121,860 research outputs found
Groups Whose Proper Subgroups are Generalized -Groups
No full textLet be a class of groups. A group is
said to be \textit{minimal non-} if all proper
subgroups of are -groups but itself is not.
The aim of this article is to study the class of minimal
non--groups, where ( is a positive integer) is a
class of generalized FC-groups introduced in [F. de Giovanni, A.
Russo, G. Vincenzi, Groups with restricted conjugacy classes,
Serdica Math. J. 28 (2002) 241-254]
Afterword. The New Dimension of EU Security in a Transnational Justice and Governance System
No full textThe title of this epilogue intends to highlight the results of the research carried out within the Jean Monnet Module ‘EU-Western Balkans Cooperation on Justice and Home Affairs’ and the ensuing insights chronicled in this book. Specifically, the findings highlight the new dimension of security in relation to protecting the EU system and its identity (‘unity in diversity’), albeit seemingly not adequately implemented at the level of EU law. Conversely, a system of justice and governance has emerged at the transnational level within the wider European area. This notion emerges from the analysis of doctrine that has long debated the exercise of public authority in the context of international institutional law, highlighting the impact of State organizations’ action in the life of international economic, social, and political relationships. However, for the purposes of this research, the exercise of public authority in the multilevel system of EU law (international, European, and national) has emphasized a model of cooperation among national public authorities that continue to operate and drive the European integration process, as well as the centralization of these cooperation activities within EU agencies
On cyclic automorphisms of a group
No full textAn endomorphism α of a group G is called a cyclic endomorphism if the subgroup is cyclic for all elements x of G. It can be proved that every cyclic endomorphism is normal, i.e. it commutes with every inner automorphism of G (see [F. de Giovanni,
M. L. Newell and A. Russo, On a class of normal endomorphisms of groups, J. Algebra its Appl. 13 (2014) 6pp.]). In this paper, some further properties of cyclic endomorphisms will be pointed out. Moreover, the structure of a group G in which the group CAut(G)
of cyclic automorphisms has finite index in Aut(G) will be investigated
On the theory of generalized FC-groups
No full textWe extend to FC *, the class of generalized FC-groups introduced in [F. de Giovanni, A. Russo, G. Vincenzi, Groups with restricted conjugacy classes, Serdica Math. J. 28 (2002) 241-254], some results known for FC-groups. The main theorem involves the extended residually finite property (ERF), i.e., all subgroups are closed in the profinite topology. The ERF-groups belonging to several large classes of groups have been determined, for example nilpotent groups [M. Menth, Nilpotent groups with every quotient residually finite, J. Group Theory 5 (2002) 199-217] and FC-groups [D.J.S. Robinson, A. Russo, G. Vincenzi, On groups whose subgroups are closed in the profinite topology, J. Pure Appl. Algebra 213 (2009) 421-429]. Here we generalize these results by classifying completely the ERF-groups belonging to FC *
On a problem of P. Hall for Engel words II
No full textThe present paper is related to some recent studies in Abdollahi and Russo [‘On a problem of P. Hall for Engel words’, Arch. Math. (Basel) (2011), 407–412] and Fernández-Alcober et al. [‘A note on conciseness of Engel words’, Comm. Algebra (2012), 2570–2576] on the position of the --Engel marginal subgroup of a group , when . Describing the size of for , we show some generalisations of classical results on the partial margins of and .
DOI:
10.1017/S000497271400009
S-Adenosyl-l-Methionine: a strategy for overcoming uL3-mediated drug resistance in p53 deleted colon cancer cells
No full textIn the field of anticancer therapy, re-sensitizing tumor cells to the drugs by exploiting novel strategies
is a promising approach to overcome the drug resistance with consequent improvement in clinical treatment.
In this context, to investigate novel therapeutic approaches taking advantage from anticancer and
antiproliferative effects of natural compounds, we focused our attention on S-adenosyl-L-methionine
(AdoMet), a ubiquitous and naturally occurring sulfonium compound. We tested its potential in overcoming
chemoresistance observed in our model of colon cancer cells lacking functional p53 and characterized by
low expression levels of uL3[1,2].
Here, we demonstrated that AdoMet exerts its cytotoxic activity in these cells and, more importantly,
restores their sensitivity to 5-fluorouracil (5-FU) treatment. In particular, AdoMet exposure impairs cell cycle
progression inducing cell cycle arrest at the S phase, which was associated with a significant increase of
Cyclin E and a decrease of Cyclin D. Furthermore, AdoMet inhibits autophagy, increases the production of
reactive oxygen species, and finally activates the caspase cascade, triggering the apoptotic pathway.
To best of our knowledge, the present study unveils, for the first time, the capability of AdoMet to resensitize
drug resistant colon cancer cells indicating this natural compound as a potential therapeutic agent
for colon cancer cells showing p53 and uL3 lower levels.
[1] A. Pecoraro, P. Carotenuto, G. Russo, A. Russo. Sci Rep. (2019), 9, 15431.
[2] A. Pecoraro, P. Carotenuto, B. Franco, R. De Cegli, G. Russo, A. Russo. Int J Mol Sci. (2020), 21, 2143
UL3 mediated nucleolar stress pathway as a new mechanism of action of antiproliferative G-quadruplex TBA derivatives in colon cancer cells
No full textThe antiproliferative G-quadruplex aptamers are a promising and challenging subject in the framework of the anticancer therapeutic oligonucleotides research field. Although several antiproliferative G-quadruplex aptamers have been identified and proven to be effective on different cancer cell lines, their mechanism of action is still unexplored. We have recently described the antiproliferative activity of a heterochiral thrombin binding aptamer (TBA) derivative, namely, LQ1. Here, we investigate the molecular mechanisms of LQ1 activity and the structural and antiproliferative properties of two further TBA derivatives, differing fromLQ1 only by the small loop base-compositions. We demonstrate that in p53 deleted colon cancer cells, LQ1 causes nucleolar stress, impairs ribosomal RNA processing, leading to the accumulation of pre-ribosomal RNAs, arrests cells in the G2/M phase and induces early apoptosis. Importantly, the depletion of uL3 abrogates all these effects, indicating that uL3 is a crucial player in the mechanism of action of LQ1. Taken together, our findings identify p53-independent and uL3-dependent nucleolar stress as a novel stress response pathway activated by a specific G-quadruplex TBA derivative. To the best of our knowledge, this investigation reveals, for the first time, the involvement of the nucleolar stress pathway in the mechanism of action of antiproliferative G-quadruplex aptamers
On Groups in Which Many Automorphisms Are Cyclic
No full textLet G be a group. An automorphism α of G is said to be a cyclic automorphism if the subgroup 〈x, xα 〉 is cyclic for every element x of G. In [F. de Giovanni, M.L. Newell, A. Russo: On a class of normal endomorphisms of groups, J. Algebra and its Applications 13, (2014), 6pp] the authors proved that every cyclic automorphism is central, namely, that every cyclic automorphism acts trivially on the factor group G/Z(G). In this paper, the class FW of groups in which every element induces by conjugation a cyclic automorphism on a (normal) subgroup of finite index will be investigated
Introducing Age.Vol.A: digital tools to promote communication between seniors, foreign caregivers and families
No full textThis presentation introduces Age.Vol.A.– Ageing, Volunteers, Assistants. Multilingual tools for
Assisting the Ageing, a research project on ageing issues focusing on the demographic and social
situation of Varese, an 80,000-inhabitant city in North-West Italy, with 13% of its population over 65
and foreigners representing over 8% of the province’s population, a significant proportion of whom
is employed as caregivers to assist elderly people at home. Age.Vol.A. starts from the assumption
that, between home-assisted Italian seniors and their non-Italian caregivers, there exists a linguistic
and cultural barrier as well as a digital divide, which tends to increase the physical and social
isolation of the elderly population (Russo et al., 2019; Vicentini & Grego, 2019; Vicentini et al.,
2020).
The paper intends to offer an overview of the output of this research project, i.e. a multilingual
website and a multilingual smartphone application aimed at providing the foreign caregivers with
terminology and practical information related to their assisted and the institutions aimed to assist
those who assist the elderly, from health and healthcare to administrative issues. The terminology is
divided into three macro areas – health, institutions, daily life – with secondary fields according to
various communicative situations. The concept of the digital tools rests on the notions of
translanguaging in migrant communities (Canagarajah, 2013; Hafner & Jones, 2015; Schreiber,
2015) as a means to deploy communication practices which digital tools can support through
adaptive moves through linguistic, textual, and audiovisual media.
References
Canagarajah, S. (2013) “Negotiating Translingual Literacy: An Enactment.” Research in the
Teaching of English 48(1):40–67.
Hafner, C. A., & Jones, R. H. (2015). Digital literacies and language learning. Language Learning &
Technology, 19(3), 1–7.
Russo, D., Luraschi, M., Grego, K., Vicentini, A., Pasquaré Mariotto, F., Rovelli, G. (2019)
“Designing a Survey for Care Workers, the Elderly and Their Families”, presentation at the
conference Seniors, foreign caregivers, families, institutions: Linguistic and multidisciplinary
perspectives, University of Insubria, Varese, Italy, 9-10/04/2019.
Schreiber. B. R. (2015). “I am what I am”: Multilingual identity and digital
translanguaging. Language Learning & Technology, 19(3), 69–87.
Vicentini, A., Grego, K. (2019) (eds) “Linguistic perspectives on ageing issues, ethics and ideology”,
Expressio, 3.
Vicentini, A., Grego, K., Russo, D., Grechi, D., Pasquaré-Mariotto, F. & Rovelli, G. (2020).
“Sociolinguistic and statistical methods to improve health communication between the elderly,
caregivers and institutions: The Age.Vol.A. research project”. presentation at the conference
Communication, Medicine and Ethics Conference (COMET) 2020, Aalborg (DK), 01-03/07/2020
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