12 research outputs found
Investigating the Wound Healing Perspectives of Silver Nanoparticles Loaded Topical Nanogels
No full textThe primary objective of the present investigation revolves around the development and evaluation of nanogel formulations by incorporating oleanolic acid-loaded silver nanoparticles. The formulation underwent a comprehensive assessment to evaluate its therapeutic attributes and topical delivery. The formulation was prepared by using carbopol 940 and triethanolamine. The parameters were analyzed as pH 5.5, viscosity 3500 cps, spreadability 6.9 g/cm/sec, and skin irritation tests showed no skin rashes. Ex-vivo drug release shows a slow release of the drug. There was 84.66% drug release in 12 hours. Additionally, Swiss albino rats were employed in this research to investigate the wound-healing capabilities of topical gel containing silver nanoparticles. Stability studies of the nanogel formulation were done. The results confirmed the spherical shape and uniform particle size of silver nanoparticles and the good stability of the nanogel. This study has provided a way for novel approaches to address wounds of various origins. The formulated topical gels loaded with silver nanoparticles exhibit promising prospects as wound healing agents. They are anticipated to enhance the natural wound healing process significantly and play a pivotal role in rat wound closure rate and epithelization. In comparison to the standard pharmaceutical agent betadine, the nanogel formulation exhibited equivalent efficacy. This discovery sheds light on the potential applications of nanoparticle-infused formulations in the conventional management of severe wound conditions, thereby revitalizing therapeutic principles within the field of modern medicine
Anti-microbial Perspective of a Chalcone, (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl) phenyl)prop-2-en-1-one: Fabrication of a Hybrid by Unification of a Natural Product with a Synthetic Component
No full textMurraya koenigii L. has been explored exhaustively and is known to possess more than 20 different carbazole-based alkaloids having multifarious therapeutic perception of this class of alkaloids, murrayanine is the highest explored alkaloid and is known to have (ethno)-pharmacological perspectives of purgative, astringent, febrifuge, anti-helminthic, anti-oxidant, anti-ulcerogenic, immunomodulation, etc. As murrayanine possess multiple sites for substituting wide-range of electron-donating / -withdrawing groups by semi-synthetic approach, in the present research, a chalcone; (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one was fabricated rationally by incorporating a natural portion (murrayanine) in the A-ring and a synthetic component (4-methylsulfonyl group) in the B-ring and screened against two bacterial species (Escherichia coli and Staphylococcus aureus) and two fungal species (Candida albicans and Aspergillus niger). The rationally designed chalcone demonstrated noteworthy anti-microbial activity. The fabricated chalcone was observed to be a better anti-bacterial agent as compared to its anti-fungal potentials. As compared to the standard drugs, the experimental molecule does hold well against pathogenic challenges. The present research therefore opened new avenues of judiciously developing a natural scaffold having an active methylsulfonyl group, which will inspire life science researchers across the globe in developing inhibitors with pronounced biological activity as compared with the parent compounds
Substituted Thiazole Linked Murrayanine-Schiff�s Base Derivatives as Potential Anti-Breast Cancer Candidates: Future EGFR Kinase Inhibitors
No full textCancer is the second leading causes of mortality across the planet which has had affected millions. In spite of massive efforts in producing new molecules and chemotherapeutic approaches for managing cancer, it continued to be the global threat. Small hybrid molecules have gained popularity in chemotherapy due to their potential and smart characteristics in modulating biological targets. The present research attempts in developing few novel hybridized derivatives of murrayanine (an active carbazole derivative) by the semi-synthetic approach to form substituted thiazole linked murrayanine-Schiffs base derivatives. The protocol involved murrayanine 1 as the template material for constructing a hybridized Schiffs base intermediate 3, which further by Hantzchs cyclization was subsequently converted to various hybridized thiazoles analogs 5a-5f. The purity of the synthesized compounds was ascertained by sophisticated analytical techniques. The anti-cancer potential was screened against breast cancer cell lines; MCF-7 and MDA-MB-231 by Sulforhodamine B (SRB) assay. The compound 5b displayed most potent anti-proliferative activity with IC50 values of 23.41?M against MCF-7 cell line and 32.15?M against MDA-MB-231 cell line. It has been observed that analogs having electron withdrawing substituents exhibited pronounced anticancer activity. The docking study was performed by Autodock Vina where the results were found to be in full agreement with the cytotoxic study, depicting that the probable cytotoxic outcome by EGFR inhibitory mechanism. The study revealed the potential of novel hybridized derivatives as active anti-breast cancer candidates. The research will encourage (medicinal) chemists in rationally designing of semi-synthetic analogs of a heterocyclic prototype having pronounced anti-cancer activity.</jats:p
Anti-microbial Perspective of a Chalcone, (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one: Fabrication of a Hybrid by Unification of a Natural Product with a Synthetic Component
No full textMurraya koenigii L. has been explored exhaustively and is known to possess more than 20 different carbazole-based alkaloids having multifarious therapeutic perception. Of this class of alkaloids, murrayanine is the highest explored alkaloid and is known to have (ethno)-pharmacological perspectives of purgative, astringent, febrifuge, anti-helminthic, anti-oxidant, anti-ulcerogenic, immunomodulation, etc. As murrayanine possess multiple sites for substituting wide-range of electron-donating / -withdrawing groups by semi-synthetic approach, in the present research, a chalcone; (E)-1-(1-methoxy-9H-carbazol-3-yl)-3-(4-(methylsulfonyl)phenyl)prop-2-en-1-one was fabricated rationally by incorporating a natural portion (murrayanine) in the A-ring and a synthetic component (4-methylsulfonyl group) in the B-ring and screened against two bacterial species (Escherichia coli and Staphylococcus aureus) and two fungal species (Candida albicans and Aspergillus niger). The rationally designed chalcone demonstrated noteworthy anti-microbial activity. The fabricated chalcone was observed to be a better anti-bacterial agent as compared to its anti-fungal potentials. As compared to the standard drugs, the experimental molecule does hold well against pathogenic challenges. The present research therefore opened new avenues of judiciously developing a natural scaffold having an active methylsulfonyl group, which will inspire life science researchers across the globe in developing inhibitors with pronounced biological activity as compared with the parent compounds
On the Cognitive Process of Abstraction
No full textAbstractConcepts are the basic elements of propositions. Concepts can be best understood as constituted by its subset of objects (Extent) and subset of attributes (Intent). Psychological capacities of human mind for example, learning, thinking, memorizing can be performed by concepts and their association. In this paper, we will explain how human will be able to generalize concrete concepts of Formal Concept Analysis into abstract concepts. In particular, we model the functionalities of concept algebra by making use of Formal Concept Analysis; we illustrate the proposed model with experiments on sample context. This model simulates the thinking process of human mind
Anti-inflammatory potentials of some novel Murrayanine containing 1, 3, 4-Oxadiazole derivatives
No full textMurrayanine-Chalcone Transformed into Novel Pyrimidine Compounds Demonstrated promising Anti-Inflammatory Activity
No full textAnxiolytic activity of some 2, 3-dihydrobenzo[b] [1, 4] oxazepine derivatives synthesized from Murrayanine-Chalcone
No full textAn electrode comprising of graphene nanopowder inserted in an enclosed structure in anodic aluminium oxide coated with PANI by using low temperature hydrothermal process
No full text
