170,397 research outputs found
Western Europe and the rest of it: the Swiss perspective
No full textIn this book Tomas Kavaliauskas discusses questions of memory, identity and political and social transformations with partners from various European countries, among others Zygmunt Bauman, Vladimir Tismaneanu and Volodymyr Kulyk. The trio of scholars from Switzerland – Christian Giordano, François Ruegg, and Paolo Ruspini – add the Swiss perspective provoking to reconsider the application of the term of “Central Europe” for the postcommunist region
Linker molecules between laminins and dystroglycan ameliorate laminin-alpha2-deficient muscular dystrophy at all disease stages
No full textMutations in laminin-alpha2 cause a severe congenital muscular dystrophy, called MDC1A. The two main receptors that interact with laminin-alpha2 are dystroglycan and alpha7beta1 integrin. We have previously shown in mouse models for MDC1A that muscle-specific overexpression of a miniaturized form of agrin (mini-agrin), which binds to dystroglycan but not to alpha7beta1 integrin, substantially ameliorates the disease (Moll, J., P. Barzaghi, S. Lin, G. Bezakova, H. Lochmuller, E. Engvall, U. Muller, and M.A. Ruegg. 2001. Nature. 413:302-307; Bentzinger, C.F., P. Barzaghi, S. Lin, and M.A. Ruegg. 2005. Matrix Biol. 24:326-332.). Now we show that late-onset expression of mini-agrin still prolongs life span and improves overall health, although not to the same extent as early expression. Furthermore, a chimeric protein containing the dystroglycan-binding domain of perlecan has the same activities as mini-agrin in ameliorating the disease. Finally, expression of full-length agrin also slows down the disease. These experiments are conceptual proof that linking the basement membrane to dystroglycan by specifically designed molecules or by endogenous ligands, could be a means to counteract MDC1A at a progressed stage of the disease, and thus opens new possibilities for the development of treatment options for this muscular dystrophy
Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-alpha2-deficient congenital muscular dystrophy (MDC1A)
No full textBACKGROUND: Laminin-alpha2-deficient congenital muscular dystrophy (MDC1A) is a severe muscle-wasting disease for which no curative treatment is available. Antagonists of the angiotensin II receptor type 1 (AT1), including the anti-hypertensive drug losartan, have been shown to block also the profibrotic action of transforming growth factor (TGF)-beta and thereby ameliorate disease progression in mouse models of Marfan syndrome. Because fibrosis and failure of muscle regeneration are the main reasons for the severe disease course of MDC1A, we tested whether L-158809, an analog derivative of losartan, could ameliorate the dystrophy in dyW/dyW mice, the best-characterized model of MDC1A. METHODS: L-158809 was given in food to dyW/dyW mice at the age of 3 weeks, and the mice were analyzed at the age of 6 to 7 weeks. We examined the effect of L-158809 on muscle histology and on muscle regeneration after injury as well as the locomotor activity and muscle strength of the mice. RESULTS: We found that TGF-beta signaling in the muscles of the dyW/dyW mice was strongly increased, and that L-158809 treatment suppressed this signaling. Consequently, L-158809 reduced fibrosis and inflammation in skeletal muscle of dyW/dyW mice, and largely restored muscle regeneration after toxin-induced injury. Mice showed improvement in their locomotor activity and grip strength, and their body weight was significantly increased. CONCLUSION: These data provide evidence that AT1 antagonists ameliorate several hallmarks of MDC1A in dyW/dyW mice, the best-characterized mouse model for this disease. Because AT1 antagonists are well tolerated in humans and widely used in clinical practice, these results suggest that losartan may offer a potential future treatment of patients with MDC1A
Firmamentum veritatis, ex Ep. 1. ad Timoth. C.3.v.15., das ist, Grundveste der Wahrheit, oder fundamentalische Erklährung, dess streittigen Haupt-Articuls von der Kirchen : Darinn grundlich dargethan und erwiesen wird, dass die alte Römisch-Catholische Kirch, dero sichtbares Ober-Haupt auff Erden der Römische Babst ist, ... die einige wahr-christliche, rechtgläubige, und Gott wolgefällige Kirch, Versamlung oder Gemeind, in dero man allein die ewige Seligkeit zusuchen, und gewüss zufinden habe
No full textin Testaments-weise verfasset ... von dem hernach umbständlich beschribenem Johann Jacob Rüegg ...Frontispiz1 Taf. von Johannes Rüeg
Geistlicher hochzeitlicher Ehrenkrantz, von etlichen Geistlichen und schönen Jugend- und Glaubens-Blümelein zusamen gesetzt und in einer Hochzeitpredig auss den weysen Sprüchen Salomons ... bey dem hochzeitlichen Ehrentag des edlen, besten, ehrenvesten Junckern, J. Ulrich Hochrütiners, Burgers zu S. Gallen und der edlen, vil ehren- und tugendreichen Frawen, Fr. Adriana-Francisca Thomasinin, Herren Hans Anthoni Lochers sel., auch Burgers und Kaufherren zu S. Gallen, ... jn der evangelischen Gmeind und Pfarrkirch Marpach im Rhyntal, den 21. Maji, a. 1650 aussgelegt und erklärt
No full textdurch Johann Jacob Rügggen von Zürich, diser Zeit Predigern am Wort Gottes daselbstBogensignaturen: A-C⁴ D²Titeleinfassun
Platinum(II) trichlorostannate chemistry. Importance of the platinum-tin linkage in hydroformylation chemistry and anovel PtC(OSnCl2)R carbene
No full textThe reactions of trans-PtCl(COR)(PPh3)2 [R = Ph, C6H4NO2-p (I), C6H4Me-p, C6H4OMe-p (II), Me, Et (III), Pr, hexyl
(IV), CH2CH2Ph, Me3C (V)] with SnCl2 and SnCl2 plus H2 are described. The reactions with SnCl2 alone afford a mixt.
of trans-Pt(SnCl3)(COR)(PPh3)2 and trans-PtCl{C(OSnCl2)R}(PPh3)2, with the last having a tin-oxygen bond. For III,
IV, and V, reactions with SnCl2 plus H2 give aldehydes and platinum(II) hydride complexes, whereas for I and II no
aldehydes are obtained. The significance of these results in relation to H2 activation in the hydroformylation reaction is
discussed. 31P, 119Sn, 195Pt and, in a few cases, 13C NMR data are presented
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
De l'enseignement de la langue dans les écoles élémentaires. D’après R. R. Ruegg, professeur à l’université de Berne, par C. Breuleux, directeur de l’école normale de Porrentruy (Suisse). Lausanne, Imer et Payot, éditeurs, 1883
No full textB. E. De l'enseignement de la langue dans les écoles élémentaires. D’après R. R. Ruegg, professeur à l’université de Berne, par C. Breuleux, directeur de l’école normale de Porrentruy (Suisse). Lausanne, Imer et Payot, éditeurs, 1883. In: La revue pédagogique, tome 3, Juillet-Décembre 1883. pp. 557-559
Preparative and 1H NMR Spectroscopic Studies on Palladium(II) and Platinum(II) Quinoline-8-carbaldehyde (1) Complexes. X-Ray Structures of the Cyclometalated Acyl Complex PdCl(C(O)C9H6N)(PPh3)PPh3 and trans-PtCl2(1)(PEt3)
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