1,721,096 research outputs found
Sparc (Osteonectin): nuevos conocimientos sobre sus funciones y regulación
No full text254 páginasLa matriz extracelular es una red compleja secretada por las células que sirve como un
elemento estructural de los tejidos y que incluso interviene en su desarrollo y fisiología
(Alberts et al., 2002). Concretamente ayuda a las células a unirse entre sí y también
regula diversas funciones celulares tales como migración, proliferación y diferenciación
(Teti, 1992). Está compuesta por factores de crecimiento, proteoglicanos, proteínas
estructurales y proteínas matricelulares.
Osteonectina, también llamada Sparc o BM-40, es una glicoproteína multifuncional que
pertenece a la familia de las proteínas matricelulares. Este grupo de proteínas modula las
interacciones entre la matriz y las células e interviene en múltiples funciones más que
limitarse a jugar un papel meramente estructural (Brekken and Sage, 2000). Sparc tiene
una alta afinidad por los iones calcio y fue descubierta por primera vez como el
componente mayoritario de la matriz extracelular de tejidos mineralizados. Más tarde, se
localizó en muchos otros tejidos. La expresión de Sparc es elevada durante el desarrollo
temprano y disminuye durante la edad adulta. Sin embargo, su expresión aumenta en
tejidos que requieren cierto grado de renovación, reparación o en tumorigénesis (Yan y
Sage, 1999). Debido a que Sparc es capaz de interactuar con múltiples moléculas, se le
han atribuido importantes funciones como antiadhesión, regulación del ciclo celular y
actividad angiogénica (Yan y Sage, 1999).Peer reviewe
Optimal and sustainable production of tailored fish protein hydrolysates from tuna canning wastes and discarded blue whiting: Effect of protein molecular weight on chemical and bioactive properties
No full text11 pages, 3 figures, 5 tables.-- Under a Creative Commons licenseThousands tons of discards of blue whiting (BW) and tuna heads (YT) by-products are generated each year in Europe. BW is the species most discarded by European fishing fleet and, in some canning factories, YT are processed for the retrieval of oil rich in omega-3, but producing a huge amount of solid remains and effluents disposal as wastes. The development of optimal and sustainable processes for both substrates is mandatory in order to reach clean solutions under the circular economy precepts. This work focused on the mathematical optimization of the production of tailored fish protein hydrolysates (FPH), from blue whiting and tuna residues, in terms of controlling average molecular weights (Mw) of proteins. For the modeling of the protein depolymerization time-course, a pseudo-mechanistic model was used, which combined a reaction mechanistic equation affected, in the kinetic parameters, by two non-lineal equations (a first-order kinetic and like-Weibull formulae). In all situations, experimental data were accurately simulated by that model achieving R2 values higher than 0.96. The validity of the experimental conditions obtained from modeling were confirmed performing productions of FPH at scale of 5 L-reactor, without pH-control in most of cases, at the different ranges of Mw selected (1–2 kDa, 2–5 kDa and 5–10 kDa). The results showed that FPH from BW with lower Mw led to a remarkable yield of production (12 % w/w of substrate), largest protein contents (77 % w/w of BW hydrolysate), greatest in vitro digestibility (>95 %), highest essential amino acid presence (43 %) and the best antioxidant (DPPH = 62 %) and antihypertensive (IC50-ACE = 80 mg/L) properties. Our results prove that the proposed procedure to produce sustainable FPH, with specific Mw characterisitics, could be extended to other fish waste substrates. Tailored FPH may have the potential to serve as valuable ingredients for functional foods and high-quality aquaculture feedThe authors acknowledge the support of research grant from Galicia Marine Science programme, part of Complementary Science Plans for Marine Science of Ministerio de Ciencia, Innovación y Universidades included in the Recovery, Transformation and Resilience Plan (PRTR-C17.I1). Funded through Xunta de Galicia with NextGenerationEU and the European Maritime Fisheries and Aquaculture Funds. Researchers from IIM-CSIC also want to thank to the project LIFE-REFISH (Project 101074323, LIFE21-ENV-ES-LIFE REFISH) and to Xunta de Galicia (Grupos de Potencial Crecimiento, IN607B 2021/11) for financial support. We acknowledge support of the publication fee by the CSIC Open Access Publication Support Initiative through its Unit of Information Resources for Research (URICI).Peer reviewe
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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