443 research outputs found
Design and evaluation of special drug delivery techniques of poorly soluble drug for enhancing skin permeability
No full textPh. D.Includes bibliographical referencesIncludes vitaby Indrajit Ghos
Why doesn’t the BJP face greater resistance from lower castes in Gujarat? Part 1
No full textLSE’s Dr Manali Desai (Department of Sociology) along with Dr Indrajit Roy (Research Fellow at Queen Elizabeth House, University of Oxford) recently conducted interviews across several communities in Ahmedabad, Gujarat, as part of the Leverhulme research project Beyond Identity? Markets and Logics of Democratisation in India, 1991-Present. The interviews reveal the contested and ambivalent character of political subjectivities among certain communities in the state, raising questions about narratives of Hindutva in Gujarat
Recommended from our members
Chinese Investments in Europe: Power, Influence, and the Liberal International Order
No full textChina’s rapidly rising investments in Europe have spawned anxieties about the future of the Liberal International Order. This introduction to the volume situates the puzzle of China’s growing resources vis-à-vis its limited influence. Departing from flattened perspectives that predict either inevitable conflict or assured cooperation, the introductory chapter urges readers to consider the extent, limits and modalities of China’s power. Its contribution is three-fold. Conceptually, the chapter offers a relational definition of power that pinpoints attention to the ways in which China translates its growing investments in Europe towards influencing the preferences of host countries. Empirically, it outlines the different modalities through which China harnesses the agency of European countries towards its own (fragmented) preferences. Theoretically, the chapter introduces a dynamic framework to understand the interaction between state-society relations in China with state-society relations in European countries to comprehensively appreciate the extent, limits and modalities of China’s influence
Why doesn’t the BJP face greater resistance from lower castes in Gujarat? Part 2
No full textIn Part 1 of this post, LSE’s Dr Manali Desai (Department of Sociology) and Dr Indrajit Roy (Research Fellow at Queen Elizabeth House) ask why the BJP does not face greater resistance from the lower castes in Gujarat. Using a political subjectivity lens, they argue that the social engineering of consensus around the promise and premise of development has generated support for Chief Minister Narendra Modi. Here, they explore two other factors for support for Modi among constituencies that one might have expected to oppose him
Iron oxide-doped niosomes as drug carriers for magnetically targeted drug delivery
No full textRidhima Juneja, Indrajit Roy Department of Chemistry, University of Delhi, New Delhi, Delhi, India Abstract: Magnetism has wide applications in various fields, such as diagnostics, drug targeting, molecular biology, cell isolation, cell purification, hyperthermia, and radioimmunoassay. In this study, we synthesized niosomes doped with iron oxide nanoparticles and a fluorophore for potential applications in magnetically targeted drug delivery. Release kinetics of the fluorophore and cytotoxicity were assessed. The results demonstrate that niosomes doped with iron oxide nanoparticles can serve as proficient and effective drug carriers in magnetically targeted drug delivery. Keywords: iron oxide nanoparticles, niosomes, fluorophores, drug carriers, magnetically targeted deliver
Social Oppression and Exploitation of Adivasis and Dalits in Contemporary India
No full textAt the 2019 general election in India, the BJP succeeded in gaining more of the Dalit, Adivasi and OBC vote. This chapter highlights the everyday politics of social oppression and exploitation faced by Dalits and Adivasis in India. India is a society of graded inequalities, with Adivasis and Dalits – who make up 25% of the population – at the bottom of the economic hierarchy. They continue to fare worse than all other groups on all main social and economic standard indicators. The focus here is on how historical relations of oppression of Dalits and Adivasis have been given new life and new meanings in modern India. Contrary to the expectations of the founders of Independent India, caste as a social category and caste-based discrimination have not withered away. Modi’s regime has exacerbated this, but the modern oppression of Dalits and Adivasis was in place well before the BJP came to power: the previous Congress Party-led governments have also been part and parcel of this development
Agrarian Crisis, Farmers' Protests and Women's Assertion
No full textDespite a declining share in GDP, agriculture still constitutes the mainstay for close to half of India’s population. Yet, with little investment in agricultural research and extension over the past two decades, lack of procurement at announced minimum support prices, and in the face of growing climatic variability, the farming community continues to experience massive distress. This has resulted in a large number of protests by farmers over the past few years, escalating since 2017, a direct response to the unmet promise made by Prime Minister Narendra Modi in his 2014 election campaign, to implement the recommendations of the National Commission on Farmers. The current protests have also seen an articulation by women farmers, seeking recognition and support for their contributions to the economy as farmers, not just as home-makers and ‘unpaid household helpers’
Synthesis and characterization of Fe3O4@SiO2@PDA@Ag core–shell nanoparticles and biological application on human lung cancer cell line and antibacterial strains
No full textNovel magnetic and metallic nanoparticles garner much attention of researchers due to their biological, chemical and catalytic properties in many chemical reactions. In this study, we have successfully prepared a core–shell Fe3O4@SiO2@PDA nanocomposite wrapped with Ag using a simple synthesis method, characterised and tested on small cell lung cancer and antibacterial strains. Incorporating Ag in Fe3O4@SiO2@PDA provides promising advantages in biomedical applications. The magnetic Fe3O4 nanoparticles were coated with SiO2 to obtain negatively charged surface which is then coated with polydopamine (PDA). Then silver nanoparticles were assembled on Fe3O4@SiO2@PDA surface, which results in the formation core–shell nanocomposite. The synthesised nanocomposite were characterized using SEM-EDAX, dynamic light scattering, XRD, FT-IR and TEM. In this work, we report the anticancer activity of silver nanoparticles against H1299 lung cancer cell line using MTT assay. The cytotoxicity data revealed that the IC50 of Fe3O4@SiO2@PDA@Ag against H1299 lung cancer nanocomposites cells was 21.52 µg/mL. Furthermore, the biological data of nanocomposites against Gram-negative ‘Pseudomonas aeruginosa’ and Gram-positive ‘Staphylococcus aureus’ were carried out. The range of minimum inhibitory concentration was found to be 115 µg/mL where gentamicin was used as a standard drug. The synthesized AgNPs proves its supremacy as an efficient biomedical agent and AgNPs may act as potential beneficial molecule in lung cancer chemoprevention and antibacterial strains
Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells
No full textEmbargo set by: Colleen Fallaw for item 102762
Lift date: 2019-08-10T21:27:21Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemRelationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal applications. In this work, we have presented the systematic synthesis of sub 50nm carbon nanoparticles (CNP) presenting neutral, anionic, and cationic surface headgroups. A subset of CNPs with ~ 10, 20, and 40nm hydrodynamic sizes are synthesized with neutral surface headgroups.
The cellular internalization of these CNPs was systematically quantified for the first time in various stages of breast cancer cells (early, late and metastatic), providing a parametric assessment of charge and size effects. Distinct activities are noticed with these systems as they interact with various stages of the cancer cells. Our results indicated that a metastatic breast cancer could be targeted with a nanosystem presenting anionic phosphate groups. On the contrary, for patients with late stage cancer, drugs could be delivered with sulfonate functionalized carbon nanoparticles with higher probability of intracellular transport.
This study will facilitate a better understanding of nanoparticle-biologic interaction and the integration of this knowledge with pathophysiology would help to engineer nanomedicine with superior likelihoods to cross the endocytic “barrier” for delivering drug inside the cancerous cells.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-05-01The student, Indrajit Srivastava, accepted the attached license on 2017-04-15 at 12:14.The student, Indrajit Srivastava, submitted this Thesis for approval on 2017-04-15 at 12:25.This Thesis was approved for publication on 2017-04-26 at 10:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #10779 on 2017-08-10 at 15:05:38Made available in DSpace on 2017-08-10T20:32:56Z (GMT). No. of bitstreams: 2
SRIVASTAVA-THESIS-2017.pdf: 5230076 bytes, checksum: c24d407b09804aeaab1bc89fb0c09813 (MD5)
LICENSE.txt: 4216 bytes, checksum: 64bc3a5d39085ef95ecf7f9c1260c7ff (MD5)
Previous issue date: 2017-04-26U of I Only Restriction Lifted for Item 102762 on 2019-08-11T09:15:21Z
Work and digital technology
No full textIt is now an almost unchallenged understanding that the future of work is going to be heavily shaped by and dependent on emerging digital technologies. And yet, globally, the terrain for the futures of work and digital technologies is uneven. In India, digitalisation is, in popular narrative, welcomed as a sign of the country’s modernisation and progress, as well as a promise for improved social inclusion. This chapter closely interrogates this understanding by reviewing the recent history of work, historical and structural inequalities, and workers’ experiences of digitalisation of work in India. In particular, it takes a close look at the boom in the services sector, particularly the information technology or IT industry in post-1990 India, engaging with debates over the measure and nature of unemployment in the country. It further explores the ways in which the influence of digital technology on work may reproduce and challenge long-standing patterns of work, such as, low female labour force participation, informal and insecure work, and caste-differentiation in work. Finally, it highlights scholarship that offers an insight into the everyday experiences of workers to understand digital futures of work in India
- …
