86,890 research outputs found
Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor.
No full textMinerva Ginecol. 2007 Oct;59(5):481-9.
Clinical practice evaluation of combination of atosiban, ritodrine and ketoprofen for inhibiting preterm labor.
Grignaffini A, Soncini E, Ronzoni E, Lo Cane F, Anfuso S, Nardelli GB.
SourceDepartment of Gynaecology, Obstetrics and Neonatology, University of Parma, Parma, Italy.
Abstract
AIM: The aim of this study was to compare the efficacy and tolerability of atosiban vs ritodrine administered as single-drug or as combination therapy with the COX inhibitor ketoprofen in the treatment of preterm labor and to investigate how frequent is the need for combination therapy with ketoprofen.
METHODS: Ninety-one women with diagnosis of threatened preterm delivery at 24-33 weeks' gestation were enrolled in an observational case-control study. Forty-seven received IV atosiban (6.75 mg initial dose, 300 microg/min loading dose for 3 hours, 100 microg/min maintenance dose for 48-96 hours) and 44 IV ritodrine (0.05-0.3 mg/min). When response to the first drug in the first 2-4 hours was unsatisfactory, ketoprofen was added (100 mg loading dose IV and 100-150 mg maintenance dose every 12 hours) for a maximum of 48 hours.
RESULTS: Ketoprofen was added in 51.1% of the atosiban group and 47.7% of the ritodrine group (P 0.75, not statistically significant). The percentages of women non delivered in the two groups were 85.1% vs 81.8% at 48 hours (P=0.44) and 59.6% vs 54.5% at 7 days (P=0.39). One woman treated with atosiban reported transient dyspnea at the administration of the bolus dose; 20.5% of women who received ritodrine developed tachycardia and 4.5% dyspnea (P=0.001). Neonatal mortality and morbidity were comparable in both groups and unrelated to ketoprofen exposure.
CONCLUSION: Atosiban efficacy was comparable to ritodrine, but with a superior safety profile. A large proportion of women in both groups required second-line ketoprofen therapy, with comparable neonatal outcome
MAINTENANCE of HEPARAN-SULFATE STRUCTURE THROUGHOUT EVOLUTION - CHEMICAL and ENZYMIC DEGRADATION, and C-13 NMR-SPECTRAL EVIDENCE
No full textIST CHIM & BIOCHIM G RONZONI,MILANO,ITALYESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04034 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04034 São Paulo,SP,BRAZILESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04034 São Paulo,SP,BRAZILWeb of Scienc
Magic Factor-1, a partial agonist of Met, induces muscle hypertrophy by protecting myogenic progenitors from apoptosis
No full textPharmacological inhibition of K-Cl cotransport alters in vivo the maturation of normal and b thalassemic human erythroid progenitors.
No full textL’importanza del controllo in corso d’opera e dei test finali a cura della Direzione Lavori
No full textVariations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Data architecture framework for reverse logistics management in reusable food packaging networks
No full textManaging agri-food supply chains requires the concurrent consideration of raw food and packaging materials flows. Unfortunately, packaging contributes to waste generation despite its vital role in ensuring safe distribution. To tackle this issue, the European Union fosters the adoption of reusable primary packaging and the introduction of sustainable closed-loop systems over the traditional based on single-use. Creating closed-loop packaging systems is achievable only through collaborative relationships among actors, stakeholders, and policymakers. Tailored data architectures facilitate the efficiency of such partnerships and collaboration, encouraging the adoption of sustainable paradigms. This paper proposes a data architecture framework that supports high-quality primary data collection for reusable primary packaging supply chains. Furthermore, the data framework aids decision-making processes within circular primary packaging systems, providing economic and environmental metrics. A flexible user interface facilitates the creation of customized output that impels the adoption of sustainability paradigms within the agri-food sector
Monte Carlo-based instance generator for agri-food supply chain operations assessment
No full textAddressing sustainability challenges within the Agri-Food system is pivotal to meeting global food demand without endangering the resilience of ecological systems. However, the complexity of Agri-Food Supply Chain (AFSC) operations and the scarcity and heterogeneity of primary data present significant obstacles to effective management. To tackle such issues, this paper illustrates a novel Agri-food supply chain Monte Carlo-based Istance GeneratOr tool (AMIGO). This tool exploits aggregated demand data and geospatial information on supply chain nodes to generate order release scheduling and realistic distribution pathways according to logistical feasibility. AMIGO design and implementation are outlined, highlighting its key components and operational principles. A case study is presented as a validation testbed. This tool is applied to generate two scenario instances for horticultural products within AFSCs. By varying supply chain features, settings, and configurations, this tool captures the nuanced dynamics of different supply chain configurations. Enabling empirical analysis, AMIGO effectively provides valuable insights into supply chain
management and decision-making. Overall, it aids agri-food industry stakeholders, supports policy-making efforts and fosters innovation in AFSC management
PEEP on quasi-static respiratory compliance and arterial oxygenation in morbidly obese patients undegoing laparoscopic gastric balding
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