591 research outputs found
Patterns of regional brain hypometabolism associated with knowledge of semantic features and categories in Alzheimer's disease
No full textThe study of semantic memory in patients with Alzheimer's disease (AD) has raised important questions about the representation of conceptual knowledge in the human brain. It is still unknown whether semantic memory impairments are caused by localized damage to specialized regions or by diffuse damage to distributed representations within nonspecialized brain areas. To our knowledge, there have been no direct correlations of neuroimaging of in vivo brain function in AD with performance on tasks differentially addressing visual and functional knowledge of living and nonliving concepts. We used a semantic verification task and resting 18-fluorodeoxyglucose positron emission tomography in a group of mild to moderate AD patients to investigate this issue. The four task conditions required semantic knowledge of (1) visual, (2) functional properties of living objects, and (3) visual or (4) functional properties of nonliving objects. Visual property verification of living objects was significantly correlated with left posterior fusiform gyrus metabolism (Brodmann's area [BA] 37/19). Effects of visual and functional property verification for nonliving objects largely overlapped in the left anterior temporal (BA 38/20) and bilateral premotor areas (BA 6), with the visual condition extending more into left lateral precentral areas. There were no associations with functional property verification for living concepts. Our results provide strong support for anatomically separable representations of living and nonliving concepts, as well as visual feature knowledge of living objects, and against distributed accounts of semantic memory that view visual and functional features of living and nonliving objects as distributed across a common set of brain area
On-chip Microdialysis System with Flow-through Glucose Sensing Capabilities
No full textThe published version of this article is available at http://www.journalofdst.org/May2007/pdf/VOL-1-3-ORG3-HSIEH.pd
Development of Cognitive and Imaging Biomarkers Predicting Risk of Self-Blaming Bias and Recurrence in Major Depression
No full textThis data-set consists of fully anonymised task-based fMRI
using a value-related moral sentiments task which probes emotions related to
self-blame such as guilt and blaming others, such as anger, structural 3
dimensional T1 weighted and resting-state fMRI data for remitted MDD and
Healthy Control participants taking part in our studies. Data sharing is
stipulated by our MRC-approved data management plan. Basic anonymised clinical
and demographic descriptors are also available.
In addition to the anonymised clinical data, the dataset
also includes anonymised results of standard questionnaires, phenomenological
psychopathology and neurocognitive tasks probing moral sentiments, emotional
memory, action tendencies, and social knowledge which were described in our
papers, alongside some unpublished data which can be used after seeking
permission from the chief investigator. Data from the following publications
are entailed in the dataset which should be cited when using the different
aspects of the data (links to all are provided in the REFERENCES section):
-Gethin
J.A., Lythe K.E., Workman C.I., Mayes A., Moll J., Zahn R. Early life stress
explains reduced positive memory biases in remitted depression. Eur
Psychiatry (2017) 45:59-64: Early life
event classification and emotional recognition memory test
-Workman
C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R.,
Zahn R. A novel resting-state functional MRI signature of resilience to
recurrent depression. Psychological Medicine (2017) 47: 597–607: Resting
state fMRI data with prospective clinical follow-up of remitted MDD
participants over 14 months
-Workman
C.I., Lythe K.E., McKie S., Moll J., Gethin J.A., Deakin J.F.W., Elliott R.,
Zahn R. Subgenual cingulate-amygdala functional disconnection and
vulnerability to melancholic depression. Neuropsychopharmacology (2016) doi:
10.1038/npp.2016.8: Resting state fMRI cross-sectional MDD vs Healthy Control
comparisons
-Lythe
K.E., Moll J., Gethin J.A., Workman C.I., Green S., Lambon Ralph M.A., Deakin
J.F., Zahn R. Self-blame-selective hyperconnectivity between anterior
temporal and subgenual cortices and prediction of recurrent depressive
episodes. JAMA Psychiatry (2015): doi:10.1001/jamapsychiatry.2015.1813:
Prospective fMRI data for prediction of 14 months clinical follow-up in
remitted MDD (Karen Lythe Sample)
-Zahn
R., Lythe K.E., Green S., Gethin J.A., Deakin J.F., Young A.H., Moll J. The
role of self-blame and worthlessness in the psychopathology of major
depressive disorder. Journal of Affective Disorders (2015) DOI: http://dx.doi.org/10.1016/j.jad.2015.08.001: Psychopathological
assessment (AMDP) and moral emotion addendum
-Zahn
R., Lythe K.E., Gethin J.A., Green S., Deakin J.F., Workman C., Moll J.
Negative emotions towards others are diminished in remitted major depression.
European Psychiatry (2015) doi: 10.1016/j.eurpsy.2015.02.005:
VMST=MST(value-related moral sentiment task)
-Green
S., Lambon Ralph M., Moll J., Zakrzewski J., Deakin J.F.W., Grafman J., Zahn
R. The neural basis of conceptual-emotional integration and its role in major
depressive disorder. Social Neuroscience (2013) 8(5): 417-433: CSKD:
conceptual social knowledge differentiation task – unpublished additional
data included in dataset
-Green
S., Moll J., Deakin J.F.W., Hulleman J., Zahn R. Proneness to decreased
negative emotions in major depressive disorder when blaming others rather
than oneself. Psychopathology (2013) 46(1): 34-44: VMST=MST(value-related
moral sentiment task)
-Green
S., Lambon Ralph M., Moll J., Deakin J.F.W., Zahn R. Guilt-selective
functional disconnection of anterior temporal and subgenual cortices in major
depressive disorder. Archives of General Psychiatry (2012) 69(10): 1014-1021:
cross-sectional fMRI (Sophie Green sample)
-Duan
S., Lawrence A., Valmaggia L., Moll J., Zahn R. The role of blame-related
action tendencies
in the vulnerability to major depressive disorder. MedRxiv 2020: https://doi.org/10.1101/2020.11.15.20232058: Action tendencies task
(action)
-Lythe
KE, Gethin JA, Workman CI, Lambon Ralph MA, Deakin JFW, Moll J, et al.
Subgenual activation and the finger of blame: individual differences and
depression vulnerability. Psychol Med 2020: 1-9: Description of autonomy and
sociotropy dimensions of self-blame and its association with fMRI results.
<br
Non-Invasive Glucose Monitoring: A Novel Approach
No full textBackground: The main concern in noninvasive (NI) glucose measurement is achieving high accuracy readings, although no blood (or other fluid) is involved in the process. Using methods based on different physical properties of a measured object can ensure the independence of each of the readings and therefore improve the validity of the end result. By using a combination of (three) independent technologies—ultrasonic, electromagnetic, and thermal—GlucoTrack™ presents a unique approach for a real-time, truly NI blood glucose spot measurement. Methods: Clinical trials were performed in two stages. Stage 1 was an initial method validation and performance verification of the device. In this stage, 50 type 1 and 2 diabetic patients, as well as healthy subjects, were evaluated with GlucoTrack against Ascensia Elite® (Bayer). In the second stage, 85 additional diabetic subjects were evaluated in half and full daytime sessions using a GlucoTrack comparison with HemoCue® (Glucose 201+). Results: A total of 135 subjects were tested during the trial period, producing 793 data pairs. Using Clarke error grid analysis, 92% of the readings fell in the clinically acceptable zones A and B, with 50% in the A zone. Mean and median relative absolute differences were 29.9 and 19.9%, respectively. Conclusions: Integrating several modalities for NI assessment of glucose level enables more accurate readings, while a possible aberration in one modality is bypassed by the others. The present generation of GlucoTrack gives promising results; however, further improvement of the accuracy of the device is needed.The published version of this article is available at http://www.journalofdst.org/amember/plugins/protect/new_rewrite/login.php?v=-any&url=/March2009/Articles/VOL-3-2-SYM4-HARMAN-BOEHM.pdf%3
Hieracium murorum subsp. cophogonium Bornm. & Zahn
No full textHieracium murorum subsp. cophogonium Bornm. & Zahn in Zahn (1925: 161). Ind. loc.: “Frontière bâloise-badoise: Hohr[sic!] M i hr près Zell (A. Krafft). Trouvé aussi par Bornmüller à Tr i bsdorf, près Weimar, dans la Thuringe.” Lectotype (designated here by Gottschlich): — GERMANY. Baden-Wuerttemberg: Hohe M i hr, 11 June 1923, A. Krafft (BREG!). — Remaining syntype: GERMANY. Thuringia: Weimar, Tr i bsdorf, westl. bei d. Bahnbrücke, 8 June 1923, J. Bornmüller (B barcode B 10 0460350!). Remarks: —Although Bornmüller is co-author of the taxon, in the protologue the collection of Krafft is cited first and is here selected as lectotype.Published as part of Vogt, Robert & Gottschlich, Günter, 2023, Type material in the Hieracium (Compositae: Cichorieae) collection of Joseph Bornmüller, pp. 81-126 in Phytotaxa 613 (2) on page 102, DOI: 10.11646/phytotaxa.613.2.1, http://zenodo.org/record/834553
European enlargement and the economic crisis : impact and lasting effects
No full textThis working paper by Rebecca Zahn looks at the effects of the economic crisis on the enlarged European Union and the European Social Model. Starting from an analysis of the well-known Viking and Laval decisions of the European Court of Justice from 2007 and 2008, the author of the report sees increasing tensions between EU member states over “social dumping”, austerity packages and growing inequality between workers. This development results in citizens questioning the benefits of further European integration and threatens the very existence of the European social model
Three hundred eighty thousand year long stable isotope and faunal records from the Red Sea : influence of global sea level change on hydrography
No full textStable isotope and faunal records from the central Red Sea show high-amplitude oscillations for the past 380,000 years. Positive δ18O anomalies indicate periods of significant salt buildup during periods of lowered sea level when water mass exchange with the Arabian Sea was reduced due to a reduced geometry of the Bab el Mandeb Strait. Salinities as high as 53‰ and 55‰ are inferred from pteropod and benthic foraminifera δ18O, respectively, for the last glacial maximum. During this period all planktonic foraminifera vanished from this part of the Red Sea. Environmental conditions improved rapidly after 13 ka as salinities decreased due to rising sea level. The foraminiferal fauna started to reappear and was fully reestablished between 9 ka and 8 ka. Spectral analysis of the planktonic δ18O record documents highest variance in the orbital eccentricity, obliquity, and precession bands, indicating a dominant influence of climatically - driven sea level change on environmental conditions in the Red Sea. Variance in the precession band is enhanced compared to the global mean marine climate record (SPECMAP), suggesting an additional influence of the Indian monsoon system on Red Sea climates
Development of Cognitive and Imaging Biomarkers Predicting Risk of Self-Blaming Bias and Recurrence in Major Depression
No full textM.A., Deakin J.F., Zahn R. Self-blame-selective hyperconnectivity between anterior temporal and subgenual cortices and prediction of recurrent depressive episodes. JAMA Psychiatry (2015): https://doi.org/10.1001/jamapsychiatry.2015.1813: Prospective fMRI data for prediction of 14 months clinical follow-up in remitted MDD (Karen Lythe Sample)-Zahn R., Lythe K.E., Green S., Gethin J.A., Deakin J.F., Young A.H., Moll J. The role of self-blame and worthlessness in the psychopathology of major depressive disorder. Journal of Affective Disorders (2015) DOI: http://dx.doi.org/10.1016/j.jad.2015.08.001: Psychopathological assessment (AMDP) and moral emotion addendum-Zahn R., Lythe K.E., Gethin J.A., Green S., Deakin J.F., Workman C., Moll J. Negative emotions towards others are diminished in remitted major depression. European Psychiatry (2015) https://doi.org/10.1016/j.eurpsy.2015.02.005: VMST=MST(value-related moral sentiment task)-Green S., Lambon Ralph M., Moll J., Zakrzewski J., Deakin J.F.W., Grafman J., Zahn R. The neural basis of conceptual-emotional integration and its role in major depressive disorder. Social Neuroscience (2013) 8(5): 417-433: CSKD: conceptual social knowledge differentiation task – unpublished additional data included in dataset-Green S., Moll J., Deakin J.F.W., Hulleman J., Zahn R. Proneness to decreased negative emotions in major depressive disorder when blaming others rather than oneself. Psychopathology (2013) 46(1): 34-44: VMST=MST(value-related moral sentiment task)-Green S., Lambon Ralph M., Moll J., Deakin J.F.W., Zahn R. Guilt-selective functional disconnection of anterior temporal and subgenual cortices in major depressive disorder. Archives of General Psychiatry (2012) 69(10): 1014-1021: cross-sectional fMRI (Sophie Green sample)-Duan S., Lawrence A., Valmaggia L., Moll J., Zahn R. The role of blame-related action tendencies in the vulnerability to major depressive disorder. MedRxiv 2020: https://doi.org/10.1101/2020.11
Hieracium lachenalii var. pseudoperscissum Zahn 1934
No full text<i>Hieracium lachenalii</i> var. <i>pseudoperscissum</i> Zahn (1934: 540). <p>Ind. loc.: “ Thüringen: Wald am Ruppberg bei Zella → Mehlis (Bornmüller)!”</p> <p> <b>Lectotype (designated here by Gottschlich):</b> — GERMANY. Thuringia: a: Thür. Wald, Zella-Mehlis, Ruppberg, Laubwald, 650 m, 20 July 1928, <i>J. Bornmüller</i>; b: Thür. Wald: Zella-Mehlis, Ruppberg, bei der Oberf i rsterei, 20 July 1928, <i>J. Bornmüller</i> (B barcode B 10 0460357!; isolectotype: GERMANY. Thuringia: Thür. Wald: Zella-Mehlis, am Ruppberg, ca. 6–700 m, 20 July 1928, <i>J. Bornmüller</i> (B barcode B 10 0460358!).—Current name: <i>Hieracium lachenalii</i> subsp. <i>lachenalii</i>.</p> <p> <b>Remarks:</b> —The lectotype bears two labels (a+b). On label “a” Zahn noted the determination. Label “b” seems to be a handwritten copy by Bornmüller. Author and type of <i>Hieracium lachenalii</i> have changed, therefore the current name is <i>H. lachenalii</i> Suter (1802: 145) (subsp. <i>lachenalii</i>). The characters of the variety fall into the phenotypic variation of the type.</p>Published as part of <i>Vogt, Robert & Gottschlich, Günter, 2023, Type material in the Hieracium (Compositae: Cichorieae) collection of Joseph Bornmüller, pp. 81-126 in Phytotaxa 613 (2)</i> on page 96, DOI: 10.11646/phytotaxa.613.2.1, <a href="http://zenodo.org/record/8345535">http://zenodo.org/record/8345535</a>
Continuous-flow, electrically-triggered, single cell-level electroporation
No full textElectroporation creates transient openings in the cell membrane, allowing for intracellular delivery of diagnostic and therapeutic substances. The degree of cell membrane permeability during electroporation plays a key role in regulating the size of the delivery payload as well as the overall cell viability. A microfl uidic platform offers the ability to electroporate single cells with impedance detection of membrane permeabilization in a high-throughput, continuous-fl ow manner. We have developed a fl ow-based electroporation microdevice that automatically detects, electroporates, and monitors individual cells for changes in permeability and delivery. We are able to achieve the advantages of electrical monitoring of cell permeabilization, heretofore only achieved with trapped or static cells, while processing the cells in a continuous-fl ow environment. We demonstrate the analysis of membrane permeabilization on individual cells before and after electroporation in a continuous-fl ow environment, which dramatically increases throughput. We have confi rmed cell membrane permeabilization by electrically measuring the changes in cell impedance from electroporation and by optically measuring the intracellular delivery of a fl uorescent probe after systematically varying the electric fi eld strength and duration and correlating the pulse parameters to cell viability. We fi nd a dramatic change in cell impedance and propidium iodide (PI) uptake at a pulse strength threshold of 0.87 kV/cm applied for a duration of 1 ms or longer. The overall cell viability was found to vary in a dose dependent manner with lower viability observed with increasing electric fi eld strength and pulse duration. Cell viability was greater than 83% for all cases except for the most aggressive pulse condition (1 kV/cm for 5 ms), where the viability dropped to 67.1%. These studies can assist in determining critical permeabilization and molecular delivery parameters while preserving viability.Peer reviewe
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