703 research outputs found
Identification of the Kna/Knb polymorphism and a method for Knops genotyping
No full textDNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)-a ligand for rosetting of Plasmodium falciparum-infected RBCs. The molecular identification of the Kna/Knb polymorphism was sought to develop a genotyping method for use in the study of the Knops blood group and malaria
CR1 Knops blood group alleles are not associated with severe malaria in the Gambia
No full textThe Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West African children living in the Gambia. While SNPs associated with Sl:2 and McC(b+) were equally distributed among malaria-infected children with severe malaria and control children not infected with malaria parasites, high allele frequencies for Sl 2 (0.800, 1,365/1,706) and McC(b) (0.385, 658/1706) were observed. Further, when compared to the Sl 1/McC(a) allele observed in all populations, the African Sl 2/McC(b) allele appears to have evolved as a result of positive selection (modified Nei-Gojobori test Ka-Ks/s.e.=1.77, P-valu
Bookreview R. Anthone, E. Janssens, S. Vervoort en J. Knops (red.), Peinzen. 49 filosofische vragen voor kinderen, Leuven: Acco, 2006
No full textR. Anthone, E. Janssens, S. Vervoort en J. Knops (red.), Peinzen. 49 filosofische vragen voor kinderen, Leuven: Acco, 200
No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes
No full textClustering of Complement Receptor 1 (CR1) in the erythrocyte membrane is important for immune-complex transfer and clearance. CR1 contains the Knops blood group antigens, including the antithetical pairs Swain-Langley 1 and 2 (Sl1 and Sl2) and McCoy a and b (McCa and McCb), whose functional effects are unknown. We tested the hypothesis that the Sl and McC polymorphisms might influence CR1 clustering on erythrocyte membranes. Blood samples from 125 healthy Kenyan children were analysed by immunofluorescence and confocal microscopy to determine CR1 cluster number and volume. In agreement with previous reports, CR1 cluster number and volume were positively associated with CR1 copy number (mean number of CR1 molecules per erythrocyte). Individuals with the McCb/McCb genotype had more clusters per cell than McCa/McCa individuals. However, this association was lost when the strong effect of CR1 copy number was included in the model. No association was observed between Sl genotype, sickle cell genotype, α+thalassaemia genotype, gender or age and CR1 cluster number or volume. Therefore, after correction for CR1 copy number, the Sl and McCoy polymorphisms did not influence erythrocyte CR1 clustering, and the effects of the Knops polymorphisms on CR1 function remains unknown
AT in UNESCO IITE project: "ICTs in Education for People with Special Needs"
No full textOne of the main UNESCO's goals is to promote equitable access to information, knowledge and data for all of citizens, including those who have special educational needs. In order to build a more inclusive Information Society, new pedagogical approaches and appropriate technologies must be developed. Following this intention, UNESCO IITE has developed the Specialized Training Course "ICTs in Education for People with Special Needs", devoted to the issues of general and specific ICT applications in education for a wide range of people with disabilities, as well as to the policy development in this sphere
Buckling of anisotropic cylindrical shells subjected to combined axial compression, normal pressure, bending and shear loading
No full textAerospace Engineerin
Computation of stress intensity factors by the mode enrichment technique with applications to geometrically nonlinear problems
No full textAerospace Engineerin
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