199 research outputs found
Distribution of the liver disease and reference groups at different cutoffs of positivity of <i>TP53 R249S</i> mutation.
No full text<p>At 150 copies/mL there is a clear distinction among the three liver cancer groups the chronic liver disease subjects and the reference group. The proportion of patients at this cut-off is higher in HCC/no cirrhosis (44%) than in all other groups (HCC/cirrhosis (21%), CC (22%), CLD (12%) and R (3)).</p
Methodics of assessing environmental noise emission while performing hydraulic fracturing operations in shale formations
No full textHydraulic fracturing operations performed at the stage of gas prospection in shale formations are aimed at opening out gas residing in rock micropores. Large quantities of fracturing fluid, with physicochemical composition adjusted to their properties, are injected to the selected interval of a horizontal well. Finally, sand (proppant) is injected along with the fracturing fluid to support the newly formed fracture. The results of a computer simulation of noise emission generated by high pressure pumps during hydraulic fracturing operations, and the results of noise measurements during such work in the north of Poland are presented in the paper. The analysis of the obtained results revealed that the noise standards for day hours in the residential area localized ca. 320 m from the well pad was not exceeded for the hydraulic fracturing operations. The noise level in the night hours was considerably higher, therefore a respective sound berm should be construed
What is the efficacy of family focused interventions for improving communication in the context of anxiety and depression in those aged 14-24 years?
No full textThe ability to communicate is integral to all human relationships. Previous research has specifically highlighted communication in families as both a risk and protective factor for anxiety disorders and/or depression. Yet, there is limited understanding about whether communication is amenable to intervention in the context of adolescent psychopathology and whether doing so improves outcomes. The aim of this systematic review was to determine in which contexts and for whom does addressing communication in families appear to work, not work, and why? From a total of 2418 papers that were screened, eight randomised controlled trials were identified from a systematic search of the literature. There was significant heterogeneity in the features of communication that were measured across these studies. There were mixed findings regarding whether family-focussed interventions led to improvements in communication. While there was limited evidence that family-focussed interventions led to improvements in communication relative to interventions without a family-focussed component, we discuss these findings in the context of the significant limitations in the studies reviewed. We conclude that further research is required to assess the efficacy of family focused interventions for improving communication in the context of anxiety and depression in those aged 14-24 years
Supplemental Material - Can digital economy improve tourism economic resilience?—Evidence from China
No full textSupplemental Material for Can digital economy improve tourism economic resilience?—Evidence from China by Rui Tang in Journal of Tourism Economics</p
Flugschr. G. Fr. 3892 (Ausst. 217 Nr. 2) - De fide meretricum in suos amatores: Questio min[us] pri[n]cipalis vrbanitat[is] [et] facetie ca[usa] in fine q[uo]dlibeti Heidelbergen[sis]
No full textVorbesitzer: Gustav Freyta
Induction of pH Sensitivity on the Fluorescence Lifetime of Quantum Dots by NIR Fluorescent Dyes
No full textModulation of the fluorescence lifetime (FLT) of CdTeSe/ZnS
quantum
dots (QDs) by near-IR (NIR) organic chromophores represents a new
strategy for generating reproducible pH-sensing nanomaterials. The
hybrid construct transfers the pH sensitivity of photolabile NIR cyanine
dyes to highly emissive and long-lifetime pH-insensitive QDs, thereby
inducing a reproducible FLT change from 29 ns at pH >7 to 12 ns
at
pH <5. This approach provides an unparalleled large dynamic FLT
range for pH sensing at NIR wavelengths
Image_2_Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.jpg
No full textBackgroundPyroptosis and prostate cancer (PCa) are closely related. The role of pyroptosis-related long non-coding RNAs (lncRNAs) (PRLs) in PCa remains elusive. This study aimed to explore the relationship between PRL and PCa prognosis.MethodsGene expression and clinical signatures were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. A PRL risk prediction model was established by survival random forest analysis and least absolute shrinkage and selection operator regression. Functional enrichment, immune status, immune checkpoints, genetic mutations, and drug susceptibility analyses related to risk scores were performed by the single-sample gene set enrichment analysis, gene set variation analysis, and copy number variation analysis. PRL expression was verified in PCa cells. Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, wound healing, transwell, and Western blotting assay were used to detect the proliferation, migration, invasion, and pyroptosis of PCa cells, respectively.ResultsPrognostic features based on six PRL (AC129507.1, AC005253.1, AC127502.2, AC068580.3, LIMD1-AS1, and LINC01852) were constructed, and patients in the high-score group had a worse prognosis than those in the low-score group. This feature was determined to be independent by Cox regression analysis, and the area under the curve of the 1-, 3-, and 5-year receiver operating characteristic curves in the testing cohort was 1, 0.93, and 0.92, respectively. Moreover, the external cohort validation confirmed the robustness of the PRL risk prediction model. There was a clear distinction between the immune status of the two groups. The expression of multiple immune checkpoints was also reduced in the high-score group. Gene mutation proportion in the high-score group increased, and the sensitivity to drugs increased significantly. Six PRLs were upregulated in PCa cells. Silencing of AC005253.1 inhibited cell proliferation, migration, and invasion in DU145 and PC-3 cells. Moreover, silencing of AC005253.1 promoted pyroptosis and inflammasome AIM2 expression.ConclusionsOverall, we constructed a prognostic model of PCa with six PRLs and identified their expression in PCa cells. The experimental verification showed that AC005253.1 could affect the proliferation, migration, and invasion abilities of PCa cells. Meanwhile, AC005253.1 may play an important role in PCa by affecting pyroptosis through the AIM2 inflammasome. This result requires further research for verification.</p
Image_1_Identification of pyroptosis-related lncRNA signature and AC005253.1 as a pyroptosis-related oncogene in prostate cancer.jpg
No full textBackgroundPyroptosis and prostate cancer (PCa) are closely related. The role of pyroptosis-related long non-coding RNAs (lncRNAs) (PRLs) in PCa remains elusive. This study aimed to explore the relationship between PRL and PCa prognosis.MethodsGene expression and clinical signatures were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. A PRL risk prediction model was established by survival random forest analysis and least absolute shrinkage and selection operator regression. Functional enrichment, immune status, immune checkpoints, genetic mutations, and drug susceptibility analyses related to risk scores were performed by the single-sample gene set enrichment analysis, gene set variation analysis, and copy number variation analysis. PRL expression was verified in PCa cells. Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, wound healing, transwell, and Western blotting assay were used to detect the proliferation, migration, invasion, and pyroptosis of PCa cells, respectively.ResultsPrognostic features based on six PRL (AC129507.1, AC005253.1, AC127502.2, AC068580.3, LIMD1-AS1, and LINC01852) were constructed, and patients in the high-score group had a worse prognosis than those in the low-score group. This feature was determined to be independent by Cox regression analysis, and the area under the curve of the 1-, 3-, and 5-year receiver operating characteristic curves in the testing cohort was 1, 0.93, and 0.92, respectively. Moreover, the external cohort validation confirmed the robustness of the PRL risk prediction model. There was a clear distinction between the immune status of the two groups. The expression of multiple immune checkpoints was also reduced in the high-score group. Gene mutation proportion in the high-score group increased, and the sensitivity to drugs increased significantly. Six PRLs were upregulated in PCa cells. Silencing of AC005253.1 inhibited cell proliferation, migration, and invasion in DU145 and PC-3 cells. Moreover, silencing of AC005253.1 promoted pyroptosis and inflammasome AIM2 expression.ConclusionsOverall, we constructed a prognostic model of PCa with six PRLs and identified their expression in PCa cells. The experimental verification showed that AC005253.1 could affect the proliferation, migration, and invasion abilities of PCa cells. Meanwhile, AC005253.1 may play an important role in PCa by affecting pyroptosis through the AIM2 inflammasome. This result requires further research for verification.</p
The Trouble with TOPO; Identification of Adventitious Impurities Beneficial to the Growth of Cadmium Selenide Quantum Dots, Rods, and Wires
No full textTri-n-octylphosphine oxide (TOPO) is a commonly used solvent for nanocrystal synthesis. Commercial TOPO samples contain varying amounts of phosphorus-containing impurities, some of which significantly influence nanocrystal growth. Consequently, nanocrystal syntheses often give irreproducible results with different batches of TOPO solvent. In this study, we identify TOPO impurities by 31P NMR, and correlate their presence with the outcomes of CdSe nanocrystal syntheses. We subsequently add the active impurity species, one by one, to purified TOPO to confirm their influence on nanocrystal syntheses. In this manner, di-n-octylphosphine oxide (DOPO) is shown to assist CdSe quantum-dot growth; di-n-octylphosphinic acid (DOPA) and mono-n-octylphosphinic acid (MOPA) are shown to assist CdSe quantum-rod growth, and DOPA is shown to assist CdSe quantum-wire growth. (The TOPO impurity n-octylphosphonic acid, OPA, has been previously shown to assist quantum-rod growth.) The beneficial impurities are prepared on multigram scales and can be added to recrystallized TOPO to provide reproducible synthetic results
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