199,503 research outputs found
Permutads
No full textLoday, JL (Loday, Jean-Louis); Ronco, M (Ronco, Maria)[ 1 ] Univ Talca, Inst Matemat & Fis, Santiago, Chile.We unravel the algebraic structure which controls the various ways of computing the word ((xy)(zt)) and its siblings. We show that it gives rise to a. new type of operads, that we call permutads. A permutad is an algebra over the monad made of surjective maps between finite sets. It turns out that this notion is equivalent to the notion of "shuffle algebra" introduced previously by the second author. It is also very close to the notion of "shuffle operad" introduced by V. Dotsenko and A. Khoroshkin. It can be seen as a noncommutative version of the notion of nonsymmetric operads. We show that the role of the associahedron in the theory of operads is played by the permutohedron in the theory of permutads. (C) 2012 Elsevier Inc. All rights reserved
In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System
No full textBackground/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure. To overcome the limitations in the amount removed by hemofilters, new sorbents with a high biocompatibility are actively being developed. Furthermore, biocompatible sorbents by their nonspecific adsorptive behavior could have great impact on detoxification treatment in exogenous intoxications. We performed an in vitro evaluation of a newly developed highly biocompatible sorbent cartridge (Betasorb(R)), examining its adsorptive capacity concerning therapeutic drugs. Methods: Uremic blood spiked with a range of therapeutic drugs was recirculated for 2 h in an in vitro hemoperfusion circuit containing a Betasorb device for hemoperfusion. The drug concentrations before and after the passage of the cartridge were measured, and the total amount removed was calculated. Results: The sorbent showed effective removal of glycopeptide antibiotics, digoxin, theophylline, phenobarbital, phenytoin, carbamazepine, and valproic acid. Moderate removal could be demonstrated for tacrolimus and cyclosporine A; aminoglycosides were removed to a small extent only. Conclusions: Betasorb hemoperfusion shows a potent adsorptive capacity concerning therapeutic drugs (except aminoglycosides) and could be of major value in the treatment of intoxications. On the other hand, drug monitoring and possible adjustments are necessary during Betasorb hemoperfusion to maintain the therapeutic ranges of the drugs in blood. Copyright (C) 2002 S. Karger AG, Basel
Foreword: Resili(g)ence - Intelligent Cities/Resilient Landscapes
No full textThe Resili(g)ence publication is part of the outputs produced within the European project KAAU, Knowledge Alliance for Advanced Urbanism (www.ka-au.net), Erasmus + program, and consists of two volumes: the first Resili(g)ence Intelligent Cities / Resilient Lanscapes offers reflections on the general framework and on the theme of resilience applied to intelligent cities and the landscape, while the second volume GOA Resili(g)ent City, analyzes the case study of Genoa
Pathophysiology of the Cardiorenal Syndromes Types 1–5: Updates from the Eleventh Consensus Conference of the Acute Dialysis Quality Initiative (ADQI)
No full textAccording to the recent definition proposed by the Consensus conference on Acute Dialysis Quality Initiative Group (Ronco in Cardiorenal Med 1:3–4, 2011), the term cardiorenal syndrome (CRS) has been used to define different clinical conditions in which heart and kidney dysfunction overlap. Type 1 CRS (acute cardiorenal syndrome) is characterized by acute worsening of cardiac function leading to AKI (Ronco in Contrib Nephrol 164:33–38, 2010; Eren et al. in Cardiorenal Med 2:168–176, 2012) in the setting of active cardiac disease such as ADHF, while type 2 CRS occurs in a setting of chronic cardiac decompensation. Type 3 CRS is closely linked to acute kidney injury (AKI), while type 4 represents cardiovascular involvement in patients with chronic kidney disease. Type 5 CRS represents cardiac and renal involvement in several diseases such as sepsis, hepatorenal syndrome, and immune-mediated diseases. Understanding the clinical phenotype of CRS is critical in initiating appropriate therapy and applying the underlying pathophysiologic principles in each subtype to achieve optimal outcomes
«Commento art. 9 D.P.R. 30 maggio 2002, n. 115», in Leggi penali complementari commentate, a cura di A. Gaito-M. Ronco
No full text- …
