1,097 research outputs found
Misoprostol v/s Cerviprime Gel for Induction of Labour
Get PDFObjective: This prospective study was conducted to compare the effect, efficacy & safety of intra-vaginal misoprostol (PGE 1) & intra-cervical dinoprostone gel (PGE 2) for induction of labour.
Methods: 100 women aged 16-35 years with single live fetus, cephalic presentation & term pregnancy, who were admitted for induction of labour were included in this study. 50women received intrvaginal 50 microgram Misoprostol (study group) & 50 women received 0.5mg of intracervical dinoprostone gel (control group). Comparison was done between the mean time taken for onset of labour, time taken for induction to delivery, mean duration of labour, requirement of Oxytocin augmentation, mode of delivery, side effects & the neonatal outcome in either of the groups.
Results: The mean time taken for onset of labour was less in the misoprostol group than in the dinoprostone group (43.22 min v/s 1 hr 40 min). Similarly duration from induction to active phase (1hr 42 min v/s 4hrs 10 min)and active phase to delivery ( 3 hrs 06 min v/s 4 hrs 54 min) was less for misoprostol group and thus the induction to delivery interval (5 hrs 02 min v/s 11hrs 12 min). None of the study group patients required Oxytocin augmentation. Cesarean section rate was less in misoprostol group (6% v/s 22%). Maternal side effects were minimal in either group & the neonatal outcome was good in both the groups. The induction cost was much less in the misoprostol group.
Conclusion: Misoprostol is safe, efficacious, cheap and mother and fetus friendly drug for the induction of labour
Synthesis and characterizations of nano sized MgO and its nano composite with poly(vinyl alcohol)
No full textEncapsulation of Lactic Acid Bacteria and γ-Amino Butyric Acid using Exopolysaccharides for Food Applications
No full textCompleted under a Cotutelle arrangement between the University of Melbourne and IIT Kharagpur© 2022 Pooja PandeyThe demand for functional foods containing probiotics and bioactives is increasing. In this thesis, lactic acid bacteria as probiotics and GABA as a bioactive were coencapsulated using different techniques viz spray drying, freeze drying and double emulsion using ultrasonication in a biocompatible matrix. Bulk encapsulation was achieved using spray and freeze drying by optimizing the wall material composition. The optimum shell composition obtained by D optimal mixture design was 0.4% inulin, 4.6% dextran, and 8.4% of maltodextrin respectively. Various homogenization techniques have been used to encapsulate bacterial cells via emulsification using homogenizers. However, the encapsulation of bacteria using ultrasound is relatively unexplored, and the survival of bacteria during ultrasonication is yet to be investigated. The possibilities of encapsulating L. plantarum and GABA in an inner aqueous phase of (W1/O) single emulsion using ultrasound was explored. The bacteria cells were treated using a 20 kHz, 3 mm microtip ultrasonic horn for varying sonication times at 10 W calorimetric power and the cell viability was assessed. No significant differences were observed in the bacterial counts of control and the sonicated samples. Single emulsions (W1/O) were prepared using W1 (2% w/v bacterial cells and 5% w/v GABA) and soyabean oil (O) with 1% w/w PGPR, with a volume ratio of 40:60 and ultrasonication (3 W/mL for 30 s) to produce a stable emulsion. Double emulsion microcapsules (W1/O/W2) were prepared using the single emulsion (W1/O) mixed with W2 (5% w/v dextran or 5% w/v whey protein solution, or 5% dextran and 5% GABA solution) by ultrasonication (3W/mL for 10 s) at volume ratio of 20:80. During sequential in vitro digestion, dextran capsules were stable in simulated stomach and small intestine juices. Dextran capsules were freeze dried to form shelf-stable true capsules. Spray dried (SD), freeze dried (FD), double emulsion (DE) and double emulsion freeze dried capsules (DFD) were compared and found that SD powders have good flowability and better shelf life compared to DFD powders. However, the DFD powders were able to provide reasonable protection to the LAB during both storage and digestion, whereas the bulk powders could confer good protection during storage but limited protection during in vitro digestion.
A grain-based functional beverage premix and cookies were developed by incorporating SD and DFD microcapsules. SD powder was added at 10 or 20% w/w to beverage premix samples and stored for 75 days under refrigerated (5 degree C, 90% RH) or ambient (25 degree C, 40 % RH) conditions. Physicochemical properties such as nutritional profile, water absorption index (WAI), water solubility index (WSI), color, the viability of probiotics, GABA content, and sensory attributes were analyzed. The incorporation of 10% w/w microencapsulated probiotic powder was adequate to retain desirable functional properties in the resulting beverages with an overall acceptability score of 7 on the hedonic scale. The results showed that beverage premix-maintained L. plantarum viability (>10^7 CFU/g) and GABA content (> 30 mg/g) during storage of up to 75 days. Free bacteria died during baking while some of the microencapsulated bacteria survived in the cookies. Microencapsulation improved the viability of L. plantarum during baking up to 15 min in oven at 160 degree C. GABA was stable during the baking process for both the control and microencapsulated cookies. Thus, the microencapsuled L. plantarum and GABA can be used in developing functional food products
sj-docx-1-eso-10.1177_23969873231211157 – Supplemental material for Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis
No full textSupplemental material, sj-docx-1-eso-10.1177_23969873231211157 for Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis by Lina Palaiodimou, Raed A Joundi, Aristeidis H Katsanos, Niaz Ahmed, Joon-Tae Kim, Nitin Goyal, Ilko L Maier, Adam de Havenon, Mohammad Anadani, Marius Matusevicius, Eva A Mistry, Pooja Khatri, Adam S Arthur, Amrou Sarraj, Shadi Yaghi, Ashkan Shoamanesh, Luciana Catanese, Marios-Nikos Psychogios, Konark Malhotra, Alejandro M Spiotta, Sofia Vassilopoulou, Konstantinos Tsioufis, Else Charlotte Sandset, Andrei V Alexandrov, Nils Petersen and Georgios Tsivgoulis in European Stroke Journal</p
Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA)
No full textIn The Pune Maternal Nutrition Study, vitamin B12 deficiency was seen in 65% of pregnant women, folate deficiency was rare. Maternal total homocysteine concentrations were inversely associated with offspring birthweight, and low vitamin B12 and high folate concentrations predicted higher offspring adiposity and insulin resistance. These findings guided a nested pre-conceptional randomised controlled trial 'Pune Rural Intervention in Young Adolescents'. The interventions included: (1) vitamin B12+multi-micronutrients as per the United Nations International Multiple Micronutrient Antenatal Preparation, and proteins (B12+MMN), (2) vitamin B12 (B12 alone), and (3) placebo. Intervention improved maternal pre-conceptional and in-pregnancy micronutrient nutrition. Gene expression analysis in cord blood mononuclear cells in 88 pregnancies revealed 75 differentially expressed genes between the B12+MMN and placebo groups. The enriched biological processes included G2/M phase transition, chromosome segregation, and nuclear division. Enriched pathways included, mitotic spindle checkpoint and DNA damage response while enriched human phenotypes were sloping forehead and decreased head circumference. Fructose-bisphosphatase 2 (FBP2) and Cell Division Cycle Associated 2 (CDCA2) genes were under-expressed in the B12 alone group. The latter, involved in chromosome segregation was under-expressed in both intervention groups. Based on the role of B-complex vitamins in the synthesis of nucleotides and S-adenosyl methionine, and the roles of vitamins A and D on gene expression, we propose that the multi-micronutrient intervention epigenetically affected cell cycle dynamics. Neonates in the B12+MMN group had the highest ponderal index. Follow-up studies will reveal if the intervention and the altered biological processes influence offspring diabesity.</p
Convex-geometric, homological and combinatorial properties of graded ideals
No full textAbstract s. "Dateien anzeigen" im 2. Fel
Design of Infrared Roaster
No full textThis Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page
Antimicrobial nanostructured hydrogel wound dressing for the treatment of chronic wounds
No full textWound care is a substantial portion of the global market and treatment of chronic wounds cost the U.S. 25 million yearly on average. Bacterial biofilms are comprised of exopolymer encased bacterial cells and pose as a major health problem, as they are present in 78% of chronic, non-healing wounds. These biofilms frequently harbor multi-drug resistant microbial organisms (MRDOs) such as Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae, which are difficult to eradicate with commercial antibiotics and greatly inhibit wound healing. Treatment is further complicated by poor blood circulation in the surrounding tissue, which hinders delivery of antibiotics to the infected region.
Our goal is to overcome the limitations of commercial antibiotics by developing a novel “GRAPLON Hydrogel” nanomedicine. The GRAPLON Hydrogel consists of unique graft polyelectrolyte surfactant (PS) nanocomplexes of cationic antimicrobial peptides (CAPs) which are known to minimize the development of microbial drug resistance. The PS-CAP nanoparticles (graft polyelectrolyte lipopeptide nanocomplexes or “GRAPLONs”) are incorporated into a biopolymeric hydrogel that will function as a topical wound dressing. We hypothesize that the surfactant properties of the graft polyelectrolyte can cause physical disruption of biofilms and simultaneously enhance transmembrane CAP delivery. In addition, the topical hydrogel can allow localized and controlled CAP delivery to the infected region, thereby reducing drug exposure and thus improving both efficacy and safety.
The physical properties of PS-CAP nanoparticles and GRAPLON hydrogels were characterized by measuring size, charge, surface tension, and viscosity. It was found that for specific graft density PS-CAPs, particle hydrodynamic sizes were <200 nanometers and were dependent on the solution they were dialyzed with. After complexing with CAPs Polymyxin B (PB) and experimental cyclic lipopeptides (CLPs), zeta potentials increased from negative to more positive, indicating self-assembling nanoparticle activity of the anionic polymer and cationic peptide through charge-charge interactions. Although critical micelle concentrations could not be determined, PS solutions did show presence of surface activity which was likely due to their graft density percentage. In hydrogel formulations, viscosities were demonstrated to be tunable based on addition of two different biocompatible thickening agents and shear thinning was observed due to the presence of CAPs and PS-CAPs. Controlled release studies demonstrated release kinetics in both aqueous and hydrogel formulations of PS-CAPs that closely fitted the Korsmeyer Peppas kinetic model. Lastly, antibacterial activity was retained in in-vitro and in-vivo studies conducted on selected gram-positive and gram-negative bacterial biofilms. The cumulative results demonstrate great potential for the GRAPLON system to be an effective means of targeting bacterial biofilms in chronic wounds and providing a treatment that overcomes the current obstacles in this area of study.M.S.Includes bibliographical reference
Sustainable utilization of biomass resources for decentralized energy generation and climate change mitigation: A regional case study in India
No full textClean energy transition via utilizing biomass resources has been projected as an important climate change mitigation strategy. A vital characteristic of biomass is its localized nature; therefore, bioenergy utilization should follow decentralized planning. Agrarian countries like India can take benefit of its large agricultural biomass waste pool to produce clean renewable energy. However, prior knowledge of spatio-temporal distribution, competing uses, and biomass characteristics are necessary for successful bioenergy planning. This paper assesses biomass resource and its power generation potential at different agro-climatic zone levels in the state of Rajasthan, India considering crop residue biomass (25 different crop residues from 14 crops) and livestock manure (from cattle, buffalo, and poultry). Uncertainties associated with the availability of biomass and the power generation potential are assessed for each agro-climatic zone under different scenarios. Greenhouse gases (GHGs) emissions from biomass-based power generations are also estimated and compared with biomass-equivalent coal power plants. It is observed that the annual biomass power potential of Rajasthan is 3056 MW (2496 MW from crop residues and 560 MW from livestock manure). Scenario analysis suggests that the potential varies from 2445 to 6045 MW under different biomass availability and power plant operating conditions. Annual GHGs emissions due to biomass power generation is 5053 kt CO2eq. Replacing coal-based power with biomass power would result in annual GHGs savings of 11412 kt CO2eq. The paper also discusses various carriers and barriers viz. logistics, institutional, financial and technical in setting up decentralized bioenergy plants. Outcomes of the present study are expected to assist renewable energy planners in India.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Sanitary Engineerin
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