132,538 research outputs found
Role of vitamin d receptor activators in cardio-renal syndromes
No full textThe involvement of vitamin D deficiency in cardiovascular morbidity and mortality is attracting great interest. In patients with chronic kidney disease this association is stronger because vitamin D levels decrease as a result of renal progressive impairment. In chronic kidney disease secondary hyperparathyroidism commonly occurs in response to persistent hypocalcemia and hyperphosphatemia; moreover, parathyroid gland volume increases, vascular calcification is accelerated, and structural and functional modifications of the left ventricle are observed. These alterations entail both cardiac and renal involvement, resulting in cardio-renal syndrome. Recent studies concluded that vitamin D administration seems to have cardioprotective and renoprotective effects and improve peripheral vascular disease, vascular calcification, cardiac outcome, and blood pressure control. In clinical practice, therefore, the use of this hormone may play an important role in cardio-renal syndrome prevention
Loggia sul fiume Ronco / Loggia Along the Ronco River
No full text"Loggia Along the Ronco River": complesso multifunzionale con parco e sistema verde in area periurbana nei pressi del fiume Ronco, Forlì.Loggia: Gallery or room with one or more open sides, especially one that forms part of a house and has one side open to the garden. Origin: mid 18th century, from Italian, ‘lodge.’
Pubblicazione di progetto in opera enciclopedica. Autore: Rem Koolhaas et al.; Editore: Taschen. Il progetto 'Loggia Along the Ronco River' (R. Pasini, A. Ranieri, D. Canali, et al.) è un complesso a uso misto con sistema verde in area di frangia urbana nei pressi del fiume Ronco (Forlì). Il progetto è selezionato insieme a Loggia Lanzi, Grand Trianon e Convento de San Antonio a Izamal per rappresentare il tipo della 'loggia'
Mineral metabolism abnormalities and vitamin D receptor activation in cardiorenal syndromes
No full textOver the last decade, it has become increasingly clear that the cardiovascular and renal systems are interdependent. Primary disorders of either system have been shown to disturb the other system. As a result, a class of cardiorenal syndromes (CRS) has been identified wherein a vicious cycle is established as an acute/chronic dysfunction of either the kidney or the heart exacerbates the loss of function in the other organ. Progressive loss of kidney function observed in patients with CRS (mostly types 2 and 4) leads to reduced production of calcitriol (active vitamin D) and an imbalance in calcium and phosphorus levels, which are correlated with increased rates of cardiovascular events and mortality. In addition, hypocalcemia can lead to prolonged and excessive secretion of parathyroid hormone (PTH), eventually leading to development of secondary hyperparathyroidism. Therefore, based on this important mechanism of organ damage, one of the major goals of therapy for patients with CRS is to restore regulatory control of PTH. Although administration of calcitriol increases serum calcium levels and reduces PTH levels, it is also associated with elevated serum levels of calcium-phosphorus product. Therefore, compounds that selectively activate vitamin D receptors, potentially reducing calcium × phosphate toxicity, are likely to enhance cardiorenal protection and provide significant clinical benefit
In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System
No full textBackground/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure. To overcome the limitations in the amount removed by hemofilters, new sorbents with a high biocompatibility are actively being developed. Furthermore, biocompatible sorbents by their nonspecific adsorptive behavior could have great impact on detoxification treatment in exogenous intoxications. We performed an in vitro evaluation of a newly developed highly biocompatible sorbent cartridge (Betasorb(R)), examining its adsorptive capacity concerning therapeutic drugs. Methods: Uremic blood spiked with a range of therapeutic drugs was recirculated for 2 h in an in vitro hemoperfusion circuit containing a Betasorb device for hemoperfusion. The drug concentrations before and after the passage of the cartridge were measured, and the total amount removed was calculated. Results: The sorbent showed effective removal of glycopeptide antibiotics, digoxin, theophylline, phenobarbital, phenytoin, carbamazepine, and valproic acid. Moderate removal could be demonstrated for tacrolimus and cyclosporine A; aminoglycosides were removed to a small extent only. Conclusions: Betasorb hemoperfusion shows a potent adsorptive capacity concerning therapeutic drugs (except aminoglycosides) and could be of major value in the treatment of intoxications. On the other hand, drug monitoring and possible adjustments are necessary during Betasorb hemoperfusion to maintain the therapeutic ranges of the drugs in blood. Copyright (C) 2002 S. Karger AG, Basel
Opinions regarding outcome differences in European and US haemodialysis patients
No full textStudy goal and design. The aim of this evaluation was to understand why outcomes seem to be different in different parts of the world. Ln an attempt to look at this question from a point of view other than that necessarily adopted by epidemiological studies, we decided to explore the personal opinion of a selected group of American (US and European (EU) experts by means of a simple questionnaire. A 13-item questionnaire was sent to 14 internationally recognized opinion leaders in the field of haemodialysis: all seven Europeans and five of the seven Americans responded. The answers to each question were stratified in order to highlight the key differences between the experts in the different continents. Results. Ten of the 12 respondents (six EU and four US) said that dialysis outcomes are better in Europe; nine (six EU and three US) confirmed their opinion after taking patient characteristics into account. When asked to suggest reasons for this difference, the highest score was given to the quality of procedures and medical training with no differences between EU and US physicians. This was followed by three other factors that received the same overall score (financial issues, doctor bedside time and quality of pre-dialysis care), but it is interesting to note that the Europeans attributed considerably greater importance to bedside time than their US counterparts. Conclusion. It seems that the reported difference in dialysis outcomes between Europe and the US is a widely accepted fact. Although directed towards few respondents, our questionnaire does suggest some differences in the approach towards dialysis and endstage renal disease patients
Giovanni Ronco — In memoriam
No full textIl 25 maggio 2022 si è improvvisamente spento a soli 69 anni Giovanni Ronco, un caro amico e uno stimato collega, ma soprattutto anima e fedele custode dell’Atlante Linguistico Italiano (ALI), un progetto a cui si è dedicato con passione e dedizione costanti per l’intero arco della sua vita accademica. La sua collaborazione con l’ALI inizia infatti nel gennaio del 1976 — in concomitanza con il conseguimento della Laurea in Lettere con una tesi in Dialettologia Italiana — dapprima nel ruolo d..
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