4,691 research outputs found
Dataset for the paper "Climate model bias indicates higher projected future temperature extremes"
No full text<div>
<div>This repository holds data and scripts used to produce the paper entitled:</div>
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<div>"Climate model bias indicates higher projected future temperature extremes"</div>
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<div>by Lei Duan, Lyssa M. Freese, Govindasamy Bala, and Ken Caldeira.</div>
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<div>The paper is currently submitted for peer review.</div>
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<div>Any questions regarding the data and paper could be sent to the corresponding author: Lei Duan ([email protected])</div>
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Alkaliskt sfingomyelinas, en antiinflamatorisk faktor som kan motverka colit och colorektal cancer
No full textAlkaliskt sfingomyelinas, en antiinflammatorisk faktor som kan motverka colit och colorektal cancer Rui-Dong Duan, Erik Hertervig, Åke NilssonBakgrund: Borstbrämsenzymet alkaliskt sfingomyelinas (alk-SMas) som vi upptäckt, renat och klonat hydrolyserar sfingomyelin (SM) och den proinflammatoriska glycerofosfolipiden platelet activating factor (PAF). Metaboliter av SM är anticarcinogena och inaktivering av PAF är antiinflammatorisk. Alk-SMas nivån är sänkt vid coloncancer (CRC) (1), familjär colonpolypos och långvarig colit. Rektal administration av rekombinant alk-SMas lindrar experimentell colit och alk-SMas knockout (KO) möss är känsligare för induktion av colontumörer i en kombinerad colit/carcinogenmodell (2). Enzymet secerneras också i human galla och vi fann låga värden i ERCP galla från patienter med PSC och cholangiocarcinom. Alk-SMas KO möss utvecklar svårare dextransulfat colit än kontrollmöss (3). Metod: Vi analyserade PAF, enzymet autotaxin och dess metabolit lysofosfatidinsyra (LPA) i mucosan hos alk-SMas KO och kontrolldjur med colit inducerad med dextransulfat (3). Både PAF och LPA är trofiska och proinflammatoriska signalsubstanser. Fynden relaterades till colitens svårighetsgrad. Studien gav en mekanistisk bakgrund till alk-SMas anticarcinogena och antiinflammatoriska effekter. Vi kan därigenom bättre bedöma alk-SMas kliniska potential. Resultat: Vi fann att alk-SMas KO möss har högre PAF nivåer i mucosan under colitens induktionsfas och att nivån av autotaxin och LPA är högre i KO djuren när inflammationen etablerats (3). Bland våra tidigare fynd vill vi lyfta fram att alk-SMas uttryck kan nedregleras av fettrik kost, och ökas av lösliga fiber, 5-ASA och ursodeoxycholsyra. Slutsats: 1. Den anticarcinogena effekten av alk-SMas kan vara sekundär till den antiinflammatoriska effekten. 2. Reduktionen av på PAF och LPA nivåer är sannolikt viktigare för effekten än bildningen av sfingolipidmetaboliter. 3. Påverkan på alk-SMas nivån bidrar till kända effekter av kost och farmaka på inflammation och carcinogenes i colon. 4. Alk-SMas är proteasresistent och kan analyseras i faeces. 5 Alk SMase kan ges som slow release eller rektal beredning. Referenser: 1.Hertervig E, Nilsson A, Nyberg L, Duan RD. Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer. 1997; 79:448-53. 2. Chen Y, Zhang P, Xu SC, Yang L, Voss U, Ekblad E, Wu Y, Min Y, Hertervig E, Nilsson Å, Duan RD. Enhanced colonic tumorigenesis in alkaline sphingomyelinase (NPP7) knockout mice. Mol Cancer Ther. 2015; 14:259-67.3. Zhang P, Chen Y, Zhang T, Zhu J, Zhao L, Li J, Wang G, Li Y, Xu S, Nilsson Å, Duan RD. Deficiency of alkaline SMase enhances dextran sulfate-induced colitis in mice with upregulation of autotaxin. J Lipid Res. 2018; 59:1841-1850
Supplemental Material, Supplementary_Table_S1 - MiR-122 Promotes the Development of Colon Cancer by Targeting <i>ALDOA In Vitro</i>
No full textSupplemental Material, Supplementary_Table_S1 for MiR-122 Promotes the Development of Colon Cancer by Targeting ALDOA In Vitro by Hong Li, Xinhua Zhang, Zhao Jin, Tao Yin, Chuanyi Duan, Junwei Sun, Rui Xiong and Zilin Li in Technology in Cancer Research & Treatment</p
Fungal polyketides from a rhizospheric soil-derived Penicillium sp. YUD17004 associated with Gastrodia elata
No full textLi, Hong-Tao, Yang, Rui-Ning, Liu, Tao, Xie, Fei, Duan, Hao-Jie, Xia, Dan-Dan, Zhou, Hao, Ding, Zhong-Tao (2023): Fungal polyketides from a rhizospheric soil-derived Penicillium sp. YUD17004 associated with Gastrodia elata. Phytochemistry (113475) 205: 1-7, DOI: 10.1016/j.phytochem.2022.113475, URL: http://dx.doi.org/10.1016/j.phytochem.2022.11347
Supplemental Material, Supplementary_Table_S2_miR-122_predicted_targets - MiR-122 Promotes the Development of Colon Cancer by Targeting <i>ALDOA In Vitro</i>
No full textSupplemental Material, Supplementary_Table_S2_miR-122_predicted_targets for MiR-122 Promotes the Development of Colon Cancer by Targeting ALDOA In Vitro by Hong Li, Xinhua Zhang, Zhao Jin, Tao Yin, Chuanyi Duan, Junwei Sun, Rui Xiong and Zilin Li in Technology in Cancer Research & Treatment</p
Analysis of the conform process: a specific form of aluminium extrusion.
No full textSince the Conform process was patented 30 years ago, there have only been approximately 200 machines sold worldwide. Given that Conform competes economically with conventional extrusion and is also reported to be a more energy
efficient process, it is surprising that the use of Conform is not more widespread in today's increasingly environmentally conscious and high-production focussed world. One explanation for this is likely to be due to the fact that there is still limited knowledge of the thermo-mechanical behaviour of the workpiece during extrusion.
Furthermore, for the aluminium industry, there are still issues remaining regarding the production of flash and the quality of the extrudate in terms of mechanical properties. This study provides the reader with the findings of the research and experimental work undertaken by the author, his co-workers and fellow specialists, in the field of aluminium extrusion including Conform. The experimental work includes both laboratory experiments performed with a direct extrusion press and an experimental machine set up to replicate the Conform process. The experimental work is also simulated using finite element modelling techniques. The results from these analyses are then validated by comparing industrial and experimental data. The finite element analyses are enhanced by using parallel processing technology and user sub-routines. The author proposes new models to allow for the study of the different sub-processes in Conform. These include the coining of the feedstock, formation of the upset zone, extrusion of the flash, the filling-up of the expansion chamber / feeder plate and the extrusion of the extrudate. The author also investigates methods which predict microstructure and surface cracks in the extrudate. The author suggests innovative techniques to improve the efficiency of finite element analysis in metal forming. Finally the author recommends procedures for the study of structural integrity and the optimisation of the tooling used in Conform
Raw, uncropped supporting Western blot files for: Duan S. ... Pagano M. Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
No full textRaw, uncropped supporting Western blot files for: Shanshan Duan, Loredana Moro, Rui Qui, Daniele Simoneschi, Hyunwoo Cho, Shaowen Jiang, Huiyong Zhao, Qing Chang, Elisa de Stanchina, Arnaldo A. Arbini, and Michele Pagano. Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Raw, uncropped supporting Western blot files for: Duan S. ... Pagano M. Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
No full textRaw, uncropped supporting Western blot files for: Shanshan Duan, Loredana Moro, Rui Qui, Daniele Simoneschi, Hyunwoo Cho, Shaowen Jiang, Huiyong Zhao, Qing Chang, Elisa de Stanchina, Arnaldo A. Arbini, and Michele Pagano. Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
sj-docx-2-taj-10.1177_20406223231197311 – Supplemental material for Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study
No full textSupplemental material, sj-docx-2-taj-10.1177_20406223231197311 for Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study by Ting Deng, Jingjing Duan, Ming Bai, Le Zhang, Hongli Li, Rui Liu, Tao Ning, Shaohua Ge, Xia Wang, Yuchong Yang, Zhi Ji, Feixue Wang and Yi Ba in Therapeutic Advances in Chronic Disease</p
sj-jpg-1-taj-10.1177_20406223231197311 – Supplemental material for Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study
No full textSupplemental material, sj-jpg-1-taj-10.1177_20406223231197311 for Third-line treatment patterns and clinical outcomes for metastatic colorectal cancer: a retrospective real-world study by Ting Deng, Jingjing Duan, Ming Bai, Le Zhang, Hongli Li, Rui Liu, Tao Ning, Shaohua Ge, Xia Wang, Yuchong Yang, Zhi Ji, Feixue Wang and Yi Ba in Therapeutic Advances in Chronic Disease</p
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