560 research outputs found
Souvenirs et paysages d'Orient. Smyrne -Éphèse-Magnésie- Constantinople-Scio. Par Maxime du Paris chez. Arthus Bertrand, Libraire Editeur de la Société géographique 1848.
No full textPreface: by the authorDedication: by the author to B.F., S. ad. 5Content description: Detailed contentsPagination: PP10+380PVolumes: 1Text Genre:Prose / Journa
Equilibrium transition study for a hybrid MAV
No full textWind tunnel testing was performed on a VTOL aircraft in order to characterize longitudinal flight behavior during an equilibrium transition between vertical and horizontal flight modes. Trim values for airspeed, pitch, motor speed and elevator position were determined. Data was collected by independently varying the trim parameters, and stability and control derivatives were identified as functions of the trim pitch angle. A linear fractional representation model was then proposed, along with several methods to improve longitudinal control of the aircraft
Recommended from our members
Democratic speech in divided times: an introduction
No full textThis is the introduction to the symposium on Maxime Lepoutre, Democratic Speech in Divided Times (Oxford: Oxford University Press, 2021). The symposium contains articles by Paul Billingham, Rachel Fraser, and Michael Hannon, and a response by the author
Ubiquitylation and SUMOylation of Cardiac Ion Channels
No full textCardiac ion channels play an essential role in the generation of the action potential of cardiomyocytes. Over the past 15 years, a new field of research called channelopathies has emerged; it regroups all diseases caused by ion channel dysfunction. Investigators have largely determined the physiological roles of cardiac ion channels, but little is known about the molecular determinants of their regulation. Two post-translational mechanisms that are crucial in determining the fate of proteins are ubiquitylation and the SUMOylation pathways, which lead to the degradation and/or regulation of modified proteins. Recently, several groups have investigated the physiological impacts of these mechanisms on the regulation of different classes of cardiac ion channels. The objective of this review is to summarize and briefly discuss these results
Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels
No full textNeuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) proteins are ubiquitin ligases, which attach ubiquitin moieties to their target proteins, a post-translational modification that is most commonly associated with protein degradation. Nedd4 ubiquitin ligases have been shown to down-regulate both potassium and sodium channels. In this study, we investigated whether Nedd4 ubiquitin ligases also regulate Ca(v) calcium channels. We expressed three Nedd4 family members, Nedd4-1, Nedd4-2, and WWP2, together with Ca(v)1.2 channels in tsA-201 cells. We found that Nedd4-1 dramatically decreased Ca(v) whole-cell currents, whereas Nedd4-2 and WWP2 failed to regulate the current. Surface biotinylation assays revealed that Nedd4-1 decreased the number of channels inserted at the plasma membrane. Western blots also showed a concomitant decrease in the total expression of the channels. Surprisingly, however, neither the Ca(v) pore-forming α1 subunit nor the associated Ca(v)β and Ca(v)α(2)δ subunits were ubiquitylated by Nedd4-1. The proteasome inhibitor MG132 prevented the degradation of Ca(v) channels, whereas monodansylcadaverine and chloroquine partially antagonized the Nedd4-1-induced regulation of Ca(v) currents. Remarkably, the effect of Nedd4-1 was fully prevented by brefeldin A. These data suggest that Nedd4-1 promotes the sorting of newly synthesized Ca(v) channels for degradation by both the proteasome and the lysosome. Most importantly, Nedd4-1-induced regulation required the co-expression of Ca(v)β subunits, known to antagonize the retention of the channels in the endoplasmic reticulum. Altogether, our results suggest that Nedd4-1 interferes with the chaperon role of Ca(v)β at the endoplasmic reticulum/Golgi level to prevent the delivery of Ca(v) channels at the plasma membrane
Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice
No full textDuchenne muscular dystrophy (DMD) is a severe striated muscle disease due to the absence of dystrophin. Dystrophin deficiency results in dysfunctional sodium channels and conduction abnormalities in hearts of mdx mice. Disease progression in the mdx mouse only modestly reflects that of DMD patients, possibly due to utrophin up-regulation. Here, we investigated mice deficient in both dystrophin and utrophin [double knockout (DKO)] to assess the role of utrophin in the regulation of the cardiac sodium channel (Na(v)1.5) in mdx mice
Les procédés d'exposition et de développement collectif dans un forum pédagogique : le cas Maxime
No full text@inproceedings{cn-Lucas-2005, author = {Lucas, Nadine}, title = {Les procédés d'exposition et de développement collectif dans un forum pédagogique : le cas Maxime}, booktitle = {Symfonic}, year = {2005}, editor = {Bruillard, Eric and Sidir, Mohamed}, address = {Amiens}, month = {janvier} }National audienc
Le paradoxe français dans la Solution finale à l'Ouest
No full textThe Final Solution and the French Paradox.
Although the French state embraced the new order and its antisemitic program, only quarter of the Jewish population of France was exterminated as opposed to half in Belgium and three quarters in the Netherlands. The author proposes an interpreta tion of this French paradox .Steinberg Maxime. Le paradoxe français dans la Solution finale à l'Ouest. In: Annales. Economies, sociétés, civilisations. 48ᵉ année, N. 3, 1993. pp. 583-594
La niche écologique des concepts théoriques aux utilisations pratiques
No full textIn concluding the discussions of the Montpellier symposium, the author emphasizes some of the operational difficulties of defining the ecological niche of a species in field conditions. The difficulty of singling out the relevant parameters (from the species viewpoint) is particularly great. A parallel is made with the genotype concept in genetics.Lamotte Maxime. La niche écologique des concepts théoriques aux utilisations pratiques. In: La Terre et La Vie, Revue d'Histoire naturelle, tome 33, n°3, 1979. pp. 509-520
Les Souvenirs d’outre-tombe de Maxime Du Camp
No full textInternational audiencePresented in the foreword as a collection of reminiscences, Du Camp's Souvenirs littéraires conceals an ambitious work that sculpts the statue of its author in order to secure his place in history. Without talking about himself directly, Maxime Du Camp achieves the feat of reinterpreting the history of Romanticism in the light of positivism, of redrawing his own trajectory in the light of what he has become, and of influencing the present debate by formulating his aesthetic ideal.Présenté dans l’avant-propos comme un recueil de souvenirs, les Souvenirs littéraires de Du Camp dissimulent une œuvre ambitieuse qui sculpte la statue de son auteur afin de lui assurer une place dans l’histoire. Sans parler de lui directement, Maxime Du Camp réussit ce tour de force de réinterpréter l’histoire du romantisme à la lumière du positivisme, de redessiner sa propre trajectoire à la lumière de ce qu’il est devenu, et de peser sur le débat présent en formulant son idéal esthétique
- …
