1,651 research outputs found
Speed of Publication of Statutes and Regulations in the United Kingdom, Canada, and the United States
No full textExamines reasons for typical delays in publication of statutes & regulations in UK,US, & Canada. Finds US federal laws published more slowly because of time taken to add marginal notes after enactmen
Legal Citation Form: Theory and Practice
No full textSets forth 13 principles as a basis for a system of legal citation forms, and critically reviews various rules in the 13th edition of A Uniform System of Citation
Normative reconstruction and social character of freedom in Axel Honneth
No full textO presente objeto de pesquisa busca proceder ao estudo e identificação dos traços essenciais envolvidos na abordagem teórica das relações sociais e políticas trazidas na obra O Direito da Liberdade do filósofo alemão Axel Honneth. Faz-se uma análise da influência hegeliana sobre o conceito de liberdade, assim como dos fatores relacionados com o suprimento das carências subjetivas, mediadas pelas diferentes “esferas” sociais. Honneth, assim, procura trazer à tona a compreensão de um novo modelo de liberdade advindo da Filosofia do Direito de Hegel, o qual se distingue substancialmente dos modelos tradicionais. O autor busca evidenciar a limitação das teorias da justiça de tradição liberal, invocando a necessidade de uma visão integrada das relações sociais experimentadas nas esferas referidas por Hegel, concebendo-se uma experiência concreta de liberdade social. Nesse sentido, evidencia-se o caráter interdisciplinar e emancipatório do método de reconstrução normativa como base teórica para a justificação pública nas sociedades modernas.This research object aims to study and identify the essential traits involved in the theoretical approach of social and political relations brought in the work Freedom’s Right by the german philosopher Axel Honneth. It analyses the hegelian influence on the concept of freedom, as well as the factors related to the supply of subjective needs, mediated by the different social "spheres". Honneth thus seeks to bring to light the understanding of a new model of freedom stemming from Hegel’s Philosophy of Law, which differs substantially from traditional models. The author seeks to highlight the limitation of liberal theories of justice, invoking the need for an integrated view of the social relations experienced in the spheres referred to by Hegel, conceiving a concrete experience of social freedom. In this sense, the interdisciplinary and emancipatory character of the normative reconstruction method is evidenced, as a theorical basis for public justification in modern societies
PSMA-Liganden PET/CT und -Therapie des Prostatakarzinoms
No full textDie PSMA-PET/CT gilt als die sensitivste und spezifischste Methode zur Rezidiv-Suche des Prostatakarzinoms (PCa). Die Kosten der PSMA-PET/CT werden aktuell von den Versicherungen routinemässig ausschließlich für biochemische Rezidive des PCa übernommen. Die PSMA-Therapie zeigt bei austherapierten Patienten im kastrationsrefraktären, metastasierten Stadium grosses Potential. Sie hat in der Schweiz vor kurzem eine temporäre Zulassung erhalten.La PSMA-PET/CT est considérée comme la méthode la plus sensible et la plus spécifique pour la recherche de récidive du cancer de la prostate (CPa). Les coûts de la PSMA-PET/CT sont
actuellement couramment couverts par les compagnies d'assurance exclusivement pour les récidives biochimiques de la PCa. La thérapie PSMA montre un énorme potentiel chez les patients réfractaires à la castration, métastasés et ayant subi un traitement. En Suisse elle a récemment reçu une autorisation temporaire
Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders
No full textPositron emission tomography (PET) provides dynamic images of the biodistribution of radioactive tracers in the brain. Through application of the principles of compartmental analysis, tracer uptake can be quantified in terms of specific physiological processes such as cerebral blood flow, cerebral metabolic rate, and the availability of receptors in brain. Whereas early PET studies in animal models of brain diseases were hampered by the limited spatial resolution of PET instruments, dedicated small-animal instruments now provide molecular images of rodent brain with resolution approaching 1 mm, the theoretic limit of the method. Major applications of PET for brain research have consisted of studies of animal models of neurological disorders, notably Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD), stroke, epilepsy and traumatic brain injury; these studies have particularly benefited from selective neurochemical lesion models (PD), and also transgenic rodent models (AD, HD). Due to their complex and uncertain pathophysiologies, corresponding models of neuropsychiatric disorders have proven more difficult to establish. Historically, there has been an emphasis on PET studies of dopamine transmission, as assessed with a range of tracers targeting dopamine synthesis, plasma membrane transporters, and receptor binding sites. However, notable recent breakthroughs in molecular imaging include the development of greatly improved tracers for subtypes of serotonin, cannabinoid, and metabotropic glutamate receptors, as well as noradrenaline transporters, amyloid-β and neuroinflammatory changes. This article reviews the considerable recent progress in preclinical PET and discusses applications relevant to a number of neurological and neuropsychiatric disorders in humans
Neuro-PET – ein Update
No full textNeurologische Fragestellungen haben in der Positronen-Emissions-Tomografie seit vielen Jahren einen festen Stellenwert. In dieser Übersichtsarbeit werden in der Klinik gängige Untersuchungsmethoden bei der Demenzdiagnostik, Abklärung von Bewegungsstörungen sowie der Epilepsiediagnostik unter Berücksichtigung aktueller Leitlinien dargestellt und durch aktuelle Entwicklungen in der Wissenschaft erweitert. Ebenso wird die nuklearmedizinische Diagnostik von Hirntumoren samt theragnostischem Ausblick aufgezeigt. In einem weiteren Subkapitel wird die Entwicklung im Bereich der Neuroinflammation erläutert. Insgesamt lässt sich festhalten, dass in der Neuronuklearmedizin in den letzten Jahren einige Neuentwicklungen hervorgebracht wurden, welche sicherlich ihren Stellenwert auch in der klinischen Routine finden werden
Bildgebung bei Epilepsie: Neue Ansätze in Forschung und Praxis
No full textNeue Entwicklungen in der computergestützten Datenklassifikation, Methoden des maschinellen Lernens, Entwicklung von spezifischen Tracersubstanzen und die klinische Anwendung der Hochfeld-MR-Technologie bei Feldstärken <3 Tesla führen zu immer rascher fortschreitenden Entwicklungen in der Epilepsiebildgebung – ein Überblick
The glyoxalase system as an example of a cellular maintenance pathway with relevance to aging
No full textCommentary on: Scheckhuber CQ et al. Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. Aging. 2010; 2:969-980
Artificial intelligence for the detection, quantification and characterization of metastatic prostate cancer in PSMA PET/CT - where are we now?
No full textProstate cancer (PCa) is the most frequent tumor entity in
men worldwide. Since their clinical introduction in 2011,
PSMA-PET/CT and radionuclide therapy with PSMA-ligands
have rapidly spread worldwide and are regarded as significant
step forwards in the diagnosis and therapy of PCa.
However, it is still an unmet challenge to evaluate and control
all tumor lesions including their volume and characteristics
in the complex context of advanced multimetastatic
disease in PSMA-PET/CT. Such a control plays an important
role, e.g. for the optimization of PSMA-ligandtherapy. In
this context, artificial intelligence (AI) could play an important
role in the near future. The rapid development of AI in
the past few years has demonstrated its superiority in extending
the human power of data processing and provides
great potential to improve the detection, quantification
and characterization of metastatic prostate cancer lesions
in PSMA-PET/CT. This paper reviews the current progress
of the development of artificial intelligence methods for
PSMA-PET/CT and discusses the potential of clinical application
- …
