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Combination therapy with etanercept in psoriasis: Retrospective analysis of efficacy and safety outcomes from real-life practice
Get PDFobjective to investigate the efficacy and safety outcomes of combination therapy used to optimize etanercept treatment in patients with psoriasis treated in real-life clinical practice.methods data from patients presenting with psoriasis, treated initially with etanercept monotherapy, were analysed retrospectively. patients subsequently treated with combination therapy were further analysed. the psoriasis area and severity Index (PASI) score was recorded for all patients receiving comedication; a subjective pain score was recorded in those with psoriatic arthritis receiving comedication after 12, 24 and 48weeks' treatment and thereafter at 6-month intervals.results from the database of 400 patients treated with etanercept, 37 patients (18 male; 19 female; mean age 59.43years) underwent combination therapy due to lack of efficacy. patients received mostly short-term (range 4-34weeks) comedication with corticosteroids, cyclosporine, methotrexate, nonsteroidal anti-inflammatory drugs, acitretin or sulphasalazine. there were significant reductions in the mean PASI score from baseline at all timepoints. there were also significant reductions in the mean pain VAS score from baseline at all timepoints in patients with psoriatic arthritis. the drug survival rate was 59.6% over a mean duration of 323weeks of etanercept treatment. the safety profile of combination therapy was satisfactory.conclusions short-term comedication in combination with etanercept may optimize treatment options and improve long-term drug survival in patients with psoriasis
Prevalence and management of panic attacks during infliximab infusion in psoriatic patients
No full textBACKGROUND:
Psoriasis is a chronic, inflammatory skin disease associated with anxiety and depression. Infliximab (IFX) is a human/mouse chimeric anti-TNF-α antibody effective in the treatment of psoriasis.
OBJECTIVE:
The aim of this study was to evaluate the prevalence of panic disorders in psoriatic patients during IFX infusions.
METHODS:
A retrospective study was performed on patients affected with psoriasis who were treated with IFX from 2002 to 2011 at a single center. Panic disorders were defined using the clinical criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition. A population of dermatological patients under treatment with IVG, rituximab, apheresis, intravenous corticosteroids and antibiotics was considered as the control group.
RESULTS:
A total of 141 patients were evaluated. Of these, 6 (4.25%) experienced panic attacks during the infusion; 16 (11.3%) had a medical history of panic attack and of those 5/16 (31%) experienced panic attacks during IFX infusion. In the control group panic attacks were not recorded.
CONCLUSION:
We describe 6 cases of patients in whom panic attacks were triggered by IFX infusion. Premedication with oral benzodiazepine and a slow rate of infusion is recommended
High-dose initiation of etanercept in plaque psoriasis and psoriatic arthritis: an italian experience
No full textInfluence of body mass index and weight on etanercept efficacy in patients with psoriasis: A retrospective study
No full textAim To investigate the role of body mass index (BMI) and weight in the long-term efficacy of etanercept in patients with psoriasis. Methods Medical records were retrospectively analysed. Extracted data included weight, BMI, comorbidities and psoriasis area severity index (PASI). Patients were stratified by weight (<80kg or 80kg) and BMI (healthy, BMI 22 - 24.99kg/m(2); overweight, BMI 25 - 29.99kg/m(2); obese, BMI 30kg/m(2)). Results The study included 66 patients. Body weight had no effect on etanercept efficacy. There was a significant reduction in etanercept efficacy in obese patients (n=12) compared with healthy weight (n=33) or overweight (n=21) patients. Conclusion Obesity has a negative effect on the efficacy of etanercept in psoriasis
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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