112,772 research outputs found
Cesare Macchi Cassia, la forma della realtà
No full textCesare Macchi Cassia was a professor, thesis, and Ph.D. supervisor of Nicola Russi, who collaborated with him in developing research and project design between 1999 and 2005.
Nicola Russi was also a subject tutor at the "Laboratory of Urban Design I" (from AA 2001/02 to AA 2006/07) and the "Urban Planning and Contemporary Design" course (in AA A.A.2006/07) of Professor Cesare Macchi Cassia at the Faculty of Civil Architecture, Politecnico di Milano.
By describing selected cases, this text identifies themes and concepts underlying Cesare Macchi Cassia's design culture that moves along the boundary between the architectural, urban, and land scales, attempting to reconcile different worlds within an ethically and aesthetically coherent framework.
/ Cesare Macchi Cassia è stato professore, relatore di tesi e di dottorato di Nicola Russi, che ha collaborato con lui allo sviluppo di ricerche e all’elaborazione di progetti tra il 1999 e il 2005.
Nicola Russi è stato inoltre cultore della materia presso il “Laboratorio di Progettazione Urbanistica I” (dall’AA 2001/02 all’AA 2006/07) e il corso “Urbanistica e Progetto Contemporaneo” (nell’AA A.A.2006/07) del Professor Cesare Macchi Cassia, presso la Facoltà di Architettura Civile del Politecnico di Milano.
Attraverso la descrizione di casi selezionati, questo testo individua temi e concetti alla base della cultura progettuale di Cesare Macchi Cassia che si muove lungo il confine tra la scala architettonica, quella urbana e territoriale, tentando di conciliare mondi diversi all’interno di un quadro eticamente ed esteticamente coerente
Archivio russo-italiano V. Russi in Italia - Russko-ital'janskij Archiv V. Russkie v Italii
No full textRedazione e cura del volume "Archivio russo-italiano V. Russi in Italia", edito nella collana della rivista "Europa Orientalis
Combining business process re-engineering concepts and object oriented technology for effective organizational design
No full textHepatitis C virus infection and mixed cryoglobulinemia
No full textHepatitis C virus (HCV) chronic infection is recognized as the major cause of mixed cryoglobulinemia (MC). Its persistence
represents a continuous stimulus for host immune system with production of circulating immune complexes (ICs), one-third of
them with cryoprecipitate property. Several factors contribute to the biological activities of ICs, many of which are not completely
known. Among them, complement factors play a crucial role in the cold-insoluble ICs-mediated vasculitis, involving primarily
small blood vessels in different tissues including skin, kidney, peripheral, and central nervous system. Liver represents the major
target of HCV infection with inflammatory infiltrates, resembling secondary lymphoid follicles. Cytokine like CXCL13 contribute
to B-cell homing in intraportal lymphoid aggregates, in which B-cell clonal selection may arise. B-cell clonal expansion starts
as an antigen-driven event and expands towards indolent and malignant B-cell proliferation. Occurrence of intrahepatic Bcell
clonalities correlates with extrahepatic clinical manifestations of HCV infection. In this context, cryoglobulinemic patients
should be considered a peculiar HCV-infected population that needs a clinical multidisciplinary approach and more articulated
therapeutic measures
Precancerous colorectal lesions (Review).
No full textColorectal cancer (CRC) is a common and often lethal tumor. Over the last 25 years, remarkable progress has been made in understanding its biological and molecular features and in elucidating the steps involved in colon carcinogenesis. This, in turn, has led to a more rational and effective clinical approach to the treatment of CRC. While colorectal adenoma is the most frequent precancerous lesion, other potentially premalignant conditions, including chronic inflammatory bowel diseases and hereditary syndromes, such as familial adenomatous polyposis, Peutz-Jeghers syndrome and juvenile polyposis, involve different sites of the gastrointestinal tract with an overall incidence of less than 5%. In all such cases, disease recognition at an early stage is essential to devise suitable preventive cancer strategies. These topics are addressed in this review, along with the most important epidemiological, pathogenetic and clinical features that lead to malignant transformation. Novel biomarkers for early cancer prediction, detection, prognostic evolution, and the response to treatment are critically assessed as well. Continued improvements in our knowledge of the molecular basis of CRC and the transfer of this information into daily clinical practice will reduce the burden of this disease
La redazione dei QA incontra l'Arch. Nicola Russi responsabile della strategia di Progetto alla scala locale
No full textT cell receptor variable beta gene repertoire in liver and peripheral blood lymphocytes of chronically hepatitis C virus-infected patients with and without mixed cryoglobulinaemia
No full textTo characterize the repertoire of T lymphocytes in chronically hepatitis C virus (HCV)-infected patients with and without mixed cryoglobulinaemia (MC). T cell receptor (TCR) variable (V) clonalities in portal tracts isolated from liver biopsy sections with a laser capture microdissection technique in 30 HCV-positive MC patients were studied by size spectratyping. Complementarity-determining region 3 (CDR3) profiles of liver-infiltrating lymphocytes (LIL) were also compared with those circulating in the blood. The representative results of TCR V by CDR3 were also obtained from liver tissues and peripheral blood lymphocytes (PBL) of 21 chronically HCV-infected patients without MC. LIL were highly restricted, with evidence of TCR V clonotypic expansions in 23 of 30 (77%) and in 15 of 21 (71%) MC and non-MC patients, respectively. The blood compartment contained TCR V expanded clones in 19 (63%) MC and 12 (57%) non-MC patients. The occurrence of LIL clonalities was detected irrespective of the degree of liver damage or circulating viral load, whereas it correlated positively with higher levels of intrahepatic HCV RNA. These results support the notion that TCR V repertoire is clonally expanded in HCV-related MC with features comparable to those found in chronically HCV-infected patients without MC
Redesigning organisations through business process re-engineering and object-orientation
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