнал теоретических и практических исследований» Научный журнал. Февраль 2022 г.
No full textEditorial Board: A. M. Abdullaev, M. S. Ashurov, E. A. Muminova, K. Kh. Abdurakhmanov, A. N. Asaul, A. V. Burkov, U. V. Gafurov, M. A. Ikramov, D. Kudbiev, E. S. Margianiti, B. Obrenovich, L. Ivars, K. E. Onarkulov, N. A. Sultanov, A. Khasanov, Sh. T. Karimov, Sh. Sh. Khamdamova, D. S. Salikhanova, U.K. Alimov, S.M. Turabdzhanov, B.A.Alimatov, R.Zh. Tozhiev, A.A. Riskulov, B.M. Tursunov, A.A. Shermukhamedov, S. F. Ergashev, Y.S. Abbasov, Kh.A. Akramov, M.Kh. Khakimov, Sh.M. Iskandarova, Z.M. Sobirova, A.M. Mukhtarova, L.M. Babakhodzhaeva
Carotid endarterectomy in acute ischemic stroke
No full textCurrently, there are no clear domestic and foreign recommendations for cerebral revascularization, also missing is a definite decision on determining the timing and possibility of carotid endarterectomy in acute ischemic stroke. A set of measures aiming at obtaining a satisfactory outcome of carotid endarterectomy in the acute ischemic cerebrovascular event is developed. To prevent hyperperfusion complications, a temporary shunt, low doses of unfractionated heparin, adequate antiplatelet, hypotensive and lipid-lowering therapy are used. The main advantages and disadvantages of all modern methods of surgical treatment of this condition are presented.Received 22 August 2017. Revised 7 December 2017. Accepted 11 December 2017.Funding: The study was supported by the Siberian Branch of Russian Academy of Sciences within the framework of the fundamental research package program.Conflict of interest: Authors declare no conflict of interest.Author contributionsDrafting the article: A.N. KazantsevResources: A.R. ShabayevArtistic design: N.N. BurkovCritical revision of the article: A.I. Anufriyev, A.V. Mironov, V.Yu. KheraskovSurgical treatment: A.N. KazantsevAssistance in surgery: N.N. Burkov, A.R. ShabayevRevascularization tactic selection: A.I. Anufriyev, A.V. Mironov, V.Yu. KheraskovNeurological examination: E.V. RubanFinal approval of the version to be published: A.N. Kazantsev, N.N. Burkov, R.S. Tarasov, A.I. Anufriyev, A.R. Shabayev, E.V. Ruban, A.V. Mironov,V.Yu. Kheraskov</p
Risk factors of adverse outcomes of various interventions when treating patients with concomitant lesions of the coronary bed and carotid arteries in 30-day follow-up
No full textAim. The study looks at clinical and instrumental factors associated with adverse outcomes in the hospital and long-term follow-up when using various surgical strategies for treatment of patients with multifocal atherosclerosis.Methods. From 2011 to 2015, three hundred ninety-one patients with combined hemodynamically significant atherosclerotic lesion of the coronary bed and internal carotid arteries were included in this study in a continuous sampling mode. A detailed analysis of the prognostic significance of a wide range of clinical-instrumental, anatomical-angiographic and perioperative factors was performed.Results. Against the background of patients’ initially severe comorbid condition, the most significant hospital risk factors were III–IV functional class angina and stroke in the anamnesis. It is important to note a high risk of complications, with bleeding reaching three points or higher on the Bleeding Academic Research Consortium (BARC) scale during simultaneous coronary artery bypass graft surgery and carotid endarterectomy. At the same time, EuroSCORE II value not higher than 2% and the duration of artificial circulation 74 minutes or less turned out to be protective factors. Conclusion. The study is not randomized and requires further research on the algorithms for choosing the optimal option of revascularization in this group of patients. The results obtained can form the basis for further research aimed at developing optimal surgical protocols for patients with multifocal atherosclerosis.Received 2 August 2017. Revised 16 October 2017. Accepted 25 October 2017.Funding: The research was done with support of the grant (No. 12090ГУ/2017) awarded by the Fund for Facilitation of Innovations within the framework of the “Umnik-2016” project (Kemerovo).Conflict of interest: Authors declare no conflict of interest.Author contributionsConception and study design: R.S. TarasovData collection and analysis: A.A. Golovin, N.N. Burkov, M.G. ZinetsDrafting the article: A.N. KazantsevCritical revision of the article: S.V. Ivanov, A.I. AnoufrievFinal approval of the version to be published: R.S. Tarasov, A.N. Kazantsev, S.V. Ivanov, A.A. Golovin, N.N. Burkov, A.I. Anoufriev, M.G. Zinets, L.S. Barbarash</p
Predictors of adverse events in the mid-term postoperative period in patients who underwent carotid endarterectomy
No full text<p><strong>Aim.</strong> Emphasis in the study was placed on the identification of unfavorable prognosis factors associated with carotid endarterectomy (CEE) during mid-term follow-up.<br /><strong>Methods.</strong> Over a period from 2015 to 2016, 222 CEE operations were performed. Most patients (n = 190; 85.5%) underwent CEE using a patch of xenopericardium, 14.4% (n = 32) received eversion CEE, and a temporary shunt was used in 14.4% (n = 32). Hybrid revascularization in the volume of percutaneous coronary intervention (PCI) + CEE was performed in 9.9% (n = 22) patients. The groups under study were compared by using a chi-square test followed by subsequent analysis of the shares, or if ordinal characters or quantitative traits with a distribution different from the normal one occurred—by using a Mann – Whitney U-test. Correction of multiple comparisons was done by calculating an average fraction of false discoveries of the hypotheses (false discovery rate). The analysis of prognostic factors was done using the odds ratio (OR) by means of the 2 × 2 tables.<br /><strong>Results.</strong> Among the complications detected in the mid-term follow-up, the most common adverse event was the development of MI in 3.6% (n = 8) of patients. According to color duplex scanning of brachiocephalic arteries, restenosis of the operated ICA was observed in 4.5% of patients. The following risk factors significantly increased the risk of adverse events: angina pectoris II–III functional class (OR = 3.84%, CI = 1.24–11.9), SYNTAX Score &gt;22 (OR = 2.83, CI = 1.137–7.086).<br /><strong>Conclusion.</strong> Based on the results of a single-center prospective retrospective study, significant risk factors for adverse outcome in the mid-term postoperative period were identified.</p><p>Received 10 May 2017. Revised 27 September 2017. Accepted 5 October 2017.</p><p><strong>Funding:</strong> The research was done with support of the grant (No. 12090ГУ/2017) awarded by the Fund for Facilitation of Innovations within the framework of the “Umnik-2016” project (Kemerovo).</p><p><strong>Conflict of interest:</strong> The authors declare no conflict of interest.</p><p><strong>Author contributions</strong><br />Conception and study design: R.S. Tarasov, A.I. Anufriyev <br />Data collection and analysis: A.R. Shabaev<br />Drafting the article: A.N. Kazantsev, N.N. Burkov <br />Critical revision of the article: A.V. Mironov<br />Final approval of the version to be published: L.S. Barbarash</p></jats:p
SURGICAL TREATMENT OF MULTIFOCAL ATHEROSCLEROSIS: CORONARY AND BRACHIOCEPHALIC PATHOLOGY AND PREDICTORS OF EARLY ADVERSE EVENTS DEVELOPMENT
Get PDFAim. Analysis of clinical and demographic, anatomic and angiographic, instrumental and perioperational factors of adverse prognosis in inpatient period for various surgical managing strategies in patients with multifocal atherosclerosis.Material and methods. The analysis is done, of surgical treatment results in 391 patient with combination lesion of coronary and brachocephalic arteries under the frame work of single center prospective registry. According to the presence of in-hospital complications (HC) all patients were selected to 2 groups: I — patients with HC (n=84); II — patients with no HC (n=307). In this selection, 4 revasculariztion tactics were realized: staged surgery within the procedures of coronary bypass and carotid endarterectomy (CEE) with various sequence (n=222, 56,8%); combinational operation of coronary bypass and CEE (n=141; 36%); hybrid revascularization within percutaneous coronary intervention and CEE (n=28; 7,2%).Results. The wide spectrum of prognostically significant factors was analized in details, including clinical and instrumental, anatomic and angiographic, perioperational factors. Adverse prognosis factors were found, and protecting parameters defined that decrease the risk of adverse cardiovascular events occurence. Predictors of adverse prognosis in post-operation period were found: clinical and demographic — older age; high surgical risk by EuroScore II ≥3; chronic renal failure; cerebrovascular — chronic cerebral ischemia III grade; the unclosed Willis circle; unstable atherosclerotic plaque or subtotal stenosis of the internal carotid arteria unilateral with operation; subtotal stenosis or occlusion of internal carotid artery contralateral.Conclusion. The results can be applied in algorithms development for selection of surgical tactics in multifocal atherosclerosis patients
Polypragmasy at treatment of <i>H. pylori</i> infection in patients with concomitant diseases of other organs and systems. How to prevent side effects related to drug interactions?
No full textThe aim of the publication. Issues of drug interaction, side effects development at patients with combined diseases, requiring eradication treatment, are taken into account.Original positions. Being based on literature data and own experience, authors demonstrated, that drug interactions are observed in vast majority of cases at simultaneous prescription of five drugs and more. As eradication therapy implicates addition to treatment of at least 3 pharmaceuticals of which antibiotics are strictly specified, it is extremely desirable to choose proton pump inhibitor (PPI) with lower affinity to cytochrome Р450. Pantoprazole conform to these requirements, and surpasses all other PPIs in this respect.Conclusion. Authors believe, taking into account available data on drug interactions, that at patients with multiple morbidity pantoprazole is preferable to other antisecretory agents
Influence of an atomic resonance on the coherent control of the photoionization process
Get PDFIn coherent control schemes, pathways connecting an initial and a final state can be independently controlled by manipulating the complex amplitudes of their transition matrix elements. For paths characterized by the absorption of multiple photons, these quantities depend on the magnitude and phase between the intermediate steps, and are expected to be strongly affected by the presence of resonances. We investigate the coherent control of the photoemission process in neon using a phase-controlled two-color extreme ultraviolet pulse with frequency in proximity of an excited energy state. Using helium as a reference, we show that the presence of such a resonance in neon modifies the amplitude and phase of the asymmetric emission of photoelectrons. Theoretical simulations based on perturbation theory are in fair agreement with the experimental observations
Chemical speciation of environmentally significant metals with inorganic ligands. Part 4: The Cd2+ + OH–, Cl–, CO32–, SO42–, and PO43– systems (IUPAC Technical Report)
Get PDFThe numerical modeling of Cd-II speciation amongst the environmental inorganic ligands Cl-, OH-, CO32-, SO42-, and PO43- requires reliable values for the relevant stability (formation) constants. This paper compiles and provides a critical review of these constants and related thermodynamic data. It recommends values of log(10) beta(p,q,r) valid at I-m = 0 mol kg(-1) and 25 degrees C (298.15 K), along with the equations and empirical reaction ion interaction coefficients, Delta epsilon, required to calculate log(10)beta(p),(,q,r) values at higher ionic strengths using the Bronsted-Guggenheim-Scatchard specific ion interaction theory (SIT). Values for the corresponding reaction enthalpies, Delta H-r, are reported where available. Unfortunately, with the exception of the Cd-II-chlorido system and (at low ionic strengths) the Cd-II-sulfato system, the equilibrium reactions for the title systems are relatively poorly characterized.
In weakly acidic fresh water systems (-log(10){[H+]/c degrees} < 6), in the absence of organic ligands (e. g., humic substances), Cd-II speciation is dominated by Cd2+(aq), with CdSO4(aq) as a minor species. In this respect, Cd-II is similar to Cu-II [2007PBa] and Pb-II [2009PBa]. However, in weakly alkaline fresh water solutions, 7.5 < -log(10) {[H+]/c degrees} < 8.6, the speciation of Cd-II is still dominated by Cd2+(aq), whereas for Cu-II [2007PBa] and Pb-II [2009PBa] the carbonato-species MCO3(aq) dominates. In weakly acidic saline systems (-log(10) {[H+]/c degrees} < 6; -log(10) {[Cl-]/c degrees} < 2.0) the speciation is dominated by CdCln(2-n)+ complexes, (n = 1-3), with Cd2+(aq) as a minor species. This is qualitatively similar to the situation for Cu-II and Pb-II. However, in weakly alkaline saline solutions, including seawater, the chlorido-complexes still dominate the speciation of Cd-II because of the relatively low stability of CdCO3(aq). In contrast, the speciation of Cu-II [2007PBa] and Pb-II [2009PBa] in seawater is dominated by the respective species MCO3(aq).
There is scope for additional high-quality measurements in the Cd2+ + H+ + CO32- system as the large uncertainties in the stability constants for the Cd2+-carbonato complexes significantly affect the speciation calculations
ПРОГНОЗИРОВАНИЕ РИСКА РАЗВИТИЯ ТРОМБОЗОВ И СТЕНОЗОВ БИОПРОТЕЗОВ «КЕМАНГИОПРОТЕЗ» ПУТЕМ ПОСТРОЕНИЯ МАТЕМАТИЧЕСКОЙ МОДЕЛИ
No full textThe purpose of this study was to create an integrated diagnostic methodology to predict and prevent the development of complications (restenosis, thrombosis) in the late postoperative period after ‘KemAngioprotez’ femoropopliteal biological prosthesis implantation. Group I (n=52) included patients with a poor outcome (restenosis in the prosthesis in 35 patients accompanied by thrombosis) and group II (n=59) consisted of patients with functioning and intact prosthesse. Almost all known clinical and several metabolic parameters were assessed. According to the multivariate analysis, four factors were significant in the development of restenosis and thrombosis, i.e. patient’s age, atherogenic index (AI), lipid profile, platelet hypoor hyperaggregation and the technique for bioprosthetic further modification. Based on the obtained data the mathematical model was developed, which allows to predict and prevent the development of complications in the long term period after «KemAngioprotez» femoropopliteal bioprosthesis implantation.Целью настоящего исследования явилось создание комплексной диагностической методики, позволяющей прогнозировать и профилактировать развитие осложнений (рестеноз, тромбоз) в отдаленном послеоперационном периоде после бедренно-подколенного протезирования биологическим протезом «КемАнгиопротез». Группу I (n=52) составили пациенты с неблагоприятным исходом (рестеноз протеза, у 35 больных сопровождавшийся тромбозом); группу II (n=59) – больные с функционирующими и неизмененными протезами. Проанализированы практически все известные клинические, ряд метаболических показателей. Согласно результатам многофакторного анализа, значимыми для развития рестенозов и тромбозов являются четыре фактора: возраст больного, индекс атерогенности (ИА) липидограммы, гипо- или гиперагрегация тромбоцитов, способ дополнительной модификации биопротеза. На основе полученных данных была разработана математическая модель, позволяющая прогнозировать и профилактировать развитие осложнений в отдаленном периоде после бедренно-подколенного протезирования биопротезом «КемАнгиопротез»
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