1,720,966 research outputs found
Electrochemotherapy: a Valid Treatment for Gorlin Goltz syndrome
Full text linkGorlin-Goltz syndrome is a rare disorder, characterized by systemic manifestations included multiple basal cell carcinomas, palmar or plantar pits, odontogenic keratocysts and ectopic calcifications of the falx cerebri. The therapy of the clinical manifestations of Gorlin-Goltz syndrome is not simple treatment. We performed electrochemotherapyin a patient affected by Gorlin-Goltz syndrome with an extensive and unresectable basal cell carcinoma on the scalp, obtaining excellentresults
Predictive factors in non-melanoma skin cancers treated with electrochemotherapy
No full textBACKGROUND: The management of non-melanoma skin cancers may benefit from alternative treatments and in this spectrum electrochemotherapy plays a pivotal role. Lhe aim was to describe the predictive features of patients with cutaneous carcinomas treated with electrochemotherapy, with regard to clinical, pathological and instrumental predictors. MELHODS: We analyzed disease free survival (DFS), and overall survival (OS) for each patient. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Cox-proportional hazards regression in both univariate and multivariate analyses. RESULLS: We can assess that in the brief-term (DFS), the patients' age, tumor-site, tumor size, photo-type and the dose of the cytotoxic drug showed a statistical significant better behavior. However, in the multivariate, only the variables tumor's site (P=0.01) and tumor appearance (P=0.03) reached the statistical significance. In the long-term, female patients, patients with a median age ≤70 years, with III-IV photo types and patients, which received a dosage of bleomycin, ≤14 mg/m2presented a significant better behavior. However in the multivariate analysis a significance was maintained for the variables tumor's appearance (HR: 11.6; 95% CI: 11.56 to 27.5; P=0.01), infiltration (HR:0.11; 95% CI: 0.012 to 0.9; P=0.04), electrode type (HR:0.19; 95% CL0.04 to 0.8; P=0.03) and photo type (HR:5.7; 95% CL1.3 to 24.3; P=0.01). CONCLUSIONS: According to our results, in electrochemotherapy different individual variables can have an important influence, which shows how this treatment could improve. Lhe refinement of the technique and the optimization of patients' selection has the aim to improve the therapeutic response
“Ipomelanosi di Ito: descrizione di un caso inusuale”.
No full textL’ipomelanosi di Ito o incontinentia pigmenti achromians (HI; OMIM 300.337) è stata descritta per la prima volta nel 1952 dal dermatologo giapponese Minor Ito, che riportò il caso di una giovane donna con lesioni ipopigmentate lineari, “a getto d’acqua”, disposte lungo le linee di Blaschko, a livello del tronco e degli arti bilateralmente. Descriviamo il caso di una bambina di 10 anni affetta da HI con insolito coinvolgimento dell’apparato nefro-urologico
Complete remission of Merkel cell carcinoma treated with electrochemotherapy and etoposide
No full text[No abstract available
Electrochemotherapy in non-melanoma head and neck skin cancers: a three centers experience and literature review.
Full text linkAIM: The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumours, to assess the local tumour control, the safety profile and its impact on the patients' quality of life.
METHODS:
This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatologic Clinic of University of Rome "La Sapienza", at the Dermatologic Clinic of University of Chieti and at the Dermatologic Clinic of University of Turin. 55 patients with head and neck cancers were recruited. The electrochemotherapy procedure was carried out according to the ESOPE guidelines. Statistical analyses were performed using Stata/SE12.0 Statistical Software RESULTS: A significant clinical response was achieved in 50/55 patients with 91% of objective response rate (OR). 33 of 55 patients showed a CR (60%); 17 treated patients had a PR (31%). A significantly higher CR rate was obtained in patients not previously treated by surgery (15/19; 79%), with respect to those with a previous excision of the tumour (14/30; 47%) (p=0.025). An additional parameter influencing response is represented by anesthesia: patients treated by ECT with general anesthesia were characterized by significantly higher CR rate (68%) than those treated with local anesthesia (27%) (p=0.014).
CONCLUSIONS:
Our experience confirmed high efficiency in local tumour control, excellent toxicity profile, tissue preservation with good cosmetic and functional results, even with repeated applications. ECT can represent a first-line treatment in the local management of head and neck cancers.AIM:
The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumours, to assess the local tumour control, the safety profile and its impact on the patients' quality of life.
METHODS:
This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatologic Clinic of University of Rome "La Sapienza", at the Dermatologic Clinic of University of Chieti and at the Dermatologic Clinic of University of Turin. 55 patients with head and neck cancers were recruited. The electrochemotherapy procedure was carried out according to the ESOPE guidelines. Statistical analyses were performed using Stata/SE12.0 Statistical Software RESULTS: A significant clinical response was achieved in 50/55 patients with 91% of objective response rate (OR). 33 of 55 patients showed a CR (60%); 17 treated patients had a PR (31%). A significantly higher CR rate was obtained in patients not previously treated by surgery (15/19; 79%), with respect to those with a previous excision of the tumour (14/30; 47%) (p=0.025). An additional parameter influencing response is represented by anesthesia: patients treated by ECT with general anesthesia were characterized by significantly higher CR rate (68%) than those treated with local anesthesia (27%) (p=0.014).
CONCLUSIONS:
Our experience confirmed high efficiency in local tumour control, excellent toxicity profile, tissue preservation with good cosmetic and functional results, even with repeated applications. ECT can represent a first-line treatment in the local management of head and neck cancers
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Prospective pilot study evaluating the effectiveness of electrochemotherapy using reduced dosages of intravenous bleomycin
No full textBackground: Electrochemotherapy (ECT) is currently used to treat cutaneous and subcutaneous tumors of different histotypes. ECT combines cytotoxic drugs and the application of high-intensity electric pulses to increase cell permeability. In 2006, a multicenter European project (ESOPE, European Standard Operating Procedures of Electrochemotherapy) defined the guidelines for ECT application. To date, a revision of the first SOP is required. The International Network for Sharing Practices on Electrochemotherapy (InspECT) database was established to improve the clinical application of ECT. The objective of this study was to evaluate the effectiveness of ECT using reduced dosages of i.v. bleomycin (BLM). Methods: Lowering of the dose of BLM is advised e.g. in patients with impaired renal function. As patients treated with ECT were registered prospectively in a common database (InspECT registry) we decided to investigate efficacy and side effects when a lower dose of BLM was used. 57 patients, uploaded by 7 European centres, were treated by ECT with respectively 7.500, 10.000 and 13.500 IU/m2 of BLM, instead of the standard 15.000 IU/m2, because of renal dysfunction. Results: We enrolled 57 patients with 147 skin lesions. Diagnosis distribution of primary tumour was: 38.6% melanoma, 22.8% squamous cell carcinoma, 17.5% basal cell carcinoma, 7% breast cancer, 7% Kaposi sarcoma, 7.1% other. Per-tumor response at 60 days was as follows: CR, 70.1%, PR, 16.3%. Per-patient response was as follows: CR, 57.9%, PR, 21.1%. Only 2 patients (4%) experienced flu-like symptoms, 1 patient (2%) nausea and 22 patients (39%) referred pain, mostly mild. Conclusions: According to the data of this pilot study, the use of dose of BLM lower than those recommended by SOP, seems to be effective. Our results suggest that also patients with renal failure may benefit from ECT treatment with a reduced BLM dose. These findings need prospective confirmations on wider cohorts of patients
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