339 research outputs found
Constitutive activity at the alpha1-adrenoceptors: past and future implications
No full textConstitutive activity at the alpha1-adrenoceptors: past and future implication
The death of drawing : architecture in the age of simulation /
No full text"The Death of Drawing explains how the shift from drawing by to hand to using building information models (BIM) is happening and the effect of this on how architects think and work. Author David Scheer helps you recognize that architectural drawings exist to represent construction and architectural simulations (BIM) exist to anticipate building performance. The values implicit in drawing - patience, care, attention to detail, knowledge of composition, appreciation of well-made things - which architects used to gain through years of drawing practice, don't apply to simulation, so Scheer discusses how losing this vital learning tool might affect your work and and the field of architecture. He also explains that simulation requires you to cast building information in the form of data, which means less of a distinction between designers and constructors, and, based on this, how your interactions with and relevance to clients and collaborators might impact your practice. Finally he reflects on this moment of profound transformation, to remember what drawing has meant to architecture so that you can anticipate what may follow"--Includes bibliographical references (pages 229-234) and index."The Death of Drawing explains how the shift from drawing by to hand to using building information models (BIM) is happening and the effect of this on how architects think and work. Author David Scheer helps you recognize that architectural drawings exist to represent construction and architectural simulations (BIM) exist to anticipate building performance. The values implicit in drawing - patience, care, attention to detail, knowledge of composition, appreciation of well-made things - which architects used to gain through years of drawing practice, don't apply to simulation, so Scheer discusses how losing this vital learning tool might affect your work and and the field of architecture. He also explains that simulation requires you to cast building information in the form of data, which means less of a distinction between designers and constructors, and, based on this, how your interactions with and relevance to clients and collaborators might impact your practice. Finally he reflects on this moment of profound transformation, to remember what drawing has meant to architecture so that you can anticipate what may follow"--Simulation and Representation -- Drawing and Architecture -- Building Information Modeling -- Performativity and Design -- Information Flow and Collaboration -- Computational Design -- Simulation and Design Thinking -- Architectures of Simulation
The MetaMIS Approach for the Specification . . .
No full textThis paper deals with the conceptual specification of management views relevant e.g. for the development of information warehouse systems or other information systems providing information for the management. The term information warehouse is used here to describe a layer oriented architecture storing materialized views on business processes in support of management's information requirements . A data warehouse is located on a central layer of an idealized layer oriented architecture connecting online cf. Scheer (1999); Scheer (2000); Scheer (1998
Helden am Himmel – Helden im Himmel. Sphärenwechsel zu den Sternen im griechischen Mythos.
No full textThe Catasterisms of Pseudo-Eratosthenes and the Astronomia, written by an author named Hyginus are the most important extant sources concerning ancient Greek star-myths. Analysing these texts this paper discusses questions about the reasons and circumstances that lead mythical heroes and heroines to changing the earthly sphere for the heavens in Greek myth. Which conse-quences did these changes inflict on the protagonists concerned? What did it mean to be put among the stars? The texts allowed their audience a wide range of possibilities “to think with”, including divine compassion, gratitude and eternal memory of great deeds as well as presenting warning examples for man-kind on earth. Since when these examples were told, is difficult to assess. The case of the Arkadian heroine Callisto shows how strata of mythical subjects (mythische Stoffe) changed over the centuries. The Homeric Odysseus was told of the ‘Bear’ as an important heavenly constellation, but it seems that it took some centuries before the heroine Callisto reached the sky and this bear finally got a personal name. Authors like Pseudo-Eratosthenes and Hyginus do not express the belief that such a changing of spheres included a happy afterlife or immortal feasting in the presence of the Olympic gods. Nevertheless their read-ers were at liberty to hope for it
Preface
No full textSymposium B of the 2012 E-MRS was held in the Palais de Congrès in Strasbourg, France in May, 2012 and was the 11th in a series of symposia on “Thin Film Chalcogenide Photovoltaic Materials”
Transforming the energy system - the evolution of the German technological system for solar cells
Get PDFTo improve our understanding of processes involved in the formation and growth of new technological systems in the energy sector and to identify the associated key challenges for policy makers managing the transformation process, we examine the development of the German technological system for solar cells over the past twenty-five years. We use a 'technological system' approach in which we will trace the evolution of actors, networks and institutions that have a bearing on the generation and diffusion of solar cells. An initial preparatory stage lasted until about 1989 and was mainly characterised by knowledge build up induced by a Federal RDD programme. This was followed by a second stage characterised by political struggle over the regulatory framework and subsequently the beginning of a virtuous circle for solar cells. In the concluding discussion, we emphasise four key features of the evolution of the technological system: (1) the role of a coalition of system builders which successfully influenced the regulatory framework so that markets could be formed: (2) the considerable length of the learning period and the large number of actors which need to learn; (3) the importance of policies which form early markets (not only early niche markets, but beyond those) as only markets may induce firms to enter and learn, and (4) the need to run market formation policies simultaneous to policies which maintain technological variety.new technology, growth and formation, solar cells, Germany
Analysis and prediction of the performance and reliability of PV modules installed in harsh climates: Case study Iraq
Get PDFThe increasing global demand for renewable energy necessitates a comprehensive understanding of solar photovoltaic (PV) system performance and reliability, particularly in harsh climates such as Iraq. Despite ambitious targets to diversify its energy sector, Iraq faces challenges in the deployment of PV projects due to limited field experience. In this study, we assess the reliability and performance of two different PV systems installed in Basrah and Baghdad, aged 3.5 and 8 years, respectively. Field analysis reveals prevalent issues including glass and cell breakage, delamination, solder bond fatigue, and encapsulant discoloration, contributing to medium degradation rates of 0.91 %/year and 2.6 %/year in Basrah and Baghdad, respectively. Our investigation attributes higher degradation rates not only to ageing but also to suboptimal operation and maintenance (O&M) practices. Additionally, since the two systems are from different manufacturers, we verify that the measured higher degradation rates are mainly attributed to harsh operating conditions rather than differences in manufacturing processes. To extrapolate our findings countrywide, we employ a physics-based model to simulate the degradation rates. Based on the simulated degradation, we proposed four degradation rate zones across the country with degradation rates ranging from 0.62 %/year to 0.96 %/year. By applying these rates to estimate lifetime energy yield across different zones, we demonstrate the trade-offs between higher irradiance zones with reduced PV lifetime and low irradiance zones with longer PV lifetimes. In the study, we compared energy yield simulations using fixed degradation rates with those employing climate-dependent degradation rates. Our analysis revealed that in certain locations in Iraq, employing a fixed degradation rate underestimates the yield by approximately 9.7 %. Conversely, in other locations, it results in overestimations ranging from approximately 10.5 %-31.1 %, highlighting the importance of accurate degradation rate modelling for PV system assessment. Furthermore, we simulate the impact of soiling losses on energy yield, revealing potential losses of up to 70 % depending on location and cleaning schedules. Our findings contribute valuable insights into PV system degradation across harsh climates, addressing critical gaps in global degradation rate data and facilitating more accurate climate-dependent assessments of PV performance and reliability.This study received no funding, and the authors declare no conflict of interest. The authors would like to acknowledge Julian AscencioVasquez ´ for providing processed climatic data used in this study for the mapping. Also, Majid Hamadi Al-Seadi in the Ministry of Oil-Iraq, for the support provided during in the site inspection
Continuation of chronic antiplatelet therapy is not associated with increased need for transfusions: a cohort study in critically ill septic patients
No full textFuchs C, Scheer CS, Wauschkuhn S, et al. Continuation of chronic antiplatelet therapy is not associated with increased need for transfusions: a cohort study in critically ill septic patients. BMC Anesthesiology . 2024;24(1): 146.BACKGROUND: The decision to maintain or halt antiplatelet medication in septic patients admitted to intensive care units presents a clinical dilemma. This is due to the necessity to balance the benefits of preventing thromboembolic incidents and leveraging anti-inflammatory properties against the increased risk of bleeding.; METHODS: This study involves a secondary analysis of data from a prospective cohort study focusing on patients diagnosed with severe sepsis or septic shock. We evaluated the outcomes of 203 patients, examining mortality rates and the requirement for transfusion. The cohort was divided into two groups: those whose antiplatelet therapy was sustained (n=114) and those in whom it was discontinued (n=89). To account for potential biases such as indication for antiplatelet therapy, propensity score matching was employed.; RESULTS: Therapy continuation did not significantly alter transfusion requirements (discontinued vs. continued in matched samples: red blood cell concentrates 51.7% vs. 68.3%, p=0.09; platelet concentrates 21.7% vs. 18.3%, p=0.82; fresh frozen plasma concentrates 38.3% vs. 33.3%, p=0.7). 90-day survival was higher within the continued group (30.0% vs. 70.0%; p0.05).; CONCLUSIONS: The findings suggest that continuing antiplatelet therapy in septic patients admitted to intensive care units could be associated with a significant survival benefit without substantially increasing the need for transfusion. These results highlight the importance of a nuanced approach to managing antiplatelet medication in the context of severe sepsis and septic shock. © 2024. The Author(s)
Review of \u3ci\u3eGovernor Lady: The Life and Times of Nellie Tayloe Ross\u3c/i\u3e By Teva J. Scheer
Get PDFNellie Tayloe Ross, governor of Wyoming from January 5, 1925-January 3, 1927, was sworn into office fifteen days before Miriam Ferguson in Texas, a precedence that earned the former a lasting legacy as the nation\u27s first woman governor. The novelty of her status and her elegant charm won Ross the attention of her contemporaries. A series of autobiographical essays titled Governor Lady, published in 1927 by Good Housekeeping, fed the interests of an admiring public. A more recent tribute is Teva Scheer\u27s Governor Lady: The Life of Times of Nellie Tayloe Ross. How should history evaluate the nation\u27s first woman governor? asks the author. For despite Ross\u27s later accomplishments as an organizer for the national Democratic Party and director of the U.S. Mint, it is as Wyoming\u27s governor that she is most remembered. Scheer\u27s evaluation, reflecting extensive research, is an affirmative one that recognizes Ross\u27s historical significance and argues her continuing importance.
Even as Ross extolled the virtues of hearth and home, after her husband\u27s death in 1924 she would seldom devote her own energies there. Ross\u27s story involves copious context, ranging from late nineteenth-century farming conditions to early twentieth-century monetary policy, from the nuances of Wyoming state politics through the years to postsuffrage feminism. Ross is described as a kindergarten teacher in Omaha and wife in Cheyenne, as gubernatorial candidate in the West and Chautauqua speaker in the East, as a political outsider among former suffragists and a Washington, D.C., insider during a succession of administrations. Explaining these shifts involves introducing a swelling cast of characters and conditions as much as portraying the woman herself.
Scheer describes Ross as the Missouri-born child of former slave owners, accounting for her Southern manners and perhaps some racist comments revealed in Ross\u27s later correspondence. She connects Ross with the typical middle-class American woman of her era, in contrast to her college-educated contemporaries who also distinguished themselves as female firsts in the public sector
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