1,721,060 research outputs found
The role of Ca2+/calmodulin-dependent kinase II in normal and abnormal early postnatal development
No full textTHE ROLE OF CA2+/CALMODULIN-DEPENDENT KINASE II
IN NORMAL AND ABNORMAL EARLY POSTNATAL DEVELOPMENT
RICHARD GUSTIN
Dissertation under the direction of Professor Roger J. Colbran
Ca2+/calmodulin-dependent kinase II (CaMKII) is known to play important roles in mechanisms underlying molecular memory and has been shown to be misregulated in adult rodent models of altered learning and memory. However, the regulation and role of CaMKII during development in vivo is poorly understood. In this dissertation I have taken advantage of three rodent models of genetic (Angelman Syndrome and CaMKIIα-Thr286Ala knock-in) and environmental (Early-Life Stress) perturbation to assess the role of CaMKII during development. I was able to show that maternal imprinting of UBE3A in a mouse model of Angelman Syndrome (AS) was not brain region specific, but extended throughout the brain as well as in peripheral tissues, presumably contributing to the broad neurological and peripheral phenotypes of the AS mice and human AS patents. Studies with this AS mouse model led me to hypothesize that the previously reported CaMKII misregulation was potentially due to deficient maternal care provided by AS dams. This led to the adoption of an early-life stress (ES) paradigm in mice, where I was able to establish that CaMKII was misregulated in the ES mice. The ES animals also showed synaptic transmission deficits lasting into adulthood that may account for some of the previously reported behavioral deficits in this model. Phosphorylation of CaMKIIα at Thr286 renders the kinase autonomously active. To specifically test the role of CaMKIIα-Thr286 phosphorylation during development I used a transgenic mouse model, CaMKIIα-Thr286Ala knock-in mouse, where I was able to identify an early-life novel object recognition deficit associated with CaMKII misregulation and altered localization. Overall, I determined that genetic and environmental perturbations that alter CaMKIIα regulation during development also alter synaptic transmission and learning and memory long-term. Furthermore, I have shown that altering the ratio of specific CaMKII isoforms that make up the holoenzyme is able to cause differential association with protein complexes that can have significant effects on learning and memory
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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