7,372 research outputs found
Data for main text figs: terahertz photocurrent probe of quantum geometry and interactions in magic-angle twisted bilayer graphene
No full textData includes photocurrent and resistivity measurements performed in the experimentsPeer reviewe
Bioinformatic analysis of human Next Generation Sequencing data; extracting additional information, optimising mapping and variant calling, and application in a rare disease
No full textWith the increased application of Next Generation Sequencing (NGS) to medicine it is important to test and develop approaches to extract the optimum information from datasets. In this thesis five aspects of NGS are investigated ranging from quality control to variant calling. Firstly a method to estimate contamination from a VCF file was developed which would be useful in cases where no BAM file was available to use existing tools. Unmapped reads were investigated to extract additional information from NGS samples and were able to detect the abundance of oral microbes from saliva samples relative to blood collected samples, but failed to identify differences between inflammatory bowel disease patients and controls. For a familial trio with a reported rare case of Sedaghatian-type spondylometaphyseal dysplasia (SSMD) sequenced both by whole exome (WES) and genome (WGS) sequencing it was shown that nearly all coding variants from WES were called in WGS despite differences in mean depth of coverage. This comparison highlighted that as sequencing costs decrease WGS will offer the greatest diagnostic value with potential for future re-analysis of cases currently unable to be resolved. Using the familial trio attempts were made to identify causal variant(s) in the gene currently implicated in causing SSMD – Glutathione peroxidase 4 (GPX4 ). However no variants either small SNPs or large structural were identified over the GPX4 gene and no plausible candidates were identified from the trio. Finally variant calling of the FCGR low affinity locus was performed using targeted NGS. FCGR genes have been highly duplicated and so by using customised references it was possible to infer the combinations of alleles across homologous sites. Using this approach it was possible to predict SNPs in the FCGR3B gene and predict human neutrophil antigen haplotypes involved in the immune response to treatments such as monoclonal antibodies
Bibliographics for the 983 eprints in the live archives of E-LIS : trends and status report up to 7th July 2004, based on author-self-archiving metadata
No full textThe priority for ideas and philosophy related to "Network Theory" have been traced back and documented by Braun(2004),and credit goes to Karinthy(1929).The IT has empowered to realise it, as the most practical phenomena and it is no more a humour. The OAI (Open Archives Initiatives)and ACIS (Academic Contributor Information System)are progressive in the direction ,which may lead to realise the "Collective Genius" at global level. Focus of present study is on Author-Self-Archiving (A-S-A)Metadata of the 983 Eprints in the Live Archives of the E-LIS (EPrints of Library and Information Science),which were approved till 7th July 2004.The A-S-A Metadata was used for librametric analysis. Self-explanatory bibliographics are illustrated.The highlights include: Conference papers (34%); highest approval, June 2004 (28%); published archives (76%);not refereed (52%); not in public domain (60%); highest self-archiving-author (De Robbio, Antonella).The Nos. of EPrints having single JITA domain specifications were: Theoretical and general aspects of libraries and information(27); Information use and sociology of information(80);Users,literacy and reading(13);Libraries as physical collections(30);Publishing and legal issues(57);Management(13);Industry, profession and education(36);Information sources, supports, channels(113) ; Information treatment for information services, Information functions and techniques (101); Technical services libraries, archives and museums(25); Housing technologies(1); Information technology and library technology(92); and Inter-domainery (395) i.e. having specifications of two or more than two JITA classes
sj-docx-1-pie-10.1177_09544089221084802 - Supplemental material for Effect of electrode negativity ratio and heat input on bead and arc characteristics in submerged arc welding
No full textSupplemental material, sj-docx-1-pie-10.1177_09544089221084802 for Effect of electrode negativity ratio and heat input on bead and arc characteristics in submerged arc welding by Ajit Kumar Naik, Rakesh Roshan, Kanwer Singh Arora, Nikhil Shajan and Subash Chandra Mishra in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
sj-docx-2-pie-10.1177_09544089221084802 - Supplemental material for Effect of electrode negativity ratio and heat input on bead and arc characteristics in submerged arc welding
No full textSupplemental material, sj-docx-2-pie-10.1177_09544089221084802 for Effect of electrode negativity ratio and heat input on bead and arc characteristics in submerged arc welding by Ajit Kumar Naik, Rakesh Roshan, Kanwer Singh Arora, Nikhil Shajan and Subash Chandra Mishra in Proceedings of the Institution of Mechanical Engineers, Part E: Journal of Process Mechanical Engineering</p
A Unified Shell model for Buoyancy-Driven Turbulence
No full textWe construct a unified shell model for stably stratified and convective turbulence. Shell model simulation of stably stratified flow in turbulent regime exhibit Bolgiano-Obukhbov (BO) scaling in which the kinetic energy spectrum varies as . However, simulation of convective turbulence shows Kolmogorov's spectrum. These results are consistent with the direct numerical simulations of Kumar {\em et al.} [Phys. Rev. E {\bf 90}, 023016 (2014)]. We also observe a dual scaling ( and ) for a limited range of parameters in stably stratified flow
Leptogenesis with Majoron dark matter
No full textWe discuss a model of neutrino mass based on the type I seesaw mechanism embedded in a spontaneously broken global lepton number framework with a Z2 symmetry. We show that the resulting Majoron is a viable freeze-in dark matter candidate. Two right-handed neutrinos are assumed to have dominant off-diagonal masses suggesting resonant leptogenesis as the origin of baryon asymmetry of the Universe. Explicit higher dimensional lepton number violating operators, are shown to play a crucial role in simultaneously controlling both the Majoron production in the early Universe and the right handed neutrino mass splitting relevant for resonant leptogenesis. We perform a combined analysis of Majoron dark matter and leptogenesis, discussing the relative importance of self energy and vertex contributions to CP asymmetry, and explore the parameter space, leading to an intricate relation between neutrino mass, dark matter and baryon asymmetry
sj-pdf-1-imr-10.1177_03000605221105356 - Supplemental material for Medical laboratory staff satisfaction and their perspective on the role of health institutions to combat COVID-19 pandemic
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221105356 for Medical laboratory staff satisfaction and their perspective on the role of health institutions to combat COVID-19 pandemic by Buddha Bahadur Basnet, Deepa Satyal, Roshan Pandit, Anjila Maharjan, Rashmi Karki, Shyam Kumar Mishra, Srijana GC, Til Bahadur Basnet in Journal of International Medical Research</p
sj-pdf-1-inq-10.1177_00469580221082783 – Supplemental Material for Knowledge, practice and psychological symptoms among medical laboratory staff during COVID-19 pandemic in Nepal: An online based survey
No full textSupplemental Material, sj-pdf-1-inq-10.1177_00469580221082783 for Knowledge, practice and psychological symptoms among medical laboratory staff during COVID-19 pandemic in Nepal: An online based survey by Buddha Bahadur Basnet, Deepa Satyal, Roshan Pandit, Til Bahadur Basnet, Sandeep Khattri and Shyam Kumar Mishra in INQUIRY: The Journal of Health Care Organization, Provision, and Financing</p
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