128 research outputs found
DS_10.1177_0363546518798768 – Supplemental material for Return to Play and In-Game Performance Statistics Among Pitchers After Ulnar Collateral Ligament Reconstruction of the Elbow: A Systematic Review
No full textSupplemental material, DS_10.1177_0363546518798768 for Return to Play and In-Game Performance Statistics Among Pitchers After Ulnar Collateral Ligament Reconstruction of the Elbow: A Systematic Review by Ryan P. Coughlin, Chetan Gohal, Nolan S. Horner, Ajaykumar Shanmugaraj, Nicole Simunovic, Edwin R. Cadet, Asheesh Bedi and Olufemi R. Ayeni in The American Journal of Sports Medicine</p
Towards a deep ecology of art, technology and being - an ontological investigation with particular reference to the rock-cut edifices of Ellora, India, and Tadao Ando’s water temple
Get PDFThis practice-based thesis is an interrogation of ‘being’, one not centred on the human being. It concerns a being that manifests through dynamic inter-relation between human and other entities and phenomena in the universe. It considers several interrelated questions, interrogating notions of 'relational being','non-anthropocentric being', 'the being of a space', ‘the space of being’. Ultimately,
one is considering the implications of relational being for ‘deep ecology’.
With regard ‘relational being’, key inter-related Buddhist ideas drive the thinking and practice: ‘relational origination’ (pratityasamutpada), and ‘emptiness’(shunyata). Furthermore at the heart of this particular history of technology is a discussion of the significance of zero. The Sanskrit term shunya, means both ‘zero’ and ‘empty’, and relates to shunyata.
There are several principal objectives. Firstly an analysis of perceived relational dynamics in Ellora’s rock-cut architecture, technology, and ontology. Secondly, scrutiny of apparent correspondence between Ellora’s Edifice Twenty-Nine and a contemporary Tantric shrine: the Water Temple, constructed in 1991. Thirdly, an examination of ideas in contemporary science and technology that engender reconsiderations of notions of ‘relational being’.
The primary practical outcomes are two films: relationship-place naka-ma and zero = every day? Both approach the question through phenomenological process, paralleling Ando’s conception of ‘architecture’ as an integrated and inter-acting entity of built edifice, wider landscape, and the spectatorship of persons who frequent it.
This research engenders ‘new knowledge’ in terms of: offering pluralistic, trans-national and trans-disciplinary insight on current thinking relating to art, architecture, technology, spectatorship, and ontological practice; evolving knowledge with regard interactions between body, humanly constructed entities, wider environments/ecologies; engendering new perspectives on considerations of cyberspace, Ellora, Ando, and the Water Temple; contributing to a counter thesis vis-à-vis the colonial project of objectification and ossification of the other
26666_Appendix – Supplemental material for Effectiveness of Valgus Offloading Knee Braces in the Treatment of Medial Compartment Knee Osteoarthritis: A Systematic Review
No full textSupplemental material, 26666_Appendix for Effectiveness of Valgus Offloading Knee Braces in the Treatment of Medial Compartment Knee Osteoarthritis: A Systematic Review by Chetan Gohal, Ajaykumar Shanmugaraj, Asheesh Bedi, Anthony Adili, and Moin Khan in Sports Health: A Multidisciplinary Approach</p
Technological practice, relational being, non-anthropocentric being, the being of a space, and the space of being
Get PDFThis article formally-thematically considers a notion of 'relational being', 'non-anthropocentric being', 'the being of space', and 'the space of being', in the context of current, past and prospective technological practice. These concepts are complex and none of them can be adequately explained in a single sentence, or even a paragraph. However it is intended that some sensing, comprehending of, and reflection on these notions is engendered through the evolution of this discussion. I am using 'technological practice' in a particular and crucial sense in this essay: referring to what might be thought of as an integrated epistemological process where art, philosophy, craft/technique and science were considered part of an integrated thinking-practice. The article re-considers the Buddhist philosophic concept of pratiyasamutpada (there is a glossary of non-English and uncommon terms such as this at the end of the article) - commonly known in English as 'dependent origination' - in the context of digital and new media art. In such context, the essay investigates Tannic thinking and practice that attempts to develop an integrated practice and dynamic entity of the body (artist and/or spectator), science, technology, art, philosophy, and nature. It discusses the veracity of such ideas in the context of particular new scientific insights. Furthermore the article interrogates a notion of a polyphonic T. Moreover, given the current proliferation of the worldwide web, the article discusses new ways of evolving current practice and thinking on themes related to the socialisation and mediatisation of 'difference'. Areas of formal and thematic investigation concern rethinking otherness, multi-culturalism, convergence; rethinking difference, identity, multiplicity, fragmentation; and developing a language of difference. The article is an evolution and expansion of an initial, shorter article on the theme (Ajaykumar, 2007). It also evolves ideas developed by the author in other articles, in public lectures, and in conference papers on related topics and disciplines. As
readers may be unfamiliar with these texts, there will be some necessary repetition to assist the flow of this discourse. The nature of composition of the article approaches a form-theme synthesis, formally engaging with some of the concepts discussed. Moreover, here it interrogates the notion of 'practice as theory' and 'theory as practice'. This brings into question the notion of difference and distinction between the two, and the some time privileging of theory over practice in art and humanities research. Moreover this may have resonance with parallel approaches such as performance-lectures and lecture-texts of John Cage (Cage, 1973); as well as 'film essays', such as some of those of Chris Marker (1983); together with some of the textual strategies of Jacques Derrida. Of particular note is Derrida's text "Tympan" (1991, pp.146-168). Furthermore, the nature of the composition also serves to question conceptions of a polyphonic T
Exploring Extracellular Hydrolytic Enzyme and Bio Flocculant-Producing Bacterial Isolates for Bioremediation of Vegetable Oil Refinery Effluent.
Get PDFThe process of vegetable oil refining generates an enormous amount of wastewater. This study focused on characterization of vegetable oil refinery effluent (VORE) sample untreated and treated by bacteria for various physicochemical parameters. The sample has high COD and BOD; 12.32g/L and 1.7g/L respectively, this highlights the need for proper treatment. The VORE samples were treated by bacteria producing extracellular hydrolytic enzymes and bioflocculant, identified as B. licheniformis, S. stutzeri, B. amiloliquificance and, S. mutabilis. The bacterial treatment was performed in a separate 250ml flask containing 100ml effluent and inoculated with 2% of respective 24h grown culture. The bacterial treatment achieved a significant decrease in BOD and COD. The treated effluent showed significant increase in seed germination representing a reduction in toxicity in comparison to untreated effluent. This highlights the suitability of present study isolates for VORE treatment with high BOD and COD
CONTROLLED SYNTHESIS OF TOPOLOGICALLY TEMPLATED CATENANE AND KNOTTY POLYMER
No full textThe topologically interesting structure of polymer catenanes and knotty polymers are of high interest for their unique chemical and physical properties. However, the practical applications of these materials have not been explored well due to synthetic obstacles in obtaining high yields. Chapter 1 reviews template directed synthesis of low molecular weight catenanes and the trefoil knot. In addition, recent advances in synthesis of topologically similar cyclic polymer via end-to-end cyclization of linear analogue or ring-expansion polymerization from cyclic catalyst/initiator are also discussed. Chapter 2 demonstrates a novel route for the synthesis of polymer catenanes using supramolecularly templated Atom Transfer Radical Polymerization (ATRP) initiator for polymerization and subsequent closing of the resulting four-armed type polymer template by Atom Transfer Radical Coupling (ATRC). Direct visualization of the interlocked topology of polymer catenane was achieved by Atomic Force Microscopy (AFM) imaging technique. Chapter 3 reports an important extension of the above mentioned methodology to obtain a catenated block copolymer. The four-armed type homopolymer template was used as macroinitiator to polymerize another monomer by ATRP. The resulting block copolymer template was subjected to template-closing via slightly modified ATRC method. Chapter 4 demonstrates another novel approach to synthesize polymer catenanes by first grafting a preformed alkyne-functionalized linear polymer to an azide-functionalized supramolecular template, followed by ATRC of the resulting polymer template. Detailed analysis of AFM image reveals important information about the side products of ATRC such as inter-molecular coupling and other isomer formation. Chapter 5 reports on a preliminary study of thermally initiated ring-expansion Reversible Addition Fragmentation Chain Transfer (RAFT) polymerization from cyclic RAFT initiator. A novel dixanthate type cyclic RAFT initiator was synthesized and used in a thermally initiated free radical polymerization of N-vinylcarbazole. The cyclic topology of the resulting polyvinylcarbazole was confirmed by Gel Permeation Chromatography (GPC) and AFM analysis. Chapter 6 demonstrates for the first time the synthesis of trefoil knot polymer (knotty polymer) via grafting of an alkyne-functionalized polymer to azide-functionalized double helical type supramolecular template. A well-defined knotty polymer was then obtained by closing the polymer template via ATRC method. Finally in Chapter 7, conclusions, perspectives, and future work on these topics are discussed.Chemistry, Department o
Functional and structural insights into one-component transcriptional regulators involved in methylenomycin production in Streptomyces coelicolor A3(2)
Get PDFIn one-component regulatory systems a transcriptional regulator (TR) protein
typically comprises both ligand and DNA binding domains to prevent or promote
the expression of target gene(s). One component TRs are present in the
methylenomycin (an antibiotic) gene cluster in Streptomyces coelicolor A3(2). These
are involved in controlling methylenomycin biosynthesis by the TR MmyB and
controlling methylenomycin resistance by the TR MmyJ. The characterisation of
these two TRs was the focus of this thesis.
Bioinformatic analysis of MmyJ indicate it to be an ArsR family (a metal sensing
family of TRs) protein with uncharacterised one-component MmyJ like systems
suggested in other actinobacteria. DNA-MmyJ binding assays revealed MmyJ binds
to two 17 base pair pseudo-palindromic regions beside one another within the
intergenic region between mmr (MFS type efflux pump and target gene of MmyJ)
and mmyJ. Bacterial hybrid assays showed MmyJ forming homodimers and
mutation of Leu25 highlighted it as a key residue for dimer formation. X-ray
diffraction of MmyJ meant its structure was solved to 1.68 Å. Structural analysis of
MmyJ corroborates it to be an ArsR family protein meaning MmyJ is the first
antibiotic sensing ArsR family protein structure to be solved.
X-ray diffraction was also used for crystals of MmyB however these did not diffract
sufficiently for structure elucidation. Using liquid chromatography mass
spectrometry, the regulation upon mmyb was able to be evaded in order for
methylenomycin biosynthesis, highlighting the significance of MmyB. This also
indicates a potential method for discovery of novel secondary metabolites through
over expression of mmyb-like genes
Maternal and obstetric outcome of women with epilepsy
No full textMedical professionals and public are concerned about the complications of pregnancy and delivery in women with epilepsy (WWE).Purpose: Our aim was to prospectively ascertain Occurrence of these complications in a cohort of WWE enrolled in a pregnancy registry.Methods: All complications during pregnancy, delivery and first 48 h Of Postpartum period were recorded according to the registry protocol. This data were compared with similar statistics (for women without epilepsy) from a large teaching hospital.Results: Between April 1998 and March 2005, there were 643 completed pregnancies in this registry. (Mean age 25.7 +/- 4.43 years; generalized epilepsy 46%; localization related epilepsy 54%: primigravida 53%.) Their complications are compared with those of 18,272 pregnancies managed in the teaching hospital (in parentheses). Spontaneous abortions 4.2% (2.38%); medical termination of pregnancies 2.64% (7.71%); anemia 0,62% (0.22%); gestational diabetes 1.56% (3.09%); pregnancy induced hypertension 3.89% (6.45%): antepartum hemorrhage 0.93% (1.64%); preterm labor 1.87% (6.12%); obstructed labor 0.62% (3%): cesarean section 33.4% (29.5%): assisted delivery 2.8% (2.68%); postpartum hemorrhage 0.31% (0.64%): peripartum seizures 1.4% (0.04%); intrauterine death 1.56% (2.2%); fibroid uterus or ovarian cyst 2.33% (0.53%): other medical illness 2.5% (2.15%); TORCH infection 0.31% (0.01%); birth weight <2.0 kg 4.19% (7.66%).Conclusions: There was no significant increase in the risk of complications of pregnancy or delivery except for spontaneous abortions, anemia, ovarian cyst, fibroid uterus, and seizures in the peripartum period which were more frequent in WWE. Frequency of cesarean section is not increased in WWE. There is no undue risk to pregnancy and childbirth in most WWE. (c) 2008 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved
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