1,721,110 research outputs found
Eicosanoids and aneurysms
No full textIn the inflammatory process underlying aneurysm onset and progression, eicosanoidsseem to have an important role. Different hypotheses have been tested to describe thecourse of action.Interestingly, the imbalanced synthesis of cyclooxygenase-derived thromboxane A2and prostacyclins seems to be involved in Marfan syndrome. Neutrophil derivedleukotriene B4 and prostaglandin E2 simultaneously have an important role in smoothmuscle cell viability, inflammatory processes and expansion of aneurysm.The involvement of eicosanoids in aneurysm pathophysiology suggested the effect ofnonsteroidal antinflammatory drugs by reducing both inflammation and proteolysis inaneurysm wal
The need for the STS Score risk stratification system for aortic root aneurysms surgery
No full textIn this editorial we discussed the need of STS score in aortic root surger
Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets
No full textAorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies,
currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult
to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data.
No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus,
their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways
involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress
(OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these
aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and
potential solutions and approaches, as well as some potential treatments
Right ventricular inflow obstruction related to late Candida albicans infection of implantable cardioverter-defibrillator leads
No full textEchocardiogram transoesophageal, CXR and positron emission tomography–computed tomography scan images showing a fungal endocarditis mass deter- mining right ventricle inflow obstruction in a 74-year-old woman with a history of fever, right ventricle failure, multiple PE and cultures were positive for Candida albicans. Intraoperative view. The mass obstructed the right ventricular inflow, attached 3 leads with silicone–polyurethane copolymer (OptimTM) and was eradicated with right atrial surgical approach
Anaortic off-pump coronary artery surgery as a primary strategy to reduce the risk of neurological complications
Full text linkEndocarditis: Cardiac Surgery Treatment/A Thrilling Challenge in Cardiac Surgery
Full text linkEndocarditis: Cardiac Surgery Treatment/A Thrilling Challenge in Cardiac Surger
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms
Full text linkAorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments
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