167 research outputs found
X-ray analysis of the accreting supermassive black hole in the radio galaxy PKS 2251+11
No full textWe investigate the dichotomy between jetted and non-jetted Active Galactic
Nuclei (AGNs), focusing on the fundamental differences of these two classes in
the accretion physics onto the central supermassive black hole (SMBH). Our aim
is to study and constrain the structure, kinematics and physical state of the
nuclear environment in the Broad Line Radio Galaxy (BLRG) PKS 2251+11. The high
X-ray luminosity and the relative proximity make such AGN an ideal candidate
for a detailed analysis of the accretion regions in radio galaxies. We
performed a spectral and timing analysis of a 64 ks observation of PKS
2251+11 in the X-ray band with XMM-Newton. We modeled the spectrum considering
an absorbed power law superimposed to a reflection component. We performed a
time-resolved spectral analysis to search for variability of the X-ray flux and
of the individual spectral components. We found that the power law has a photon
index , absorbed by an ionized partial covering medium with
a column density cm, a ionization
parameter erg s cm and a covering factor
. Considering a density of the absorber typical of the Broad Line
Region (BLR), its distance from the central SMBH is of the order of
pc. An Fe K emission line is found at 6.4 keV, whose intensity shows
variability on time scales of hours. We derived that the reflecting material is
located at a distance , where is the Schwarzschild
radius. Concerning the X-ray properties, we found that PKS 2251+11 does not
differ significantly from the non-jetted AGNs, confirming the validity of the
unified model in describing the inner regions around the central SMBH, but the
lack of information regarding the state of the very innermost disk and SMBH
spin still leave unconstrained the origin of the jet
The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children
No full textPediatric non-Down-syndrome acute megakaryoblastic leukemia (non-DS-AMKL) is a heterogeneous subtype of leukemia that has historically been associated with poor prognosis. Until the advent of large-scale genomic sequencing, the management of patients with non-DS-AMKL was very difficult due to the absence of reliable biological prognostic markers. The sequencing of large cohort of pediatric non-DS-AMKL samples led to the discovery of novel genetic aberrations, including high-frequency fusions, such as CBFA2T3-GLIS2 and NUP98-KDM5 A, as well as less frequent aberrations, such as HOX rearrangements. These new insights into the genetic landscape of pediatric non-DS-AMKL has allowed refining the risk-group stratification, leading to important changes in the prognostic scenario of these patients. This review summarizes the most important molecular pathogenic mechanisms of pediatric non-DS-AMKL. A critical discussion on how novel genetic abnormalities have refined the risk profile assessment and changed the management of these patients in clinical practice is also provided
Absence of microsatellite instability in breast carcinomas with both p53 and c-erbB-2 alterations
No full textMethoxylation modifies the activity of 1,2-benzisoxazole-3-acetic acid: 6,7-dimethoxy-1,2-benzisoxazole-3-acetic acid is an auxin antagonist in cytokinin mediated processes
No full text
Nasal obstruction and snoring: three unusual cases as a lesson for the paediatrician
No full textNasal obstruction with or without snoring is a frequent condition and, as such, it is easily disregarded by paediatricians and by parents as well. The paper describes three “unforgettable” clinical cases that must be a warning to investigate and not to underestimate those atypical and/or characteristic aspects, such as the nasal obstruction that rapidly becomes severe. Such aspects must induce to deepen investigations to exclude much more rare pathologies that if not promptly diagnosed would have serious prognostic repercussions on the child. Surely, the first alarm signal is time (recent onset and/or snoring that rapidly becomes severe), with worsening of symptoms. Surely, lymphadenopathy is another alarm signal, especially when bilateral and large. Furthermore, the onset of epistasis associated with oral cavity bleeding must not be underestimated
Efficacy of venetoclax based salvage chemotherapy followed by “Minimal Residual Disease driven”-venetoclax maintenance therapy post-allotransplant in a young patient with high risk primary refractory acute myeloid leukemia
No full textDentro il labirinto. Autoreferenzialità e intertestualità in Luigi Malerba. II
No full textRarely, critical readings of Luigi Malerba’s work have considered the question of the sources or, more generally, of intertextuality, confirming instead the image of a self-referential author, due especially to his remarkable originality within the narrative survey of late twentieth century. This essay aims to suggest that this self-referentiality should be verified and, at least, partly reconsidered. In fact, whereas on the one hand, Malerba refers mostly to himself, repeating his own themes, scenes, characters, and language, on the other hand, in his works it is possible to find out a wide network of documentary sources, and accurate and provable references to works of other authors, such as Svevo and Pirandello or Borges and Marquez. Also, it is possible to suppose that the author’s will to conceal his models is suitable to a precise poetic and answers to a precise idea of the novel function as well
Modular time-of-flight image sensor for light detection and ranging: A digital approach to LIDAR
No full textConstant increase in data processing efficiency has enabled, among many other things, the intensive use of depth mapping technologies. Consumer applications, such as gaming, augmented and virtual realities (AR/VR), and other human-machine interfaces, are typically based on intensive image processing, either by triangulation and/or structured light, which has limitations on speed, resolution, range, and robustness to background noise. On the other hand, TOF depth sensing has been investigated in the academic and industrial engineering communities for several years, as an alternative to solve such restrictions, and few products are emerging. Direct time-of-flight (dTOF), specifically, requires more elaborate detectors and data processing, but it has the potential of reaching much longer distances at higher speed and accuracy, with the advantage of being robust to high background noise, making it suitable for space, automotive and consumer applications. One known drawback of dTOF, however, is data volume. For instance, automotive applications require over 100m range, only few centimeters accuracy, and multiple measurements for a reasonable precision, which produce data rates that can reach tens or even hundreds of Gbps, in large sensors, thus setting processing constraints to even very efficient GPUs, as well as chip readout capability. It is essential to provide as much on-chip processing as possible, in order to reduce data throughput, thus reducing power consumption and speeding up processing time. Some architectures have been proposed attempting to solve this problem, but the required memory renders them only feasible for an SiPM, single-pixel approach. Another known issue with light detection and ranging (LiDAR) is regarding the interference of multiple systems on each other. A software-based approach has been implemented, but requiring intensive post-processing resources. In this thesis, a novel approach for on-chip processing is proposed. With the use of cutting-edge 3D-stacking technologies, more flexibility and computational power can be spent on the chip, while not compromising fill factor. A novel proposal for dealing with external interferes is introduced, as well as novel phase/frequency locking solution at the sensor level, as a reference for timing measurements.(OLD)Applied Quantum Architecture
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