289 research outputs found
Supplementary Materials for Schell et al. 2022
No full textSupplementary Materials for Schell et al. 2022. Genetics. Genetic Basis of a Spontaneous Mutation's Expressivit
Jonathan Schell, the renowned scholar and author of The Fate of the Earth, sch
No full textJonathan Schell, the renowned scholar and author of The Fate of the Earth, scheduled a press conference at the Portland International Jetport on June 5 to call for the abolition of nuclear weapons, but nobody showed up. Schell\u27s visit to Maine was sponsored by Peace Action Maine and Physicians for Social Responsibility. Its purpose was to support local resolutions calling for the abolition of nuclear weapons. Schell also wanted to call attention to the fact that U.S. Senators Olympia Snowe and Susan Collins have not yet taken a position on the issue. Schell is convinced that sound arguments and voices of reason will ultimately prevail, and he hopes the recent nuclear testing by India and Pakistan will provide the impetus needed to finally resolve the problem
Jonathan Schell, Author Who Explored War, Dies at 70 [NYT]
No full text[ndlr] Décès à l'âge de 70 ans de l'auteur de la monographie Le village de Ben Suc publiée pendant la guerre (1967). Article de Margalit Fox dans le NYT. Jonathan Schell, a best-selling nonfiction author whose books explored warfare in its myriad 20th-century incarnations, from a scathing indictment of United States policy in Vietnam to a sobering portrait of the world in the aftermath of a nuclear holocaust, died on Tuesday at his home in Brooklyn. He was 70. The cause was cancer, his compa..
Jonathan Schell, Author Who Explored War, Dies at 70 [NYT]
No full text[ndlr] Décès à l'âge de 70 ans de l'auteur de la monographie Le village de Ben Suc publiée pendant la guerre (1967). Article de Margalit Fox dans le NYT. Jonathan Schell, a best-selling nonfiction author whose books explored warfare in its myriad 20th-century incarnations, from a scathing indictment of United States policy in Vietnam to a sobering portrait of the world in the aftermath of a nuclear holocaust, died on Tuesday at his home in Brooklyn. He was 70. The cause was cancer, his compa..
Nuclear Weapons, Extinction and the Anthropocene:Reappraising Jonathan Schell
No full textIn the Anthropocene, International Relations must confront the possibility of anthropogenic extinction. Recent, insightful attempts to advance new vocabularies of planet politics tend to demote the profound historical and intellectual links between our current predicament and the nuclear age. In contrast, we argue that it is vital to revisit the nuclear-environment nexus of the Cold War to trace genealogies of today's intricate constellation of security problems. We do so by reappraising the work of Jonathan Schell (1943-2014), author of The Fate of the Earth (1982), who came to regard extinction as a defining feature of the nuclear age. We show how a deep engagement with nuclear weapons led Schell to an understanding of the Earth as a complex, delicate ecology and fed into a sophisticated, Arendtian theory of extinction. Despite its limitations and tensions, we argue that Schell's work remains deeply relevant for rethinking human-Earth relations and confronting the Anthropocene.</p
Exploring mammalian preimplantation development and pluripotency
No full textOur current understanding of how stem cells arise and transition during embryonic development has been limited by analysis tools that have lacked single-cell, whole-genome resolution. This thesis emphasizes the use of novel techniques and cutting-edge technology to better evaluate the biological underpinning of stem cell dynamics in both mouse and human. Development relies on stem cells to establish different lineage potentials from the same starting material. Stem cell populations are produced during embryogenesis at multiple stages, existing in various cellular states. These cells have unique self-renewal properties that allow them to divide without differentiating. Stem cell plasticity becomes more restricted as development progresses. A totipotent stem cell state arises after fertilization once embryo cells can generate exact copies of themselves. Totipotent cells maintain the competency for specification into both embryonic (organism) and extraembryonic (placenta and yolk sack) lineages. Once the mammalian blastocyst is formed, the embryonic lineage is maintained exclusively in epiblast (EPI) cells. Both pre- and postimplantation EPI cells are considered pluripotent stem cells, which lack the capacity for generating extraembryonic tissues but maintain full competency to develop into all embryonic germ lineages. During embryogenesis EPI cells transition through several definable pluripotent states, several of which can be maintained in vitro. This thesis focuses on utilizing better methods for evaluating how well in vitro stem cell culture systems recapitulate endogenous developmental cell types.In Paper I we assessed pre- and postimplantation mouse embryonic stem cells and compared their allelic and transcriptional profiles with developing in vivo cell types. We were able to make unprecedented observations of X chromosome inactivation (XCI) dynamics, elucidating evidence that in vitro mouse XCI does not follow the perceived dogma that preimplantation stem cells express two fully active X chromosomes. By assessing the full length of each X chromosome with allelic resolution we found that XCI is initiated heterogeneously in preimplantation female stem cells with an observable elongated transition between stem cell states. In Paper II we screen two states of human pluripotent stem cells and preimplantation human embryos to define cell surface markers that attempts to effectively separate preimplantation from postimplantation epiblast. The markers provide a sorting method for state conversions. Paper III and IV complement one another in their intent to define the limits of mouse totipotency using transcriptomics and implementation of functional aggregation assays that effectively evaluate lineage specification and commitment. We determined when the first lineage segregation is defined and used an assortment of molecular tools to evaluate embryonic and extraembryonic contribution. This establishes a benchmark for defining totipotency.Together the findings presented in this thesis add significant contribution toward an improved understanding of mammalian embryonic development and stem cell biology.List of scientific papersI. Chen G, SCHELL JP**, Benitez JA, Petropoulos S,Yilmaz M, Reinius B, Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q. (2016). Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation. Genome Research. 26(10):1342-1354. *First author, **Second author. https://doi.org/10.1101/gr.201954.115 II. Collier AJ*, Panula SP*, SCHELL JP**, Chovanec P, Plaza Reyes A, Petropoulos S, Corcoran AE, Walker R, Douagi I, Lanner F, Rugg-Gunn PJ. (2017). Comprehensive Cell Surface Protein Profiling Identifies Specific Markers of Human Naive and Primed Pluripotent States. Cell Stem Cell. 20(6):874-890.e7. *First author, **Second author. https://doi.org/10.1016/j.stem.2017.02.014 III. Posfai E, Petropoulos S, de Barros F, SCHELL JP, Jurisica I, Sandberg R, Lanner F, Rossant J. (2017). Position- and Hippo signalling-dependent plasticity during lineage segregation in the early mouse embryo. Elife. 6:e22906. https://doi.org/10.7554/eLife.22906 IV. Posfai E*, SCHELL JP*, Adrian Janiszewski*,Isidora R, Murray A, Bradshaw B, Pardon T, Bakkali M, Talon I, Geest N, Kumar P, To S, Petropoulos S, Jurisicova A, Pasque V, Lanner F, Rossant J. (2020). Defining Totipotency Using Criteria of Increasing Stringency. bioRxiv. *First author. [Manuscript] https://doi.org/10.1101/2020.03.02.972893</p
Premarital correspondence of Friedrich Ferdinand Dalberg and his fiancée Kunigunda Vittinhoff-Schell
No full textThe topic of presented bachelor thesis is premarital correspondence of Friedrich Ferdinand Dalberg and his fiancée Kunigunda Vittinhoff-Schell, dated to 1846. The thesis tries to analyse the letters in their context, pinpointing their most frequent topics. Through this analysis, the author attempts to take a glimpse into the thoughts and emotions of these two fiancés in the changing society of the 19th century. An extensive collection of premarital and other correspondence, located in the archive of the Dalberg family at Moravský zemský archiv in Brno, forms a basis of the thesis
Officers of the 102nd Canadian Infantry Battalion while on R&R
No full textB (L-R): Lt. Pae, Packman, Morrison, Van Cobec, Leese, McLenahan, Mann, Wilson, Dawson, Manning, Moore, Devine, Chagnon. M (L-R): Goodyear, Livingstone, Waite, Peers, McDarmid, Stanley, Henderson, Mitchell, Duncan, Pentriath, Schell, Niblett, Lloyd, French. F (L-R): Peers, Dunlop, Stead, Walwyn, Brimacombe, Major Gary, Ryan, O'Kell, Atkins, Knight, Fallon, Dunlop, Fitzmaurice, Lamrock
SISTEM INFORMASI MANAJEMEN
No full textKarya ini merupakan sebuah modul untuk perkuliahan Sistem Informasi Manajemen untuk mempermudah pemahaman mahasisw
- …
