54 research outputs found
Pain in neurodegenerative disease:current knowledge and future perspectives
No full textNeurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington's disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed
Opposite Effects of Stress on Pain Modulation Depend on the Magnitude of Individual Stress Response
No full textOpposite effects of isometric exercise on pain sensitivity of healthy individuals: the role of pain modulation
No full textAbstract. Introduction:. Exercise-induced hypoalgesia (EIHypo) among healthy individuals is well documented; however, the opposite effect of exercise, ie, exercise-induced hyperalgesia (EIHyper), has mainly been described in patients with chronic pain or after intense/painful exercise.
Objectives:. We investigated the extent to which EIHypo and/or EIHyper occur among healthy participants and whether these responses are associated with individuals' pain modulation capacity.
Methods:. Fifty-seven participants (mean age 29.20 ± 5.21 years) underwent testing of pressure pain threshold as an index of EIHypo/EIHyper: pain adaptation, offset analgesia (OA), and conditioned pain modulation as indices of pain modulation, prior to and immediately postsubmaximal isometric exercise (n = 40) or rest (n = 17, control group). Body awareness and exercise-evoked stress were also evaluated. Test–retest repeatability of the pain modulation indices was performed as well.
Results:. Twenty-four participants (60%) exhibited EIHypo, whereas 16 (40%) exhibited EIHyper. Pressure pain threshold did not change in the control group. Baseline (preexercise) OA efficacy predicted EIHypo/EIHyper. Furthermore, OA significantly decreased postexercise in the EIHyper subgroup and slightly increased in the EIHypo subgroup. Exercise-induced hypoalgesia was associated with magnitude of daily exercise while EIHyper was associated with increased exercise-evoked stress and body awareness.
Conclusion:. Submaximal isometric exercise can induce opposite effects on pain sensitivity among healthy participants—EIHypo or EIHyper. Descending pain inhibition pathways, and top-down influences over these pathways, seem to be involved in EIHypo/EIHyper effects. As such isometric exercise is often preferred in early stages of rehabilitation, preliminary screening individuals' vulnerability to this exercise is important; OA test may be used for this purpose
Pain perception in people with Down syndrome: A synthesis of clinical and experimental research.
No full textPeople with an intellectual disability experience both acute and chronic pain with at least the same frequency as the general population. However, considerably less is known about the pain perception of people with Down syndrome. In this review paper, we evaluated the available clinical and experimental evidence. Some experimental studies of acute pain have indicated that pain threshold was higher than normal but only when using a reaction time method to measure pain sensitivity. However, when reaction time is not part of the calculation of the pain threshold, pain sensitivity in people with Down syndrome is in fact lower than normal (more sensitive to pain). Clinical studies of chronic pain have shown that people with an intellectual disability experience chronic pain and within that population, people with Down syndrome also experience chronic pain, but the precise prevalence of chronic pain in Down syndrome has yet to be established. Taken together, the literature suggests that people with Down syndrome experience pain, both acute and chronic, with at least the same frequency as the rest of the population. Furthermore, the evidence suggests that although acute pain expression appears to be delayed, once pain is registered, there appears to be a magnified pain response. We conclude by proposing an agenda for future research in this area
Observing Pain in Individuals with Cognitive Impairment:A Pilot Comparison Attempt across Countries and across Different Types of Cognitive Impairment
No full textFacial expression is a key aspect in observational scales developed to improve pain assessment in individuals with cognitive impairments. Although these scales are used internationally in individuals with different types of cognitive impairments, it is not known whether observing facial expressions of pain might differ between regions or between different types of cognitive impairments. In a pilot study, facial responses to standardized experimental pressure pain were assessed among individuals with different types of cognitive impairments (dementia, mild cognitive impairment, Huntington's disease, and intellectual disability) from different countries (Denmark, Germany, Italy, Israel, and Spain) and were analyzed using facial descriptors from the PAIC scale (Pain Assessment in Impaired Cognition). We found high inter-rater reliability between observers from different countries. Moreover, facial responses to pain did not differ between individuals with dementia from different countries (Denmark, Germany, and Spain). However, the type of cognitive impairment had a significant impact; with individuals with intellectual disability (all being from Israel) showing the strongest facial responses. Our pilot data suggest that the country of origin does not strongly affect how pain is facially expressed or how facial responses are being scored. However, the type of cognitive impairment showed a clear effect in our pilot study, with elevated facial responses in individuals with intellectual disability.</p
The traumatized body: Long-term PTSD and its implications for the orientation towards bodily signals
No full textOrientation to bodily signals is defined as the way somatic sensations are attended, perceived and interpreted. Research suggests that trauma exposure, particularly the pathological reaction to trauma (i.e., PTSD), is associated with catastrophic and frightful orientation to bodily signals. However, little is known regarding the long-term ramifications of trauma exposure and PTSD for orientation to bodily signals. Less is known regarding which PTSD symptom cluster manifests in the 'somatic route' through which orientation to bodily signals is altered. The current study examined the long-term implications of trauma and PTSD trajectories on orientation to bodily signals. Fifty-nine ex-prisoners of war (ex-POWs) and 44 controls were assessed for PTSD along three time-points (18, 30 and 35 years post-war). Orientation to bodily signals (pain catastrophizing and anxiety sensitivity-physical concerns) was assessed at T3. Participants with a chronic PTSD trajectory had higher pain catastrophizing compared to participants with no PTSD. PTSD symptom severity at T2 and T3 mediated the association between captivity and orientation. Among PTSD symptom clusters, hyperarousal at two time-points and intrusion at three time-point mediated the association between captivity and orientation. These findings allude to the cardinal role of long-term PTSD in the subjective experience of the body following trauma.</p
Dysfunctional Pain Modulation in Torture Survivors: The Mediating Effect of PTSD
No full textTrauma survivors, and particularly torture survivors, suffer from high rates of chronic pain and posttraumatic stress disorder (PTSD) for years afterward, along with alterations in the function of the pain system. On the basis of longitudinal data on PTSD symptomatology, we tested whether exposure to torture, PTSD or PTSD trajectories accounted for chronic pain and altered pain perception. Participants were 59 torture survivors and 44 age-matched healthy control subjects. Chronic pain was characterized. Pain threshold, pain tolerance, conditioned pain modulation (CPM), and temporal summation of pain were measured. Three PTSD trajectories were identified among torture survivors; chronic, delayed, and resilient. Lack of CPM and more intense chronic pain was found among the chronic and delayed groups compared with the resilient and healthy control groups. Temporal summation of pain was strongest among the chronic group. PTSD trajectories mediated the relationship between torture and CPM. It appears that the duration and severity of posttraumatic distress, rather than the exposure to trauma, are crucial factors that mediate the association between trauma and chronic pain. Because PTSD and its resultant distress are measurable, their evaluation seems particularly important in the management of pain among trauma survivors. The results may be generalized to other instances in which chronic pain persists after traumatic events. Perspective This article presents the mediation effect of PTSD trajectory on pain modulation among trauma survivors suggesting that it is the duration and severity of PTSD/distress, rather than the exposure to trauma per se, that influence the perception and modulation of pain.</p
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