532 research outputs found
Supplemental_Material_for_Optopatch_VS_IWB_Nav1.7_screen_final – Supplemental material for Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of Na<sub>V</sub>1.7 Inhibitors
No full textSupplemental material, Supplemental_Material_for_Optopatch_VS_IWB_Nav1.7_screen_final for Correlation of Optical and Automated Patch Clamp Electrophysiology for Identification of NaV1.7 Inhibitors by Hongkang Zhang, Bryan D. Moyer, Violeta Yu, Joseph G. McGivern, Michael Jarosh, Christopher A. Werley, Vivian C. Hecht, Ryan J. Babcock, Kevin Dong, Graham T. Dempsey, Owen B. McManus and Chris M. Hempel in SLAS Discovery</p
Building Bridges: A Case Study of the Perceptions of Parents of Students with Autism Spectrum Disorder (ASD) Towards Family/School Partnerships
No full textThis qualitative case study examines the perceptions of parents of students with autism spectrum disorder (ASD) towards family/school partnerships. Interviews were conducted with parents of children with autism that belonged to a parent support group in western Pennsylvania. The resulting interviews cast light on the motivators and barriers that influence parental decisions to enter into partnerships with educational professionals. The parents were motivated towards family/school partnerships through the concepts of invitation to involvement, trust, emotional connect, and parental efficacy. Role construction, team approach, parent’s knowledge, and “it’s the law” served as lesser motivators. The motivators toward family/school partnerships also have the ability to serve as barriers against family/school partnerships. Whether a concept serves to motivator or stand as a barrier depends on how the interactions occur between families and educational professionals.
Furthermore, analysis centers on the rights and responsibilities of parents found under family/school partnerships and special education law. As parents of children receiving services due to a recognized disability, the parents have additional rights and responsibilities in the area of school collaboration. The law mandates that parents be included fully in the six major principles contained within the law: due process safeguards, shared decision-making, zero reject, nondiscriminatory identification and evaluation, free appropriate public education, and least restrictive environment (IDEIA, 2004). Since 2004 the law incorporates a sense of responsibility for parents to do all that they can to engage actively in participatory behaviors. As a result of this study, the complexity of participatory behaviors of parents of children with ASD towards family/school collaboration emerges. Bronfenbrenner’s (1992) bio-ecological theory of human development and Epstein’s (2001d) overlapping spheres of influences serve as the conceptual framework for the study. The environment works on the person as the person works on the environment creating the constancy and change that occurs over the course of a lifetime.
This understanding serves to shed light on motivating behaviors that can be adopted by educational professionals to ensure parents of children with ASD develop positive perceptions towards family/school partnerships
LINKING UK REPOSITORIES: Technical and organisational models to support user-oriented services across institutional and other digital repositories. SCOPING STUDY REPORT
No full textThe JISC commissioned the project partners to undertake a scoping study whose aim is to identify sustainable technical and organisational models to support user-oriented services across digital repositories. Open access repositories of interest to UK further and higher education communities were cited as having particular relevance. The study is intended to inform strategies to support access and use of repositories, with a view to the establishment of a national repository services infrastructure or framework
Same-sex parented families in Australia
No full textThis paper reviews and synthesises Australian and international literature on same-sex parented families.
Introduction: This research paper reviews and synthesises Australian and international literature on same-sex parented families. It includes discussion of the different modes of conception or family formation, different family structures, and the small number of studies on bisexual and transgender parents. Particular attention is paid to research on the emotional, social and educational outcomes for children raised by lesbian and gay parents, and the methodological strengths and weaknesses of this body of work.
Key Messages:
About 11% of Australian gay men and 33% of lesbians have children. Children may have been
conceived in the context of previous heterosexual relationships, or raised from birth by a co-parenting
gay or lesbian couple or single parent.
Overall, research to date considerably challenges the point of view that same-sex parented families
are harmful to children. Children in such families do as well emotionally, socially and educationally as
their peers from heterosexual couple families.
Some researchers have concluded there are benefits for children raised by lesbian couples in that they
experience higher quality parenting, sons display greater gender flexibility, and sons and daughter
display more open-mindedness towards sexual, gender and family diversity.
The possible effect of important socio-economic family factors, such as income and parental education,
were not always considered in the studies reviewed in this paper.
Although many Australian lesbian-parented families appear to be receiving good support from their
health care providers, there is evidence that more could be done to develop policies and practices
supportive of same-sex parented families in the Australian health, education, child protection and
foster care systems.
Additional key messages, relating to specific family structures and psychosocial outcomes for children
raised by lesbian and gay parents, are included throughout the paper
The key to sustainable urban development in UK cities? The influence of density on social sustainability
No full textStewardship of the evolving scholarly record: from the invisible hand to conscious coordination
No full textThe scholarly record is increasingly digital and networked, while at the same time expanding in both the volume and diversity of the material it contains. The long-term future of the scholarly record cannot be effectively secured with traditional stewardship models developed for print materials. This report describes the key features of future stewardship models adapted to the characteristics of a digital, networked scholarly record, and discusses some practical implications of implementing these models.
Key highlights include:
As the scholarly record continues to evolve, conscious coordination will become an important organizing principle for stewardship models.
Past stewardship models were built on an "invisible hand" approach that relied on the uncoordinated, institution-scale efforts of individual academic libraries acting autonomously to maintain local collections.
Future stewardship of the evolving scholarly record requires conscious coordination of context, commitments, specialization, and reciprocity.
With conscious coordination, local stewardship efforts leverage scale by collecting more of less.
Keys to conscious coordination include right-scaling consolidation, cooperation, and community mix.
Reducing transaction costs and building trust facilitate conscious coordination.
Incentives to participate in cooperative stewardship activities should be linked to broader institutional priorities.
The long-term future of the scholarly record in its fullest expression cannot be effectively secured with stewardship strategies designed for print materials. The features of the evolving scholarly record suggest that traditional stewardship strategies, built on an “invisible hand” approach that relies on the uncoordinated, institution-scale efforts of individual academic libraries acting autonomously to maintain local collections, is no longer suitable for collecting, organizing, making available, and preserving the outputs of scholarly inquiry.
As the scholarly record continues to evolve, conscious coordination will become an important organizing principle for stewardship models. Conscious coordination calls for stewardship strategies that incorporate a broader awareness of the system-wide stewardship context; declarations of explicit commitments around portions of the local collection; formal divisions of labor within cooperative arrangements; and robust networks for reciprocal access. Stewardship strategies based on conscious coordination involve an acceleration of an already perceptible transition away from relatively autonomous local collections to ones built on networks of cooperation across many organizations, within and outside the traditional cultural heritage community
The Colorado Trust’s Healthy Communities Initiative: Results and Lessons for Comprehensive Community Initiatives
No full text· This article summarizes how 29 diverse communities throughout Colorado implemented the Colorado Healthy Communities Initiative (CHCI), which was conceived and funded by The Colorado Trust to engage community residents in the development of locally relevant strategies to improve community health.
· In line with the World Health Organization’s Healthy Cities model, CHCI emphasized (a) inclusive, representative planning; (b) a broad definition of “health”; (c) consensus decision making; and (d) capacity building among local stakeholder groups.
· Communities implemented an array of projects (on average, six per community) that extended well beyond traditional health promotion and disease prevention. The most common action projects focused on community problem solving, civic engagement, and youth development. Many of the grantees established projects or new institutions that had a long-term community impact.
· Key success factors for CHCI included (a) a wellspecified planning model, (b) a planning process facilitated by expert consultants, (c) a unifying “healthy community” vision developed at the beginning of the process by diverse stakeholders, (d) a willingness by stakeholders to work collaboratively to define “key performance areas” and then to implement “action projects” to achieve them, and (e) an appropriate level of funding for implementation ($50,000 per site per year).
· The outcomes and impacts of CHCI might have been improved by better anticipating the requirements for sustaining the energy and work initiated during the planning process.
· At the end of the initiative, CHCI provided the funders with a broader, deeper understanding of the requirements, opportunities, and realities associated with promoting “community health.
One Hundred Years of Graduates Creighton University School of Law Class of 2005
No full textGraduates|Abboud, Frederick L., Jr.; Anderson, Jennifer; Antonini, Charles John, III; Appenzeller, Krista L.; Argotsinger, Todd J.; Armitage, Anne M.; Arora, Kavita Bajaj; Bailey, Ryan; Becker, Amy C.; Beller, Emily A.; Boeser, Joseph T.; Bowman, Timothy; Brack, Margaret K.; Braun, Lindsay G.; Brewer, Michael; Broder, Kelly; Brown, Richard L., III; Buge, Brian W. (Treasurer); Buhrfield, Daniel C.; Carroll, John F.; Carter, Justin F.; Cimino, Matt; Cizek, Sara S.; Cole, Patrick J.; Connelly, John A.; Craft, James; Cross, Jeremy J.; Daley, Jill; Daniels, Leanna C.; Dempsey, Alison; Eldredge, Trevor B.; Enriques, Gerald K.; Ferguson, Carrie; Fix, Jill; Flechler, Rebecca; Flynn, Erin M.; Funkhouser, Angela K.; Gadzikowski, Leah; Gang, Damien; Gass, Jonathan F.; Glass, Oliver J.; Going, Scott M.; Gore, John D.; Green, Katherine; Greenamyre, Julie A.; Greenfield, Kourtney A.; Grillot, Nicholas; Gruber-Gardner, Angela; Hacker, John D.; Haferbier, Jodie; Hamm, Brandon; Hansen, R. Christian; Harmon, Jared C.; Harp, Kristina; Haumont, Bradley; Hebenstreit, Julia; Heelan, Melissa C.; Hefflinger, Joe; Heine, John D.; Hengl, Ryan C.; Hermanson, Tessa P.; Herrboldt, Katrine M.; High, Justin; Hoarty, Daniel; Hoffman, Ryan; Holst, Luke Charles; Hopson, Diane Tomka; Huggins, Richard; Hunt, Joshua F.; Hunter, Jeri; Ingraham, Robert M.; Jacobs, Mark F.; Jacoby, Brandie; Jensen, Michael W.; Jones, Craig T.; Jones, Lisa Nicole (3L Representative); Judy, Brian; Kahla, Roxanne M.; Katz, Philip; Kaufman-McNamara, Suzanne D.; Keenan, Sara L.; Kennedy, Micki J.; King, William; Kinney, Brandon G.; Knipp, Joseph; Kunz, Aaron J.; Liberty, Robert L.; Lichti, Amber L.; Linman, Nissa; Lipes, Maegan; Lippincott, Emily; Luebbert, Kyla L.; Majeski, Penny; Meredith, Andrew S. (3L Representative); Meyer, Heather S.; Miller, Casey E.; Milligan, Amy; Mitchell, Alton Elie; Munyon, Matthew; Murvin, Daniel J.; Naglosky, Jeffrey S.; Nair, Nisha; Newland, Steven J.; O'Neill, David M.; Penning, Steven M.; Pepper, Patrick D.; Peters, Ryan V.; Peterson, Meghan M.; Petricevic, Bosko; Polzer, Natalie M.; Potts, Karen C.; Quinn, Kendra; Reece, Todd A.; Reed, Angela M.; Rupp, Kristine M.; Rush, Timothy J.; Schaefer, Kristina M.; Schanbacher, Kristena M.; Skolaut, Paul J.; Slavin, Dan; St. Clair, Jessica; Svee, Scott; Symonds, Casey J.; Talati, Umang Dilipkumar; Tarpley, Tim; Tate, Allen M.; Taylor, Jennifer J.; Teiken, Thomas L.; Tomich, Richard M.; Vaterlaus, John B.; Vermillion, Melissa A.; Walker, John M.; Walkingstick, Jennifer D.; Wayne, Justin T. (President); Wirth, Lucas A.; Witt, Stacy; Wolf, Kylie A.; Wolff, Lisa M.; Woodard, Aaron; Woods, Gregory A.; Wright, Damien J.; Yudelson, David A.; Ziolkowski, Nicholas A.; Downing, Jillana J. (not pictured); Hall, Megan (not pictured); Mueller, Jonathan (not pictured); Nickla, Jason (not pictured); Rohling, Anne (not pictured); Rosfjord, Christopher (not pictured); Ryan, Stacy (not pictured); Simpson, Edith (not pictured); Singer, Matthew (not pictured); Waltemath, Peter (not pictured)|39 x 30 in. (landscape
The Santa Barbara Binary−disk Code Comparison
No full textWe have performed numerical calculations of a binary interacting with a gas disk, using 11 different numerical methods and a standard binary−disk setup. The goal of this study is to determine whether all codes agree on a numerically converged solution and to determine the necessary resolution for convergence and the number of binary orbits that must be computed to reach an agreed-upon relaxed state of the binary−disk system. We find that all codes can agree on a converged solution (depending on the diagnostic being measured). The zone spacing required for most codes to reach a converged measurement of the torques applied to the binary by the disk is roughly 1% of the binary separation in the vicinity of the binary components. For our disk model to reach a relaxed state, codes must be run for at least 200 binary orbits, corresponding to about a viscous time for our parameters, 0.2(a 2ΩB /ν) binary orbits, where ν is the kinematic viscosity. The largest discrepancies between codes resulted from the dimensionality of the setup (3D vs. 2D disks). We find good agreement in the total torque on the binary between codes, although the partition of this torque between the gravitational torque, orbital accretion torque, and spin accretion torque depends sensitively on the sink prescriptions employed. In agreement with previous studies, we find a modest difference in torques and accretion variability between 2D and 3D disk models. We find cavity precession rates to be appreciably faster in 3D than in 2D
Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury
No full textThe first successful transplantation of a human kidney was performed more than 50 years ago by Murray and colleagues in 1954 between identical twins. The success of this transplantation was due to the fact that no significant rejection occurs between genetically identical twins and therefore immunosuppression was not necessary in this particular case (Merrill et al., 1956).
However, solid-organ transplantation could not be considered truly successful until the 1970’s after significant technical and pharmacological advances. In particular, the discovery and development of the calcineurin inhibitors (CNIs) has made allograft transplantation routinely successful with greatly reduced risk of acute rejection. In the absence of pharmacological agents to address the primary pathological mechanisms involved, renal transplantation has now been the standard management of end stage renal failure for the past four decades (Wolfe
et al., 1999). Short-term renal allograft and allograft recipient survival rates have increased significantly during the last decade largely due to improved patient monitoring. However, allograft half-life beyond 1 year post-transplant remains largely unchanged. While rates of early allograft failure have significantly reduced, late renal allograft dysfunction remains a significant problem in the transplant population (de Fijter). Chronic allograft injury (CAI) is the most prevalent cause of allograft dysfunction in the first decade after transplantation. The term CAI is used to describe deterioration of renal allograft function and structure due to
immunological processes (i.e. chronic rejection) and/or a range of simultaneous nonimmunological factors such as CNI-induced nephrotoxicity, hypertension and infection. This chapter will outline the pathophysiology and etiology of CAI and the role that CNI nephrotoxicity plays in this disease process. It will also review experimental studies that have identified important molecular mechanisms involved and discuss strategies utilised to minimise the development and progression of CAI.Science Foundation IrelandHigher Education AuthorityIrish Research Council for Science, Engineering and TechnologyEuropean Research CouncilHealth Research BoardEnterprise Irelandti, ke, ab, de - TS 29.03.1
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