3,872 research outputs found
Meeting with the Hebrew author Elias Hurwitz
No full textWhite paper; handpainted; on the reverse of Luftwaffe uniform pattern. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Obituary announcement about author and labor activist Sh. Mendelson
No full textBrown paper; handpainted. Digitized posters are related to the activities of Jewish displaced persons drawn from the Records of Displaced Persons Camps and Centers in Germany (RG 294.2) Italy (RG 294.3) and Austria (RG 294.4) held by YIVO Archives. Please consult the historical note for those record groups for further information.Digital ImageDigital finding aid available
Sweeping has no effect on renormalized turbulent viscosity
No full textWe perform renormalization group analysis (RG) of the Navier-Stokes equation in the presence of constant mean velocity field , and show that the renormalized viscosity is unaffected by , thus negating the ``sweeping effect", proposed by Kraichnan [Phys. Fluids {\bf 7}, 1723 (1964)] using random Galilean invariance. Using direct numerical simulation, we show that the correlation functions for and differ from each other, but the renormalized viscosity for the two cases are the same. Our numerical results are consistent with the RG calculations
Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors
No full textWe have investigated whether a 1:1 combination of botanical extracts enriched in either Delta(9)-tetrahydrocannabinol (Delta(9.)-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, is neuroprotective in Huntington's disease (HD), using an experimental model of this disease generated by unilateral lesions of the striatum with the mitochondrial complex II inhibitor malonate. This toxin damages striatal neurons by mechanisms that primarily involve apoptosis and microglial activation. We monitored the extent of this damage and the possible preservation of the striatal parenchyma by treatment with a Sativex-like combination of phytocannabinoids using different histological and biochemical markers. Results were as follows: (i) malonate increased the volume of edema measured by in vivo NMR imaging and the Sativex-like combination of phytocannabinoids partially reduced this increase; (ii) malonate reduced the number of Nissl-stained cells, while enhancing the number of degenerating cells stained with FluoroJade-B, and the Sativex-like combination of phytocannabinoids reversed both effects; (iii) malonate caused a strong glial activation (i.e., reactive microglia labeled with Iba-1, and astrogliosis labeled with GFAP) and the Sativex-like combination of phytocannabinoids attenuated both responses; and (iv) malonate increased the expression of inducible nitric oxide synthase and the neurotrophin IGF-1, and both responses were attenuated after the treatment with the Sativex-like combination of phytocannabinoids. We also wanted to establish whether targets within the endocannabinoid system (i.e., CB1 and CB2 receptors) are involved in the beneficial effects induced in this model by the Sativex-like combination of phytocannabinoids. This we did using selective antagonists for both receptor types (i.e., SR141716 and AM630) combined with the Sativex-like phytocannabinoid combination. Our results indicated that the effects of this combination are blocked by these antagonists and hence that they do result from an activation of both CB1 and CB2 receptors. In summary, this study provides preclinical evidence in support of a beneficial effect of the cannabis-based medicine Sativex as a neuroprotective agent capable of delaying signs of disease progression in a proinflammatory model of HD, which adds to previous data obtained in models priming oxidative mechanisms of striatal injury. However, the interest here is that, in contrast with these previous data, we have now obtained evidence that both CB1 and CB2 receptors appear to be involved in the effects produced by a Sativex-like phytocannabinoid combination, thus stressing the broad-spectrum properties of Sativex that may combine activity at the CB1 and/or CB2 receptors with cannabinoid receptor-independent actions
Neuroprotective Effects of Phytocannabinoid-Based Medicines in Experimental Models of Huntington's Disease
No full textWe studied whether combinations of botanical extracts enriched in either Delta(9)-tetrahydrocannabinol (Delta(9)-THC) or cannabidiol (CBD), which are the main constituents of the cannabis-based medicine Sativex, provide neuroprotection in rat models of Huntington's disease (HD). We used rats intoxicated with 3-nitropropionate (3NP) that were given combinations of Delta(9)-THC-and CBD-enriched botanical extracts. The issue was also studied in malonate-lesioned rats. The administration of Delta(9)-THC-and CBD-enriched botanical extracts combined in a ratio of 1: 1 as in Sativex attenuated 3NP-induced GABA deficiency, loss of Nissl-stained neurons, down-regulation of CB1 receptor and IGF-1 expression, and up-regulation of calpain expression, whereas it completely reversed the reduction in superoxide dismutase-1 expression. Similar responses were generally found with other combinations of Delta(9)-THC- and CBD-enriched botanical extracts, suggesting that these effects are probably related to the antioxidant and CB(1) and CB(2) receptor-independent properties of both phytocannabinoids. In fact, selective antagonists for both receptor types, i.e., SR141716 and AM630, respectively, were unable to prevent the positive effects on calpain expression caused in 3NP-intoxicated rats by the 1: 1 combination of Delta(9)-THC and CBD. Finally, this combination also reversed the up-regulation of proinflammatory markers such as inducible nitric oxide synthase observed in malonate-lesioned rats. In conclusion, this study provides preclinical evidence in support of a beneficial effect of the cannabis-based medicine Sativex as a neuroprotective agent capable of delaying disease progression in HD, a disorder that is currently poorly managed in the clinic, prompting an urgent need for clinical trials with agents showing positive results in preclinical studies. (C) 2011 Wiley-Liss, Inc
Jurisdictional Colonisation in the Spanish and British Empires: Some Reflections on a Global Public Order and the Sacred
No full textA public legal order that aspires to be global must involve the possibility of the sacred. The international legal system should thus be open to the sacred if it strives to create order among states in global governance. These claims arise from a reflection on international law in which we have tried to move beyond imperialistic conceptions of order and modern fears about the role of religion in international law. Here we examine the relation between religion and international law by applying a genealogical approach to two important legal international projects for ordering the world: one theological, the other humanist. Two imperial stories of universalism, redemption, conquest and conversion are recounted. The first occurred during the initial conquest of the New World, and its main characters are the Spanish Empire and the indigenous people of South America. The second story concerns the British Empire and European colonisation in North America
BONDING AND DYNAMICS OF CNRg AND CRg COMPLEXES
No full textAuthor Institution: Department of Chemistry, Emory University, Atlanta, GA 30322The van der Waals complexes of CN and C with rare gas atoms (Rg) are of interest from the perspectives of their bonding characteristics and predissociation dynamics. Matrix isolation data indicate that that the bonding ranges from a weak van der Waals interaction for the Ne complexes to incipient chemical bonding for Xe. The low-lying vibronic states of CN and C are interleaved, which facilitates electronic energy transfer. Consequently, electronic predissociation of CNRg and CRg complexes provides a useful means to examine the detailed dynamics of electronic energy transfer. Predissociation processes for CNRg complexes have been characterized using double resonance techniques. The final state distributions exhibit symmetry preferences that yield insights concerning the topologies of the relevant potential energy surfaces. In addition, bond energies can be deduced from the predissociation dynamics. Data for the binary complexes CNRg (Rg=Ne, Ar, Kr, and Xe) and CRg will be presented, along with theoretical analyses based on potential energy surfaces
René Géronimo Favaloro : pioneer of Cardiac Surgery
No full textDr. René G. Favaloro moved to the Cleveland Clinic in 1962 and proceeded to reshape the face of cardiac surgery as we knew it. Together with his colleagues at the Cleveland Clinic, Drs. Effler, Sones, Proudfit, Groves, Sheldon and countless others, he contributed to the double internal mammary arterymyocardial implantation by the Vineberg method, and by May 1967, he reconstructed the right coronary artery by the saphenous vein graft interposition. These landmark procedures paved the way for the aorto-coronary saphenous vein bypass graft in October 1967. Many similar breakthroughs ensued, with the application of the bypass technique to the left coronary artery, the combination of coronary artery bypass graft with left ventricular reconstruction and valve repair/replacement and finally, by December, a double bypass to the right coronary artery and anterior descending branch of the left coronary artery. In June, 1971, Dr. Favaloro decided to leave the Cleveland Clinic and return to Argentina where he created a medical centre, a teaching unit, a research department and finally an Institute of Cardiology and Cardiovascular Surgery. This was his greatest personal ambition. Over and above his brilliant mind and craft, Dr. Favaloro was a man of integrity, courage, honesty and humility, whose name will never cease to reverberate throughout the history of medicine.peer-reviewe
A non-classical synthetic strategy for organic mesocrystals
No full textMesocrystals are ordered nanoparticle superstructures, often with internal porosity, which receive much recent research interest in catalysis, energy storage, sensors, and biomedicine area. Understanding the mechanism of synthetic routes is essential for precise control of size and structure that affect the function of mesocrystals. The classical synthetic strategy of mesocrystal was formed via self-assembly of nanoparticles with a faceted inorganic core but a denser (or thicker) shell of organic molecules. However, the potential materials and synthetic handles still need to be explored to meet new applications. In this work, we develop a non-classical synthetic strategy for organic molecules, such as tetrakis (4-hydroxyphenyl) ethylene (TPE-4OH), tetrakis (4-bromophenyl) ethylene (TPE-4Br), and benzopinacole, to produce mesocrystals with composed of microrod arrays via co-solvent-induced crystal transformation. The aligned nanorods are grown epitaxially onto organic microplates, directed by small lattice mismatch between plates and rods. Thus, the present work offers general synthetic handle for establishing well-organized organic mesocrystals.Ministry of Education (MOE)Published versionThe author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the MOE of Singapore (RG 14/13 and RG 5/16), the National Natural Science Foundation of China (No. 21673117), recruitment Program of Global Experts, Jiangsu Provincial Foundation for Specially-Appointed Professor, start-up fund at Nanjing Tech University (39837102), SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials, and Jiangsu Science and Technology Plan (Project No. BK20211258)
Modeling P-Rg conversions from isolated topographic features near the NORESS array
No full textUsing the T-matrix, or extended boundary condition, method, seismic-wave scattering is modelled from earth models with one-dimensional (1D) isolated topographic features. This study is motivated by observations suggesting that surface topography generates coda waves, which are relatively large-amplitude arrivals following major seismic phases. For sinusoidal periodic surfaces, large-amplitude anomalies in the surface displacement spectrum correspond to P-to-Rayleigh (P-Rg), S-to-Rayleigh (S-Rg), and other mode conversions. For isolated topographic features, these conversions still exist. Teleseismic P-Rg conversions from isolated hills were modelled in order to understand and confirm the origin of observed conversions near the NORESS array. -from Author
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