1,886 research outputs found
Five Decades of Transplant for AML
No full textBurnham Lecture Series: Five Decades of Transplant for AML, Jacob Rowe, MD, Chief - Department of Hematology and the Ann and Pinky Sohn Chair in Hemato-Oncology at the Shaare Zedek Medical Center, Jerusalem, and Emeritus Professor at the Technion Israel Institute of Technology, Haifa.
Objectives: Understanding of the historic hurdles in allogeneic transplantation that allowed the successes in current practice. Overcoming the age barrier in transplantation. Crucial role of supportive care in transplantation. Understanding that “everyone has a donor”
Jacob Viner’s Reminiscences from the New Deal (February 11, 1953)
No full textThis paper presents and reproduces an unpublished oral history interview given by Jacob Viner in 1953. The interview released by Viner for the Columbia Oral History Project gives us a valuable opportunity to throw light on his advisory activity during the New Deal Era. In our introduction we attempt to make a critical appraisal of Viner's reminiscences and to state the contribution they can provide to our general knowledge of the period. In addition, we also attempt to find out some biographical and interpretative elements useful to understand Viner’s own vision and his contribution to important economic policy processes during the New Deal.
Les Mathématiques naturelles
No full text@book{OL-CHEMILLIER-2007, author = {Chemillier, M.}, editor = {}, title = {Les Mathématiques naturelles}, publisher = {Odile Jacob}, year = {2007}, address = {Paris}, series = {240 pages}
Smith, George Rowe
No full textGeorge Rowe Smith, LL.B.
Central City, Kentucky
Heavyweight Boxing Championship \u2712; President Freshman Class; Varsity Track (1); Varsity Football (4) ; Union Literary Society; Democratic Club; Y. M. C. A. Cabinet; Prohibition Club.
If well thou hast begun, go on fore-right; It is the end that crowns us, not the fight. George R. began life in the Prep and has had many a delightful day since he could first call himself a Freshman. He admits that he is differently constituted from the rest since no one can hurt him. He has measured arms with some sturdy fighters but still holds his championship in boxing. His crowning glory came when he received his letter in football after many years of faithful toil.
-The Kentuckian, 1915---------------------------------
George Rowe Smith (January 16, 1890 - December 18, 1975) was born in Central City, Kentucky to George Smith and Martha Eleanor Rowe. Smith stayed in Lexington and entered into a law partnership with fellow class of 1915 student Jacob Owen Reynolds. Smith practiced law in Lexington for over 50 years before retiring in 1972. Smith was also involved in Lexington\u27s motel industry. He married twice--his wives were Ella Mae Clark and Mattie Stella Clark.https://uknowledge.uky.edu/klapp_1915/1029/thumbnail.jp
The works of Jacob Behmen, the Teutonic theosopher : to which is prefixed, the life of the author /
No full textFrontispiece, v. 1, is engraved port. of the author. Vol. 3 includes Law's diagrams. Fig. 1 is a folded, hand-colored engraving entitled: The true principles of all things. Fig. 2 is a hand-colored engraving entitled: The tree of the soul. Plates numbered I-XIII are untitled, and are mostly cosmic diagrams. Fig. I, no. 1 is entitled: The origin of things and the process of Christ; it consists of 2 folded leaves joined together to form a single plate hinged in at the center fold, with an additional folded sheet overlaying. Fig. II, a single leaf, is entitled: The constituent parts of man. Three final plates ("The first [second, third] table") are single leaves depicting the human body with up to 8 levels of overlays. The first and second tables show males, the third female.Vol. 3-4 have publisher: Printed for G. Robinson in Pater-noster Row.v. 1. The aurora. The three principles -- v. 2. The threefold life of man. The answers to forty questions concerning the soul. The treatise of the incarnation. The clavis, or, An explanation of some principal points and expressions in his writings -- v. 3. The mysterium magnum, or, An explanation of Genesis. Four tables of divine revelation -- v. 4. Signatura rerum. Of the election of grace, or, Of God's will towards man, commonly called predestination. The way to Christ. A discourse between a soul hungry and thirsty after the fountain of life, the sweet love of Jesus Christ; and a soul enlightened. Of the four complexions. Of Christ's testaments, baptism, and the supper.Hogart, R. Alchemy,Mode of access: Internet
Efficacy and Safety Profile of Ivosidenib in the Management of Patients with Acute Myeloid Leukemia (AML): An Update on the Emerging Evidence
No full textGalia Stemer,1 Jacob M Rowe,2– 4 Yishai Ofran2,4 1Institute of Hematology, Ha’Emek Medical Center, Afula, Israel; 2Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel; 3Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel; 4The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, IsraelCorrespondence: Jacob M RoweDepartment of Hematology, Shaare Zedek Medical Center, Shmu’el Bait St 12, Jerusalem, 91031, IsraelTel +972-2-6555204Fax +972-2-6555755Email [email protected]: The isocitrate dehydrogenase enzyme, catalyzing isocitrate conversion to α-ketoglutarate (αKG) in both the cell cytoplasm and mitochondria, contributes to the production of dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as a reductive potential in various cellular processes. IDH1 gene mutations are revealed in up to 20% of the patients with acute myeloid leukemia (AML). A mutant IDH enzyme, existing in the cell cytoplasm and possessing neomorphic activity, converts αKG into oncometabolite R-2-hydroxyglutarate (R-2-HG) that accumulates in high amounts in the cell and inhibits αKG-dependent enzymes, including epigenetic regulators. The resultant alteration in gene expression and blockade of differentiation ultimately lead to leukemia development. Myeloid differentiation capacity can be restored by obstruction of the mutant enzyme, inducing substantial reduction in R-2-HG levels. Ivosidenib, a potent selective inhibitor of mutant IDH1, is a differentiating agent shown to be clinically effective in newly diagnosed AML (ND-AML) and relapsed/refractory (R/R) AML harboring this mutation. The drug is approved by the Food and Drug Administration (FDA) as a single-agent treatment for R/R AML. Significance of mutated IDH1 targeting and a potential role of ivosidenib in AML management, when used either as a single agent or as part of combination therapies, will be reviewed herein.Keywords: mutant IDH1, acute myeloid leukemia, ivosideni
Reiley, Joseph (Death, 1903-12-26)
No full textAddress: Ohio Maternity HospitalAge at death: 9 daysPg 130/554/1903/M WS/City/Dr. James W. Rowe/Jacob F. Eyrich/City CemeteryOriginal record filed in drawer labeled 'REIK-REMY'
McMullen, Oliver (Death, 1904-02-22)
No full textAddress: Ohio Maternity HospitalAge at death: 14 days609/Pg. 29/1904/M W S/City/Dr. James W. Rowe/Jacob Eyrich/City CemeteryOriginal record filed in drawer labeled 'MCLAUGHLIN, P-MACK, R'
Mueller, David (Death, 1908-11-04)
No full textAddress: 1716 Hughes St.Age at death: 2 Mos 9days75/Pg. 131/1908/M W S/B. P. - City/Dr. Jas. W. Rowe/Jacob F. Eyrich/Carthage Rd.Original record filed in drawer labeled 'MUELLER-MULLER'
The theme of 'blessing for the nations' in the patriarchal narratives of genesis.
No full textThe universalistic promise expressed by a formula with the theme
"Blessing for the Nations" in the Old Testament is primarily
found in the patriarchal narratives (Gen. l2-35). This aspect
of the patriarchal narratives however has not been adequately
studied. Previous discussions of the theme, based primarily
on 12:1-3, and conducted within the framework of the Yahwist's
work, are shown to be inadequate in our survey in shedding light
on the positioning and significance of the theme in the overall
patriarchal narratives. The survey indicates a literary analysis
of these narratives could probably yield more positive results.
2. A. formulaic analysis shows that the niphal form is
used at the beginning of a
patriarchs career to express a
probationary, and the hithpael form to express a
reaffirmatory, relationship of the patriarch to the promised
universal destiny. Strikingly, the 'seed' plays a prominent
role in the destiny. The formula also serves to link the
patriarchs' calling to the primeval history and the history of
the early formative period of the Israelite people.
3. The Abraham story (Gen.12-.22) is encased by the theme. A
double-chiastic arrangement of the narratives (in two groups)
shows a movement of horizon from the particularistic to the
universalistic. The universal horizon of Abraham's initial call
(12:1-3), displaced in the first half of the structure, is
reaffirmed in the latter half. Gen. l6 stands out as the nadir
and turning-point of the overall story. The notices of Isaac's
birth are instructively "positioned' in the universalistic
sector of the double-chiasmus. Moreover, the formula is
pronounced in narratives which portray Abraham as reversing the
negative results of the key events in the primeval history.
4. The Isaac narrative (Gen. 26) is shown to be "demonstration-material" of the initial actualisation of the theme. The
narrative is coherently structured around an emphatic divine
command, a unique twin-promise, and Isaac's response in a series
of movements, climaxing in Abimelech's sudden visit to and
significant confession of Isaac's status. Gen.26 is also
shown to be a "quintessence" of the Abraham story and forms a
critique of and model for Jacob's understanding and actualisation of his destiny.
5. The theme is shown to underline the Jacob story (Gen.25-35),
especially in the Jacob-.Esau cycles. Jacob's character transformation and reconciliation with Esau are necessary pre-requisites
before the reaffirmation' of the universal destiny to him at
Bethel. Significantly, the creation mandate is re-issued to
Jacob-Israel the seed of Abraham and Isaac, when a. formula
pronouncement is expected.. Finally, Jacob-Israel is shown to
form a parallel with Abraham whose call also expresses Yahwehs
re-affirmation of his creational intentions for mankind
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