263 research outputs found
Magnetooptical investigations of large transport currents in YBCO-thin films
No full textMagnetooptical investigations of large transport currents in YBCO-thin films / B. Schey ... – In: IEEE Transactions on applied superconductivity. 11. 2001. S. 3178-318
William Francis Schey
No full textWilliam Francis Schey was born on January 5, 1857 at Hoxton, Newtown London. He was the Son of Gerard Marius James Schey, Accountants Clerk and Ellen née Puddick. He was educated at London Middle Class School, and completed a ships apprenticeship on the White Star Lines. In 1875 he visited Sydney and gained a Second Mates Certificate. He later sailed with Shaw, Saville and Albion Co Ltd and the New Zealand Shipping Company. He also briefly taught at a naval school near Auckland. (1) In 1877 stranded in Sydney through illness, he worked as a labourer to support himself. He subsequently joined the railways branch of the Department of Public Works, where he worked as a porter, shunter and parcels clerk. (2) In 1879 Schey was active in the formation of the Railways and Tramways Employees Association, and became its unpaid secretary. Upon the formation of the NSW Amalgamated Railways and Tramways Service Association in 1886, Schey resigned from the Department of public works, and became the associations paid Secretary. Whilst employed as secretary, Schey succeeding in expanding the Friendly Society activities of the Union. (3) Schey was supported by his fellow railwaymen in 1887 to make a bid for parliament in order to represent the Unions concerns, such as provision of an eight-hour day. He was 'An extremely able speaker with a remarkable ability to communicate with working men'. (4) Schey was elected to the Legislative Assembly as a member for Redfern in 1887 and held the seat until 1894. He won the Seat of Darlington in 1894, and held the seat until 1898. (5) During his time in Parliament Schey tried from 1887 until 1897 to introduce the Eight Hours Bill, but his attempts were unsuccessful. He also supported the passing of the Government Railways Act 1888 (Victoria 51 Act No 35). (6) This Act established the Railway Commissioners as independent administrators of the Railway function. (7) In 1892 a Royal Commission investigated allegations Schey made against E.M.G. Eddy the Railway Commissioner. The Commission found that none of the allegations of nepotism, or mismanagement of Railway affairs could be substantiated. (8) Schey was appointed a Chief Labour Commissioner, from May 1900 until 1905. In 1905 he was appointed Director of the State Labour Bureau, and continued on in that post until 1912. (9) His chief achievement in these posts was the administration of the Casual Labour Farm, Pitt Town which provided training in farm work for the unemployed. Schey also administered and established the Government Agricultural Training Farm, Scheyville, which provided training in farm work for young men from the city. The young men were often recruited from the United Kingdom through assisted migrations schemes such as the Dreadnought and Big Brother Schemes. Schey was a member of several Associations. He was a prominent Freemason, and held office as past master of Lodge United Service. He was a member of Mark Master lodge and Robert Burns Royal Arch Chapter. He published two brief histories of the Freemasonry. He was also an Orangemen. (10) He married Charlotte Dorothea Weyang, a dressmaker from Hanover, Germany on 22 May 1880. The couple had a daughter and two sons. He died on 18 July 1913, and was buried in Gore Hill Cemetery. (11) Footnotes (1) Australian Dictionary of Biography Nes - Smi 1891 - 1939 University of Melbourne Press, Carlton 1966 - 2000 p.535 (2) Ibid p.535 (3) Ibid p.535 (4) Ibid p.535 (5 NSW Parliamentary Record, 1824 - 1999, Sydney, The Clerk of the Parliaments, vol 6., 1st edn, 1999 p.180 (6) Op Cit. Australian Dictionary of Biography p. 535 (7) An Act to make better provision for the management of the Government Railways and Tramways of NSW 1888. Preamble, s.2, s.6 (8) Report of The Royal Commission appointed to inquiry Charges against Mr E.M.G Eddy Preferred by Mr W.F.Schey M.L.A p.24 in NSW Parliamentary Papers 1892 - 1893 Vol. 5 p.566 (9) Report of the Department of Labour and Industry for the year 1918 p.64 - 66 in NSW Parliamentary Papers 1919 Vol 1. P.521 - 523 (10) Op Cit. Australian Dictionary of Biography p.536 (11) Ibid p. 535 - 536PER-174Director State Labour Bureau 1905 - 1912<br/>Chief Labour Commissioner 1900 - 1905<br/>A member of the Legislative Assembly 1887 - 1895<br/>
To the Statistics of the Jewry of the Kingdom of Serbs, Croats and Slovenes
No full textU petom godištu "Jevrejskog almanaha" (1929) prilog statistici jevrejstva Kraljevine SHS koji je napisao Leon Kamhi, odnosi se na Jevreje Bitolja. Poslednih godina otomanske vladavine, tačnije 1910. godine njihov broj je iznosio 7.000, a u vreme objavljivanja petog godišta Almanaha taj broj je prepolovljen. 1910. godine počinje emigracija za Severnu Ameriku (najviše Njujork, zatim Ročester, Indianopolis). Emigracija je bila aktuelna dugi niz godina i dostigla broj od oko 4.000 Jevreja iz Bitolja, ali više nije bila moguća zbog postojeće zabrane useljenja od strane vlasti SAD. Osim u Ameriku Jevreji Bitolja iseljavali su se i u Čile i Palestinu. U tekstu su opisane mnoge važne karakteristike bitoljske jevrejske zajednice. Drugi deo ovog priloga koji je napisao profesor Rudolf Schey, odnosi se na Jevreje iz Bjelovara i Đakova.In the fifth volume of the "Jewish Almanac" (1929), a contribution to the statistics of Judaism of the Kingdom of Serbs, Croats and Slovenes, written by Leon Kamhi, refers to the Jews of Bitola. In the last years of Ottoman rule, more precisely in 1910, their number was 7,000, and at the time of the fifth year of the Almanac, that number was halved. In 1910, emigration to North America began (mostly New York, then Rochester, Indianapolis). Emigration was current for many years and reached the number of about 4,000 Jews from Bitola, but it is no longer possible due to the existing ban on immigration by the US authorities. Except for America, the Jews of Bitola also emigrated to Chile and Palestine. The text describes many important characteristics of the Bitola Jewish community. The second part of this article, written by Professor Rudolf Schey, refers to Jews from Bjelovar and Đakovo
Excitation of the 2s State of Atomic Hydrogen by Electron Impact in the Distorted-Wave Approximation - Angular Distributions
No full textThe excitation of ground-state hydrogen atoms to the 2s state by the impact of electrons with energies of 1 to 50 Ry (13.6 to 680.3 eV) has been calculated in the distorted-wave approximation with exchange included. The angular distributions of the scattered electrons at 1 and 4 Ry are compared with those derived from the close-coupling calculations by Burke, Schey, and Smith, and are compared with four different plane-wave theories at all energies calculated. Taking the close-coupling results as a standard, it is found that the distorted-wave angular distributions represent an improvement over those of the plane-wave theories
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma
No full textBackground: The purpose of this study was to assess the efficacy and safety of ISIS 3521, an antisense phosphorothioate oligonucleotide to protein kinase C {alpha} in patients with relapsed low-grade non-Hodgkin's lymphoma (NHL).Patients and methods: Twenty-six patients received ISIS 3521 (2 mg/kg/day) as a continuous infusion over 21 days of each 28-day cycle.Results: The median age of the patients was 53 years (range 37–77). Histological subtypes were low-grade follicular lymphoma (n=22) and B-cell small lymphocytic lymphoma (n=4). Twenty-one (81%) had stage III/IV disease. The median number of previous lines of chemotherapy was two (range one to six). A total of 87 cycles of ISIS 3521 were administered. Twenty-three patients were assessable for response. Three patients achieved a partial response. No complete responses were observed. Ten patients had stable disease. Grade 3–4 toxicity was as follows: neutropenia (3.8%) and thrombocytopenia (26.9%).Conclusions: ISIS 3521 has demonstrated anti-tumour activity in patients with relapsed low-grade NHL. There may be a potential role for this agent in combination with conventional chemotherapy for advanced low-grade lymphoma, and further trials are warranted
Lieder und Weisen. 1 : disques d'enseignement / publiés sous la direction de Pierre Auclert, inspecteur principal de l'enseignement musical et d'Albert Spaeth, professeur d'Allemand, agrégé de l'Université
No full textTitre uniforme : Schubert, Franz (1797-1828). Compositeur. [Erlkönig. D 328]Titre uniforme : Brahms, Johannes (1833-1897). Compositeur. [Sandmännchen. WoO 31, no 4]Titre uniforme : Loewe, Carl (1796-1869). Compositeur. [Der Erlkönig. Op. 1, no 3]Comprend : Die Lorelei / orchestre de l'Opéra de Berlin ; H. Schlusnus, BAR ; Der Erlkönig / Franz Schubert, comp. ; H. Schlusnus, BAR ; Franz Rupp, p ; Sandmännchen / Johannes Brahms, comp. ; N. Wetchor, S ; Pierre Auclert, p ; Das Männlein im Walde / Petits chanteurs de Vienne, ens. voc. ; Orchestre symphonique de Vienne ; Der Erlkönig / Carl Loewe, comp. ; H. Schey, BAR ; F. de Nobel, pBnF-Partenariats, Collection sonore - BelieveContient une table des matière
Thalidomide in the Management of Multiple Myeloma
No full textThe discovery that multiple myeloma is associated with new vessel formation and is correlated with survival and proliferation led initially to the use of thalidomide for patients with relapsed or refractory disease. The outcome with conventional chemotherapy in this setting has historically been very poor. New insights into the biology of the disease suggests that thalidomide may work via a number of other mechanisms and the advent of the thalidomide analogues with their differential effects on survival and proliferation pathways has opened up a new era in the understanding and treatment of the disease. The encouraging results from phase I/II trials of these agents has meant that for the first time in 50 years there is the opportunity to improve outcome. Further work is in progress to define how best to use these drugs and their role in treatment at different stages of the disease. [References: 96
Les Noces ; Mass ; Pater noster...[etc.] / Stravinsky, comp. ; The Netherlands Chamber choir ; Felix de Nobel, dir.
No full textTitre uniforme : Stravinsky, Igor (1882-1971). Compositeur. [Svadebka. W 37] (français)Titre uniforme : Stravinsky, Igor (1882-1971). Compositeur. [Messe. W 87]Titre uniforme : Stravinsky, Igor (1882-1971). Compositeur. [Otče naš. W 55]Titre uniforme : Stravinsky, Igor (1882-1971). Compositeur. [Bogorodice devo. W 65]Comprend : Les Noces / Stravinsky, comp. ; Corrie Bijster, S ; Cora Canne Meyer, MS ; Ernst Häfliger, T ; Herman Schey, B ; The Netherlands Chamber choir ; Felix de Nobel, dir. ; Mass / Stravinsky, comp. ; The Netherlands Chamber choir ; Felix de Nobel, dir. ; Pater noster / Stravinsky, comp. ; The Netherlands Chamber choir ; Felix de Nobel, dir. ; Ave Maria / Stravinsky, comp. ; The Netherlands Chamber choir ; Felix de Nobel, dir.Enregistrement : (Pays-Bas) : Holland festival, 00-00-1954BnF-Partenariats, Collection sonore - BelieveContient une table des matière
High Spatial Resolution Multi-omic Investigations of Staphylococcus aureus Biofilm Layers: Visualizing Daptomycin-Resistance
No full textStaphylococcus aureus infections pose a serious threat to human health with the increasing incidence of microbial resistance to last-line antibiotics such as daptomycin. Many S. aureus infections present as a biofilm wherein molecular heterogeneity of bacterial subpopulations has been observed, further confounding their burden on human health. Here, the utility of matrix-assisted laser desorption/ionization trapped ion mobility spectrometry imaging mass spectrometry (MALDI TIMS IMS) was assessed for the multi-omic spatial investigations of S. aureus biofilm layer heterogeneity. To achieve high spatial resolution molecular investigation of S. aureus biofilms by MALDI TIMS IMS, a workflow was first developed to prepare these samples for interrogating lipids, peptides, and intact proteins. Most lipids were observed to localize primarily to a single biofilm layer. Methods for on-biofilm trypsin digestion of bacterial proteins for bacterial tryptic peptide analysis were developed and applied toward spatial interrogation of S. aureus biofilms. Next, development of novel instrumental methods for high-mass analysis by MALDI TIMS IMS resulted in the detection of bacterial proteins up to m/z ~16,000. Both spatial proteomic approaches uncovered heterogeneity between biofilm layers, further underscoring the molecular differences between these biofilm subpopulations. Finally, biofilms grown with daptomycin-susceptible and -resistant clinical isolates of S. aureus were found to exhibit differences in abundance and distributions of lysyl-PG lipids between layers under normal growth conditions. Furthermore, MALDI TIMS IMS revealed a dose-dependent bacterial response to daptomycin treatment only in the daptomycin-resistant clinical isolate when exposed to varying doses of antibiotic. Intriguingly, although lysyl-PG lipids are associated with the proposed mechanism of daptomycin-resistance, these spatial investigations uncovered a shift in localization of these lipid species away from antibiotic penetration. Further work to confirm bacterial viability within the biofilm indicated that these shifts in spatial distribution may be the result of a coordinated localized biofilm response to the antibiotic. This elucidation of a coordinated biofilm response to antibiotic may provide a new avenue for localized biofilm treatment
Future Directions in Multiple Myeloma Treatment
No full textFuture therapy options for multiple myeloma may be directed at asymptomatic disease, as only symptomatic myeloma is treated currently. Additional genetic information from gene array analysis will mean that the identification of cases with poor prognosis will become more sophisticated. New markers are being discovered constantly, and these continuously change the picture regarding prognostic factors. More intensive treatment options increase the depth of remissions, thereby improving outcomes. In pilot studies, cyclophosphamide, thalidomide and dexamethasone (CTD) was a highly effective, well-tolerated regimen for patients refractory to initial therapy with VAD or with relapsed disease. It is being further evaluated as induction therapy in the current MRC Myeloma IX trial. Also under investigation is a small molecule derivative of thalidomide, CC-4047 (Actimid). It has between 1,000 and 10,000 times more potent antitumour necrosis factor alpha activity, with an additional immunomodulatory effect. It has been shown to be between 50 and 2,000 times more potent in the stimulation of T-cell proliferation and 50-100 times more potent in augmenting interleukin-2 and interferon-gamma production. With many possible approaches to study and work through, future strategies will revolve around exploration of the effectiveness of combinations that incorporate new agents in various disease and treatment settings. The use of genetic profiles to further delineate groups for different treatment approaches should enable the introduction of patient-specific treatment programmes in the future. Copyright (c) 2005 S. Karger AG, Base
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