13,300 research outputs found
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
An Analysis of <i>Judge Lin</i>
No full textBiography of Lin Wen Zhong Gong has another way to call, that is Judge Lin. The leading character is Lin Ze-Xu. This book is based on functionary experience of Lin Ze-Xu, with the captivating plots of court case, helping by highly skilled military attach\uc3\ua9s and chivalrous knights, and the history facts of Opium War. It makes Lin Ze-Xu\ue2s Confucian temperament and tragic mood more, also contrasts with author\ue2s sorrow and furiousness for the politics at the time. History, court case, martial arts\ue2\ua6\ue2\ua6etc. are essence of this book and it broadens the way of this writing style.
The topic of the thesis is \ue2An Analysis of Judge Lin\ue2. The following thesis will be divided into six different chapters. The introduction is Chapter one of the thesis, which is including researching motive and purpose, literature review of predecessors, researching version by existing information, raising questions, choosing research methods and arranging chapters. In chapter Two, I discuss the study of characters of Lin Ze-Xu, also makes a deep analysis of author\u27s purpose of writing him. In chapter Three, I analyze supporting actors and actress. Meanwhile, I illustrate author\u27s purpose of writing supporting actress because the author had different manner to describe supporting actress. Moving to the Chapter Four, I mainly focus on the plots of Judge Lin, and organize cases of Lin Ze-Xu and his subordinates to understand features of cases. In Chapter Five, I represent the causes of Opium War. China and England had difference of opinions of opium. Therefore, it is easier to comprehend what the author\u27s purpose is. In the last chapter I summarize the main points of the preceding chapters and confirm particularity of Judge Lin
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Lowest electronic states of neutral and ionic LiN
No full textWe have investigated the potential energy curves (PECs) of the LiN heteronuclear diatomic molecule, including its ionic species LiN+ and LiN−, using explicitly correlated multi-reference configuration interaction (MRCI-F12) calculations in conjunction with the correlation consistent quintuple- basis set. The effect of core–valence correlation, scalar relativistic effects, and the size of the basis sets has been investigated. A comprehensive set of spectroscopic constants determined based on the above-mentioned calculations are also reported for the lowest electronic states and all systems, including dissociation energies, harmonic and anharmonic vibrational frequencies, and rotational constants. Additional parameters, such as the dipole moments, equilibrium spin-orbit constants, excitation energies, and rovibrational energy levels, are also documented. We found that the three triplet states of LiN, namely, X 3∑−, A 3Π, and 2 3∑−, exhibit substantial potential wells in the PEC diagrams, while the quintet states are repulsive in nature. The ground state of the anion also shows a deep potential well in the vicinity of its equilibrium geometry. In contrast, the ground and excited states of the cation are very loosely bound. Charge transfer properties of each of these states are also analyzed to obtain an in-depth understanding of the interatomic interactions. We found that the core–valence correlation has a substantial effect on the calculated spectroscopic constants.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Atmospheric Remote Sensin
William E. Hoy, letter to Mr. Ralph Elliot Lin Weber, July 8, 1943, with envelope and newspaper articles
No full textThis letter was sent from William E. Hoy to Mr. Ralph Elliot Lin Weber and is dated July 8, 1943. The letter recounts information about the only baseball game where Hoy, a deaf athlete, was at-bat against Taylor, also a deaf athlete. Mentioned in the letter is a typewritten play by play of the same game, copied from the Enquirer of May 17, 1902. Also included is an envelope and newspaper articles. The envelope, from International League Information, is addressed to Ralph E Lin Weber and has handwritten lists of players of N.Y. and Cincinnati. The newspaper articles are from the Dayton Daily News and the Cincinnati Enquirer and feature pictures of William E. Hoy, the author of the letter
Does Downloading PowerPoint Slides Before the Lecture Lead to Better Student Achievement?: Reply
No full textThis reply responds to a comment by Cannon (2011) that opens the debate on consistency of the effect of downloading PowerPoint slides before lectures on students’ exam performance. Cannon (2011) points out potential endogeneity problems in Chen and Lin (2008) and attempts to explore the unconditional mean effect of downloading PowerPoint slides for the full sample. In this reply, we firstly argue that the estimates in our original article are consistent since the effect of interest is the “conditional†treatment effect but not the unconditional mean effect. We provide explanations for our rationale of estimating the “conditional†treatment effect. Secondly, we propose a modified downloading variable to replicate Cannon’s analysis. Our results suggest that downloading PowerPoint slides before the exam does not produce a significant effect on absent students’ exam performance which is different from the results in Cannon (2011). Our analysis does support Cannon’s argument that students fixed effects are different across different attendance status.
Sophoraflavenone G is the major active compound of sophora flavecens against HCV replication
No full textPlant-derived compounds can provide an alternative approach to new medical therapies with features including effectiveness, lower cost of production and milder side effects in clinical experiments compared with conventional treatments. SF is an important ingredient in a number of Chinese medications used for the treatment of chronic HCV infection and represents an important and largely untapped source of potential antiviral compounds. Results of preliminary screening indicated that SF is the most effective and specific medicine against HCV replication among the 45 test Chinese medicines in HCV-JFH-1 infectious assay. Based on anti-viral guided extraction and fractionation, we discovered the most active anti-HCV compound of SF and MS, 1H NMR, 13C NMR, HMBC and NOESY assays confirm it to be SFG. SFG significantly suppressed HCV replication by almost 90% at a concentration of 10μm. In the HCV replicon system, we demonstrated that SFG inhibited HCV RNA replication. No significant cytotoxicity was observed with higher concentrations of SFG. We further showed that SFG induced lipid storage and increases in LDs size. Enlarged LDs are able to induce changes in the environment around LDs and thus interfere with HCV replication complex formation. Additionally, SFG significantly induced both HO-1 production and antiviral interferon responses that are able to affect different aspects of the HCV life cycle. These findings suggested that SFG could be a new potential drug for HCV treatment in the future.Les composés dérivés de plantes peuvent fournir une approche alternative aux nouvelles thérapies médicales, de par leur efficacité, leur coût de production faible et leurs effets secondaires bénins pendant les expériences cliniques comparé aux traitements conventionnels. SF est un ingrédient important dans de nombreux médicaments chinois utilisés pour le traitement des infections chroniques au virus de le HCV, et représente une source importante et largement inexploitée de composés potentiellement antiviraux. Suite au criblage de composés isolés de SF contre le HCV, dans des expériences d'infectivité du HCV-JFH-1, nous avons découvert le composé le plus actif, et les tests MS, 1H NMR, 13C NMR, HMBC et NOESY ont permis de l'identifier comme étant le SFG. SFG inhibe significativement la réplication du HVC (presque 90%) à une concentration de 10µM. Dans le système de réplicon du HCV, nous avons démontré que le SFG inhibe la réplication de l'ARN du HCV. Aucune cytotoxicité significative n'a été observée avec des concentrations plus élevées de SFG. Nous avons par la suite montrée que le SFG induit le stockage des lipides et l'augmentation de la taille des corps lipidiques. Des LDs plus grands peuvent induire des changements de l'environnement autour des LDs et donc d'interférer avec la formation du complexe de réplication du HCV. De plus, le SFG augmente de façon significative la production de la HO-1 et induit des réponses antivirales de type interféron, qui sont capables d'affecter différents aspects du cycle de vie du HCV. Ces résultats suggèrent que le SFG pourrait potentiellement devenir une nouvelle drogue pour le traitement du HCV dans le futur
[[alternative]]A Study on the Relation of the Citizen’s SubjectiveI Impression on the Spouses from Mainland China and Vietnam and Community Educational Policies in Shu Lin City in Taipei ounty.
No full text[[abstract]]A Study on the Relation of the Citizen’s SubjectiveI Impression on the Spouses from Mainland China and Vietnam and Community Educational Policies in Shu Lin City in Taipei ounty.
Abstract
By：Chou chen- tsung Advisor：Lin en-chung
The purpose of this research is to understand the current situation of the citizen’s subjective impressions on the spouses from Mainland China and Vietnam in Shu Lin City. The survey is carried out by self-designed questionnaires. The parents of the students in 10 ele mentary schools of Shu Lin City were taken as samples, 1000 que stionnaires were released, in which 825 effective copies were responded and returned (reaching a 93.0% share of all return questionnaires). The methods for analyzing the data are adopted from SPSS Statistic Software, which includes avera
ges, standard deviation,t-test,ANOVA…etc to analyze.The main findings are as below:
1. The subjective impression of Shu Lin citizens on the
Mainland spouses tends to be “ordinary” to “slightly
good.”
2. Regarding the subjective impression of Shu Lin citizens
on the Mainland spouses, there is a significant
difference on the four out of six different variants,
which are gender, occupations, marital status, and their
experience of contacting Mainland China spouses.
3. The subjective impression of Shu Lin citizens on the
Vietnamese spouses tends to be “ordinary”to “slightly
good.”
4. Regarding the subjective impression of Shu Lin citizens
on the Vietnamese spouses, there is a significant
difference on the three out of six different variants,
which are occupations, marital status, and educational
background.
5. There is a significant difference on the citizens’
subjective impres sion between the spouses from Mainland
China and those from Vietnam.
“Focus Group Interview” was also practiced to enrich the study. Based on the research result, some suggestions regarding the effective community educational policies are proposed.
1.Publicize the positive impressions of Shu Lin citizens
toward the spouses from Mainland China and Vietnam.
2.More researches and studies should be done by th
government and the academic institutes in order to
facilitate the positive understanding.
3.Encourage the positive reports from the media which
should be carefully regulated by the government and the
non-gover nmental organizations.
4.For schools, enhance multicultural teaching
environment;for the government, host more multicultural
exhibitions about the spouses from Mainland and Vietnam.
5.Make good use of the resources from schools and
communities to popularize the idea of “multicultural
community educati on” as well as to facilitate the
integration of different races.
6.The spouses from Mainland and Vietnam should learn
actively and positively to adapt themselves to the
lifestyles of the ir family and the community; therefore,
they are able to gain more positive interaction and
feedback from the peoplein the community.
Key words: Mainland China spouses, Vietnamese spouses,
Transnational marriage, Subjective impression
Molecular mechanisms of monocyte depletion and CD4+ T-cell persistence during human T-cell leukemia virus infection
No full textHuman T-cell Leukemia Virus type 1 (HTLV-1) was the first human retrovirus discovered in 1980. It is the causal agent of two well characterized human diseases, Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Few treatment options have been developed for ATL and HAM/TSP; the median survival times for ATL remains under a year, and treatment options of HAM/TSP remain palliative in nature. Thankfully the incidence of disease in HTLV-1 infected patients is relatively low, with only approximately 5% of individuals developing ATL and 2% HAM/TSP. One major obstacle in the development of effective therapies is a lack of understanding regarding the factors that determine HTLV-1 associated pathology. The route of transmission, contaminated breast milk and blood, almost exclusively lead to ATL or HAM/TSP development respectively, but it is unclear as to why. This suggests that the early events of HTLV-1 infection may be key in discerning pathological outcomes. Unfortunately this time point is understudied, in part due to the fact that de novo infection is asymptomatic. The activity of cytotoxic T-cell lymphocytes seems to be vital in controlling viral replication, and is likely a key determinant in disease progression. We thus set out to study the early events of HTLV-1 infection in two important immunologically relevant peripheral blood mononuclear cell populations, monocytes and CD4+ T-cells. HTLV-1 infection of primary human monocytes resulted in the depletion of this cell type. This was not mediated by viral accessory proteins, as host restriction factor SAMHD1 prevented the completion of reverse transcription. The DNA by-products of this inhibition induced a potent STING-mediated immunological response, that triggered Bax and IRF3 activation and complex formation that led to apoptosis. Infection of activated CD4+ T-cells on the other hand, resulted in persistent cellular survival. This was mediated by the viral accessory protein Tax, known to have oncogenic properties. Tax expression activated the AKT pathway, which resulted in the inactivation of the pro-apoptotic FOXO3a transcription factor. This led to the long-term survival of an activated CD4+ T-cell population that was capable of viral transmission. Overall this work has demonstrated the molecular consequences of HTLV-1 infection in two important cell types, monocytes and CD4+ T-cells. These events likely shape the subsequent immunological events that control viral replication and likely influence HTLV-1 disease pathology.Le virus T-lymphotropique humain de type 1 (HTLV-1) a été le premier rétrovirus humain à avoir été découvert en 1980. Il est l'agent causal de deux maladies humaines bien caractérisées, la leucémie lymphocytaire de l'adulte (ATL) et la myélopathie associée au HTLV-1/Paraparésie spastique tropicale (HAM / TSP). Peu d'options de traitement ont été développées pour l'ATL et la HAM/TSP; les temps de survie médians pour l'ATL restent inférieurs à un an, et les options thérapeutiques de la HAM/TSP sont de nature palliative. Cependant, l'incidence de la maladie chez les patients infectés par le HTLV-1 est relativement faible, avec seulement environ 5% des individus développant l'ATL et 2% la HAM/TSP. L'obstacle majeur au développement de thérapies efficaces est le manque de compréhension des facteurs qui déterminent la pathologie associée au HTLV-1. Les voies de transmission, le lait maternel contaminé et le sang, entraînent presque exclusivement le développement de l'ATL ou de la HAM/TSP, mais la cause de ceci n'est pas connue. Cela suggère que les premiers événements de l'infection par le HTLV-1 peuvent être la clé pour révéler les conséquences pathologiques de la maladie. Malheureusement, les étapes précoces de l'infection sont peu étudiées, dû au fait que l'infection de novo est asymptomatique. L'activité des lymphocytes T cytotoxiques semble être essentielle pour contrôler la réplication virale et est probablement un facteur clé dans la progression de la maladie. Nous avons donc entrepris d'étudier les premiers événements de l'infection par le HTLV-1 dans deux populations cellulaires mononuclées importantes et immunologiquement pertinentes du sang périphérique, les monocytes et les lymphocytes T CD4+. L'infection des monocytes primaires humains par le HTLV-1 a entraîné la déplétion de ce type cellulaire. Cela n'est pas médiée par les protéines accessoires virales, car le facteur de restriction SAMHD1 a empêché l'achèvement de la transcription inverse. Les sous-produits de l'ADN produits lors de cette inhibition ont induit une réponse immunologique puissante médiée par STING. Ceci a déclenché l'activation des protéines Bax et IRF3 et la formation de complexes qui ont conduit à l'apoptose des cellules.D'autre part, l'infection par le virus des cellules T CD4+ activées, les a fait entrer dans un état de survie cellulaire persistante. Le transactivateur viral Tax en est responsable car il est connu pour ses propriétés oncogéniques. La seule expression de Tax a activé la voie AKT, entraînant l'inactivation du facteur de transcription pro-apoptotique FOXO3a. Cela a conduit à la survie à long terme d'une population de lymphocytes T CD4+ activés capables de transmettre le virus. Ce travail de doctorat a permis de démontrer les conséquences moléculaires de l'infection par HTLV-1 dans deux types cellulaires importants, les monocytes et les cellules T CD4+. Ces événements ont une conséquence sur les évènements immunologiques qui en découlent et qui contrôlent la réplication virale et influencent probablement la pathologie de la maladie dû au HTLV-1
Review of Mayer, R.; Knothe, F.; Shuo, H. (2022) Reflected beauty: Chinese reverse glass paintings from the Mei Lin Collection
No full textIn this well-documented, bilingual, and richly illustrated catalogue, published for the long-anticipated exhibition Reflected Beauty: Chinese Reverse Glass Paintings from the Mei Lin Collection at the University Museum and Art Gallery of the University of Hong Kong (September 2021-January 2022), the authors give us a profound insight into the phenomenon of reverse painting on glass and mirror paintings, with a particular focus on those from the Mei Lin Collection assembled by the Sinologist, author, and translator Rupprecht Mayer and his wife Haitang Mayer-Liem. Composed of over one hundred works acquired in East Asia between 1968 and 2012, this is one of the world's most important collections of Chinese reverse glass paintings from the late nineteenth and twentieth centuries.Modern and Contemporary Studie
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