1,816 research outputs found
Whittier House donor letter and list from Frederick P. Craig
No full textWhittier House scrapbooks document Whittier House programs, events, and anniversary celebrations through newspaper clippings, lecture fliers, newsletters, event programs, and ticket stubs. Newspaper clippings are primarily from the Jersey Journal. There is also Whittier House fundraising materials, including pamphlets, appeal letters, brochures, and postcards. The Whittier House Social Settlement, the first settlement house in New Jersey, was established in Jersey City, N.J. (Hudson County) in 1894. Founded by Cornelia Foster Bradford, who would remain with the organization as headworker until 1926, Whittier House was based on the settlement house, Toynbee Hall, in England. Whittier House provided various recreational and educational programs, along with much needed social services, for the immigrant populations of Jersey City. Many of these successful services were used as models for large-scale social reform movements through the state. In 1935, the Whittier House was taken over by the Boys' Club of Jersey City
Building Expert System
No full textReading,Mass.: Addison-Wesley Pub., 1983. 1: include bibliography: p. 405-420 -- (Teknowledge Series in Knowledge Engineering. Hayes-Roth, Frederick, series editor). This book is a collaboration of 38 expert system researchers and developers. It provides a broad introduction to the concepts and methods necessary for an understanding of how these systems wor
THE WARS OF FREDERICK THE GREAT
No full textThe study of the wars of Frederick the Great by Dennis E. Showalter is both fascinating and informative. King Frederick II ruled Prussia from 1740 to 1786. During his reign Prussia was involved in a number of wars (notably the Seven Years War). The reign of Frederick is acknowledged as the era in which Prussia was establish as a first ranking power in Europe. Yet, the Wars of Frederick the Great is more than just a campaign history of Frederick's wars. In this study the author places Frederick's wars, Frederick's reign in Prussia and the art of war and statecraft within the context of the time, which makes this work an important contribution to the study of Military History and power politics in the eighteenth century.</p
Getting new biodiversity from a single strain: the story of 32 spores
No full textThe loss of biodiversity is becoming a common phenomenon in many different environments, including the winemaking one (Renouf et al., 2007). Several biological surveys for the discovering and the exploitation of the hidden oenological potential of the yeast biodiversity in our wine-producing regions are underway (Pretorius et al., 1999). Many intrinsic characteristics of peculiar strains can be selected and improved for such development protocols (Rodríguez et al., 2010). The auto-diploidization ability of natural homotallic strains is one of such properties that can be used in classical breeding projects on yeast spores, in order to obtain a population of homozygous at all loci individuals (Solieri et al., 2015). These strains can be screened for particular oenological traits and therefore selected for a wider application, not only in food related environments. The subsequent analysis of their genomes can link their prominent abilities to specific sequences, called Quantitative Trait Loci (QTL) (Steinmetz et al., 2002). In our study, 30 haploid genomes were obtained from a classical breeding project, after the sporulation of a Saccharomyces cerevisiae strain usually employed in our region in white winemaking. These genomes, together with the two of the parental strains, were sequenced using a shot-gun technology. The resulting reads were then assembled and the genomes of the spores were compared with the parental strains, in order to try to highlight the differences obtained with the breeding. The next step will be the annotation of these genomes, to assign all these differences to specific QTLs, linked to their oenological abilities
Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.
No full textSystematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent genome-wide analyses in yeast identified a significant number of within-pathway negative genetic interactions. The molecular mechanisms leading to within-pathway SL are not fully understood. Here, we propose a novel mechanism leading to within-pathway SL involving two genes functioning in a single non-essential pathway. This type of SL termed within-reversible-pathway SL involves reversible pathway steps, catalyzed by different enzymes in the forward and backward directions, and kinetic trapping of a potentially toxic intermediate. Experimental data with recombinational DNA repair genes validate the concept. Mathematical modeling recapitulates the possibility of kinetic trapping and revealed the potential contributions of synthetic, dosage-lethal interactions in such a genetic system as well as the possibility of within-pathway positive masking interactions. Analysis of yeast gene interaction and pathway data suggests broad applicability of this novel concept. These observations extend the canonical interpretation of synthetic-lethal or synthetic-sick interactions with direct implications to reconstruct molecular pathways and improve therapeutic approaches to diseases such as cancer
Phoebus 6, number1: Chinese Painting under the Qianlong Emperor
No full texttableOfContents: Preface p. 7
The Time of Qianlong, 1736-1795 by Wen Fong p. 9
The Intellectual Climate in Eighteenth-century China: Glimpses of Beijing, Suzhou and Yangzhou in the Qianlong Period by Frederick Mote p.17
The Qianlong Emperor's Skill in the Connoisseurship of Chinese Painting by Kohara Hironobu p. 56
An Overview of Stylistic Development in the Qianlong Painting Academy by
She Cheng p. 74
Document and Portrait: The Southern Tour Paintings of Kangxi and Qianlong by Maxwell Hearn p.91
Tangdai: A Biographical Sketch by Ju-hsi Chou p.132
For Love of God: Castiglione at the Court of Qianlong by Howard Rogers p.141
Epilog: Approaches to Painting at the Qianlong Court by Claudia Brown p163
Notes p. 16
Computational Tools and Analyses for Improved Inference of Variant Effects
No full textPersonalized medicine requires rapid and accurate classification of pathogenic human variation. With over 50% of clinically interpreted missense variants classified as “variants of uncertain significance” (VUSes), multiple approaches are needed to improve variant interpretation. Multiplexed assays of variant effect (MAVEs) can experimentally test nearly all possible missense variants in selected protein targets, while computational methods seek to infer missense variant impacts using statistical modelling. Here I describe work to assist and exploit both MAVE and computational studies.To assist in planning and to promote collaboration and efficient communication for MAVE studies, I developed: 1) strategies to prioritize genes likely to have a greater impact on clinical variant interpretation, 2) MaveQuest, a resource to help researchers identify MAVE target genes and explore potential assays, and 3) MaveRegistry, a community resource for sharing MAVE progress and finding collaborators. To compare the performance of variant effect predictors and to exploit both experimental and computational information about variant impact, I 1) assessed computational variant effect predictors using a large prospective cohort, and 2) developed a pipeline to screen human pseudogenes for which different genetic variant interpretation might re-classify these pseudogenes to be protein-coding genes, refining human genome annotation.Ph.D
Sequencing Protein Interaction Dynamics at Proteome Scale
No full textProtein interactions link genotypes to phenotypes. Although phenotypes are known to depend on environmental context, the response of protein interactions to environmental change has not yet been explored at the scale of proteome. Here, I engineered and validated the fluorescence Barcode Fusion Genetics Yeast-Two Hybrid (fBFG-Y2H) technology, which enables multi-environment proteome-scale interaction measurements via recombinatorial barcode sequencing. I demonstrate two proteome-scale applications of fBFG-Y2H: First, I describe the use of fBFG-Y2H to generate the first binary protein interaction map connecting SARS-CoV-2 and human proteins. The identified human protein targets are enriched for interactors of proteins in severe COVID-19-associated loci, suggesting mechanistic connections involving vesicle trafficking and TNF-signaling. Second, I describe the application of fBFG-Y2H to generate an interaction map amongst ~30 million yeast protein pairs under baseline, DNA damage, carbon starvation, and oxidative stress environments, yielding the first proteome-scale atlas of dynamic protein interactions for any organism. Integrating the dynamic interactome map with transcriptome and phosphoproteome measurements in matching conditions reveals both local mechanisms underlying individual pathways and global patterns of cellular response to changing environments. Finally, I provide proof-of-principle results for a messenger BFG-Y2H (mBFG-Y2H) technology, which counts transcripts bearing recombinatorial barcode loci and has the potential to capture global protein interaction dynamics at an unprecedented 10-minute resolution.Ph.D.2024-03-13 00:00:0
1918 Bureau of Standards personnel negative set 12
No full text(top row) Frederick J. Liscomb; Walter C. Fedde; James J. McNulty; W. H. Stevenson
(middle row) Alice I. Whitson; James C. Phelps; Harley A. Nelson; Lee Trubek
(bottom row) Theron P. Sager; E. W. Roth; Harry A. Bright; Frederick H. Tucker
This item is part of the Bureau of Standards Personnel 1918 collection
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