2,839 research outputs found
G runs in cystathionine beta-synthase c.833C/c.844_845ins68 mRNA are splicing silencers of pathogenic 3' splice sites.
No full textThe c.844_845ins68 is an evolutionary conserved polymorphism of the cystathionine beta-synthase gene that segregates with the pathogenic c.833C mutation and consists of a 68nt insertion duplicating the 3' splice site between intron 7 and exon 8. The gene rearrangement brought two GGGG runs close to each other and generated a splicing control element that allows the constitutive selection of the more distal 3' splice site in the c.844_854ins68 carriers. In this study, we have characterized functionally the two G4 runs within the duplication and have found that they work as silencers of the upstream potentially pathogenic 3' splice sites has been functionally characterized. This selection allows skipping of both the 68nt-insertion and the c.833C mutation, and is essential to preserve the wild-type ORF. Knocking down hnRNP H and F expression modulated the rescue of the proximal 3' splice site more than hnRNP H alone. These observations suggest that hnRNP H/F contribute jointly to prevention of CBS deficiency in c.844_854ins68 carriers by silencing the potentially pathogenic upstream acceptor site
Maurizio SANNIBALE, Le armi della collezione Gorga al Museo Nazionale Romano.
No full textVan Wonterghem Frank. Maurizio SANNIBALE, Le armi della collezione Gorga al Museo Nazionale Romano.. In: L'antiquité classique, Tome 69, 2000. pp. 568-569
Maurizio Fora, Epigrafía anfiteatrale dell' Occidente Romano. IV. Regio Italiae I : Latium
No full textRaepsaet-Charlier Marie-Thérèse. Maurizio Fora, Epigrafía anfiteatrale dell' Occidente Romano. IV. Regio Italiae I : Latium. In: L'antiquité classique, Tome 67, 1998. p. 431
I “decostituiti" della "Sapienza”. Santi Romano, Maurizio Maraviglia e Carlo Costamagna
No full textIl contributo analizza le figure dei tre giuspubblicisti dell'Università di Roma "La Sapienza" (Santi Romano, Maurizio Maraviglia e Carlo Costamagna) sottoposti a procedimento di epurazione dopo la cadutra del fascismo
Impresa pubblica e cooperazione allo sviluppo. Italia e Africa tra esperienza storica e attualità
No full textIn light of the teachings of the Magisterium on issues of development and international solidarity, the article outlines the essential characteristics and main economic, cultural and productive implications of the system of collaboration established in the decades following the Second World War by the Italian public companies IRI and ENI with African countries. Starting from the insights offered by historical experience, the article concludes with a reflection on the current state of Italy-Africa relations, marked by the implementation of the Mattei Plan
Tra esigenze nazionali e sviluppo condiviso: Iri ed Eni in Africa negli anni Cinquanta e Sessanta del Novecento
No full textTaking the cue from the recent historiography on the relations between emergent countries and industrialised nations, the essay analyses in a comparative way the industrial, commercial, and cultural implications of the initiatives of collaboration put into action by Eni and Iri in the context of the relations with the African continent in the 1950s-60s
L’Eni in Tunisia. Dalle origini alla nazionalizzazione delle attività petrolifere (1959-1975)
No full textThe article explores the events of the oil collaboration between Eni and Tunisia from the late 1950s to the effects of the oil shock in the first half of the 1970s
Impresa pubblica, internazionalizzazione e rapporti con i paesi in via di sviluppo. Il caso Iri (anni Sessanta – inizio Settanta)
No full textThe contribution aims at providing new elements of analysis on the cooperative strategy put into practice by Istituto per la ricostruzione industriale (Iri) in the context of the relations established with the developing countries, from the beginning of the Sixties to early Seventies of the Twentieth Century
Città, territorio, risorse per l’edilizia. La Veneranda Fabbrica del Duomo di Milano nell’Ottocento preunitario
No full textIl contributo ricostruisce la funzione svolta dalla Veneranda Fabbrica del Duomo di Milano quale polo di sintesi dei rapporti tra centro e periferia, pianura, vie d’acqua e realtà montane dal punto di vista delle relazioni instaurate con il mercato di approvvigionamento dei materiali per l’edilizia nei decenni dell’Ottocento preunitario
‘The originator of Eni’s ideas’. Marcello Boldrini at the top of Agip/Eni (1948–1967)
No full textThe essay highlights Marcello Boldrini’s contribution to the elaboration of Eni’s cultural strategy, focused on the reflection concerning the role played by the State-owned enterprise in the economic development process. Secondly, the international profile of Boldrini's work as a public manager is analysed, particularly with respect to the relationships between Eni and the emerging oil producing countries
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