275 research outputs found
Good Night, Bat! : Good Morning, Squirrel! by P. Meisel
No full textMeisel, Paul. Good Night, Bat! : Good Morning, Squirrel! Highlights, 2016.Paul Meisel, Geisel Honor award winning author and illustrator, creates a humorous story about friendship and miscommunication. This fictional picture book follows homeless Bat on his journey to finding the perfect new home. Through whimsical mis-read notes the friendship between Bat and Squirrel blossoms.The literary content in this story is invaluable for young readers. Meisel demonstrates the complexities of the English language by playing with simple words and phrases while demanding that readers also read the images. This play on words offers a charming world in which young children can explore and expand upon their vocabulary.Complimenting this hilarious story are illustrations that demand the reader’s attention. At a first glance, the visuals appear gloomy due to the brown, green and grey tones. However, the expressions of Bat and Squirrel, along with the simple but easily misunderstood leaf note’s enable young readers to become enthralled in the world of Bat and Squirrel.Combining the two essential features of playing with language and reading illustrations, Good Night, Bat! Good Morning, Squirrel! is an essential read-aloud story for any early childhood classroom.Highly Recommended: 4 out of 4 starsReviewer: Leah Den HaanLeah Den Haan is a grade one French immersion teacher with Edmonton Public Schools. She has always enjoyed children’s literature and loves sharing her love of reading with her students on a daily basis.</jats:p
Un film peut en cacher un autre. À propos des différentes versions du Cuirassé Potemkine et de la réapparition de la mise en musique d’Edmund Meisel
No full textLe Cuirassé Potemkine d’Eisenstein connut, lors de sa distribution en Allemagne, un accompagnement musical dû au compositeur Edmund Meisel qui fit sensation et enthousiasma le réalisateur quand il put l’entendre. Cet accompagnement mythique, perdu puis retrouvé, donna lieu à des projections-concerts dans les dernières décennies. Cependant la découverte récente au Musée des techniques de Vienne de disques appartenant à la version sonorisée du film lors de sa ressortie en 1931 est un événement sans doute plus important : c’est Meisel lui-même qui reprit sa partition, introduisit des chœurs chantés par la troupe de Piscator, dans cette version « oubliée » du film dont on avait retranché les cartons pour en faire un film sonore. L’auteur retrace l’ensemble de la question des différentes versions du film et des différentes musiques qu’on lui adjoignit, question qui révèle bien d’autres enjeux que simplement musicaux : idéologiques, politiques, économiques.Eisenstein’s Battleship Potemkin, when shown in Germany, was accompanied by a musical composition by Edmund Meisel, which thrilled audiences and its director, upon hearing it. The rediscovery of this mythic accompaniment has given way to several silent film concerts over the past few decades. Yet, the recent unearthing at the Vienna Museum of Technology of records from the 1931 synchronized sound release is an even more important event. In this « forgotten » sound version of the film, whose subtitles had been removed, Meisel himself reworked his score and introduced choruses sung by the Piscator company. The author retraces the question of different film versions and their associated music, a question that reveals many other stakes beyond music : ideological, political, economic
Corrigendum: Efficient in vitro generation of IL-22-secreting ILC3 from CD34+ hematopoietic progenitors in a human mesenchymal stem cell niche
No full textHuman iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature
No full textBackground: Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSCs that circumvent these aging-associated drawbacks. To date, the extent of the retention of aging-hallmarks in iMSCs differentiated from iPSCs derived from elderly donors remains unclear. Methods: Fetal femur-derived MSCs (fMSCs) and adult bone marrow MSCs (aMSCs) were isolated, corresponding iPSCs were generated, and iMSCs were differentiated from fMSC-iPSCs, from aMSC-iPSCs, and from human embryonic stem cells (ESCs) H1. In addition, typical MSC characterization such as cell surface marker expression, differentiation capacity, secretome profile, and trancriptome analysis were conducted for the three distinct iMSC preparations - fMSC-iMSCs, aMSC-iMSCs, and ESC-iMSCs. To verify these results, previously published data sets were used, and also, additional aMSCs and iMSCs were analyzed. Results: fMSCs and aMSCs both express the typical MSC cell surface markers and can be differentiated into osteogenic, adipogenic, and chondrogenic lineages in vitro. However, the transcriptome analysis revealed overlapping and distinct gene expression patterns and showed that fMSCs express more genes in common with ESCs than with aMSCs. fMSC-iMSCs, aMSC-iMSCs, and ESC-iMSCs met the criteria set out for MSCs. Dendrogram analyses confirmed that the transcriptomes of all iMSCs clustered together with the parental MSCs and separated from the MSC-iPSCs and ESCs. iMSCs irrespective of donor age and cell type acquired a rejuvenation-associated gene signature, specifically, the expression of INHBE, DNMT3B, POU5F1P1, CDKN1C, and GCNT2 which are also expressed in pluripotent stem cells (iPSCs and ESC) but not in the parental aMSCs. iMSCs expressed more genes in common with fMSCs than with aMSCs. Independent real-time PCR comparing aMSCs, fMSCs, and iMSCs confirmed the differential expression of the rejuvenation (COX7A, EZA2, and TMEM119) and aging (CXADR and IGSF3) signatures. Importantly, in terms of regenerative medicine, iMSCs acquired a secretome (e.g., angiogenin, DKK-1, IL-8, PDGF-AA, osteopontin, SERPINE1, and VEGF) similar to that of fMSCs and aMSCs, thus highlighting their ability to act via paracrine signaling. Conclusions: iMSCs irrespective of donor age and cell source acquire a rejuvenation gene signature. The iMSC concept could allow circumventing the drawbacks associated with the use of adult MSCs und thus provide a promising tool for use in various clinical settings in the future.</p
Efficient In Vitro Generation of IL-22-Secreting ILC3 From CD34+ Hematopoietic Progenitors in a Human Mesenchymal Stem Cell Niche
No full textInnate lymphoid cells (ILCs) and in particular ILC3s have been described to be vital for mucosal barrier functions and homeostasis within the gastrointestinal (GI) tract. Importantly, IL-22-secreting ILC3 have been implicated in the control of inflammatory bowel disease (IBD) and were shown to reduce the incidence of graft-versus-host disease (GvHD) as well as the risk of transplant rejection. Unfortunately, IL-22-secreting ILC3 are primarily located in mucosal tissues and are not found within the circulation, making access to them in humans challenging. On this account, there is a growing desire for clinically applicable protocols for in vitro generation of effector ILC3. Here, we present an approach for faithful generation of functionally competent human ILC3s from cord blood-derived CD34+ hematopoietic progenitors on layers of human mesenchymal stem cells (MSCs) generated in good manufacturing practice (GMP) quality. The in vitro-generated ILC3s phenotypically, functionally, and transcriptionally resemble bona fide tissue ILC3 with high expression of the transcription factors (TF) RorγT, AHR, and ID2, as well as the surface receptors CD117, CD56, and NKp44. Importantly, the majority of ILC3 belonged to the desired effector subtype with high IL-22 and low IL-17 production. The protocol thus combines the advantages of avoiding xenogeneic components, which were necessary in previous protocols, with a high propensity for generation of IL-22-producing ILC3. The present approach is suitable for the generation of large amounts of ILC3 in an all-human system, which could facilitate development of clinical strategies for ILC3-based therapy in inflammatory diseases and cancer
La narrativa subversiva en la fotografía de moda de Steven Meisel
No full textEn esta tesis se aborda la obra fotográfica de Steven Meisel (1954–), caracterizada por un
posicionamiento activista dentro del mundo de la moda, en el que se inscribe, que lo hacen
singular. En la hipótesis principal se señala cómo un discurso subversivo como el suyo aúna
el enfoque comercial propio de la fotografía de moda y el artivismo. De este modo, en el
análisis en profundidad de su producción se incluye un cuestionamiento sobre los impulsos
que le han motivado a adoptar un discurso de este tipo, y se aborda comparativamente,
entre otras, obras de LaChapelle, Knight, Leibovitz, Weber, Toscani o Avedon. También
se alude a las teorías de Crane o Gans, que muestran la desarticulación de los modos de
producción cultural, al tiempo que se compara las posiciones sobre el concepto mismo de
arte en Krauss y Becker.
En el trabajo, estructurado en dos partes, se ha empleado una metodología inductiva y
correlacional que rastrea las correspondencias dadas entre las praxis plásticas revolucionarias
y la fotografía de moda en una horquilla cronológica que va desde el invento del medio
hasta la actualidad. Esto ha permitido identificar las connotaciones activistas, definir su
dimensión plástica y creativa, además de estudiar su influencia sociocultural. Como
conclusión, se afirma que su imaginario y estrategias creativas, cargados de crítica social,
cultural y política, rebasan la mera función comercial propia de la fotografía de moda para
establecerse en una alternativa creativa insurgente. Igualmente, el análisis semántico e
iconográfico de su producción destaca el modo en el que sus imágenes interaccionan con
conceptos y valores culturales diferentes según las temáticas que este autor trata.This thesis deals with the photographic work of Steven Meisel (1954–), characterized by
an activist stance in the fashion world, to which he belongs, making him unique. In the
main hypothesis, we signal how a subversive discourse as his own brings together the
commercial approach, characteristic of the fashion world, as well as artivism. This way, the
in-depth analysis of his production includes a reconsideration of the impulses that have
driven him to embrace such a discourse, and there is a comparative approach of, amongst
others, the works of LaChapelle, Knight, Leibovitz, Weber, Toscani or Avedon. There is also
an allusion to the theories of Crane or Gans, which show the dislocation of every mean of
cultural production, whilst comparing the stands about the very concept of art of Krauss
and Becker.
The paper, structured in two sections, uses an inductive and correlational methodology that
traces the correlations arising between the ground breaking aesthetic praxis and fashion
photography in the time spawn ranging from the invention of the medium up to present
days. This has made it possible to identify the activist connotations, defining its plastic
and creative dimension, as well as studying its sociocultural influence. To conclude, it’s
claimed that its imaginary and creative strategies, loaded with social, cultural, and political
criticism, surpass the mere commercial function intrinsic to fashion photography to stablish
themselves in an insurgent creative alternative. Likewise, the semantic and iconographic
analysis of its production outlines the way in which its images interact with concepts and
cultural values that vary depending on the topic discussed by the author
A Playground for Skopje: A Tension Between Freedom and Constraints
No full textThe graduation project is a playground in and around the former Post Office of Skopje which is composed of three main elements. Firstly, the terrain of the complex is divided into four main fields, which vary from their immediate surroundings towards the city. Furthermore, the element of the bridge, which grows with its tentacles into these different zones, is located on the axis from the city to the river and thus decentralises the existing building. Lastly, the circular Post Office plays the role of the cohesive host of all the elements, bringing with it the factor of time.Positions in PracticeArchitecture, Urbanism and Building Science
Gas Taxes
No full textResearch of Fuel Motor Tax and a Proposal to Reduce federal tax rateSpring 2012 PMAccompanied by video fil
Darkness: Joseph Conrad and Harriet Beecher Stowe
No full textThe article focusses on a multi-aspect comparative analysis of J. Conrad’s Heart of Darkness and H. B. Stowe’s Uncle Tom’s Cabin. Taking into account the obvious differences between the works, the author analyses the hell of slavery and exploitation of Africa by the colonial states that built systems that created criminals such as Kurtz and Legree. The author presents the genealogy of Conrad’s image of tortured Africa, the prefiguration of which is found in Polish romantic messianism. The article also presents a similar reception of both works. First, they gained recognition, then in the postwar period, they were criticized for the forms of racism hidden in them, and finally, in recent decades, they have been rehabilitated by new readings. The perspective presented here shows how women’s popular prose covertly influenced Conrad’s intertextual tendency, both his poetics and the worldview of his prose
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DESIGN FOR(E!) ADDITIVE MANUFACTURING: IN SEARCH OF A COMPREHENSIVE DESIGN CHALLENGE SUITABLE ACROSS AM EDUCATION
No full textModern engineering design education relies heavily on the concept of problem-based learning
(PBL). Driven by the constructivist theory of education, PBL enables students to build
knowledge organically, rather than through rote memorization. As such, design for additive
manufacturing (DfAM) education also tends to emphasize the use of PBL to encourage student
learning. Unfortunately, dedicated DfAM education is still nascent. The result is a wide range of
educators leveraging an equally wide, and often unproven, range of design challenges to support
DfAM PBL. Because of this, there is the possibility that a chosen design challenge will not
represent AM as a true end-use manufacturing process nor promote a design space that can
benefit from the full consideration of all opportunistic and restrictive DfAM concepts. In this
paper, the author discusses the creation and implementation of a comprehensive design challenge
that is suitable across the range of AM education. Specifically, the author proposes the use of a
golf putter DfAM design challenge. This concept draws from lessons learned over years of
DfAM instruction at undergraduate and graduate levels and is based in the need for three key
aspects for a successful DfAM challenge in education: (1) clarity, (2) applicability, and (3)
demonstrability.Mechanical Engineerin
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