778 research outputs found
Combined Laparoscopic Revision of the Gastric Pouch and Distalization of the Roux Limb After Failure of Weight Loss Following Roux-en-Y Gastric Bypass
No full textPurpose: After failed Roux-en-Y gastric bypass (RYGB), the choice of a secondary procedure falls into many pathways: revision of the gastric pouch, distalization of the bypass (DRYGB), addition of an adjustable gastric band, and conversion to a duodenal switch (BPD/DS). Material and Methods: We present the case of a 54-year-old man with initial BMI of 51.5 kg/m2, who first underwent laparoscopic sleeve gastrectomy (SG) in 2010. In 2012, he underwent a RYGB procedure, and in 2015, a pouch resizing for weight regain. In 2018, he reached a BMI of 41.2 kg/m2. A 3D volumetric CT scan measured a gastric pouch volume of 220 cm3 and a gastrojejunal anastomosis diameter of 20 mm. Results: As shown in the video, the patient underwent a combined revision of the gastric pouch and the gastrojejunal anastomosis associated to the distalization of the Roux limb. The gastrojejunal anastomosis is identified, and vertical division of the stomach is performed along a 36 French bougie, in order to create a 30 cm3 gastric pouch. Then, the jejunojejunal anastomosis is identified, and the Roux limb at the jejunojejunostomy is divided and transposed distally 100 cm to create a total alimentary length of 250 cm. The postoperative course was uneventful. At 1 year, his BMI was 31.2 kg/m2. No nutritional deficiencies were noted. Conclusion: Combined laparoscopic pouch resizing and distalization are safe and can lead to adequate weight loss. This technique allows the combination of an added restriction and malabsorption to the previous RYGB and could lead to an improved weight loss
Optimal group decision: A matter of confidence calibration
No full textThe failure of groups to make optimal decisions is an important topic in human sciences. Recently this issue has been studied in perceptual settings where the problem could be reduced to the question of an optimal integration of multiple signals. The main result of these studies asserts that inefficiencies in group decisions increase with the heterogeneity of its members in terms of performances. We assume that the ability of agents to appropriately combine their private information depends on how well they evaluate the relative precision of their information. We run two perceptual experiments with dyadic interaction and confidence elicitation. The results show that predicting the performance of a group is improved by taking into account its members’ confidence in their own precision. Doing so allows us to revisit previous results on the relation between the performance of a group and the heterogeneity of its members’ abilities
Supplemental Material, sj-docx-1-vet-10.1177_03009858211045931 - Disseminated coelomic xanthogranulomatosis in eclectus parrots (<i>Eclectus roratus</i>) and budgerigars (<i>Melopsittacus undulatus</i>)
No full textSupplemental Material, sj-docx-1-vet-10.1177_03009858211045931 for Disseminated coelomic xanthogranulomatosis in eclectus parrots (Eclectus roratus) and budgerigars (Melopsittacus undulatus) by Taryn A. Donovan, Michael M. Garner, David Phalen, Drury Reavill, Sebastien Monette, Alexandre B. Le Roux, Melissa Hanson, Sue Chen, Cyndi Brown, Catalina Echeverri and Katherine Quesenberry in Veterinary Pathology</p
Sebastien Rale vs. New England: A Case Study of Frontier Conflict
No full textAuthor\u27s original abstract: A study was made of the Jesuit missionary, Sebastien Rale, and his role in New England-New France relations. French and English primary and secondary materials were examined to give the broadest possible view of the man and to place him in historical context.
It was found that Sebastien Rale was not an agent of New France. The conflicting opinions surrounding the mission of Norridgewock and the border war of the 1720\u27s were traced to the problems of Massachusetts-Abnaki relations. Rale\u27s frequent and testy letters to the government of the Bay Colony were blunt reactions to what he viewed as religious and territorial threats against his mission.
The frontier conflict between 1713 and 1722 was not the result of French Imperial policy. The French insisted that the Abnakis were allies but refused active participation in the Indians\u27 quarrel with New England. Policy was developed in Maine by the Jesuits. The missionaries were only secondarily interested in Quebec\u27s desire to prevent Massachusetts\u27 settlement of the Kennebec. With the declaration of war in July, 1722, however, the Jesuits left the Abnakis in the hands of the governor and the intendant of New France on whom the Indians relied for vital war supplies.
Finally, the controversial attack on Norridgewock was appraised. It was found that no secondary account had fully evaluated the sources. Examination led to the discovery of crucial inconsistencies in the primary accounts of New England. The French sources were found to be based on the understandably confused impressions of the fleeing Indians. In large measure the English sources present the more valid picture: the sudden attack, the panicked confusion, and Sebastien Rale dying with gun in hand. After Rale\u27s death the war drew to a close. Without Sebastien Rale\u27s persuasion and determination, the Abnakis were not able to present a united front against colonial expansion
Steve J. Chavez recital thesis 2012
No full textThesis (M.M.)
California State University, Los Angeles, 2012Committee members: Sebastien Vallee, Jeffrey Benedict, John KennedyThe musical selections from this Master recital were not chosen with a specific theme in mind, rather each selection was carefully selected to represent the requisite musical styles stemming from the 18th to 20th century.All the literature was selected based on the requirements of the music department representing the technical skill level worthy of a graduate student from the institution of California State University, Los Angeles. This written project is the presentation of historical and musical research gathered by this author in preparation for this recital. The selections of Bach, Handel, Beethoven, Schubert, Faure, Menotti, Hoiby, and Barber are discussed in turn
Considerations sur l'ordre de Cincinnatus, [electronic resource] : ou imitation d'un pamphlet anglo-americain. Par le comte de Mirabeau. Suivies de plusieurs pieces relatives a cette institution; ... d'un pamphlet du Docteur Price, intitule: Observations on the importance of the American Revolution, ...
No full textSebastien Roch Nicholas Chamfort is given as joint author by Querard and Barbier.A reissue of the 1784 Londres edition, with a different title-page.Sig. H1 is a cancel - The 'Avis' is dated: Londres, 20 septembre, 1784.Printer's name from colophon.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Surgical treatment of supracondylar fractures in children: should the pins be buried or left exposed? Comparative study of functional and radiographic results of two surgical protocols
No full textIntroduction: The osteosynthesis of supracondylar fractures (SC) using pins buried under the skin (PB) or externalized (PE) is a subject of debate. The aim of this study was to compare two treatment protocols, one using PB and the other using PE, in terms of clinical and radiographic outcomes, complication rates.
Hypothesis: The hypothesis of the study was that both protocols are equivalent in terms of clinical, radiological outcomes, and complication rates.
Materials and methods: This was a retrospective bicentric comparative study analyzing 296 boys and 267 girls (mean age 6.2 ± 2.7 years) who underwent SC fracture surgery between 1/1/2010 and 31/12/2020 using two therapeutic protocols. The first protocol (group A; n = 210) involved osteosynthesis with PB, immobilization (6–7 weeks), and pin removal in the operating room under general anesthesia. The second protocol (group B; n = 353) was characterized by osteosynthesis with PE, immobilization (4–6 weeks), and pin removal in an outpatient setting. Functional outcomes were assessed using the QuickDASH questionnaire, radiographic outcomes [Baumann angle, lateral capitulum-humeral angle (LCHA), rotational disorders according to the Von Laer quotient], and postoperative complication rates (infection, recurrent fracture, stiffness, vasculo-nerve complications).
Results: No patients were lost to follow-up (n = 563) and the mean follow-up was 6.6 ± 7.3 months (3–70). The mean immobilization duration was longer in group A (45.8 ± 7.4 vs 39.7 ± 12.0 days; p < 0.001). Clinical and functional outcomes were similar (p = 0.316), and the pre- and postoperative complication rates were comparable between the two groups (A-B = 8 %/8.6 %-6 %/7.1 %; p = 0.733 and p = 0.512), while the postoperative
Baumann angle, LCHA, number of rotational disorders, and Von Laer quotient were significantly different [A-B = 71.5◦-74◦ (p < 0.001); A-B = 32.8◦-35.6◦ (p < 0.001); A-B = 32–10 (p < 0.001); A-B = 0.2–0.1 (p = 0.020)].
Discussion: This retrospective study compared two surgical protocols for pediatric supracondylar (SC) fractures in 563 children. Functional and clinical outcomes were similar between groups, with no significant difference in complication rates. Group B had better radiographic results and a lower rate of postoperative rotational deformities.
Pin buried (Group A) increased costs and required a second general anesthesia for removal. Group B’s protocol allowed outpatient pin removal under nitrous oxide, reducing risks and costs. Infection rates were no significant different between both groups. Whereas the decrease of number of rotational disorsders, the increase of Baumann angle and decrease of LCHA in this patient show that decrease of rotational disorders is more likely related to osteolysis of rotational spur than bone remodeling. Despite limitations, this is the largest French series comparing these two protocols, showing equivalent functional outcomes but greater efficiency and safety in Group B.
Conclusion: Both therapeutic protocols have comparable clinical outcomes and complication rates. Leaving pins exposed does not increase the risk of infection.
Level of evidence: III comparative retrospective stud
Limit Theorem for a Modified Leland Hedging Strategy under Constant Transaction Costs rate
No full textWe study the Leland model for hedging portfolios in the presence of a constant proportional transaction costs coefficient. The modified Leland's strategy recently defined by the second author, contrarily to the classical one, ensures the asymptotic replication of a large class of payoff. In this setting, we prove a limit theorem for the deviation between the real portfolio and the payoff. As Pergamenshchikov did in the framework of the usual Leland's strategy, we identify the rate of convergence and the associated limit distribution. This rate turns out to be improved using the modified strategy and non periodic revision dates.Asymptotic hedging ; Leland-Lott strategy ; Transaction costs ; Martingale limit theorem.
Going Serverless with Knative on Kubernetes
No full textAbstract:
After reviewing some of the latest evolutions in Kubernetes we will discuss the serverless computing paradigm and highlight a few application use-cases. We will then introduce Knative, a system built on top of Kubernetes which provides components to build and serve applications as well as manage events. Through quick demos will demonstrate several key capabilities like scaling to zero and also highlight future directions with service mesh technologies.
Bio:
Sebastien is the co-founder of TriggerMesh (https://triggermesh.com) a serverless management platform built on Knative. He is the author of the Docker and Kubernetes O'Reilly cookbooks and was the CMS Tier-2 site lead at Purdue University more than 10 years ago
GALDIERO is CO-FIRST AUTHOR. Phagocytes as Corrupted Policemen in Cancer-Related Inflammation
No full textInflammation is a key component of the tumor microenvironment. Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) are prototypic inflammatory cells in cancer-related inflammation. Macrophages provide a first line of resistance against infectious agents but in the ecological niche of cancer behave as corrupted policemen. TAMs promote tumor growth and metastasis by direct interactions with cancer cells, including cancer stem cells, as well as by promoting angiogenesis and tissue remodeling and suppressing effective adaptive immunity. In addition, the efficacy of chemotherapy, radiotherapy, and checkpoint blockade inhibitors is profoundly affected by regulation of TAMs. In particular, TAMs can protect and rescue tumor cells from cytotoxic therapy by orchestrating a misguided tissue repair response. Following extensive preclinical studies, there is now proof of concept that targeting tumor-promoting macrophages by diverse strategies (e.g., Trabectedin, anti-colony-stimulating factor-1 receptor antibodies) can result in antitumor activity in human cancer and further studies are ongoing. Neutrophils have long been overlooked as a minor component of the tumor microenvironment, but there is evidence for an important role of TANs in tumor progression. Targeting phagocytes (TAMs and TANs) as corrupted policemen in cancer may pave the way to innovative therapeutic strategies complementing cytoreductive therapies and immunotherapy
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