1,354,715 research outputs found
Alanus de Rupe. Michael Francisci de Insulis
No full textALANUS DE RUPE. MICHAEL FRANCISCI DE INSULIS
Alanus de Rupe. Michael Francisci de Insulis (1r)
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Besitzeintrag. Liber sancte Marie virginis in Bardesholm … (Ir)
Psalterium magnum trinitatis. (1r)
Incipit prologus devoti doctoris Alani de Rupe in magnum psalterium trinitatis beatissime. (1r)
Prologus in prima quinquagenam. (1r)
Prologus in prima denariam. (1r)
Supplicatio. (1r)
Supplicationes ad sanctam trinitatem. (13r)
Chapter (13r)
Suscipe divinissimum psalterium sancta trinitas hoc glorisissimum … (13r)
Ave Maria Ave beata a ve. Predestinata cum spe vatum o salve … (13r)
Alia expositio glossata secundum eundem. (15r)
Prima rosarum corona liliorum incarnationis Ihesu mirandorum. De beata vita Mariae que est sponsa patris eterni. (15r)
Glosse. Ab eterna providencia desiderii creature angelice … (15r)
Suscipe divinissimum psalterium sancta trinitas hoc gloriosissimum … (19r)
Exemplum de psalterio BMV. (21r)
Centum et quinquaginta articuli psalterii. (22r)
Sequuntur igitur centum et quinquaginta articuli psalterii domini nostri Ihesu Christi devotissimi a domina nostra virgine Marie revelati temporibus modernis ut dictum est per hunc modum. (22r)
Conclusio. Hii sunt filii et dulcis sponse centum et quinquaginta articuli … (31v)
Modus contemplandi in psalterio BMV. (32r)
Prologus. Cum igitur prefatus domine nostre Marie dulcissime sponsus psalterium predictum domini nostri Ihesu Christi assidue omni die decantaret … (32r)
Textus. Sequitur modus contemplandi in psalterio beatissime Marie virginis pater noster Ave Marie. (32r)
Hymnus. (37r)
leere Seiten (43r)
Psalterium magnum. (49r)
Prologus in primam denariam. Altissima trinitas misericordissima pater et filius et sponsus sanctus ex quo omnia per quem omnia in quo omnia [CAO 2751] … (49r)
Textus. Amorosissima virgo mater dei Maria beatissima propterea deificam a tota trinitate ab eterno predestinacione … (49r)
Psalterium beatae Mariae virginis. (88r)
Alanus de Rupe. Prologus magistri Alanis de Rupe ordinis predicatorum in psalterium beati Dominici confessoris. Incipit in nomine domini. Amen. (88r)
Ps.-Dominicus: Psalterium beatae Mariae virginis. (90r)
Praefacio. Incipit prologus in psalterium beati Dominici ordinis predicatorum institutoris mirifici. (90r)
Psalterium. Incipit psalterium beatissimi Dominici ordinis fratrum predicatorum institutoris mirifici. Pater noster. (90r)
… sicut vacabit et secundum quod dominus inspirabit. … Deo gracias pro fine. (95v)
Determinatio abbreviata de veritate fraternitatis rosarii BMV. (95v)
Incipit materia abbreviata de veritate fraternitatis rosarii sive psalterii generose domine glorioseque virginis Marie. Sequitur prologus. (95v)
Inter ecclesie fraternitates illa pocior esse censetur … (96r)
leere Seiten (99v)
Dialogus sponsi et sponsae. (101r)
Sermo in capitulo generali congregationis Hollandiae ordinis praedicatorum. (209r)
Tractatulus de simonia. (222r)
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RUPE-phospho: Rapid Ultrasound-Assisted Peptide-Identification-Enhanced Phosphoproteomics Workflow for Microscale Samples
No full textGlobal
phosphoproteome profiling can provide insights into cellular
signaling and disease pathogenesis. To achieve comprehensive phosphoproteomic
analyses with minute quantities of material, we developed a rapid
and sensitive phosphoproteomics sample preparation strategy based
on ultrasound. We found that ultrasonication-assisted digestion can
significantly improve peptide identification by 20% due to the generation
of longer peptides that can be detected by mass spectrometry. By integrating
this rapid ultrasound-assisted peptide-identification-enhanced proteomic
method (RUPE) with streamlined phosphopeptide enrichment steps, we
established RUPE-phospho, a fast and efficient strategy to characterize
protein phosphorylation in mass-limited samples. This approach dramatically
reduces the sample loss and processing time: 24 samples can be processed
in 3 h; 5325 phosphosites, 4549 phosphopeptides, and 1888 phosphoproteins
were quantified from 5 μg of human embryonic kidney (HEK) 293T
cell lysate. In addition, 9219 phosphosites were quantified from 1–2
mg of OCT-embedded mouse brain with 120 min streamlined RUPE-phospho
workflow. RUPE-phospho facilitates phosphoproteome profiling for microscale
samples and will provide a powerful tool for proteomics-driven precision
medicine research
Rupe-Type Rearrangement Intercepted by Diels–Alder Cycloaddition on Osmium
No full textAn
orthometallated 1-naphthylketone has been generated on osmium
by coupling of γ-hydroxyalkynyl and diphenylallenylidene ligands.
Treatment of Os{CC–C(OH)Ph2}2(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}(1) with HBF4 leads to [Os{κ2-O,C-[OC(CHPh2)-naphthyl-Ph]}(C–CHCPh2){κ3-P,O,P-[xant(PiPr2)2]}](BF4)2 (2), which gives [Os{κ2-O,C-[OC(CHPh2)-naphthyl-Ph]}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (3) by deprotonation with (piperidinomethyl)polystyrene. The formation
of the ketone of 2 and 3 is an HF-catalyzed
process. The H+ and F– fragments of HF
are introduced sequentially with two different HBF4 molecules.
The first molecule delivers H+, while the second provides
F–. The proton from the first molecule adds to the
Cβ atom of the diphenylallenylidene ligand of 1 to form [Os{CC–C(OH)Ph2}2(C–CHCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (4). The
hydroxide group from a γ-hydroxyalkynyl of 4 is
removed with the proton of the second HBF4 molecule, whereas
the osmium center abstracts a fluoride of [BF4]−, to give [OsF{C[−CC–C(OH)Ph2]–CHCPh2}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (5). Once both fragments of HF are
strategically located, the alkenyl-(γ-hydroxyalkynyl)alkylidene
ligand experiences a Rupe-type rearrangement intercepted by a Diels–Alder
cycloaddition, in two steps. A dehydration intercepted by Diels–Alder
cycloaddition initially occurs, which affords the fluoroalkenylnaphthyl
derivative [Os{κ2-F,C-[FC(CPh2)-naphthyl-Ph]}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (7). The subsequent reaction of the
latter with water yields the orthometallated 1-naphthylketone of 3, releasing HF. The protonation of 3 with HBF4 leads to 2
La Geologia della Rupe di San Leo
No full textL’articolo illustra una nuova carta geologica in scala 1/2000 della Rupe di San Leo, che è una spettacolare e delicata forma del rilievo posta al centro della Coltre della Val Marecchia. La Rupe è costituita da una successione epiligure che comprende i calcari della F.ne di San Marino e le arenarie della F.ne di Monte Fumaiolo, mentre il substrato della Rupe è costituito da unità liguri prevalentemente argillose. Per mostrare la geometria tridimensionale degli ammassi rocciosi che compongono la Rupe, alla carta geologica 1/2000 sono stati aggiunti dieci line-drawing dei confini geologici affioranti nelle pareti perimetrali. Dall’interpretazione dei dati rilevati sono stati ricavati caratteri stratigrafici inediti e una ben definita cronologia di deformazione. L’elemento tettonico più interessante è la grande faglia distensiva a basso angolo, di origine gravitativa, che affiora alla base delle pareti W, S ed E della Rupe. La faglia di San Leo fa parte di un sistema riconoscibile dal Monte Fumaiolo a Perticara, Torriana, Verucchio e San Marino. Il rilevamento e la datazione di questo sistema di faglie è essenziale per ricostruire la cinematica della coltre della Val Marecchia
Rupe-Type Rearrangement Intercepted by Diels–Alder Cycloaddition on Osmium
No full textAn
orthometallated 1-naphthylketone has been generated on osmium
by coupling of γ-hydroxyalkynyl and diphenylallenylidene ligands.
Treatment of Os{CC–C(OH)Ph2}2(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}(1) with HBF4 leads to [Os{κ2-O,C-[OC(CHPh2)-naphthyl-Ph]}(C–CHCPh2){κ3-P,O,P-[xant(PiPr2)2]}](BF4)2 (2), which gives [Os{κ2-O,C-[OC(CHPh2)-naphthyl-Ph]}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (3) by deprotonation with (piperidinomethyl)polystyrene. The formation
of the ketone of 2 and 3 is an HF-catalyzed
process. The H+ and F– fragments of HF
are introduced sequentially with two different HBF4 molecules.
The first molecule delivers H+, while the second provides
F–. The proton from the first molecule adds to the
Cβ atom of the diphenylallenylidene ligand of 1 to form [Os{CC–C(OH)Ph2}2(C–CHCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (4). The
hydroxide group from a γ-hydroxyalkynyl of 4 is
removed with the proton of the second HBF4 molecule, whereas
the osmium center abstracts a fluoride of [BF4]−, to give [OsF{C[−CC–C(OH)Ph2]–CHCPh2}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (5). Once both fragments of HF are
strategically located, the alkenyl-(γ-hydroxyalkynyl)alkylidene
ligand experiences a Rupe-type rearrangement intercepted by a Diels–Alder
cycloaddition, in two steps. A dehydration intercepted by Diels–Alder
cycloaddition initially occurs, which affords the fluoroalkenylnaphthyl
derivative [Os{κ2-F,C-[FC(CPh2)-naphthyl-Ph]}(CCCPh2){κ3-P,O,P-[xant(PiPr2)2]}]BF4 (7). The subsequent reaction of the
latter with water yields the orthometallated 1-naphthylketone of 3, releasing HF. The protonation of 3 with HBF4 leads to 2
Clinician- and patient-reported outcomes following the surgical treatment of single gingival recession defects: A systematic review
No full textTo analyze the effect of root coverage surgical therapy for the treatment of single gingival recession defects (GRD) in terms of clinician- and patient-reported outcomes (CROs and PROs), with an emphasis on esthetic perception. The protocol of this PRISMA 2020-compliant systematic review was registered in PROSPERO (CRD517050). Relevant articles reporting the outcomes of randomized controlled trials (RCTs) were identified through a literature search. After final article selection, according to specific eligibility criteria, data were extracted and categorized. Primary outcomes were clinician-reported root coverage esthetic scores (RES) and patient-reported esthetic perception and satisfaction using different assessment methods, such as standardized visual analog scales (VAS). Data were analyzed and the risk of bias in all included studies was assessed. Fifty-eight articles pertaining to 50 different RCTs were selected. A total of 1820 subjects presenting 2219 single GRDs were treated. Key findings derived from the pooled estimates indicated that root coverage and gingival phenotype modification therapy positively influenced both RES and patient-reported esthetic perception and satisfaction values. Compared to the use of a coronally advanced flap (CAF) alone (i.e., monolaminar technique), the use of a CAF in conjunction with a subepithelial connective tissue graft (i.e., bilaminar technique) had a positive impact on both RES and VAS values, whereas CAF in conjunction with soft tissue substitutes only had a beneficial effect on VAS values. Surgical approaches based on lateral flap displacement were associated with superior mean RES values compared to techniques involving coronal flap displacement. Meta-regression analyses revealed a statistically significant positive association between mean root coverage and RES (i.e., the greater the percentage of root coverage, the higher the RES). Conversely, the association between patient-reported esthetic perception and MRC was not statistically significant. In addition, it was observed that dentinal hypersensitivity can be substantially reduced with surgical root coverage therapy, regardless of the treatment modality. Surgical therapy for the correction of single GRDs had a positive effect on both clinician-reported esthetic scores and patient-reported esthetic perception and satisfaction. Bilaminar techniques are generally associated with superior results. © 2025 The Author(s). Periodontology 2000 published by John Wiley & Sons Ltd
Cross‐Linked Volume‐Stable Collagen Matrix Versus Connective Tissue Graft for Soft Tissue Augmentation at Implant Site. A Non‐Inferiority, Multicenter Randomized Clinical Trial
No full textAims: To compare the efficacy of cross-linked volume-stable collagen matrix (VCMX) versus connective tissue graft (CTG) to increase buccal peri-implant mucosal thickness (MT) around dental implants. Methods: The present is a parallel, randomized multi-center clinical trial, according to the CONSORT statement. Clinical centers were four Italian periodontal settings. All patients received a soft tissue augmentation procedure, by means of CTG or VCMX. The primary outcome variable was peri-implant mucosal thickness (MT) difference at 12 months follow-up. The statistical unit was the patient. An analysis of covariance was performed for this outcome variable. Secondary outcomes were patient-reported outcome measures (PROMs), complications, variability among operators, and changes in keratinized mucosa width (KMW). Results: A total of 98 patients completed the study, 49 in each group. MT increase was 1.0 ± 0.75 in the CTG group and 0.66 ± 0.58 mm in the VCMX group. CTG showed superior results to VCMX for MT gain (0.37 mm, 95% CI: 0.13–0.61, p = 0.002). In cases of Baseline MT ≥ 2 mm, CTG and VCMX yielded comparable results. VCMX was associated with shorter chair time (diff: 10.0 min; 95% CI: 5.02 to 14.98; p < 0.0001). Patients in the VCMX group experienced fewer days of discomfort (0.46 days, 95% CI: 0.06–0.99, p = 0.05), while no differences were found for final aesthetic and general satisfaction (CTG: 99.28 ± 2.28, VCMX: 98.48 ± 3.92, p = 0.22). Conclusions: Both techniques improved MT, and CTG yielded better outcomes. VCMX was associated with shorter chair time and less postoperative discomfort, but both procedures achieved excellent final patient satisfaction
Edentulous Mandibles Restored with Fiber-Reinforced Composite Prostheses Supported by 5.0 mm Ultra-Short Implants: Ten-Year Follow-Up
No full textBackground/Objectives: This study aimed to assess the long-term clinical performance of full-arch fixed restorations made of fiber-reinforced composite (FRC) supported by four ultra-short implants (4.0 × 5.0 mm) in patients with edentulous, atrophic mandibles. Methods: Ten patients were treated at Sapienza University of Rome and monitored over a 10-year period. Each case involved the placement of four plateau-design implants with a pure conometric connection and a calcium phosphate-treated surface. The final prostheses were fabricated using CAD/CAM-milled Trinia® fiber-reinforced composite frameworks. Clinical parameters included implant and prosthesis survival, marginal bone level (MBL), peri-implant probing depth (PPD), and patient-reported outcome measures (PROMs). Results: Implant and prosthesis survival reached 100% over the 10-year follow-up. MBL data showed a minor bone gain of approximately 0.11 mm per 5 years (p < 0.0001). PPD remained stable under 3 mm, with a minimal increase of 0.16 mm over the same period (p < 0.0001). PROMs reflected sustained high patient satisfaction. No technical complications, such as chipping or framework fracture, were observed. Conclusions: Rehabilitation of the edentulous mandible with ultra-short implants and metal-free FRC prostheses proved to be a minimally invasive and long-lasting treatment option. The 10-year follow-up confirmed excellent implant and prosthetic outcomes, favorable peri-implant tissue health, and strong patient satisfaction. Nonetheless, further studies with larger sample sizes are needed to confirm these encouraging results and strengthen the clinical evidence. © 2025 by the authors
La Geologia della Rupe di San Leo
No full textL’obiettivo principale di questo articolo è di presentare la nuova carta geologica in scala 1/2000 della Rupe di San Leo (versione ridotta in Figura 1). La carta è il primo passo dell’elaborazione di un modello tridimensionale che possa esprimere in modo immediato le relazioni tra stratigrafia, tettonica e geomorfologia che hanno determinato lo sviluppo di questa spettacolare e delicata forma del rilievo in Val Marecchia
Alanus de Rupe
No full textALANUS DE RUPE
Alanus de Rupe (1r)
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Expositio regulae beati Augustini (1r)
Praefatio. In psalterio decem cordarum psallite illi [Ps 32,2] scilicet domino Ihesu Christo patri religionum cunctarum … (1r)
Kapitelübersicht. Tabula seu divisio huius tractatus. (2r)
Oratio. O amantissimi sponsi in omni fide spe et caritate … (2r)
Textus. Primum capitulum huius tractatus scilicet regule beati Augustini. De caritate religiosorum completa ad quam decem regule requiruntur observande ibi. Hec igitur sunt etc. que faciunt decem primas rosas psalterii religiosi sponsi et sponse. (3v)
Speculum peccatricis animae (39r)
Prologus. Incipit speculum peccatricis anime. Prologus. (39r)
Textus. Prima oratio ad virginem Mariam et sanctissimum Dominicum contra vicium infidelitatis. (39v)
Exemplum (61v)
Expositio brevis super Ave Maria (67v)
Exempla (68r)
Cum Adrianus nobilis valde esset corpore et scientia ac eloquentia excelsus … (68r)
Exemplum de quadam Benedicta. (69v)
Sequitur miraculum legentibus stupendum. (70r)
De quodam gentili converso. (73v)
Exemplum aliud de quadam virgine nobili nomine Allexandra que predicationibus sancti Dominici in regno Arrogonie a multis annis confratriam intraverat psalterii mei … (75v)
Aliud exemplum. (75v)
Psalterium Marie virginis frequencius a vanitate mundi revocat … iuvenem fuisse prope nostra tempora in partibus Germanie natus et moratus … (76v)
Sermo de sancto Bernhardo (77r)
Donatus moralisatus (86r)
Exempla (91r)
Psalterium beate Marie semper virginis cottidie decantans a carnali concupiscentia retrahit. Legitur enim de quodam milite devoto qui postea dyabolo instigante … (91r)
Ad idem fuit quidam alius qui mirabiliter ardebat in amorem cuiusdam mulieris et deperiebat in amorem eius … (91v)
Psalterium beate virginis cottidie dicens a potestate demonum misericorditer est ereptus. Conversus quidam cisterciensis beate Marie devotus dicebat cottidie psalterium eius … (92r)
Erat quedam monialis satis devota beate virginis in dicendo Ave Maria coram altari eius … (92v)
Quidam clericus habens matrem devotam et edoctus ab ea servivit beate virgini a inventute dicendo psalterium eius … (92v)
Fuit quidam rector scolarium vite perverse ac lubrice … (93r)
Temporibus beati Dominici in terra Albigencium Christianis predicaret bella exercebantur contra infideles … (94r)
Beatus Dominicus reginam Francie Blancam nomine matrem beati Ludowici regis Francie sepultam in conventu fratrem predicatorum … (95r)
Quidam clericus solebat in monasterio singulis diebus dicere ante prandium CL Ave Maria … (95r)
Fuit quedam sanctimonialis honorans dominam matrem que totiens dicebat Ave Maria … (95v)
O dulcis sponse aliud exemplum adduco de cardinali quodam sanctissimo Dominico contemporaneo … (95v)
In Ytaliis[sic] tempore quo beatus Dominicus predicabat fuit presbiterus in eius predicacione quidam potens miles … (96v)
Contigit tempore Dominici ipso predicante in Albigio cum non proficeret praedicando … (97v)
Aliud exemplum contigit in Ytalia fuit quidam usurarius nomine Iacobus permaxime famosus … (98v)
Aliud exemplum. Bartholomeus quidam comes in Ytalia potencia viciis et iniquitatibus famosissimus fuit … (99v)
Quam utile legere psalterium virginis Marie. (100v)
Quam utile sit solum portare psalterium beate virginis idest patriloquium. (101v)
Quidam in psalterio beate Marie virginis devotissimus monachus post tempora longa merito huius psalterii fuit raptus ad superna … (101v)
De quodam nauta exemplum. (102r)
De predonibus conversis aliud exemplum. (102r)
De capra a lupis defensa exemplum. (102v)
De sancta Johanna moniali exemplum. (102v)
De sancta Katherina moniali. (104r)
De beata virgine Maria et beato Dominico exemplum. (104v)
De quodam Alano milite. (105r)
Exemplum stupendum quod nostris temporibus accidit. (105v)
Exemplum aliud satis mirabile. (105v)
De quadam sancta Maria comitissa exemplum. (106r)
Epistula ad Jacobum Cartusianum domus Legis Mariae prope Rostock (106v)
Nota. (110v)
Psalterium sponsi et sponsae videlicet Iesu Christi ac virginis Mariae. Excerpta (111r)
Conscientia. Psalterium beatissime trinitatis mirabilissime conscientiam trepidantem confortat … (111r)
Scientia. Psalterium clementissime trinitatis scientiam confert illis qui ipsum amant et amando laudant sponsum et sponsam in tam iocundo cantico … (116v)
Distinctio. Per psalterium virginis Marie poterimus peccata quindecim discernere et distinguere … (123r)
Laudate eum in psalterio … [Ps 150,3]. (125r)
Sermo sive principatio in III sententiarum (143r)
… et quam optabilis universis. Sed cur hoc … (143v)
Ex secunda petre proprietate sumebatur quod est supra se fundare et fundata … (154v)
Exempla (163v)
Exemplum pulchrum de quodam Cartusiensi. (163v)
De quadam meretrice per psalterium virginis Marie conversa. (165v)
Pulchra visio ostensa magistro Alano sponso novello Marie virginis. (167v)
Sermo super salutatione angelica ad pertimescendum extremum dei iudicium (168r)
Epilogus compendii (175v)
Exempla. Sequuntur brevissima miracula moderna super orationem Dominicam. (178r)
Revelatio et articuli (180r)
Exempla (187v)
De quadam sancta muliere pulcrum exemplum. (187v)
De quodam principe Alfoncio nomine pulcrum exemplum. (188v)
De tribus sororibus exemplum. (189v)
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