1,721,247 research outputs found
From activated leukocyte cell adhesion molecule to melanoma metastasis: towards the unravelling of a paradox
Full text linkContains fulltext :
83281.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 24 juni 2009Promotores : Pruijn, G.J.M., Ruiter, D.J. Co-promotor : Swart, G.W.M.269 p
Measurement of components of the plasminogen activation system by enzyme-linked immunosorbent assays: prognostic factors in patients with breast cancer
No full textItem does not contain fulltextKUN, 02 december 1998Promotores : Benraad, T.J., Ruiter, D.J. Co-promotores : Foekens, J.A., Sweep, C.G.J.189 p
Heparan sulfate proteoglycans and vascular pathology in Alzheimer's disease.
Full text linkContains fulltext :
19605_hepasupra.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 04 maart 2005Promotor : Ruiter, D.J. Co-promotores : Verbeek, M.M., Waal, R.M.W. de168 p
Challenging students to improve learning. Intervention studies in medical education
No full textContains fulltext :
161377.pdf (Publisher’s version ) (Closed access)Radboud University, 21 december 2016Promotor : Ruiter, D.J. Co-promotores : Donders, A.R.T., Waal, R.M.W. d
The Past, Present and Future of Dutch Teratological Collections. From enigmatic specimens to paradigm breakers
Full text linkContains fulltext :
206293.pdf (Publisher’s version ) (Open Access)Radboud University, 18 september 2019Promotores : Ruiter, D.J., Oostra, R.J. Co-promotores : Schepens-Franke, A.N., Klein, W.M
Central nervous system melanoma metastasis. Experimental studies on pathogenesis, diagnosis and therapy.
Full text linkContains fulltext :
27420.pdf (Publisher’s version ) (Open Access)
Contains fulltext :
50259.pdf (Publisher’s version ) (Open Access)RU Radboud Universiteit Nijmegen, 10 april 2006Promotor : Ruiter, D.J. Co-promotores : Waal, R.M.W. de, Wesseling, P.160 p
Imaging fibres in the brain
Full text linkContains fulltext :
127118.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 19 mei 2014Promotores : Ruiter, D.J., Norris, D.G. Co-promotores : Cappellen van Walsum, A.M. van, Barth, M
Hyperproliferation and genetic instability in cervical lesions
Full text linkContains fulltext :
144810.pdf (Publisher’s version ) (Open Access)Katholieke Universiteit Nijmegen, 08 november 2000Promotores : Ruiter, D.J., Boonstra, H. Co-promotores : Hanselaar, A.G.J.M., Wilde, P.C.M. de153 p
Genetic Alterations in melanocytic lesions -towards diagnostic use of molecular genetic analysis
Full text linkContains fulltext :
27367.pdf (Publisher’s version ) (Open Access)Melanoma is one of the most aggressive types of skin cancer and thick lesions. Obviously, a correct diagnosis is needed for an adequate therapy and proper information on the prognosis of the patient. But even a panel of expert pathologist cannot always arrive at a certain diagnosis; therefore, additional methods to support the diagnosis are needed. To find additional diagnostic markers we directed our efforts on routinely processed formalin-fixed paraffin-embedded tissue. We critically evaluate the various molecular techniques used to analyse genetic alterations on the DNA level in formalin fixed lesions and review the results published so far. Initially, Allelic Imbalance (AI) analysis showed some promise as a useful technique to analyse these gains and losses; however, only a few loci can be analyzed per experiment and gains cannot be distinguished from losses. Recently, a new technique to analyse gains and losses called Multiplex Ligation-dependent Probe Amplification (MLPA) was marketed; this technique solved the most important drawbacks from AI analysis. More recently, mutation of the BRAF gene in melanomas was reported, that could have diagnostic implications. We show a striking difference in frequency: no BRAF or NRAS mutations were detected in (atypical) Spitz naevi, whereas these genes were very frequent mutated in spitzoid melanomas. In borderline lesions a lower percentage was detected. In contrast to the AI findings these results suggest that these spitzoid lesions might not be part of a biologic spectrum but two separate subtypes. We showed that BRAF, NRAS and HRAS mutation analysis and MLPA provide additional information to arrive at correct diagnosis.RU Radboud Universiteit Nijmegen, 13 januari 2006Promotor : Ruiter, D.J. Co-promotor : Jeuken, J.W.M.156 p
Analysis of molecular changes during human melanocytic tumor progression.
Full text linkContains fulltext :
19619.pdf (Publisher’s version ) (Open Access)Melanoma is one of the most aggressive types of cancer, due to its potency to disseminate early in tumor progression. The incidence is still rising, even though the rate of change has leveled off in the last decade. As melanoma cells are relatively insensitive to classical systemic therapies, like chemotherapy and radiation therapy, the most effective treatment for melanoma patients is still surgical resection of the tumor before onset of the metastatic growth phase. Therefore, an accurate diagnosis of thin, biologically early melanoma lesions is very important. Despite the numerous melanoma markers that were previously identified, novel markers that could improve establishment of diagnosis and prognosis are still very welcome. Moreover, understanding of the processes involved in melanocytic tumorigenesis could be the basis for development of new diagnostic and prognostic tools and for the design of effective therapeutic protocols. To gain more insight in the molecular changes during melanoma progression, in this study, multiple array technologies were used to identify genes that show differential gene expression in different stages of melanocytic tumor progression. One differentially expressed gene, named MMA-1, was further characterized and its tissue-restricted expression showed that this gene belongs to the family of cancer/testis antigens. Various members of this family are already used in melanoma diagnostics and vaccination therapies for treatment of patients. Beside MMA-1, also other genes that showed differential expression in this study are candidate players in melanocytic tumor progression and are potent targets for diagnostic, prognostic and/or therapeutic interventionsRU Radboud Universiteit Nijmegen, 07 april 2005Promotor : Ruiter, D.J. Co-promotor : Muijen, G.N.P. van184 p
- …
