1,721,005 research outputs found
Cytoreductive surgery followed by HIPEC repetition for secondary ovarian cancer recurrence.
Full text linkSecondary and tertiary cytoreductive surgery was associated with improved overall survival in platinum-sensitive recurrent ovarian cancer (ROC). Hyperthermic intraoperative intra-peritoneal chemotherapy (HIPEC) is considered an attractive method in the treatment of ROC to deliver chemotherapy with enhanced effect directly at the tumor site. However, another deserving aspect is the feasibility and the oncologic role of HIPEC repetition. Twelve patients affected by secondary ovarian cancer recurrence previously submitted to cytoreduction followed by HIPEC were enrolled for the present study to receive tertiary cytoreduction followed by HIPEC repetition. The median operative time, including time for HIPEC procedure, was 360 min (range 240–540). Average EBL was 325 ml (from 100 to 500 ml). The median hospital stay was of 5 days, from 4 to 10. Low-grade post operatory complications occurred in 2 patients (16.6%) and high-grade complication in 1 case (8.3%). Our study report encouraging data about safety of HIPEC repetition in ovarian cancer treatment
Proteomic Biomarkers for Early Detection and Patients’ Stratification in Ovarian Cancer: A Brief Overview.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Laparo-assisted vaginal radical hysterectomy as a safe option for Minimal Invasive Surgery in early stage cervical cancer: A systematic review and meta-analysis.
Full text linkVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Laparo-assisted vaginal radical hysterectomy as a safe option for minimal invasive surgery in early stage cervical cancer: A systematic review and meta-analysis (vol 166, Pg 188, 2022)
No full textOncovascular surgery in gynecologic oncology: en bloc metastatic lymph node and infiltrated inferior vena cava resection followed by patch reconstruction
No full textAdvanced or recurrent gynecologic cancers with retro-
peritoneal lymphatic disease may involve the inferior
vena cava (IVC) and achieving radical debulking of
the disease in this scenario is challenging.1 2 The
concept ‘oncovascular surgery’ defines the case of
tumor resection with simultaneous reconstruction of
the great vessels when the tumor infiltrates or firmly
adheres to the great vessels.3
The aim of this video is to demonstrate the surgical
procedures for radical en bloc resection of metastatic
lymph nodes and the infiltrated IVC with simultaneous
vascular reconstruction.
The indication for the debulking surgery was a
first isolated recurrence of endometrioid endometrial
cancer grade 2 (first diagnosis International Feder-
ation of Gynecology and Obstetrics (FIGO) stage IB
followed by pelvic external beam radiotherapy) in a patient with good performance status. Bulky precaval
lymph nodes with infiltration of the IVC were identi-
fied, while other distant metastases were excluded.
The multidisciplinary tumor board approved surgery as a treatment option. The lymph node metastasis infiltrated the
IVC with absence of a reliable dissection plane. After systemic
heparin infusion and proximal and distal clamping of the vessel,
we performed an en bloc resection of metastatic lymph nodes
along with the infiltrated portion of the IVC. Subsequent vascular
reconstruction was performed with a bovine patch. A running poly-
propylene suture (Prolene 5/0) was used to fix the patch in place
(Figure 1). An intravascular heparin bolus was injected at the end
of the procedure. Complete removal of macroscopic disease was
achieved. No intra- operative or post- operative complications were
observed.
Tumor debulking with en bloc vascular resection and subsequent
reconstruction is a feasible procedure but requires accurate pre-operative
planning and an experienced surgical team. Gynecologic
oncologists need to be familiar with the concept of ‘oncovascular
surgery’ in order to provide the best curative treatment even in the
challenging case of advanced cancers with vascular involvemen
Cystopexy raises the post-operative complication rate during laparoscopic hysterectomy for uterine prolapse
No full textObjectives: This study aims to compare the outcomes of laparoscopic colposuspension sec Shull (LCSS) and laparoscopic colposacropexy (LCSP) with and without the addition of cystopexy for the treatment of pelvic organ prolapse (POP) in terms of postoperative complications, recurrence rates, and overall effectiveness. Materials and methods: A retrospective case-control analysis was conducted on women treated for grade 3–4 POP-Q uterine prolapse at the Academic Departments of Gynaecology and Obstetrics of “G. Martino” of Messina, Italy, and “L. Vanvitelli” of Napoli, Italy, between November 2020 and February 2022. Group A consisted of patients who underwent laparoscopic hysterectomy followed by LCSS or LCSP without cystopexy. At the same time, Group B included patients who had the same procedures with the addition of cystopexy. Data on complications were collected using the Clavien-Dindo classification, and prolapse recurrence was monitored according to the POP-Q system. Statistical analysis was performed using Fisher's exact, Chi-squared, and Wilcoxon rank-sum tests. Results: A total of 148 patients were included, with 125 in Group A and 23 in Group B. Group B showed a significantly higher rate of postoperative complications (16%) compared to Group A (2.4%) (p = 0.016), with an Odds Ratio of 7.62 (95% CI 1.59–36.51, p = 0.0017). No significant difference between the groups was found in the recurrence rate of prolapse at 24 months (p > 0.9). Conclusion: Adding cystopexy to LCSS or LCSP increases the risk of postoperative complications without reducing prolapse recurrence rates. Further research is needed to identify patients who may benefit from cystopexy and to evaluate its impact on stress incontinence and patient satisfaction
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