1,720,977 research outputs found
Characterization of the Signaling Pathways Implicated in the AMPK-Mediated Assembly of Epithelial Tight Junctions/Caract\ue9risation des voies de signalisation de lAMPK impliqu\ue9es dans la formation des jonctions serr\ue9es \ue9pith\ue9liales
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Caractérisation des voies de signalisation de l’AMPK impliquées dans la formation des jonctions serrées épithéliales
No full textThe formation of tight junctions (TJ) between epithelial cells is a complex and still poorly understood process that involves the cooperation of many proteins and the coordination of different signaling pathways. Disruption of the structure and function of TJ is an important feature in a number of pathologies. It is therefore relevant to understand the processes that promote the integration of epithelial TJ. In the first part of this work, we studied in vitro the signaling pathways that participate downstream of the AMP-activated protein kinase (AMPK) in TJ assembly. Our data suggest that AMPK-mediated TJ formation is a dynamic process and involves the participation of many junction proteins, such as atypical protein kinase C (aPKC), playing a central role in this process. Expression of afadin-phosphodefective mutants (S216A – aPKC consensus phosphorylation site) perturbed ZO-1 localization to the plasma membrane during AMPK-induced TJ assembly. Expression of S216A increased the ZO-1/afadin interaction, while S1083A (AMPK consensus phosphorylation site) reduced this interaction during extracellular calcium-induced TJ assembly. Inhibition of aPKC activity also increased the ZO-1/afadin interaction. Taken together, these data suggest that aPKC-mediated phosphorylation of afadin terminates the ZO-1/afadin interaction, and thus permits the later stages of TJ assembly. In the second part of this work, our in vitro studies aim to determine the respective contribution of AMPK upstream kinases in Ca2+-induced AMPK activation at the time of TJ formation. AMPK activity is modulated by two major upstream kinases: LKB1 and CaMKK. Our observations support a role for CaMKK in the Ca2+-induced AMPK activation, independently of LKB1 activity. Hence, the pharmacological inhibition of CaMKK hampered AMPK phosphorylation and ZO-1 relocation during a Ca2+ switch, whereas the inactivation of LKB1 did not significantly influence these processes. Additionally, we have studied the impact of non-epithelial cells, namely mesenchymal stromal cells (MSC), on the AMPK-mediated TJ assembly. MSC may accelerate the AMPK-mediated formation of epithelial TJ by both direct cell-cell contacts and indirect paracrine ways, as suggested by the exposure to MSC-conditioned medium. In conclusion, the present PhD thesis helps to decipher the down- and up-stream mechanisms involved in the AMPK-mediated cascade of TJ assembly in epithelial cells. Furthermore, we postulate the involvement of non-epithelial cells, i.e. MSC, as positive mediators in TJ modulation
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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