1,721,080 research outputs found
Editorial: Ocular motor and vestibular deficits in neurometabolic, neurogenetic, and neurodegenerative diseases
Full text linkGastrointestinal Surgery and Wernicke Encephalopathy
No full textWernicke encephalopathy (WE) is a cause of rapidly progressive but reversible dementia due to deficit of thiamine (the B1 vitamin). In developed countries, WE is principally described in chronic alcoholism; however, it can also develop in other, probably underestimated and undiagnosed, nonalcoholic conditions. The nonalcoholic conditions causing reduced intake (malnutrition, reduced or absent absorption) or increased consumption of thiamine can be physiologic (aging) or pathologic. Abdominal surgery for cancer is an underestimated cause of atypical WE leading to high morbidity and mortality in which the diagnosis is often missed or delayed. Alongside acute neurological emergence, chronic deficit of thiamine may contribute to the neurodegenerative process leading to senile dementia and Alzheimer's disease. This chapter provides an overview of (1) the main metabolic effects of thiamine in specific brain areas; (2) the natural history of WE in patients who have undergone abdominal surgery for cancer; (3) the mechanisms linking thiamine deficiency to Alzheimer's disease; and (4) alternative causes of rapidly progressive dementias that should be differentiated from atypical WE
A unified computational framework for visual attention dynamics
No full textEye movements are an essential part of human vision as they drive the fovea and, consequently, selective visual attention toward a region of interest in space. Free visual exploration is an inherently stochastic process depending on image statistics but also individual variability of cognitive and attentive state. We propose a theory of free visual exploration entirely formulated within the framework of physics and based on the general Principle of Least Action. Within this framework, differential laws describing eye movements emerge in accordance with bottom-up functional principles. In addition, we integrate top-down semantic information captured by deep convolutional neural networks pre-trained for the classification of common objects. To stress the model, we used a wide collection of images including basic features as well as high level semantic content. Results in a task of saliency prediction validate the theory.
© 2019 Elsevier B.V
Quantitative analysis of horizontal slow saccades in spinocerebellar ataxia type 2
No full textIn a case of spinocerebellar ataxia type 2, Wadia-subtype (SCA2), with slow horizontal saccades, we used parvalbumin immunohistochemistry to identify the omnipause (OPNs) excitatory (EBNs), and inhibitory burst neurons (IBNs) of the saccade generator. Nissl sections was used to measure neuronal diameters, and synaptophysin staining to estimate of synaptic density on the cell somata. Morphometric and synaptic density measurements of the abducens motoneurons were identical in SCA2 and the control. A significant cell loss and reduced synaptic density on somata was found only in the EBN area. We conclude that degeneration of the EBNs is the most likely cause for the slowing of horizontal saccades
Multidimensional assessment of visual short-term memory: simultaneous characterisation of change detection, awareness and localisation
No full textA cross-recurrence analysis of the pupil size fluctuations in steady scotopic conditions
Full text linkPupil size fluctuations during stationary scotopic conditions may convey information about the cortical state activity at rest. An important link between neuronal network state modulation and pupil fluctuations is the cholinergic and noradrenergic neuromodulatory tone, which is active at cortical level and in the peripheral terminals of the autonomic nervous system (ANS). This work aimed at studying the low- and high-frequency coupled oscillators in the autonomic spectrum (0-0.45 Hz) which, reportedly, drive the spontaneous pupillary fluctuations. To assess the interaction between the oscillators, we focused on the patterns of their trajectories in the phase-space. Firstly, the frequency spectrum of the pupil signal was determined by empirical mode decomposition. Secondly, cross-recurrence quantification analysis was used to unfold the non-linear dynamics. The global and local patterns of recurrence of the trajectories were estimated by two parameters: determinism and entropy. An elliptic region in the entropy-determinism plane (95% prediction area) yielded health-related values of entropy and determinism. We hypothesize that the data points inside the ellipse would likely represent balanced activity in the ANS. Interestingly, the Epworth Sleepiness Scale scores scaled up along with the entropy and determinism parameters. Although other non-linear methods like Short Time Fourier Transform and wavelets are usually applied for analyzing the pupillary oscillations, they rely on strong assumptions like the stationarity of the signal or the a priori knowledge of the shape of the single basis wave. Instead, the cross-recurrence analysis of the non-linear dynamics of the pupil size oscillations is an adaptable diagnostic tool for identifying the different weight of the autonomic nervous system components in the modulation of pupil size changes at rest in non-luminance conditions.
Copyright © 2019 Piu, Serchi, Rosini and Rufa
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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