180,927 research outputs found
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Portrait of Clifford P. Rowe
No full textPortrait of Clifford P. Rowe, Pacific University alumni. He later served as a coach at a high school in Idaho.[Back 1] Clifford P. Rowe; students and alumni Q - R [Back 2] Clifford Rowe/Coach at Kimberly High School, Kimberly, Idaho; students and alumni Q -
World War I record of service survey for Guy I. Rowe, signed 27 February 1926.
No full textQuestionnaire about Guy Ichabod Rowe's service in World War I, 1917-1919, signed by Rowe on 27 February 1926.Questionnaire originally part of a survey of Norwich University alumni conducted by a “Norwich in the World War” committee consisting of Charles N. Barber (chairman), Carl V. Woodbury, K.R.B. Flint, and Gustaf A. Nelson. Data from these questionnaires may have been used in a chapter of "Vermont in the world war, 1917-1919" by Harold P. Sheldon (1928)
Marylee Meredith posing with a golf club
No full textA photo of Marylee Meredith, a Pacific University student from Spokane, Washington, posing with a golf club.[back] Marylee Meredith - Spokan, Wash., Property of C. P. Rowe, P. U. Stinker 5
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Getting behind the blue curtain: managing police integrity
No full textThis chapter explores emerging strategies designed to reduce police officer corruption and malfeasance. Codes of ethical conduct, disciplinary measures, cultural programmes, training and professionalisation of policing have developed in response to various challenges to police integrity. It also explores each of these drawing on international examples. The chapter considers how they operate in relation to dominant police subcultural values of loyalty and camaraderie that have often amounted to a 'blue curtain' that prevents officers reporting concerns about the misconduct of their colleagues. It outlines some changes to the nature of challenges to police integrity that have featured in recent debates about accountability and police integrity. A recurrent challenge to police accountability is that a great deal of policing is conducted in conditions of low visibility and therefore relatively difficult for managers or leaders to interrogate. Finally, the chapter concludes that responses to misconduct by police have developed in useful ways, significant challenges remain
Influences without footnotes: Sibyl Moholy-Nagy and Colin Rowe
No full textColin Rowe es considerado como uno de los pensadores más relevantes en el campo arquitectónico desde la década de los 60. Su complejo andamiaje teórico muestra a una persona capaz de reconciliar críticamente gran variedad de las corrientes y discursos de su época, de ahí la riqueza y complejidad de sus textos. En el caso de Collage City, su propuesta se enmarca en un periodo crítico en relación a las doctrinas urbanas resultantes del pensamiento adscrito a la arquitectura moderna. La publicación se deriva del trabajo realizado en el Urban Design Program, dirigido por Rowe, en la Universidad de Cornell a partir de 1965. La teoría perceptiva de la Gestalt, la crítica estructuralista de Claude Levi-Strauss, la utopía política de Judith Shklaar o el método antihistoricista de Karl Popper, se puede rastrear de manera más o menos directa entre sus fuentes. Recientemente, la publicación de the letter of Colin Rowe: !ve decades o correpondence (2016), editada por Daniel Naegele, nos permite adentrarnos en la intrahistoria más privada del profesor. Entre toda esta correspondencia infraestructural, una mención en particular abre un nuevo camino de interpretación de la obra. Matrix of Man (1968) un libro dedicado a la historia urbana, escrito por la historiadora Sibyl Moholy-Nagy, parece haber sido uno de los libros guía que Rowe consultaba durante el proceso editorial de Collage City. Sin embargo, no existe ninguna mención de esta publicación en la obra de Fred Koetter y Colin Rowe. Este artículo intentará analizar hasta qué punto el libro de Sibyl Moholy-Nagy pudo in!uir en Colin Rowe, proponiendo nuevas aristas de interpretación de Collage City.Postprint (published version
The functional demand (FD) placed on the knee and hip of older adults during everyday activities
No full textAge-related decline in physical capacity and diminishing physiological reserves may increase the demand placed on lower extremity joints during everyday activities. This study aimed to characterise the functional demand at the knee and hip joints of older adults during various mobility activities. Eighty-four healthy participants (60-88 years) performed strength tests using a custom-built dynamometer. Biomechanical assessment of gait, chair rise and sit-down, stair ascent and descent was performed using an 8-camera VICON system (120Hz) and Kistler force plates. Comparisons between groups (60’s, 70’s, and 80’s) were made using ANOVA.The functional demand (FD) was defined as the muscle moment generated during a task, divided by the maximum isometric strength (expressed as a percentage). FD was higher in the 80’s age group compared to those in the 60’s. The demand on hip and knee extensors was normally higher than those of flexors across all the activities. The knee extensor demand during gait (101%), stair ascent (103%) and stair descent (120%); and hip extensor demand during gait (127%) were high requiring moments in excess of the maximum isometric strength available at these joints. FD during chair rise and sit-down were comparatively lower with knee extensor demands of 73% and 69% and hip extensor demands of 88% and 51% respectively. Gait, stair ascent and descent placed high demands on the knee extensors while hip extensor demand was high for gait, chair rise, sit-down and stair ascent. The levels of demand leave little reserve capacity for the older adult to draw on in unexpected circumstances
Importance and nature of short-range excitonic interactions in light harvesting complexes and organic semiconductors
No full textThe singlet excitonic coupling between many pairs of chromophores is evaluated in three different light harvesting complexes (LHCs) and two organic semiconductors (amorphous and crystalline). This large database of structures is used to assess the relative importance of short-range (exchange, overlap, orbital) and long-range (Coulombic) excitonic coupling. We find that Mulliken atomic transition charges can introduce systematic errors in the Coulombic coupling and that the dipole–dipole interaction fails to capture the true Coulombic coupling even at intermolecular distances of up to 50 Å. The non-Coulombic short-range contribution to the excitonic coupling is found to represent up to ∼70% of the total value for molecules in close contact, while, as expected, it is found to be negligible for dimers not in close contact. For the face-to-face dimers considered here, the sign of the short-range interaction is found to correlate with the sign of the Coulombic coupling, i.e. reinforcing it when it is already strong. We conclude that for molecules in van der Waals contact the inclusion of short-range effects is essential for a quantitative description of the exciton dynamics
The Plays and Poems of Nicholas Rowe: The Late Plays
No full textNicholas Rowe was the first Poet Laureate of the Georgian era. A fascinating and important yet largely overlooked figure in eighteenth-century literature, he is the ‘lost Augustan’. His plays are important both for the way they address the political and social concerns of the day and for reflecting a period in which the theatre was in crisis. This edition sets out to demonstrate Rowe’s mastery of the early eighteenth century theatre, especially his providing significant roles for women, and examines the political and historical stances of his plays. It also highlights his work as a translator, which was both innovative and deeply in tune with current practices as exemplified by John Dryden and Alexander Pope. This is the first scholarly edition of all Rowe’s plays and poems and is accompanied by 15 musical scores and 31 black and white illustrations
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