77 research outputs found

    DNA Methylation

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    Epigenetic Control of Gene Expression

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    Methylation: Evolution

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    Methylation: Evolution

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    Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing

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    The Oxford Nanopore (ONT) platform provides portable and rapid genome sequencing, and its ability to natively profile DNA methylation without complex sample processing is attractive for point-of-care real-time sequencing. We recently demonstrated ONT shallow whole-genome sequencing to detect copy number alterations (CNAs) from the circulating tumor DNA (ctDNA) of cancer patients. Here, we show that cell type and cancer-specific methylation changes can also be detected, as well as cancer-associated fragmentation signatures. This feasibility study suggests that ONT shallow WGS could be a powerful tool for liquid biopsy. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-022-02710-1

    The Influence of Mizrahi Jews on Israeli Music and Food

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    abstract: The Mizrahi Jews have greatly influenced current Israeli culture through their music and food. The Mizrahi immigrated from Middle Eastern countries and brought with them their music and food. Their music has changed slowly over time. Musiqa Mizrahit started as music the Mizrahi brought with them when the immigrated to Israel. As they adjusted to Israeli society, they began switching the Arabic words to Hebrew. Musiqa Mizrahit really took off with the creation of cassette recordings that allowed anyone to cheaply record music and share it. As Musiqa Mizrahit became more accessible, it slowly gained popularity across Israel. As popularity for the genre, it slowly became accepted in Israeli society. Up until then, Musiqa Mizrahit had been discriminated against and was not considered part of Israeli culture. Nowadays, Musiqa Mizrahit is very popular and widely accepted in Israel. The food was accepted by the Ashkenazi in the first two decades of the countries existence by the widespread Israeli pushback in Mandatory Palestine and into the existence of the brand new country. now many of the Mizrahi foods are considered part of the Israeli national cuisine
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